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Conserved domains on  [gi|767991525|ref|XP_011521927|]
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F-box/WD repeat-containing protein 10 isoform X12 [Homo sapiens]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 18134605)

F-box/WD repeat-containing protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|2.130.10.10
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-704 2.63e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 2.63e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 469 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 548
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 549 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 623
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 624 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMaFKHPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNCM 699
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECV 254


                 ....*
gi 767991525 700 KVLKA 704
Cdd:cd00200  255 QTLSG 259
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 299-367 1.84e-12

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22136:

Pssm-ID: 459239  Cd Length: 40  Bit Score: 62.26  E-value: 1.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991525 299 FIRYLPIHLSKYILSMLgcmrgfprhlpswpssgvsgsifffpgmlDRHTLNKCASVSQHWAAMAQQVK 367
Cdd:cd22136    1 FIRCLPVHLSKYILSML-----------------------------DKKSLNNCLCVSQHWRALTEEVK 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-704 2.63e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 2.63e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 469 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 548
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 549 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 623
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 624 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMaFKHPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNCM 699
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECV 254


                 ....*
gi 767991525 700 KVLKA 704
Cdd:cd00200  255 QTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
473-722 6.15e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 6.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 473 GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 627
Cdd:COG2319  211 AFSPDgkLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 628 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllF----LRVISACADGKIRIYNFLNGNCMK 700
Cdd:COG2319  291 VNSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FspdgKTLASGSDDGTVRLWDLATGELLR 366

                        250       260
                 ....*....|....*....|....
gi 767991525 701 VLKanGRGDPV--LSFFIQGNRMV 722
Cdd:COG2319  367 TLT--GHTGAVtsVAFSPDGRTLA 388
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 299-367 1.84e-12

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 62.26  E-value: 1.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991525 299 FIRYLPIHLSKYILSMLgcmrgfprhlpswpssgvsgsifffpgmlDRHTLNKCASVSQHWAAMAQQVK 367
Cdd:cd22136    1 FIRCLPVHLSKYILSML-----------------------------DKKSLNNCLCVSQHWRALTEEVK 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 535-572 1.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767991525   535 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
536-572 8.91e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 8.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767991525  536 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 572
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-704 2.63e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 2.63e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 469 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 548
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 549 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 623
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 624 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMaFKHPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNCM 699
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECV 254


                 ....*
gi 767991525 700 KVLKA 704
Cdd:cd00200  255 QTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
473-722 6.15e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 6.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 473 GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 627
Cdd:COG2319  211 AFSPDgkLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 628 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllF----LRVISACADGKIRIYNFLNGNCMK 700
Cdd:COG2319  291 VNSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FspdgKTLASGSDDGTVRLWDLATGELLR 366

                        250       260
                 ....*....|....*....|....
gi 767991525 701 VLKanGRGDPV--LSFFIQGNRMV 722
Cdd:COG2319  367 TLT--GHTGAVtsVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 499-723 1.07e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 499 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTG 576
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 577 KCLKTFR-HKDPILATRIN-DTYIVSSCER-GLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 651
Cdd:cd00200   84 ECVRTLTgHTSYVSSVAFSpDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767991525 652 MvgKYERCLMAFK-HPKEVLDVSLL--FLRVISACADGKIRIYNFLNGNCMKVLKanGRGDPVLSF-FIQGNRMVV 723
Cdd:cd00200  164 L--RTGKCVATLTgHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLR--GHENGVNSVaFSPDGYLLA 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 476-692 2.92e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 2.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 476 LIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITC--MD 553
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSvaFS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 554 LCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKC 630
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767991525 631 LFFDQWHLL--SGSTDGLVMAWSMVGKyeRCLMAFK-HPKEV--LDVSLLFLRVISACADGKIRIYN 692
Cdd:cd00200  225 VAFSPDGYLlaSGSEDGTIRVWDLRTG--ECVQTLSgHTNSVtsLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
456-713 1.35e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.35e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 456 VRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQvKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 535
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 536 GVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVW 610
Cdd:COG2319  152 GKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFspDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 611 HIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFKHPK-EVLDVSllFL----RVISAC 683
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSgGVNSVA--FSpdgkLLASGS 307

