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Conserved domains on  [gi|767985069|ref|XP_011520241|]
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tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11420945)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.02e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457    6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457   70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                        170       180
                 ....*....|....*....|....
gi 767985069 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457  127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767985069  314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.02e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457    6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457   70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                        170       180
                 ....*....|....*....|....
gi 767985069 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457  127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767985069  314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_12 pfam13424
Tetratricopeptide repeat;
186-254 3.31e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767985069  186 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.02e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  85 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 164
Cdd:COG0457    6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 165 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 244
Cdd:COG0457   70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                        170       180
                 ....*....|....*....|....
gi 767985069 245 DVSINHFLQAhliiLSRSPSQVEA 268
Cdd:COG0457  127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
314-386 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767985069  314 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_12 pfam13424
Tetratricopeptide repeat;
186-254 3.31e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767985069  186 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 100-386 3.84e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 100 LKGLSLQAKQHAEKARQILANsIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQcgriike 179
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEE-ALELDPET-------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 180 ewieieARIRLsfAQVYQGQKKSKEALSHYQAALEyveiskgeTSRECVPILRELAGVEQALGLHDVSINHFLQAHLIIL 259
Cdd:COG2956   78 ------ALLEL--AQDYLKAGLLDRAEELLEKLLE--------LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGP 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 260 SRSPSQVEAADSAHivahaavasgRHEHHDVAEQYFQESMAHLKDSEgmgRTKFLSIQdefchFLQMTGQKERATSILRE 339
Cdd:COG2956  142 ENAHAYCELAELYL----------EQGDYDEAIEALEKALKLDPDCA---RALLLLAE-----LYLEQGDYEEAIAALER 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767985069 340 SLEAkveafgdfSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 386
Cdd:COG2956  204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALELD 242
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 87-214 7.78e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 7.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  87 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQIlansiVPPYsentdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG3914  112 AEALFNLGNLLLAL-GRLEEALAALRRALAL-----NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767985069 167 SKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG3914  176 DPDN---------------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-254 8.46e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  31 KLLQTALfQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRicygdshwKLAEAHVNLAQGYLQLKGLSlQAKQH 110
Cdd:COG2956   63 RIHQKLL-ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDP--------DDAEALRLLAEIYEQEGDWE-KAIEV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 111 AEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgriikeewieiEARIRL 190
Cdd:COG2956  133 LERLLKLGPENA---------------HAYCELAELYLEQGDYDEAIEALEKALKLDPD---------------CARALL 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767985069 191 SFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:COG2956  183 LLAELYLEQGDYEEAIAALERALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKA 238
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-254 1.17e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  97 YLQLKGLSLQAKQHAEKARQILaNSIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgri 176
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALL-EKALELDPDN-------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767985069 177 ikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 254
Cdd:COG4783   71 --------EPEARLNLGLALLKAGDYDEALALLEKALKL--------DPEHPEAYLRLARAYRALGRPDEAIAALEKA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 87-214 2.64e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  87 AEAHVNLAQGYLQLKGLSlQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG4783   38 PEAFALLGEILLQLGDLD-EAIVLLHEALELDPDEP---------------EARLNLGLALLKAGDYDEALALLEKALKL 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767985069 167 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG4783  102 DPE---------------HPEAYLRLARAYRALGRPDEAIAALEKALE 134
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
52-215 3.64e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  52 AKSYSNSHEYKQAVHELVRCVALtricygdsHWKLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentd 131
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQALEL--------DPDDAEALNNLGLALQAL-GRYEEALEDYDKALELDPDDA--------- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069 132 vfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQA 211
Cdd:COG0457  111 ------EALYNLGLALLELGRYDEAIEAYERALELDPDD---------------ADALYNLGIALEKLGRYEEALELLEK 169


                 ....
gi 767985069 212 ALEY 215
Cdd:COG0457  170 LEAA 173
TPR_12 pfam13424
Tetratricopeptide repeat;
143-214 4.42e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 4.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767985069  143 MGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 87-214 6.01e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985069  87 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANsivppysentdvfkfSIELFHTMGRALLSLQKFKEAAENLTKAERL 166
Cdd:COG4235   17 AEGWLLLGRAYLRL-GRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767985069 167 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG4235   81 DPD---------------NPEALYLLGLAAFQQGDYAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 136-214 9.88e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 9.88e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767985069 136 SIELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 214
Cdd:COG4235   16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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