NCBI Conserved Domain Search

Conserved domains on [gi|767965311|ref|XP_011518165|]

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BLOC-2 complex member HPS5 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH: 2.130.10.10

Gene Ontology: GO:0005515

PubMed: 30069656|29026209

SCOP: 4002744

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

WD40 super family

cl43672

WD40 repeat [General function prediction only];

38-150

1.64e-04

WD40 repeat [General function prediction only];

The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 45.29 E-value: 1.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965311   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767965311  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319   324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378

Name

Accession

Description

Interval

E-value

WD40

COG2319

WD40 repeat [General function prediction only];

38-150

1.64e-04

WD40 repeat [General function prediction only];

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 45.29 E-value: 1.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965311   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767965311  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319   324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378

Name

Accession

Description

Interval

E-value

WD40

COG2319

WD40 repeat [General function prediction only];

38-150

1.64e-04

WD40 repeat [General function prediction only];

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 45.29 E-value: 1.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965311   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767965311  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319   324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378

WD40

COG2319

WD40 repeat [General function prediction only];

38-131

1.65e-03

WD40 repeat [General function prediction only];

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 42.21 E-value: 1.65e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965311   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNqerRGKPEQM 115
Cdd:COG2319   208 RSVAFSPdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRLWDLA---TGELLRT 283

                          90
                  ....*....|....*.
gi 767965311  116 YvssEHKGRRVTALCW 131
Cdd:COG2319   284 L---TGHSGGVNSVAF 296

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01