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Conserved domains on  [gi|767965216|ref|XP_011518121|]
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tetraspanin-32 isoform X7 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626493)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 83-165 1.23e-42

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


:

Pssm-ID: 239406  Cd Length: 87  Bit Score: 141.89  E-value: 1.23e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216  83 LHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAARE----DCLQGIR 158
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREvamlLCLFLWF 80


                 ....*..
gi 767965216 159 SFLRTHQ 165
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
19-191 1.03e-07

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   19 LEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAA------ATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQ---- 88
Cdd:pfam00335  26 LLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVgflgccGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKlsgl 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   89 ----VEDAMLDTYDLVYEQAMKGTSHVRRqelaaIQDVFLCCGkkspfsrlgsteadlcqgeeaareDCLQGIRSFLRTH 164
Cdd:pfam00335 106 lsnwLKKSLEDGYRDWLDLYSCLNSALDS-----LQSEFGCCG------------------------GCKEKLLEWLRKN 156

                         170       180
                  ....*....|....*....|....*...
gi 767965216  165 -QQVASSLTSIGLaLTVSALLFSSFLWF 191
Cdd:pfam00335 157 lKIIGAGVIALGV-IQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 83-165 1.23e-42

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 141.89  E-value: 1.23e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216  83 LHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAARE----DCLQGIR 158
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREvamlLCLFLWF 80


                 ....*..
gi 767965216 159 SFLRTHQ 165
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
19-191 1.03e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   19 LEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAA------ATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQ---- 88
Cdd:pfam00335  26 LLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVgflgccGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKlsgl 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   89 ----VEDAMLDTYDLVYEQAMKGTSHVRRqelaaIQDVFLCCGkkspfsrlgsteadlcqgeeaareDCLQGIRSFLRTH 164
Cdd:pfam00335 106 lsnwLKKSLEDGYRDWLDLYSCLNSALDS-----LQSEFGCCG------------------------GCKEKLLEWLRKN 156

                         170       180
                  ....*....|....*....|....*...
gi 767965216  165 -QQVASSLTSIGLaLTVSALLFSSFLWF 191
Cdd:pfam00335 157 lKIIGAGVIALGV-IQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 83-165 1.23e-42

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 141.89  E-value: 1.23e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216  83 LHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAARE----DCLQGIR 158
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREvamlLCLFLWF 80


                 ....*..
gi 767965216 159 SFLRTHQ 165
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
19-191 1.03e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   19 LEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAA------ATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQ---- 88
Cdd:pfam00335  26 LLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVgflgccGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKlsgl 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216   89 ----VEDAMLDTYDLVYEQAMKGTSHVRRqelaaIQDVFLCCGkkspfsrlgsteadlcqgeeaareDCLQGIRSFLRTH 164
Cdd:pfam00335 106 lsnwLKKSLEDGYRDWLDLYSCLNSALDS-----LQSEFGCCG------------------------GCKEKLLEWLRKN 156

                         170       180
                  ....*....|....*....|....*...
gi 767965216  165 -QQVASSLTSIGLaLTVSALLFSSFLWF 191
Cdd:pfam00335 157 lKIIGAGVIALGV-IQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 87-164 9.43e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 37.87  E-value: 9.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965216  87 TQVEDAMLDTYDLVYEQamKGTSHVRRQELAAIQDVFLCCGKKSP--FSRLGST-------EADLCQGEEAAREDCLQGI 157
Cdd:cd03127    5 DQLESLVSDTLNDAWDE--YYVDDDFQEAMDALQSTFECCGVNGPtdYLDLRLLvpsscckGTDGNCGLNLYTEGCLEKL 82


                 ....*..
gi 767965216 158 RSFLRTH 164
Cdd:cd03127   83 VDFLRSN 89
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 88-161 5.33e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 35.47  E-value: 5.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767965216  88 QVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLC-QGEEAAREDCLQGIRSFL 161
Cdd:cd03151    6 QIIKEVQNFYDSAYQDAVTDTRSKGTAVLKTFHSTLDCCGKGNLTALLSLLSTDLCpKKLLLDTKDCHQEIDDLF 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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