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Conserved domains on  [gi|767957107|ref|XP_011516859|]
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protein crumbs homolog 2 isoform X4 [Homo sapiens]

Protein Classification

EGF_CA and LamG domain-containing protein( domain architecture ID 10810331)

EGF_CA and LamG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 400-523 2.23e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   400 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 478
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767957107   479 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 523
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 588-708 1.00e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  588 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 657
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957107  658 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 708
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 256-291 6.35e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  256 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 291
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 82-117 2.18e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.18e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107   82 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 117
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 43-79 2.65e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767957107   43 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 79
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 119-156 1.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767957107  119 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 156
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 835-959 5.73e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member pfam00054:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 5.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   835 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 911
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767957107   912 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 959
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 293-328 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  293 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 328
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 746-776 2.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   746 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 776
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 161-194 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767957107  161 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 194
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 995-1025 2.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   995 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1025
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-575 9.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 767957107  548 PCVHGGSCVDLWTHFRCDCARPHRGPTC 575
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 400-523 2.23e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   400 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 478
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767957107   479 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 523
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 588-708 1.00e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  588 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 657
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957107  658 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 708
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
396-523 6.30e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 6.30e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    396 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 473
Cdd:smart00282    2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767957107    474 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 523
Cdd:smart00282   79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
606-709 1.90e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 1.90e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    606 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 658
Cdd:smart00282    1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767957107    659 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 709
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 611-709 4.83e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 4.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   611 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 665
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767957107   666 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 709
Cdd:pfam02210   81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 256-291 6.35e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  256 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 291
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 82-117 2.18e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.18e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107   82 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 117
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 43-79 2.65e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767957107   43 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 79
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
255-291 4.52e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.52e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107    255 EVDECASR-PCLNGGHCQDLPNGFQCHCPDGY-AGPTCE 291
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
81-117 8.05e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 8.05e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107     81 EVDECASA-PCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 117
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
43-79 1.42e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.42e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107     43 DIDECASR-PCHHGATCRNLADRYECHCPLGY-AGVTCE 79
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 119-156 1.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767957107  119 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 156
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
835-959 5.73e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 5.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   835 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 911
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767957107   912 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 959
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA smart00179
Calcium-binding EGF-like domain;
119-156 7.09e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.09e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107    119 DLDECQS-QPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 156
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 293-328 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  293 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 328
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 396-521 1.78e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  396 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 473
Cdd:cd00110    24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767957107  474 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 521
Cdd:cd00110   100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 807-952 2.53e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  807 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 884
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957107  885 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 952
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
831-956 2.60e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 2.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    831 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 908
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767957107    909 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 956
Cdd:smart00282   75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
293-328 6.77e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767957107    293 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 328
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 259-289 9.29e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.29e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   259 CASRPCLNGGHCQDLPNGFQCHCPDGYAGPT 289
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 746-776 2.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   746 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 776
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 747-777 3.61e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.61e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767957107  747 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 777
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 47-75 6.74e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 6.74e-05
                           10        20
                   ....*....|....*....|....*....
gi 767957107    47 CASRPCHHGATCRNLADRYECHCPLGYAG 75
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 161-194 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767957107  161 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 194
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 85-115 2.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.56e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107    85 CASAPCLHGGSCLDGVGSFRCVCAPGYGGTR 115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
161-194 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.39e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767957107    161 ECASA-PCEHNASCLEGLGSFRCLCWPGYS-GELCE 194
Cdd:smart00179    4 ECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 297-327 1.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   297 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 327
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 995-1025 2.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   995 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1025
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 997-1027 4.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.56e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767957107  997 PSPCLHDGACRDLFDAFACACGPGWEGPRCE 1027
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 162-191 8.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.40e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 767957107   162 CASAPCEHNASCLEGLGSFRCLCWPGYSGE 191
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
791-985 9.08e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 40.00  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  791 PATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRG 870
Cdd:COG0515   255 YQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAAAAA 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  871 GHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLG 950
Cdd:COG0515   335 ALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAAAAA 414

