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Conserved domains on  [gi|767989923|ref|XP_011521388|]
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diphosphomevalonate decarboxylase isoform X1 [Homo sapiens]

Protein Classification

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein( domain architecture ID 706585)

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein similar to diphosphomevalonate decarboxylase (DMD) that catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP), and mevalonate 3,5-bisphosphate decarboxylase (MBD) that catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate

EC:  4.1.1.-
Gene Ontology:  GO:0016831|GO:0008299
PubMed:  8382990|7947744|31268677

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MDD_C super family cl28577
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 10-371 4.69e-153

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


The actual alignment was detected with superfamily member PLN02407:

Pssm-ID: 475042  Cd Length: 343  Bit Score: 437.30  E-value: 4.69e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  10 VTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCL 89
Cdd:PLN02407   4 VTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  90 ARKRRNSRDGDPLPSSL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQ 167
Cdd:PLN02407  84 ATDVEDEEKGIKITKKDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 168 htytlarvygvesdLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTV 247
Cdd:PLN02407 148 --------------LSAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 248 GMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNA 327
Cdd:PLN02407 214 GMRESVETSPLLQHRAKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNR 293

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767989923 328 HHGDTKVAYTFDAGPNAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 371
Cdd:PLN02407 294 SEGTPQVAYTFDAGPNAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 10-371 4.69e-153

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 437.30  E-value: 4.69e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  10 VTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCL 89
Cdd:PLN02407   4 VTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  90 ARKRRNSRDGDPLPSSL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQ 167
Cdd:PLN02407  84 ATDVEDEEKGIKITKKDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 168 htytlarvygvesdLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTV 247
Cdd:PLN02407 148 --------------LSAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 248 GMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNA 327
Cdd:PLN02407 214 GMRESVETSPLLQHRAKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNR 293

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767989923 328 HHGDTKVAYTFDAGPNAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 371
Cdd:PLN02407 294 SEGTPQVAYTFDAGPNAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 231-416 1.19e-116

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 338.38  E-value: 1.19e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  231 VLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISY 310
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  311 LNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQA 390
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQFFKGLPVLPSELSEELKA 160

                         170       180
                  ....*....|....*....|....*.
gi 767989923  391 ALAMEPTPGGVKYIIVTQVGPGPQIL 416
Cdd:pfam18376 161 SLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 10-364 5.52e-84

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 259.88  E-value: 5.52e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   10 VTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREE-DVGQPRLQACLREIRc 88
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQhSIDNEKTSNCLDDFR- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   89 larkrrnsrdgdpLPSSLSCKVHVASVNNFPTAaglassaagyACLVAAGVGLSPVIPVLKRLMgekhcrpgvqdQPGQH 168
Cdd:TIGR01240  78 -------------QLRKEQEKLHIVSQNNFPTA----------AGLASSASGLAALVSACAKLY-----------QLPLD 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  169 TytlarvygveSDLSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVG 248
Cdd:TIGR01240 124 T----------SELSRIARKGSGSACRSLFGGYVAWEKGK--DDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQG 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  249 MRASVETSPLLRFRAESVVPaRMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNah 328
Cdd:TIGR01240 192 MQLTVATSELFKEWIEHVVP-DFEV*RKAIKTKDFATFGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLR-- 268

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 767989923  329 HGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGF 364
Cdd:TIGR01240 269 QGGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 9-415 1.44e-80

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 251.27  E-value: 1.44e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   9 AVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREED-VGQPRLQACLREIR 87
Cdd:COG3407    5 SATARAHSNIALIKYWGKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKgKFLPKISKFLDRVR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  88 CLARKRRnsrdgdplpsslscKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvlkrlmgekhcrpgvqdqpgq 167
Cdd:COG3407   83 ALAGKSY--------------HARIESENNFPTAAGLASSASGFAALALA------------------------------ 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 168 htytLARVYGVESD---LSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPEsHWPeLRVLILVVSAEKKLTG 244
Cdd:COG3407  119 ----ANSAEGLDLDdrkLSRLARLGSGSACRSIFGGFVEWGKGE--DDEDSYAVPIPAE-DWD-LADIILVVDKGEKKVS 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 245 STVGMRaSVETSPLLRFRAESvVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHR 324
Cdd:COG3407  191 SREGMK-TAETSPFYPAWVEQ-AEEDLEKLKEAIKAGDFEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVRE 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 325 FNAhhGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAvwhgfppgsngdtflkglqvrpapLSAELqaalameptpgGVKYI 404
Cdd:COG3407  269 LRE--EGLPVYFTLDAGPNVKVLCPEEDAEKVAAF------------------------LAAEL-----------VNGQV 311