                        250       260       270
                 ....*....|....*....|....*....|
gi 767991525 684 ADGKIRIYNFLNGNCMKVLKanGRGDPVLS 713
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLT--GHTGAVRS 335
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-651 1.97e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 1.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 469 IHYSGGDLIAVSSNR--KIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQ 546
Cdd:cd00200   99 VAFSPDGRILSSSSRdkTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 547 GTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-DTYIVSSC-ERGLVKVWHIAMAQLVKTL 621
Cdd:cd00200  178 GEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSpDGYLLASGsEDGTIRVWDLRTGECVQTL 257

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767991525 622 SGHEGAVKCLFFDQW--HLLSGSTDGLVMAWS 651
Cdd:cd00200  258 SGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
474-692 7.47e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 7.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 474 GDLIAVSS-NRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  174 GKLLASGSdDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 627
Cdd:COG2319  253 AFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767991525 628 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACADGKIRIYN 692
Cdd:COG2319  333 VRSVAFspDGKTLASGSDDGTVRLWDLATG--ELLRTLTgHTGAVTSVA--FSpdgrTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
457-713 4.87e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 4.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 457 RILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSG 536
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 537 VCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWH 611
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 612 IAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACA 684
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATG--KLLRTLTgHSGSVRSVA--FSpdgrLLASGSA 266

                        250       260
                 ....*....|....*....|....*....
gi 767991525 685 DGKIRIYNFLNGNCMKVLKanGRGDPVLS 713
Cdd:COG2319  267 DGTVRLWDLATGELLRTLT--GHSGGVNS 293
WD40 COG2319
WD40 repeat [General function prediction only];
474-652 5.13e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 5.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 474 GDLIAVSS-NRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  216 GKLLASGSaDGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 627
Cdd:COG2319  295 AFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        170       180
                 ....*....|....*....|....*..
gi 767991525 628 VKCLFFDQW--HLLSGSTDGLVMAWSM 652
Cdd:COG2319  375 VTSVAFSPDgrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 538-732 1.95e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 538 CTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHI 612
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 613 AMAQLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWSMvgKYERCLMAFK-HPKEVLDVSLLF--LRVISACADGK 687
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDV--ETGKCLTTLRgHTDWVNSVAFSPdgTFVASSSQDGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767991525 688 IRIYNFLNGNCMKVLKanGRGDPV--LSFFIQGNRMVVNTESNVLMF 732
Cdd:cd00200  159 IKLWDLRTGKCVATLT--GHTGEVnsVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
474-713 4.13e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 474 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM- 552
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVa 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 553 -DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAV 628
Cdd:COG2319   86 fSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 629 KCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACADGKIRIYNFLNGNCMKV 701
Cdd:COG2319  166 TSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FSpdgkLLASGSADGTVRLWDLATGKLLRT 241

                        250
                 ....*....|..
gi 767991525 702 LKanGRGDPVLS 713
Cdd:COG2319  242 LT--GHSGSVRS 251
WD40 COG2319
WD40 repeat [General function prediction only];
474-613 6.43e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 6.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 474 GDLIAVSS-NRKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  258 GRLLASGSaDGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCERGLVKVWHIA 613
Cdd:COG2319  337 AFSPDgkTLASGSDDGTVRLWDLATGELLRTLTgHTGAVtsVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
474-575 3.59e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 474 GDLIAVSSN-RKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 552
Cdd:COG2319  300 GKLLASGSDdGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 767991525 553 DLCKN--RLVSGGRDCQVKVWDVDT 575
Cdd:COG2319  379 AFSPDgrTLASGSADGTVRLWDLAT 403
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 299-367 1.84e-12

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 62.26  E-value: 1.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991525 299 FIRYLPIHLSKYILSMLgcmrgfprhlpswpssgvsgsifffpgmlDRHTLNKCASVSQHWAAMAQQVK 367
Cdd:cd22136    1 FIRCLPVHLSKYILSML-----------------------------DKKSLNNCLCVSQHWRALTEEVK 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 535-572 1.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767991525   535 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
536-572 8.91e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 8.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767991525  536 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 572
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
456-535 1.71e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991525 456 VRILSDTWDQNRVIHYS--GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 533
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401


                 ..
gi 767991525 534 KS 535
Cdd:COG2319  402 AT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 616-651 1.81e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767991525   616 QLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 651
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 499-532 5.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 5.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767991525   499 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 532
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
499-532 6.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 6.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767991525  499 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 532
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
616-651 2.47e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767991525  616 QLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWS 651
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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