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Conserved domains on  [gi|767992213|ref|XP_011522191|]
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sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8 [Homo sapiens]

Protein Classification

calcium-transporting ATPase( domain architecture ID 11550595)

calcium-transporting ATPase such as sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle, which re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083     1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083    81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083   160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083   240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083   320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083   399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083   479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083   555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083   635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083   715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083   795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083   875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                         970       980
                  ....*....|....*....|....*
gi 767992213  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083   955 AEWIAVIKISLPVILLDELLKFIAR 979
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083     1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083    81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083   160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083   240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083   320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083   399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083   479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083   555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083   635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083   715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083   795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083   875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                         970       980
                  ....*....|....*....|....*
gi 767992213  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083   955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1466.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116   81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116  157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116  237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116  314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116  394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116  468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116  547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116  627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116  707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116  787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767992213   927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116  855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 951.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474     5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474    79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474   152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474   229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474   289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474   353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474   406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474   475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474   546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474   622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474   702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474   768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|
gi 767992213  950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474   831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 2.04e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 2.04e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517   52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517  121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517  197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517  271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517  338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517  400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517  436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517  508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517  579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517  653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992213  789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517  731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 9.04e-47

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.44  E-value: 9.04e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122    1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122   66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 767992213   281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122  139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.55e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992213      5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083     1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083    81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083   160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083   240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083   320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083   399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083   479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083   555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083   635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083   715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083   795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083   875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                         970       980
                  ....*....|....*....|....*
gi 767992213  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083   955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1466.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116   81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116  157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116  237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116  314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116  394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116  468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116  547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116  627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116  707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116  787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767992213   927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116  855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 951.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474     5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474    79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474   152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474   229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474   289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474   353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474   406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474   475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474   546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474   622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474   702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474   768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|
gi 767992213  950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474   831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
23-822 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 755.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEEtttafVEPLVIMLILVANA 102
Cdd:cd02089     1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL-----GEY-----VDAIVIIAIVILNA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02089    71 VLGFVQEYKAEKALAALKKMSAPTAKVLRDGKK--QEIPARELVPGDIVLLEAGDYVPADGRLIE--SASLRVEESSLTG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02089   147 ESEPVEKDADTLLEEDVPLGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAI 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  263 AISVICVAVWVINIGHFADPAhgGSWLRG---AVyyfkiavalavAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSV 339
Cdd:cd02089   227 AALIICALVFALGLLRGEDLL--DMLLTAvslAV-----------AAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAV 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  340 ETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelatical 419
Cdd:cd02089   294 ETLGSVSVICSDKTGTLTQNKMTVEKIYTI-------------------------------------------------- 323
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  420 cndsaldyneakgvyekvGEATETALTCLVEKMNVFDTDLQALSRveragacntvikqlmrKEFTLEFSRDRKSMSVYct 499
Cdd:cd02089   324 ------------------GDPTETALIRAARKAGLDKEELEKKYP----------------RIAEIPFDSERKLMTTV-- 367
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  500 ptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCLALATR--DAPPRKEDME 577
Cdd:cd02089   368 ----HKDAGKYIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSE--EALRVLAVAYKplDEDPTESSED 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  578 LddcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvAGKAYTGRE 657
Cdd:cd02089   442 L---------ENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILED----GDKALTGEE 508
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  658 FDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLS 736
Cdd:cd02089   509 LDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILT 588
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  737 DDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDI 816
Cdd:cd02089   589 DDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDI 668

