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Conserved domains on  [gi|767965608|ref|XP_011518282|]
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F-box only protein 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
283-404 5.63e-34

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


:

Pssm-ID: 442207  Cd Length: 119  Bit Score: 123.67  E-value: 5.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608 283 DITVSVSTSFLPELSSVHPPHYFFTYRIRIEmskdALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYE 362
Cdd:COG2967    2 GIKVSVETEYLPEQSDPEEGRYVFAYTITIE----NLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFE 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767965608 363 YTSCTTFSTTSGYMEGYYtfHFLYFKDKIFNVAIPRFHMACP 404
Cdd:COG2967   78 YTSGCVLETPVGTMQGSY--QMVDEDGERFDVPIPPFSLAAP 117
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
13-61 6.93e-28

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438856  Cd Length: 49  Bit Score: 105.03  E-value: 6.93e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
121-249 2.14e-14

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


:

Pssm-ID: 430545  Cd Length: 120  Bit Score: 69.39  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767965608  199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118
 
Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
283-404 5.63e-34

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 123.67  E-value: 5.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608 283 DITVSVSTSFLPELSSVHPPHYFFTYRIRIEmskdALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYE 362
Cdd:COG2967    2 GIKVSVETEYLPEQSDPEEGRYVFAYTITIE----NLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFE 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767965608 363 YTSCTTFSTTSGYMEGYYtfHFLYFKDKIFNVAIPRFHMACP 404
Cdd:COG2967   78 YTSGCVLETPVGTMQGSY--QMVDEDGERFDVPIPPFSLAAP 117
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
279-404 7.39e-33

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 121.02  E-value: 7.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608 279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSKDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767965608 358 GRVYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KIFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
294-382 1.89e-32

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 118.72  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  294 PELSSVHPPHYFFTYRIRIEMskdaLPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYEYTSCTTFSTTS 373
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIEN----LGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPS 76

                  ....*....
gi 767965608  374 GYMEGYYTF 382
Cdd:pfam04379  77 GSMEGSYTM 85
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
13-61 6.93e-28

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 105.03  E-value: 6.93e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
121-249 2.14e-14

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 69.39  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767965608  199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118
SMI1 COG4282
Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane ...
94-190 2.27e-14

Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443423  Cd Length: 188  Bit Score: 71.22  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  94 AAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQK-LVVPGLLGsmalsnhyrSE 172
Cdd:COG4282    2 ASVAESWERIEAWLAEHAPDLLAALRPGASEADIAALEAALGVELPEDLRALYRIHNGQGdDALPGLFG---------NY 72
                         90
                 ....*....|....*...
gi 767965608 173 DLLDVDTAAGGFQQRQGL 190
Cdd:COG4282   73 RLLSLEEILDEWEVWKEL 90
F-box-like pfam12937
F-box-like; This is an F-box-like family.
13-57 3.77e-12

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 60.57  E-value: 3.77e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767965608   13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
121-249 9.06e-09

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 53.80  E-value: 9.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767965608   198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127
FBOX smart00256
A Receptor for Ubiquitination Targets;
16-56 2.74e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965608    16 LPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRH 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
283-404 5.63e-34

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 123.67  E-value: 5.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608 283 DITVSVSTSFLPELSSVHPPHYFFTYRIRIEmskdALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYE 362
Cdd:COG2967    2 GIKVSVETEYLPEQSDPEEGRYVFAYTITIE----NLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFE 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767965608 363 YTSCTTFSTTSGYMEGYYtfHFLYFKDKIFNVAIPRFHMACP 404
Cdd:COG2967   78 YTSGCVLETPVGTMQGSY--QMVDEDGERFDVPIPPFSLAAP 117
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
279-404 7.39e-33

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 121.02  E-value: 7.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608 279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSKDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767965608 358 GRVYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KIFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
294-382 1.89e-32

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 118.72  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  294 PELSSVHPPHYFFTYRIRIEMskdaLPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYEYTSCTTFSTTS 373
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIEN----LGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPS 76

                  ....*....
gi 767965608  374 GYMEGYYTF 382
Cdd:pfam04379  77 GSMEGSYTM 85
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
13-61 6.93e-28

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 105.03  E-value: 6.93e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
121-249 2.14e-14

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 69.39  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767965608  199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118
SMI1 COG4282
Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane ...
94-190 2.27e-14

Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443423  Cd Length: 188  Bit Score: 71.22  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608  94 AAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQK-LVVPGLLGsmalsnhyrSE 172
Cdd:COG4282    2 ASVAESWERIEAWLAEHAPDLLAALRPGASEADIAALEAALGVELPEDLRALYRIHNGQGdDALPGLFG---------NY 72
                         90
                 ....*....|....*...
gi 767965608 173 DLLDVDTAAGGFQQRQGL 190
Cdd:COG4282   73 RLLSLEEILDEWEVWKEL 90
F-box-like pfam12937
F-box-like; This is an F-box-like family.
13-57 3.77e-12