                        410
                 ....*....|.
gi 767989923 405 IVTQVGPGPQI 415
Cdd:COG3407  312 IVDKPGPGARL 322
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 10-371 4.69e-153

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 437.30  E-value: 4.69e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  10 VTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCL 89
Cdd:PLN02407   4 VTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  90 ARKRRNSRDGDPLPSSL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQ 167
Cdd:PLN02407  84 ATDVEDEEKGIKITKKDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 168 htytlarvygvesdLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTV 247
Cdd:PLN02407 148 --------------LSAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 248 GMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNA 327
Cdd:PLN02407 214 GMRESVETSPLLQHRAKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNR 293

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767989923 328 HHGDTKVAYTFDAGPNAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 371
Cdd:PLN02407 294 SEGTPQVAYTFDAGPNAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 231-416 1.19e-116

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 338.38  E-value: 1.19e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  231 VLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISY 310
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  311 LNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQA 390
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQFFKGLPVLPSELSEELKA 160

                         170       180
                  ....*....|....*....|....*.
gi 767989923  391 ALAMEPTPGGVKYIIVTQVGPGPQIL 416
Cdd:pfam18376 161 SLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 10-364 5.52e-84

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 259.88  E-value: 5.52e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   10 VTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREE-DVGQPRLQACLREIRc 88
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQhSIDNEKTSNCLDDFR- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   89 larkrrnsrdgdpLPSSLSCKVHVASVNNFPTAaglassaagyACLVAAGVGLSPVIPVLKRLMgekhcrpgvqdQPGQH 168
Cdd:TIGR01240  78 -------------QLRKEQEKLHIVSQNNFPTA----------AGLASSASGLAALVSACAKLY-----------QLPLD 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  169 TytlarvygveSDLSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVG 248
Cdd:TIGR01240 124 T----------SELSRIARKGSGSACRSLFGGYVAWEKGK--DDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQG 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  249 MRASVETSPLLRFRAESVVPaRMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNah 328
Cdd:TIGR01240 192 MQLTVATSELFKEWIEHVVP-DFEV*RKAIKTKDFATFGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLR-- 268

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 767989923  329 HGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGF 364
Cdd:TIGR01240 269 QGGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 9-415 1.44e-80

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 251.27  E-value: 1.44e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923   9 AVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREED-VGQPRLQACLREIR 87
Cdd:COG3407    5 SATARAHSNIALIKYWGKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKgKFLPKISKFLDRVR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923  88 CLARKRRnsrdgdplpsslscKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvlkrlmgekhcrpgvqdqpgq 167
Cdd:COG3407   83 ALAGKSY--------------HARIESENNFPTAAGLASSASGFAALALA------------------------------ 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 168 htytLARVYGVESD---LSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPEsHWPeLRVLILVVSAEKKLTG 244
Cdd:COG3407  119 ----ANSAEGLDLDdrkLSRLARLGSGSACRSIFGGFVEWGKGE--DDEDSYAVPIPAE-DWD-LADIILVVDKGEKKVS 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 245 STVGMRaSVETSPLLRFRAESvVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHR 324
Cdd:COG3407  191 SREGMK-TAETSPFYPAWVEQ-AEEDLEKLKEAIKAGDFEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVRE 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989923 325 FNAhhGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAvwhgfppgsngdtflkglqvrpapLSAELqaalameptpgGVKYI 404
Cdd:COG3407  269 LRE--EGLPVYFTLDAGPNVKVLCPEEDAEKVAAF------------------------LAAEL-----------VNGQV 311

                        410
                 ....*....|.
gi 767989923 405 IVTQVGPGPQI 415
Cdd:COG3407  312 IVDKPGPGARL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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