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Conserved domains on  [gi|767957309|ref|XP_011516931|]
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tenascin isoform X17 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1525-1734 2.84e-116

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 366.08  E-value: 2.84e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1525 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1603
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1604 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1675
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957309  1676 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1734
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 5.51e-21

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 5.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401   263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401   336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1070 STAKEPEIGNL-NVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVY----L 1144
Cdd:COG3401   416 TTASAASGESLtASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSvttgS 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1145 SGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFD--NFVLKIRDTKKQSEPLEITLLAPERTRDI 1222
Cdd:COG3401   496 LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDvlITDLVSLTTSASSSVSGAGLGSGNLYLIT 575

                         410
                  ....*....|....*....
gi 767957309 1223 TGLREATEYEIELYGISKG 1241
Cdd:COG3401   576 TLGGSLLTTTSTNTNDVAG 594
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1153-1504 6.24e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 6.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1153 TKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYE 1232
Cdd:COG3401    37 LVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1233 IELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRL 1311
Cdd:COG3401   117 VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1312 VKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEI 1386
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPF 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1387 TRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS- 1458
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAd 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 767957309 1459 VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1504
Cdd:COG3401   355 VTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
804-884 1.20e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 767957309   881 SSNP 884
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
713-793 6.47e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 6.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 767957309   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
624-779 4.94e-10

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 4.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401   234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401   311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                  ....*
gi 767957309  775 PGQEY 779
Cdd:COG3401   389 PGTTY 393
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.99e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 44.60  E-value: 4.99e-06
                           10        20
                   ....*....|....*....|....*...
gi 767957309   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.13e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 42.67  E-value: 2.13e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.22e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 42.29  E-value: 3.22e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 5.59e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.82  E-value: 5.59e-04
                           10        20
                   ....*....|....*....|....*...
gi 767957309   594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 1.42e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.66  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.44e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.66  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 2.26e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.28  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 2.28e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.28  E-value: 2.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 3.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.51  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.18e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.40  E-value: 8.18e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1525-1734 2.84e-116

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 366.08  E-value: 2.84e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1525 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1603
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1604 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1675
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957309  1676 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1734
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1524-1733 4.11e-107

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 339.99  E-value: 4.11e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1524 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 1603
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1604 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 1682
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767957309 1683 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1733
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1525-1733 2.80e-106

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 337.71  E-value: 2.80e-106
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1525 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 1604
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1605 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 1682
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767957309   1683 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1733
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 5.51e-21

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 5.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401   263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401   336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1070 STAKEPEIGNL-NVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVY----L 1144
Cdd:COG3401   416 TTASAASGESLtASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSvttgS 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1145 SGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFD--NFVLKIRDTKKQSEPLEITLLAPERTRDI 1222
Cdd:COG3401   496 LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDvlITDLVSLTTSASSSVSGAGLGSGNLYLIT 575

                         410
                  ....*....|....*....
gi 767957309 1223 TGLREATEYEIELYGISKG 1241
Cdd:COG3401   576 TLGGSLLTTTSTNTNDVAG 594
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1153-1504 6.24e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 6.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1153 TKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYE 1232
Cdd:COG3401    37 LVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1233 IELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRL 1311
Cdd:COG3401   117 VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1312 VKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEI 1386
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPF 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1387 TRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS- 1458
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAd 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 767957309 1459 VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1504
Cdd:COG3401   355 VTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1433-1505 2.60e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 2.60e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309  1433 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1505
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
894-976 2.28e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 767957309   970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1433-1505 1.67e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.64  E-value: 1.67e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309   1433 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1505
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.72e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                  ....*...
gi 767957309  971 DKESNPAT 978
Cdd:cd00063    80 GGESPPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1256-1342 4.61e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.37  E-value: 4.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1256 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1331
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 767957309 1332 ESEPV-SGSFTT 1342
Cdd:cd00063    82 ESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
804-884 1.20e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 767957309   881 SSNP 884
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
713-793 6.47e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 6.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 767957309   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 6.99e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 6.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  667 QFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401   264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401   341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401   418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         330       340
                  ....*....|....*....|....*..
gi 767957309  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401   498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 1.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 1.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309   1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 4.94e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 4.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401   234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401   311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                  ....*
gi 767957309  775 PGQEY 779
Cdd:COG3401   389 PGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 1.93e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.93e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309    881 SS 882
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 1.65e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.65e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767957309   624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 1.81e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENK 699
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 767957309  700 KSIPVSARVAT 710
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 1.07e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 767957309  790 TRGPGLKRVTTT 801
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.34e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 767957309    791 RGPG 794
Cdd:smart00060   80 AGEG 83
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1535-1568 4.30e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 47.94  E-value: 4.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767957309 1535 NGDTTSGLYTIYLNGDKA-EALEVFCDMTSDGGGW 1568
Cdd:NF040941    9 GPSAPSGVYWIDPDGMGGlAPFQVYCDMTTDGGGW 43
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.99e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.60  E-value: 4.99e-06
                           10        20
                   ....*....|....*....|....*...
gi 767957309   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.13e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.67  E-value: 2.13e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.22e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.29  E-value: 3.22e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 1.18e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.18e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309    624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 5.59e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 5.59e-04
                           10        20
                   ....*....|....*....|....*...
gi 767957309   594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 1.42e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.44e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 2.26e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 2.28e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 3.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.18e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.40  E-value: 8.18e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1525-1734 2.84e-116

