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Conserved domains on  [gi|767987506|ref|XP_011520907|]
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matrix metalloproteinase-25 isoform X3 [Homo sapiens]

Protein Classification

zinc metalloprotease; M10 family metallopeptidase domain-containing protein( domain architecture ID 10208879)

zinc metalloprotease may be a member of the astacin-like protease family or the adamalysin/reprolysin-like protease family; M10 family metallopeptidase domain-containing protein is a metalloendopeptidase similar to matrix metalloproteinases that may be endopeptidases that degrade various components of the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 104-298 1.49e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 185.21  E-value: 1.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 104 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 182
Cdd:cd00094    1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 183 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 259
Cdd:cd00094   76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767987506 260 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 298
Cdd:cd00094  156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 11-70 1.02e-28

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04278:

Pssm-ID: 469599 [Multi-domain]  Cd Length: 157  Bit Score: 108.83  E-value: 1.02e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506  11 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 70
Cdd:cd04278  101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 104-298 1.49e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 185.21  E-value: 1.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 104 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 182
Cdd:cd00094    1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 183 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 259
Cdd:cd00094   76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767987506 260 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 298
Cdd:cd00094  156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 11-70 1.02e-28

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 108.83  E-value: 1.02e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506  11 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 70
Cdd:cd04278  101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 9-70 9.64e-27

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 103.47  E-value: 9.64e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987506    9 EEDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDGLQQLYG 70
Cdd:pfam00413 100 SDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKGIQQLYG 159
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 11-71 3.88e-12

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 63.14  E-value: 3.88e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767987506    11 DGEGTDLFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDDRDGLQQLYGK 71
Cdd:smart00235  78 LGNGCINTGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDDSLGIPYDYGS 139
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-252 4.45e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.47  E-value: 4.45e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767987506   206 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 252
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-252 5.01e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 51.41  E-value: 5.01e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767987506  206 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 252
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 14-69 1.06e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 48.91  E-value: 1.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767987506  14 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 69
Cdd:COG5549  179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 104-298 1.49e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 185.21  E-value: 1.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 104 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 182
Cdd:cd00094    1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506 183 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 259
Cdd:cd00094   76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767987506 260 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 298
Cdd:cd00094  156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 11-70 1.02e-28

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 108.83  E-value: 1.02e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506  11 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 70
Cdd:cd04278  101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 9-70 9.64e-27

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 103.47  E-value: 9.64e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987506    9 EEDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDGLQQLYG 70
Cdd:pfam00413 100 SDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKGIQQLYG 159
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 11-71 3.88e-12

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 63.14  E-value: 3.88e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767987506    11 DGEGTDLFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDDRDGLQQLYGK 71
Cdd:smart00235  78 LGNGCINTGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDDSLGIPYDYGS 139
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 14-70 1.01e-11

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 62.47  E-value: 1.01e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767987506  14 GTDLFAVAVHEFGHALGLGHSSA-PNSIMRPFY-QGPVGDPdkyRLSQDDRDGLQQLYG 70
Cdd:cd04279  101 AENLQAIALHELGHALGLWHHSDrPEDAMYPSQgQGPDGNP---TLSARDVATLKRLYG 156
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-252 4.45e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.47  E-value: 4.45e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767987506   206 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 252
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 206-252 5.01e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 51.41  E-value: 5.01e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767987506  206 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 252
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 17-69 3.84e-08

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 52.11  E-value: 3.84e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987506  17 LFAVAVHEFGHALGLGHSSA----------------PNSIM---RPFYQGPVGDPDKYRLSQDDRDGLQQLY 69
Cdd:cd04268   94 LRNTAEHELGHALGLRHNFAasdrddnvdllaekgdTSSVMdyaPSNFSIQLGDGQKYTIGPYDIAAIKKLY 165
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 16-69 2.26e-07

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 50.21  E-value: 2.26e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767987506  16 DLFAVAVHEFGHALGLGHSS--------------------APNSIMRPFYqGPVGDPDKYRLSQDDRDGLQQLY 69
Cdd:cd00203   95 EGAQTIAHELGHALGFYHDHdrkdrddyptiddtlnaeddDYYSVMSYTK-GSFSDGQRKDFSQCDIDQINKLY 167
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 14-69 1.06e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 48.91  E-value: 1.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767987506  14 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 69
Cdd:COG5549  179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 111-154 6.72e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 42.61  E-value: 6.72e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767987506   111 FDAIA-NIRGETFFFKGPWFWRLQPsGQLVSPRPARLHRFWEGLP 154
Cdd:smart00120   1 IDAAFeLRDGKTYFFKGDKYWRFDP-KRVDPGYPKLISSFFPGLP 44
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 11-70 8.05e-05

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.79  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987506  11 DGEGTDLFAVAVHEFGHALGLGHS----------------SAPNSIMRpfYQGPVGDPD--KYRLSQ----DDRDGLQQL 68
Cdd:cd04277  107 DSPGSYGYQTIIHEIGHALGLEHPgdynggdpvpptyaldSREYTVMS--YNSGYGNGAsaGGGYPQtpmlLDIAALQYL 184


                 ..
gi 767987506  69 YG 70
Cdd:cd04277  185 YG 186
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
4-43 5.07e-04

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 40.33  E-value: 5.07e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767987506   4 ERQGREEDGEgtdLFA-----VAVHEFGHALGLGHSSAPNSIMRP 43
Cdd:COG1913  108 EFYGLPPDEE---LFLervlkEAVHELGHLFGLGHCPNPRCVMHF 149
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 111-154 1.40e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767987506  111 FDAIANIR-GETFFFKGPWFWRLQPsGQLVSPRPARLHRFWeGLP 154
Cdd:pfam00045   1 IDAAFEDRdGKTYFFKGRKYWRFDP-QRVEPGYPKLISDFP-GLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 255-276 3.75e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|..
gi 767987506  255 DDVTVSNAGDTYFFKGAHYWRF 276
Cdd:pfam00045   2 DAAFEDRDGKTYFFKGRKYWRF 23
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 12-33 7.97e-03

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 36.88  E-value: 7.97e-03
                          10        20
                  ....*....|....*....|..
gi 767987506   12 GEGTDLFAVAVHEFGHALGLGH 33
Cdd:pfam01400  75 GDGCDKFGIIVHELGHALGFFH 96
Peptidase_M54 cd11375
Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 ...
 20-43 8.35e-03

Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eukaryotes, including two human members, archaemetzincin-1 and -2 (AMZ1 and AMZ2). AMZ1 is mainly found in the liver and heart while AMZ2 is primarily expressed in testis and heart; both have been reported to degrade synthetic substrates and peptides. The Peptidase M54 family contains an extended metzincin concensus sequence of HEXXHXXGX3CX4CXMX17CXXC such that a second zinc ion is bound to four cysteines, thus resembling a zinc finger. Phylogenetic analysis of this family reveals a complex evolutionary process involving a series of lateral gene transfer, gene loss and genetic duplication events.


Pssm-ID: 213029  Cd Length: 173  Bit Score: 36.89  E-value: 8.35e-03
                         10        20
                 ....*....|....*....|....
gi 767987506  20 VAVHEFGHALGLGHSSAPNSIMRP 43
Cdd:cd11375  126 EAVHELGHLFGLDHCPYYACVMNF 149
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 160-202 9.77e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 33.69  E-value: 9.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767987506  160 VQAAYaRHRDGRILLFSGPQFWVFQDRQLE-GGARPLTEL-GLPP 202
Cdd:pfam00045   1 IDAAF-EDRDGKTYFFKGRKYWRFDPQRVEpGYPKLISDFpGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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