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Conserved domains on  [gi|767985834|ref|XP_011520538|]
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GPI mannosyltransferase 3 isoform X2 [Homo sapiens]

Protein Classification

Glyco_transf_22 domain-containing protein( domain architecture ID 10511211)

Glyco_transf_22 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-414 4.18e-103

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


:

Pssm-ID: 281842  Cd Length: 414  Bit Score: 315.46  E-value: 4.18e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  140 F-----------------------------------FCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 181
Cdd:pfam03901  80 FyaprlllglfsalcdyylyravcrkygleiarwalLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  182 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 255
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  256 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 331
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  332 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 399
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985834  400 IMMPCHSTPYYSHVH 414
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-414 4.18e-103

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 315.46  E-value: 4.18e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  140 F-----------------------------------FCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 181
Cdd:pfam03901  80 FyaprlllglfsalcdyylyravcrkygleiarwalLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  182 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 255
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  256 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 331
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  332 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 399
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985834  400 IMMPCHSTPYYSHVH 414
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
63-505 4.35e-101

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 314.66  E-value: 4.35e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  63 LLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDS------- 135
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTpyimika 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 136 ---VQLLF-------------------------FCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 184
Cdd:PLN02816 121 prlMQSIFsaigdlylyklsdalyggnvatwslFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 185 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 263
Cdd:PLN02816 201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 264 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 343
Cdd:PLN02816 281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 344 THLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSI 398
Cdd:PLN02816 359 AQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SI 435
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 399 FIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLI 478
Cdd:PLN02816 436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMI 513
                        490       500
                 ....*....|....*....|....*...
gi 767985834 479 SSNYKRTAVFFHTHLPEGR-IGSHIYVY 505
Cdd:PLN02816 514 QHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-414 4.18e-103

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 315.46  E-value: 4.18e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  140 F-----------------------------------FCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 181
Cdd:pfam03901  80 FyaprlllglfsalcdyylyravcrkygleiarwalLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  182 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 255
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  256 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 331
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  332 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 399
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985834  400 IMMPCHSTPYYSHVH 414
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
63-505 4.35e-101

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 314.66  E-value: 4.35e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834  63 LLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDS------- 135
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTpyimika 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 136 ---VQLLF-------------------------FCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 184
Cdd:PLN02816 121 prlMQSIFsaigdlylyklsdalyggnvatwslFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 185 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 263
Cdd:PLN02816 201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 264 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 343
Cdd:PLN02816 281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 344 THLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSI 398
Cdd:PLN02816 359 AQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SI 435
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985834 399 FIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLI 478
Cdd:PLN02816 436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMI 513
                        490       500
                 ....*....|....*....|....*...
gi 767985834 479 SSNYKRTAVFFHTHLPEGR-IGSHIYVY 505
Cdd:PLN02816 514 QHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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