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Conserved domains on  [gi|767958677|ref|XP_011517481|]
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cytoplasmic dynein 2 intermediate chain 2 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-486 8.63e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 8.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 358 FTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKgDVQLFDL 437
Cdd:cd00200    3 RTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767958677 438 qkssQKPTVLIKQTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQLST 486
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
164-486 4.91e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 4.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 164 VTSISWNSTGSVVACAygrldhGDWSTLKsfvcAWNLDRRDLRpqqpSAVVEVPSAVLCLAFHPTQpSHVAGGLYSGEVL 243
Cdd:COG2319  165 VTSVAFSPDGKLLASG------SDDGTVR----LWDLATGKLL----RTLTGHTGAVRSVAFSPDG-KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 244 VWDLSRledpllWRTGLTDDTHTDPVsqgigvgqlqltegfalvmqqlprstklkkhprgetevgaTAVAFSSfDPRLFI 323
Cdd:COG2319  230 LWDLAT------GKLLRTLTGHSGSV----------------------------------------RSVAFSP-DGRLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 324 LGTEGGfplkcslaagEAALTRMPSSVPLRapaqfTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSL 403
Cdd:COG2319  263 SGSADG----------TVRLWDLATGELLR-----TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 404 QLSLKYLFAVRWSPVRPLVfAAASGKGDVQLFDLQKSSQKPTVlikqTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQ 483
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTL----TGHTGAVTSVAF-SPDGRTLASGSADGTVRLWD 400


                 ...
gi 767958677 484 LST 486
Cdd:COG2319  401 LAT 403
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-486 8.63e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 8.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 358 FTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKgDVQLFDL 437
Cdd:cd00200    3 RTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767958677 438 qkssQKPTVLIKQTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQLST 486
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
164-486 4.91e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 4.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 164 VTSISWNSTGSVVACAygrldhGDWSTLKsfvcAWNLDRRDLRpqqpSAVVEVPSAVLCLAFHPTQpSHVAGGLYSGEVL 243
Cdd:COG2319  165 VTSVAFSPDGKLLASG------SDDGTVR----LWDLATGKLL----RTLTGHTGAVRSVAFSPDG-KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 244 VWDLSRledpllWRTGLTDDTHTDPVsqgigvgqlqltegfalvmqqlprstklkkhprgetevgaTAVAFSSfDPRLFI 323
Cdd:COG2319  230 LWDLAT------GKLLRTLTGHSGSV----------------------------------------RSVAFSP-DGRLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 324 LGTEGGfplkcslaagEAALTRMPSSVPLRapaqfTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSL 403
Cdd:COG2319  263 SGSADG----------TVRLWDLATGELLR-----TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 404 QLSLKYLFAVRWSPVRPLVfAAASGKGDVQLFDLQKSSQKPTVlikqTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQ 483
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTL----TGHTGAVTSVAF-SPDGRTLASGSADGTVRLWD 400


                 ...
gi 767958677 484 LST 486
Cdd:COG2319  401 LAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-393 2.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767958677   358 FTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYS 393
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-486 8.63e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 8.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 358 FTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKgDVQLFDL 437
Cdd:cd00200    3 RTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767958677 438 qkssQKPTVLIKQTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQLST 486
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
164-486 4.91e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 4.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 164 VTSISWNSTGSVVACAygrldhGDWSTLKsfvcAWNLDRRDLRpqqpSAVVEVPSAVLCLAFHPTQpSHVAGGLYSGEVL 243
Cdd:COG2319  165 VTSVAFSPDGKLLASG------SDDGTVR----LWDLATGKLL----RTLTGHTGAVRSVAFSPDG-KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 244 VWDLSRledpllWRTGLTDDTHTDPVsqgigvgqlqltegfalvmqqlprstklkkhprgetevgaTAVAFSSfDPRLFI 323
Cdd:COG2319  230 LWDLAT------GKLLRTLTGHSGSV----------------------------------------RSVAFSP-DGRLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 324 LGTEGGfplkcslaagEAALTRMPSSVPLRapaqfTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSL 403
Cdd:COG2319  263 SGSADG----------TVRLWDLATGELLR-----TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 404 QLSLKYLFAVRWSPVRPLVfAAASGKGDVQLFDLQKSSQKPTVlikqTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQ 483
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTL----TGHTGAVTSVAF-SPDGRTLASGSADGTVRLWD 400


                 ...
gi 767958677 484 LST 486
Cdd:COG2319  401 LAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-487 4.53e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 4.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 217 PSAVLCLAFHPtQPSHVAGGLYSGEVLVWDLSRLEDPLlwrtglTDDTHTDPVSQGIGVGQLQL-----TEGFALV--MQ 289
Cdd:cd00200    9 TGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR------TLKGHTGPVRDVAASADGTYlasgsSDKTIRLwdLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 290 QLPRSTKLKKHprgETEVgaTAVAFSSfDPRLFIlgteggfplkCSLAAGEAALTRMPSSVPLrapaqFTFSPHGGPIYS 369
Cdd:cd00200   82 TGECVRTLTGH---TSYV--SSVAFSP-DGRILS----------SSSRDKTIKVWDVETGKCL-----TTLRGHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 370 VSCSPFHRnLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLvFAAASGKGDVQLFDLQKSSQKPTVlik 449
Cdd:cd00200  141 VAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGTL--- 215

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767958677 450 qTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQLSTE 487
Cdd:cd00200  216 -RGHENGVNSVAF-SPDGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-483 8.78e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 8.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 359 TFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRpLVFAAASGKGDVQLFDLQ 438
Cdd:cd00200  172 TLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLR 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767958677 439 KSSQKPTVlikqTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQ 483
Cdd:cd00200  250 TGECVQTL----SGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
197-486 1.08e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 197 AWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEdpLLWRTGLTDDTHTDPVSQGigvG 276
Cdd:COG2319   16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL--LATLLGHTAAVLSVAFSPD---G 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 277 QLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSfDPRLFILGTEGGfplkcslaagEAALTRMPSSVPLRapa 356
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADG----------TVRLWDLATGKLLR--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 357 qfTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVfAAASGKGDVQLFD 436
Cdd:COG2319  157 --TLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWD 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767958677 437 LQKSSQKPTVlikqTQDESPVYCLEFnSQQTQLLAAGDAQGTVKVWQLST 486
Cdd:COG2319  233 LATGKLLRTL----TGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLAT 277
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-393 2.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767958677   358 FTFSPHGGPIYSVSCSPfHRNLFLSAGTDGHVHLYS 393
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 403-487 2.66e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958677 403 LQLSLKYLFAVRWSPVRPLVfAAASGKGDVQLFDLQKSsqkpTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAqGTVKVW 482
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLL-ATGSGDGTIKVWDLETG----ELLRTLKGHTGPVRDVAASADGTYLASGSSD-KTIRLW 78


                 ....*
gi 767958677 483 QLSTE 487
Cdd:cd00200   79 DLETG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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