NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|767960717|ref|XP_011518054|]

View

integrin alpha-8 isoform X1 [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha is a transmembrane receptor that facilitates cell-extracellular matrix (ECM) adhesion

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

Integrin_alpha2

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...

484-795

5.75e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.

:

Pssm-ID: 462478 [Multi-domain] Cd Length: 449 Bit Score: 415.57 E-value: 5.75e-138

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767960717  717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGLEPP 795
Cdd:pfam08441 236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKP 314

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

383-437

7.14e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

:

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 63.93 E-value: 7.14e-13

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

317-365

4.34e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

:

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 53.15 E-value: 4.34e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767960717   317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

54-112

8.36e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

:

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 46.60 E-value: 8.36e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960717    54 GSYFGYAVDFHIPDAR--TASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191   2 GSYFGYSVAGVGDVNGdgYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

448-492

5.59e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

:

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 41.59 E-value: 5.59e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767960717   448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

263-311

7.75e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

:

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 35.43 E-value: 7.75e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56

Name

Accession

Description

Interval

E-value

Integrin_alpha2

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...

484-795

5.75e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.

Pssm-ID: 462478 [Multi-domain] Cd Length: 449 Bit Score: 415.57 E-value: 5.75e-138

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767960717  717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGLEPP 795
Cdd:pfam08441 236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKP 314

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

383-437

7.14e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 63.93 E-value: 7.14e-13

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

317-365

4.34e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 53.15 E-value: 4.34e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767960717   317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44

FG-GAP

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...

386-422

4.49e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.

Pssm-ID: 460357 Cd Length: 36 Bit Score: 46.73 E-value: 4.49e-07

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767960717  386 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 422
Cdd:pfam01839   1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

54-112

8.36e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 46.60 E-value: 8.36e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960717    54 GSYFGYAVDFHIPDAR--TASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191   2 GSYFGYSVAGVGDVNGdgYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57

FG-GAP

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...

321-363

1.82e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.

Pssm-ID: 460357 Cd Length: 36 Bit Score: 44.81 E-value: 1.82e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767960717  321 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 363
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

448-492

5.59e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 41.59 E-value: 5.59e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767960717   448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

263-311

7.75e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 35.43 E-value: 7.75e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56

Name

Accession

Description

Interval

E-value

Integrin_alpha2

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...

484-795

5.75e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.

Pssm-ID: 462478 [Multi-domain] Cd Length: 449 Bit Score: 415.57 E-value: 5.75e-138

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960717  641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767960717  717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGLEPP 795
Cdd:pfam08441 236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKP 314

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

383-437

7.14e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 63.93 E-value: 7.14e-13

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

317-365

4.34e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 53.15 E-value: 4.34e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767960717   317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44

FG-GAP

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...

386-422

4.49e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.

Pssm-ID: 460357 Cd Length: 36 Bit Score: 46.73 E-value: 4.49e-07

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767960717  386 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 422
Cdd:pfam01839   1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

54-112

8.36e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 46.60 E-value: 8.36e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960717    54 GSYFGYAVDFHIPDAR--TASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191   2 GSYFGYSVAGVGDVNGdgYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57

FG-GAP

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...

321-363

1.82e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.

Pssm-ID: 460357 Cd Length: 36 Bit Score: 44.81 E-value: 1.82e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767960717  321 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 363
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

448-492

5.59e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 41.59 E-value: 5.59e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767960717   448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

329-406

1.20e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 40.67 E-value: 1.20e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767960717  329 DVNSDGLDDVLVGAPlfmerefesnprevGQIYLYLQVSSLLFRDPQILTGTETFGRFGsamAHLGDLNQDGYNDIAI 406
Cdd:pfam13517   1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLS---VAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

395-470

3.00e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 36.82 E-value: 3.00e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717  395 DLNQDGYNDIaigvpFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVpsgFGftlrgdsDIDKNDYPDLIV 470
Cdd:pfam13517   1 DLDGDGKLDL-----VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VG-------DLDGDGRLDLLV 61

Int_alpha

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...

263-311

7.75e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.

Pssm-ID: 214549 [Multi-domain] Cd Length: 57 Bit Score: 35.43 E-value: 7.75e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960717   263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options