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 60.57  E-value: 3.77e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767965608   13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
121-249 9.06e-09

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 53.80  E-value: 9.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965608   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767965608   198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
13-55 3.95e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.08  E-value: 3.95e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767965608   13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
12-58 8.58e-08

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 48.36  E-value: 8.58e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767965608  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
13-58 3.73e-07

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 46.48  E-value: 3.73e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd22093    1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
14-48 4.23e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 46.28  E-value: 4.23e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767965608  14 ESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSS 48
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
16-57 1.01e-06

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 45.31  E-value: 1.01e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767965608  16 LPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22139    4 LPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
15-57 4.75e-06

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 43.52  E-value: 4.75e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767965608  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22137    2 QLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
16-55 8.80e-06

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 42.65  E-value: 8.80e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767965608  16 LPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:cd22148    5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
13-57 1.38e-05

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 42.30  E-value: 1.38e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22147    2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
16-56 2.74e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965608    16 LPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRH 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
13-57 3.61e-05

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 41.16  E-value: 3.61e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767965608  13 LESLPT-DPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22109    2 LESLRRrDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
12-57 4.92e-05

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 40.86  E-value: 4.92e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767965608  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22085    2 LLNHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFL 47
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
13-55 7.21e-05

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 40.25  E-value: 7.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:cd22106    1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEK 43
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
15-58 8.70e-05

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 40.10  E-value: 8.70e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767965608  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCK 58
Cdd:cd22102    3 DLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQRRCK 46
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
12-55 1.10e-04

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 39.52  E-value: 1.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767965608  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSShDPLWRR 55
Cdd:cd22143    1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLAL-PELWRS 43
F-box_AtSKIP22-like cd22165
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ...
13-57 1.59e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438936  Cd Length: 46  Bit Score: 39.18  E-value: 1.59e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22165    2 LMRLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQKF 46
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
15-57 3.02e-04

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 38.51  E-value: 3.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767965608  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22134    6 QLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
12-55 5.09e-04

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 37.99  E-value: 5.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767965608  12 TLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQL-SSHDPLWRR 55
Cdd:cd22082    1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLiDSNPSLWAN 45
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
16-41 7.19e-04

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 37.31  E-value: 7.19e-04
                         10        20
                 ....*....|....*....|....*.
gi 767965608  16 LPTDPLLLILSFLDYRDLINCCYVSR 41
Cdd:cd22131    6 LPLELSFYLLSFLDPESLLTCCLVSK 31
F-box_AtSKIP31-like cd22166
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ...
13-55 9.91e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438937  Cd Length: 46  Bit Score: 37.05  E-value: 9.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:cd22166    1 LTKLPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWRR 43
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
13-57 2.07e-03

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 36.12  E-value: 2.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22087    1 LLALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
16-56 2.29e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 2.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767965608  16 LPtDPLLL-ILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRH 56
Cdd:cd22132    4 LP-DSLLLhIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
15-59 2.47e-03

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 36.00  E-value: 2.47e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767965608  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKK 59
Cdd:cd22141    3 NLPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLLIS 47
F-box_FBXO2 cd22167
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ...
13-79 2.74e-03

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438938 [Multi-domain]  Cd Length: 72  Bit Score: 36.64  E-value: 2.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCC-YVSRRLSQLSSHDPLWRRHCKKYWLISEEEKTQKNQcWKSLF 79
Cdd:cd22167    1 MESLPEAVLVRILAYLPAEELVLVCrLVCSQWKELVDGAALWILKCQQEGFSPTELEEEPDN-WQTFY 67
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
15-57 2.95e-03

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 35.37  E-value: 2.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767965608  15 SLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHC 57
Cdd:cd22151    2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
13-57 3.26e-03

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 35.37  E-value: 3.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQL-SSHDPLWRRHC 57
Cdd:cd22113    1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLiENSDYLWRPHC 46
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
14-55 3.32e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 35.43  E-value: 3.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767965608  14 ESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRR 55
Cdd:cd22149    2 ERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
13-53 5.88e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 34.62  E-value: 5.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767965608  13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLW 53
Cdd:cd22118    1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
24-59 9.02e-03

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 34.39  E-value: 9.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767965608  24 ILSFLDYRDLINCCYVSRRlsqlsshdplWRRHCKK 59
Cdd:cd22086   15 ILSYLSPEDLCRVSCVSKT----------WRQICLS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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