                  ....*.
gi 767992213  817 MEKLPR 822
Cdd:cd02089   669 MDRKPR 674
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
23-985 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 743.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEETTTAfveplVIMLILVANA 102
Cdd:cd02080     1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL-----GHWVDAI-----VIFGVVLINA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILTG 182
Cdd:cd02080    71 IIGYIQEGKAEKALAAIKNMLSPEATVLRDGKK--LTIDAEELVPGDIVLLEAGDKVPADLRLIEARN--LQIDESALTG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  183 ESVSVTKHTEAIPdPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02080   147 ESVPVEKQEGPLE-EDTPLGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLI 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  263 AISVICVAVWVInighfadpahgGSWLRG--AVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVE 340
Cdd:cd02080   226 VILVLAALTFVF-----------GLLRGDysLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVE 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  341 TLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelaticALC 420
Cdd:cd02080   295 TLGSVTVICSDKTGTLTRNEMTVQAIV--------------------------------------------------TLC 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  421 NDSALDYNEakGVYEKVGEATETALTCLVEKMNVFDTDLqaLSRVERAGacntvikqlmrkefTLEFSRDRKSMSvyctp 500
Cdd:cd02080   325 NDAQLHQED--GHWKITGDPTEGALLVLAAKAGLDPDRL--ASSYPRVD--------------KIPFDSAYRYMA----- 381
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  501 TRpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLtptSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMELDD 580
Cdd:cd02080   382 TL-HRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAEDLAK--QGLRVLAFAYREVDSEVEEIDHAD 455
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  581 CskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvaGKAYTGREFDD 660
Cdd:cd02080   456 L------EGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDG-----KKVLTGAELDA 524
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDN 739
Cdd:cd02080   525 LDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEVAKEAADMVLADDN 604
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEK 819
Cdd:cd02080   605 FATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKR 684
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  820 LPRSPREALISGWLFFRYlaigVYVGLATVAAATWWFVYDaegphinfyqlrnflkcsednpLFAGIDCEvfesrFPTTM 899
Cdd:cd02080   685 PPRDPSEPLLSRELIWRI----LLVSLLMLGGAFGLFLWA----------------------LDRGYSLE-----TARTM 733
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  900 ALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVIL 979
Cdd:cd02080   734 AVNTIVVAQIFYLFNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFI 813

                  ....*.
gi 767992213  980 LDEALK 985
Cdd:cd02080   814 VVELEK 819
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
33-985 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 572.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfveplviMLILVANAIVgvwQERNA 112
Cdd:cd02085     2 RKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVA-------ILIVVTVAFV---QEYRS 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  113 ESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02085    72 EKSLEALNKLVPPECHCLRDGK--LEHFLARELVPGDLVCLSIGDRIPADLRLFE--ATDLSIDESSLTGETEPCSKTTE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  193 AIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLShAISVICVAV 271
Cdd:cd02085   148 VIPKASNGDlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLS-LYSFIIIGV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  272 WVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSD 351
Cdd:cd02085   227 IML-IGWL----QGKNLLE----MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSD 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  352 KTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrCGqfdglvelaticALCNDSALDYNEAk 431
Cdd:cd02085   298 KTGTLTKNEMTVTKIV------------------------------------TG------------CVCNNAVIRNNTL- 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  432 gvyekVGEATETALTCLVEKMNVFDTDlqalsrveragacNTVIkqlmRKEFtLEFSRDRKSMSVYCtptRPHPTGQGSK 511
Cdd:cd02085   329 -----MGQPTEGALIALAMKMGLSDIR-------------ETYI----RKQE-IPFSSEQKWMAVKC---IPKYNSDNEE 382
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  512 M-FVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRDWGSGSdtLRCLALAtrdappRKEDMElddcskfvqyet 589
Cdd:cd02085   383 IyFMKGALEQVLDYCTTYNSSDGSAlPLTQQQRSEINEEEKEMGSKG--LRVLALA------SGPELG------------ 442
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQA 669
Cdd:cd02085   443 DLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL----QALSGEEVDQMSDSQLASV 518
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  670 CRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd02085   519 VRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAAIE 598
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  749 EGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREAL 828
Cdd:cd02085   599 EGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPI 678
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  829 ISGWLFFRYLaigvyVGLATVAAATWWfvydaegphINFYQLRNFLKCSEDnplfagidcevfesrfpTTMALSVLVTIE 908
Cdd:cd02085   679 LTRSLILNVL-----LSAAIIVSGTLW---------VFWKEMSDDNVTPRD-----------------TTMTFTCFVFFD 727
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767992213  909 MCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALK 985
Cdd:cd02085   728 MFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
7-989 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 565.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213     7 LPAADVLRHFSVTAEGGLSPAQ-VTGARERYGPNELPSEEGKSLWELVLEQF-EDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01522    7 LSVEETCSKLQTDLQNGLNSSQeASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDDAVSI 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    85 TTAfveplviMLILVAnaiVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:TIGR01522   87 TLA-------ILIVVT---VGFVQEYRSEKSLEALNKLVPPECHLIREGKL--EHVLASTLVPGDLVCLSVGDRVPADLR 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   165 LIEikSTTLRVDQSILTGESVSVTKHTEAIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:TIGR01522  155 IVE--AVDLSIDESNLTGETTPVSKVTAPIPAATNGDlAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   244 PERTPLQRKLDEFGRQLShAISVICVAVWVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGT 323
Cdd:TIGR01522  233 KPKTPLQKSMDLLGKQLS-LVSFGVIGVICL-VGWF----QGKDWLE----MFTISVSLAVAAIPEGLPIIVTVTLALGV 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeaDAGSCLLheftiSGTTYTPEGEVRQGDQPVR 403
Cdd:TIGR01522  303 LRMSKKRAIVRKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWTS---DGLHTML-----NAVSLNQFGEVIVDGDVLH 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   404 CGQFDGLVELATICALCNDSALDyNEAKGVyekVGEATETALTCLVEKMNVFDTDlQALSRVERagacntvikqlmrkef 483
Cdd:TIGR01522  375 GFYTVAVSRILEAGNLCNNAKFR-NEADTL---LGNPTDVALIELLMKFGLDDLR-ETYIRVAE---------------- 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   484 tLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSS-VRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:TIGR01522  434 -VPFSSERKWMAVKCV----HRQDRSEMCFMKGAYEQVLKYCTYyQKKDGKTLTLTQQQRDVIQEEAAEMAS--AGLRVI 506
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   563 ALAtrdapprkedmelddcSKFVQYEtdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:TIGR01522  507 AFA----------------SGPEKGQ--LTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGMP 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   643 GDTedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
Cdd:TIGR01522  569 SKT----SQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMGq 644
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:TIGR01522  645 TGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMDG 724
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   802 LPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaatwwFVYdaegphinFYQLRNFLKCSEDnp 881
Cdd:TIGR01522  725 PPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTL------FVF--------VREMQDGVITARD-- 788
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   882 lfagidcevfesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTP 961
Cdd:TIGR01522  789 ---------------TTMTFTCFVFFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEA 853
                          970       980
                   ....*....|....*....|....*...
gi 767992213   962 LSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01522  854 LSIKDLLFLLLITSSVCIVDEIRKKVER 881
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
33-830 4.24e-167

