Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 217
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767987690 218 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08707   77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690  60 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFcSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 129
Cdd:cd11582    1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 217
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767987690 218 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08707   77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690   137 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 216
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767987690   217 IKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 259
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690   834 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 911
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 767987690   912 VEKVD 916
Cdd:smart00021  79 LVSVE 83

Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of Axin-1.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987690   60 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPY 131
Cdd:pfam16646   4 DGGGSFREDAPRPPVPGEEGEVPGCGPQHGSFGPSSKKEALKKEASVASTPRRNEDGLGEEPEGSASPDPPL 75

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 217
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767987690 218 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08707   77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690   137 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 216
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767987690   217 IKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 259
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690   834 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 911
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 767987690   912 VEKVD 916
Cdd:smart00021  79 LVSVE 83

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690  60 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFcSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 129
Cdd:cd11582    1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPcdsnEEKRLKLARAIYRKYI---------LDNngivsrQ 208
Cdd:cd08713    1 LEKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKS----QSKMASRAKKIFAEYIaiqsckevnLDS------Y 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767987690 209 TKPATKSFIkgcimkQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08713   71 TREHTKENL------QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnngivsrQTKPATK--- 214
Cdd:cd08717    1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPLKMATK----AKKIYEEFI---------QTEAPKEvni 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767987690 215 -SFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08717   68 dHFTKDVTMKNLVEPSSssFDLAQKRIFALMEKDSLPRFVRSEFYQE 114

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLepcdSNEEKRLKLARAIYRKYiLDNNGI----VSRQTKpat 213
Cdd:cd08706    1 FERLLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKI----PDKKQLVQEAREIYDTF-LSSKASspvnIDSQAQ--- 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767987690 214 ksfikgCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08706   73 ------LAEEMLEEPHpdMFQKQQLQIFNLMKFDSYSRFLKSPLYQQ 113

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 134 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnnGIVSRQtKPAT 213
Cdd:cd08745    1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEK----ARLIYEDYI----SILSPK-EVSL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767987690 214 KSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 256
Cdd:cd08745   72 DSRVREGINRKMQEPSshTFDDAQLQIYTLMHRDSYPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 138 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNngiVSRQTKPATKSFI 217
Cdd:cd08741    1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQ----DKTQMQEKAKEIYMTFLSSK---ASSQVNVEGQSRL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767987690 218 KGCIMKQlIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08741   74 NEKILEE-PHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLK 113

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 141 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIldnngivsrqTKPATKSF---- 216
Cdd:cd08709    4 LLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTK----SPQKLTSKAKKIYTDFI----------EKEAPKEInidf 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767987690 217 -IKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08709   70 qTKTLIAQNIQEATSgcFTAAQKRVYSLMENNSYPRFLESEFYQE 114

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 141 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNNGI---VSRQTKPATKSFI 217
Cdd:cd08710    4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIR----SATKLASRAHHIFEEFIRSEAPKevnIDHETRELTRTNL 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767987690 218 KGCImkqlidPAMFDQAQTEIQATMEENTYPSFLKSDIY 256
Cdd:cd08710   80 QAAT------TSCFDVAQGKTRTLMEKDSYPRFLKSPAY 112

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 130 PYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSneEKRLKLARAIYRKYildnngIVSRQT 209
Cdd:cd08743    3 SVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDT--QQLAQEARKIYNEF------LSSSSQ 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767987690 210 KPAT--KSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08743   75 SPVNidQQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQD 125

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 147 GISLFRTFLKQEGCADLLDFWFACTGFRKLepcdSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCimkQLI 226
Cdd:cd08716   10 GPIIYATYLKTEHSDENIEFWLACETYKKI----ASQRKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNI---QEP 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 767987690 227 DPAMFDQAQTEIQATMEENTYPSFLKSDIY 256
Cdd:cd08716   83 TQSCFDEAQRIVYMHMERDSYPRFLESKFY 112

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767987690  519 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 550
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 133 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsnEEKRLKLARAIYRKYILDNngiVSRQTKPA 212
Cdd:cd08740    5 RWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRYGE-----QSKIPELVDSVYQQFLAPG---ATRWVNID 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767987690 213 TKSFIKgcIMKQLIDPAMF--DQAQTEIQATMEENTYPSFLKSDIY 256
Cdd:cd08740   77 SKTMER--TLEGLKQPHRYvlDDAQMHIYMLMKKDSYPRFLKSDLY 120

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 141 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlKLARAIYRKYildnngIVSRQTKPATKSfikgc 220
Cdd:cd08742    4 LLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELS--YRAREIFSKF------LCSKATTPVNID----- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767987690 221 IMKQLID-------PAMFDQAQTEIQATMEENTYPSFLKSDIYLE 258
Cdd:cd08742   71 SQAQLADdilnaphPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 142 LDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLA------------RAIYRKYILDNNGI--VSR 207
Cdd:cd08729    1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkediAMIYETYFSDPSPSlnVPK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767987690 208 QTKPATKSFIKgCIMKQLIDP-------AMFdQAQTEIQATMEENTYPSFLKSDIYL 257
Cdd:cd08729   81 ASRDPIRLFLN-AGVNASPNEqyrkarrAVL-MAQRAVYEEMEEEDFPEFKKSELFY 135

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3); The RGS domain is an essential part of the GRK2 (G protein-coupled receptor kinases 2) and the GRK3 proteins, which are members of the beta-adrenergic receptor kinases subfamily. GRK2 and GRK3 are ubiquitously expressed and can phosphorylate many different GPCR. The C-terminus of GRK2 and 3 contains a plekstrin homology domain (PH) with binding sites for the membrane phospholipid PIP2 and free G#? subunits. These specific interactions could help to maintain a membrane-bound population of GRK2 prior to the agonist-dependent overt GRK2 translocation. GRK2 and GRK3 are members of the GRK kinase family which includes three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987690 147 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNngIVSrQTKPATKS---FIKGCI 221
Cdd:cd08747   35 GYLLFKDFCENvsEEPVPQLKFYEEIKKYEKLD----TEEERIKKAREIYDNYIMKE--LLS-CSHPFSKSaveHVQKHL 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767987690 222 MKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDiylEYTR 261
Cdd:cd08747  108 SKKEVPVDLFEPYIEEICDSLRGDVFQKFLESD---KFTR 144