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 366.08  E-value: 2.84e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1525 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1603
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1604 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1675
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957309  1676 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1734
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1524-1733 4.11e-107

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 339.99  E-value: 4.11e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1524 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 1603
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1604 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 1682
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767957309 1683 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1733
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1525-1733 2.80e-106

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 337.71  E-value: 2.80e-106
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1525 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 1604
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1605 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 1682
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767957309   1683 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1733
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 5.51e-21

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 5.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401   263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401   336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1070 STAKEPEIGNL-NVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVY----L 1144
Cdd:COG3401   416 TTASAASGESLtASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSvttgS 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1145 SGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFD--NFVLKIRDTKKQSEPLEITLLAPERTRDI 1222
Cdd:COG3401   496 LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDvlITDLVSLTTSASSSVSGAGLGSGNLYLIT 575

                         410
                  ....*....|....*....
gi 767957309 1223 TGLREATEYEIELYGISKG 1241
Cdd:COG3401   576 TLGGSLLTTTSTNTNDVAG 594
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1153-1504 6.24e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 6.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1153 TKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYE 1232
Cdd:COG3401    37 LVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1233 IELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRL 1311
Cdd:COG3401   117 VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1312 VKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEI 1386
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPF 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1387 TRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS- 1458
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAd 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 767957309 1459 VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1504
Cdd:COG3401   355 VTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1433-1505 2.60e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 2.60e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309  1433 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1505
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
894-976 2.28e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 767957309   970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1433-1505 1.67e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.64  E-value: 1.67e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309   1433 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1505
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
1256-1335 2.24e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1256 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1331
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 767957309  1332 ESEP 1335
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
986-1064 2.42e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYSLPTGQ--WVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 767957309  1061 KSKP 1064
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.72e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                  ....*...
gi 767957309  971 DKESNPAT 978
Cdd:cd00063    80 GGESPPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1256-1342 4.61e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.37  E-value: 4.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1256 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1331
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 767957309 1332 ESEPV-SGSFTT 1342
Cdd:cd00063    82 ESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
804-884 1.20e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 767957309   881 SSNP 884
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1433-1518 1.59e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1433 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTAKIQALNGPL 1507
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 767957309 1508 RSNMIQTI-FTT 1518
Cdd:cd00063    82 ESPPSESVtVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 986-1065 1.70e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYS-LPTGQWVGVQLPR-NTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 767957309 1061 KSKPA 1065
Cdd:cd00063    82 ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
713-793 6.47e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 6.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 767957309   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 6.99e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 6.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  667 QFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401   264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401   341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401   418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         330       340
                  ....*....|....*....|....*..
gi 767957309  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401   498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 767957309  881 SSNPAK-ETFTT 891
Cdd:cd00063    82 ESPPSEsVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 1.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 1.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309   1061 KS 1062
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1166-1245 8.66e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 8.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  1166 PEVDNLLVSDATPDGFRLSWTADE---GVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGR 1242
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 767957309  1243 RSQ 1245
Cdd:pfam00041   81 EGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1246-1505 1.11e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1246 TVSAIATTAMGSPKEVIFSDITENSATVSWRAP-TAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSI 1324
Cdd:COG3401    42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGtTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1325 IAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEP 1404
Cdd:COG3401   122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1405 ATEYTLRIFA---EKGPQKSSTITA-KFTTDLDSPRDLTATEVQSETALLTWRP-PRASVTGYLLVYESVDGTVKEVIVG 1479
Cdd:COG3401   202 GTTYYYRVAAtdtGGESAPSNEVSVtTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVAT 281