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 507.51  E-value: 4.24e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEE--GEETTTAFVEPLVIMLILVANAIVGVWQER 110
Cdd:cd02081     5 REVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPfgEGEGKTGWIEGVAILVAVILVVLVTAGNDY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  111 NAESAIEAL-KEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTK 189
Cdd:cd02081    85 QKEKQFRKLnSKKEDQKVTVIRDGE--VIQISVFDIVVGDIVQLKYGDLIPADGLLIE--GNDLKIDESSLTGESDPIKK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  190 HTEaipdpravNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICV 269
Cdd:cd02081   161 TPD--------NQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIVAA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  270 AVWVINIGHFA-DPAHGGSWLRGAVY------YFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02081   233 LTFIVLIIRFIiDGFVNDGKSFSAEDlqefvnFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETM 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  343 GCTSVICSDKTGTLTTNQMSVCRMFVvaeadaGSCllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcnd 422
Cdd:cd02081   313 GNATAICSDKTGTLTQNRMTVVQGYI------GNK--------------------------------------------- 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  423 saldyneakgvyekvgeaTETALTCLVEKmnvfdtdLQALSRVERAGACNTVIKQlmrkeFTleFSRDRKSMSVYCtptr 502
Cdd:cd02081   342 ------------------TECALLGFVLE-------LGGDYRYREKRPEEKVLKV-----YP--FNSARKRMSTVV---- 385
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  503 PHPTGqGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQIL-AKIRDWGSgsDTLRCLALATRDAPPRKEDMELDDC 581
Cdd:cd02081   386 RLKDG-GYRLYVKGASEIVLKKCSYILNSDGEVVFLTSEKKEEIkRVIEPMAS--DSLRTIGLAYRDFSPDEEPTAERDW 462
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  582 SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdTEDVAGKAYTGREFDDL 661
Cdd:cd02081   463 DDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGIL--TEGEDGLVLEGKEFREL 540
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  662 SPEQQRQACRTA--------RCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAE 732
Cdd:cd02081   541 IDEEVGEVCQEKfdkiwpklRVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGiAGTEVAKEASD 620
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  733 MVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPP 812
Cdd:cd02081   621 IILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPP 700
                         810
                  ....*....|....*...
gi 767992213  813 DLDIMEKLPRSPREALIS 830
Cdd:cd02081   701 TEDLLKRKPYGRDKPLIS 718
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
23-989 4.15e-166