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767957107  951 RVALGGLPLPLARPRPGAAPGAREHFASWPGTPAP 985
Cdd:COG0515   415 AAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAA 449
EGF_CA smart00179
Calcium-binding EGF-like domain;
747-777 9.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.33e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767957107    747 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 777
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-575 9.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 767957107  548 PCVHGGSCVDLWTHFRCDCARPHRGPTC 575
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 400-523 2.23e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   400 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 478
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767957107   479 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 523
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 588-708 1.00e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  588 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 657
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957107  658 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 708
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
396-523 6.30e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 6.30e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    396 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 473
Cdd:smart00282    2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767957107    474 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 523
Cdd:smart00282   79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
606-709 1.90e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 1.90e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    606 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 658
Cdd:smart00282    1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767957107    659 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 709
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 611-709 4.83e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 4.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   611 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 665
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767957107   666 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 709
Cdd:pfam02210   81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 256-291 6.35e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  256 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 291
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 82-117 2.18e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.18e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107   82 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 117
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 43-79 2.65e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767957107   43 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 79
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
255-291 4.52e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.52e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107    255 EVDECASR-PCLNGGHCQDLPNGFQCHCPDGY-AGPTCE 291
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
81-117 8.05e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 8.05e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107     81 EVDECASA-PCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 117
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
43-79 1.42e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.42e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107     43 DIDECASR-PCHHGATCRNLADRYECHCPLGY-AGVTCE 79
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 119-156 1.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767957107  119 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 156
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
835-959 5.73e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 5.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   835 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 911
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767957107   912 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 959
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA smart00179
Calcium-binding EGF-like domain;
119-156 7.09e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.09e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767957107    119 DLDECQS-QPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 156
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 293-328 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957107  293 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 328
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 396-521 1.78e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  396 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 473
Cdd:cd00110    24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767957107  474 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 521
Cdd:cd00110   100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 807-952 2.53e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  807 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 884
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957107  885 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 952
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
831-956 2.60e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 2.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107    831 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 908
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767957107    909 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 956
Cdd:smart00282   75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
400-526 4.39e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 4.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   400 FRTTLPAGTLAT--RNDTKESLELALVAATLQaTLWSYSTTVLVLRLPDLaLNDGHWHQVEVVL--HLATLELRlwheGC 475
Cdd:pfam00054    1 FRTTEPSGLLLYngTQTERDFLALELRDGRLE-VSYDLGSGAAVVRSGDK-LNDGKWHSVELERngRSGTLSVD----GE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767957107   476 pARLCVAS--GP-----------VALASTASATPLPAGISSAqlgdatFAGCLQDVRVDGHLLL 526
Cdd:pfam00054   75 -ARPTGESplGAttdldvdgplyVGGLPSLGVKKRRLAISPS------FDGCIRDVIVNGKPLD 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
293-328 6.77e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767957107    293 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 328
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 259-289 9.29e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.29e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   259 CASRPCLNGGHCQDLPNGFQCHCPDGYAGPT 289
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 835-956 1.46e-05

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 45.87  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107   835 FRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVlpIPGPRVADGAWHRVRLAMERPAATtsrwlLWLDG 914
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL--SSGKNLNDGQWHSVRVERNGNTLT-----LSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767957107   915 AATPVALRGLASDLGFLQGP---GAVRILLA-------ENFTGCLGRVALGG 956
Cdd:pfam02210   74 QTVVSSLPPGESLLLNLNGPlylGGLPPLLLlpalpvrAGFVGCIRDVRVNG 125
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 746-776 2.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   746 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 776
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 747-777 3.61e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.61e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767957107  747 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 777
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 47-75 6.74e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 6.74e-05
                           10        20
                   ....*....|....*....|....*....
gi 767957107    47 CASRPCHHGATCRNLADRYECHCPLGYAG 75
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 161-194 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767957107  161 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 194
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 85-115 2.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.56e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107    85 CASAPCLHGGSCLDGVGSFRCVCAPGYGGTR 115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 258-291 3.55e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767957107  258 ECA-SRPCLNGGHCQDLPNGFQCHCPDGYAGP-TCE 291
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
161-194 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.39e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767957107    161 ECASA-PCEHNASCLEGLGSFRCLCWPGYS-GELCE 194
Cdd:smart00179    4 ECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 84-117 1.52e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767957107   84 ECA-SAPCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 117
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYtGDRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 297-327 1.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   297 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 327
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 264-285 2.05e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.05e-03
                           10        20
                   ....*....|....*....|..
gi 767957107   264 CLNGGHCQDLPNGFQCHCPDGY 285
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 995-1025 2.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767957107   995 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1025
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 46-79 2.95e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 2.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767957107   46 ECA-SRPCHHGATCRNLADRYECHCPLGYAGV-TCE 79
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 997-1027 4.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.56e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767957107  997 PSPCLHDGACRDLFDAFACACGPGWEGPRCE 1027
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 90-111 4.73e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 4.73e-03
                           10        20
                   ....*....|....*....|..
gi 767957107    90 CLHGGSCLDGVGSFRCVCAPGY 111
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 162-191 8.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.40e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 767957107   162 CASAPCEHNASCLEGLGSFRCLCWPGYSGE 191
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
791-985 9.08e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 40.00  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  791 PATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRG 870
Cdd:COG0515   255 YQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAAAAA 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957107  871 GHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLG 950
Cdd:COG0515   335 ALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAAAAA 414

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767957107  951 RVALGGLPLPLARPRPGAAPGAREHFASWPGTPAP 985
Cdd:COG0515   415 AAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAA 449
EGF_CA smart00179
Calcium-binding EGF-like domain;
747-777 9.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.33e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767957107    747 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 777
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-575 9.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 767957107  548 PCVHGGSCVDLWTHFRCDCARPHRGPTC 575
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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