                         250       260
                  ....*....|....*....|....*.
gi 767957309 1480 PDTTSYSLADLSPSTHYTAKIQALNG 1505
Cdd:COG3401   282 VTTTSYTDTGLTNGTTYYYRVTAVDA 307
fn3 pfam00041
Fibronectin type III domain;
1347-1417 2.06e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 2.06e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767957309  1347 PSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKG 1417
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 4.94e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 4.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401   234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401   311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                  ....*
gi 767957309  775 PGQEY 779
Cdd:COG3401   389 PGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 894-974 5.82e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 5.82e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    894 DAPRNLRRVSQTDNSITLEWR-----NGKAAIDSYRIKYAPiSGGDHAEVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAV 968
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYRE-EGSEWKEVNVTPS---STSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 767957309    969 KEDKES 974
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 1.93e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.93e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309    881 SS 882
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1075-1144 2.46e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.46e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767957309  1075 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1144
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1256-1333 3.95e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 3.95e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1256 GSPKEVIFSDITENSATVSWRAPT-AQVESFRITYVPITGGTPS---MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1331
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309   1332 ES 1333
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 1.65e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.65e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767957309   624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 1.81e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENK 699
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 767957309  700 KSIPVSARVAT 710
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1345-1421 4.08e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 4.08e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1345 DGPSGLVTANITDSEALARWQ-PAIATVDSYVISYTGEKVPEITR----TVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1419
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSEwkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309   1420 KS 1421
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1345-1430 7.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1345 DGPSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1419
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 767957309 1420 KS-STITAKFTT 1430
Cdd:cd00063    82 ESpPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 1.07e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 767957309  790 TRGPGLKRVTTT 801
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.34e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309    713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 767957309    791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1168-1253 2.47e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1168 VDNLLVSDATPDGFRLSWTA---DEGVFDNFVLKIRDtKKQSEPLEITLLAPERTR-DITGLREATEYEIELYGISKGRR 1243
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|.
gi 767957309 1244 SQ-TVSAIATT 1253
Cdd:cd00063    83 SPpSESVTVTT 93
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1535-1568 4.30e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 47.94  E-value: 4.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767957309 1535 NGDTTSGLYTIYLNGDKA-EALEVFCDMTSDGGGW 1568
Cdd:NF040941    9 GPSAPSGVYWIDPDGMGGlAPFQVYCDMTTDGGGW 43
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.99e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.60  E-value: 4.99e-06
                           10        20
                   ....*....|....*....|....*...
gi 767957309   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.13e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.67  E-value: 2.13e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1166-1244 2.15e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.15e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309   1166 PEVDNLLVSDATPDGFRLSWTA-DEGVFDNFVLKIRDTKKQSEPLEITLLAPERTR--DITGLREATEYEIELYGISKGR 1242
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 767957309   1243 RS 1244
Cdd:smart00060   82 EG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.22e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.29  E-value: 3.22e-05
                           10        20
                   ....*....|....*....|....*...
gi 767957309   190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1347-1717 1.02e-04

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 46.69  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1347 PSGLVTANITDSEALARWQPAIAT--VDSYVISYTGEKVpeitRTVSGNTvEYALTDLEPATEYTLrifaekgpqkssTI 1424
Cdd:COG3979     6 PTGLTASNVTSSSVSLSWDASTDNvgVTGYDVYRGGDQV----ATVTGLT-AWTVTGLTPGTEYTF------------TV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1425 TAKFTTDLDSPR--DLTATEVQSETALLTWRPPRASVTGYllvyeSVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQA 1502
Cdd:COG3979    69 GACDAAGNVSAAsgTSTAMFGGSSTTLGSAEGVADTSGNL-----AASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1503 LNGplRSNMIQTIFTTIGLLYPFPKDcsQAMLNGDTTSGLYTIYLNGDKAEALEVFC------DMTSDGGGWIVFLRRKN 1576
Cdd:COG3979   144 GTG--GSGGTTTIITTGVEGGGGSKT--AQSLNAITAAGTAALNGGVVGGADEVLTCsavkddGSGGAGAGNTYWALNTL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957309 1577 G------RENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEG 1650
Cdd:COG3979   220 GvsdtpsGTTATGGTVGITSAYGAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAAN 299

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957309 1651 YSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHW 1717
Cdd:COG3979   300 GPTGGYGATGTTVAGAAGVGGTKSGTGALGLSGAGGAGAAVSGTATGDDDAGADDSTAGVSGAGSTT 366
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 1.18e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.18e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767957309    624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 713-783 3.85e-04

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 41.03  E-value: 3.85e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767957309   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893    3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 5.59e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 5.59e-04
                           10        20
                   ....*....|....*....|....*...
gi 767957309   594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 1.42e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.44e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.51e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.51e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 412-434 2.03e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.03e-03
                           10        20
                   ....*....|....*....|....*
gi 767957309   412 CSGHGRCVN--GQCVCDEGYTGEDC 434
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 2.26e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 2.28e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 767957309   346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 2.94e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 2.94e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 3.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|....*..
gi 767957309   563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 504-527 7.86e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.40  E-value: 7.86e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   504 DCSNRGLCVD--GQCVCEDGFTGPDC 527
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.18e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.40  E-value: 8.18e-03
                           10        20
                   ....*....|....*....|....*.
gi 767957309   535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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