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 511.62  E-value: 4.15e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSF-VLAWFEEGeetttafveplVIMLILVAN 101
Cdd:cd02086     1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFaVKDWIEGG-----------VIAAVIALN 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILT 181
Cdd:cd02086    70 VIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGK--TETISSKDVVPGDIVLLKVGDTVPADLRLIETKN--FETDEALLT 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  182 GESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI----RSQMAAVEPER--------- 246
Cdd:cd02086   146 GESLPVIKDAELVfgKEEDVSVGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIakalRGKGGLISRDRvkswlygtl 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  247 ----------------TPLQRKLDEFGRQLsHAISVIC-VAVWVINIGHFADpahggswlRGAVYyfkiAVALAVAAIPE 309
Cdd:cd02086   226 ivtwdavgrflgtnvgTPLQRKLSKLAYLL-FFIAVILaIIVFAVNKFDVDN--------EVIIY----AIALAISMIPE 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  310 GLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgtty 389
Cdd:cd02086   293 SLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVV-------------------------- 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  390 tpegevRQGDQPvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtDLQALSRVERAG 469
Cdd:cd02086   347 ------RQVWIP---------------AALCNIATVFKDEETDCWKAHGDPTEIALQVFATKF-----DMGKNALTKGGS 400
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  470 ACNTVIKqlmrkEFTleFSRDRKSMSVYCTPTRphptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKI 549
Cdd:cd02086   401 AQFQHVA-----EFP--FDSTVKRMSVVYYNNQ----AGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKNV 469
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  550 RDWGSgsDTLRCLALATRDAPPR-KEDMELDDC-SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGD 627
Cdd:cd02086   470 ESLAS--QGLRVLAFASRSFTKAqFNDDQLKNItLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGD 547
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  628 NKGTAVAICRRLGIF------GDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMT 701
Cdd:cd02086   548 HPGTAKAIAREVGILppnsyhYSQEIMDSMVMTASQFDGLSDEEVDALPVLPLVIARCSPQTKVRMIEALHRRKKFCAMT 627
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  702 GDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVvcIFLTAI 780
Cdd:cd02086   628 GDGVNDSPSLKMADVGIAMGlNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQV--ILLLIG 705
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  781 LGLPEA-------LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAat 853
Cdd:cd02086   706 LAFKDEdglsvfpLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVLCLAS-- 783
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  854 wwFVYDAEGphINFYQLrnflkcsednplfaGIDCE---------VFESRFPTTMALSVLVTIemcNALNSVSENQSLLR 924
Cdd:cd02086   784 --FTLVIYG--IGNGDL--------------GSDCNesynsscedVFRARAAVFATLTWCALI---LAWEVVDMRRSFFN 842
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767992213  925 MPP-------------WMNPWLLVAVAMSMALHFLILLV-PPLPLIFQVTPLsGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02086   843 MHPdtdspvksffktlWKNKFLFWSVVLGFVSVFPTLYIpVINDDVFKHTGI-GWEWGLVIACTVAFFAGVELWKAGKR 920
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
93-807 9.82e-163

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 489.91  E-value: 9.82e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    93 VIMLILVANAIVGVWQERNAESAIEALKEYEpEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTT 172
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSL-VNTATVLVLRNGWKEISSKDLVPGDVVLVKSGDTVPADGVLL---SGS 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   173 LRVDQSILTGESVSVTKHTEaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRK 252
Cdd:TIGR01494   77 AFVDESSLTGESLPVLKTAL----------PDGDAVFAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSK 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   253 LDEFGRQL-SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAValavaaiPEGLPAVITTCLALGTRRMARKNA 331
Cdd:TIGR01494  147 ADKFENFIfILFLLLLALAVFLLLPIGGWDGNSIYKAILRALAVLVIAI-------PCALPLAVSVALAVGDARMAKKGI 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftisgttytpegevrqgdqpvrcgqfDGLV 411
Cdd:TIGR01494  220 LVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVII---------------------------------------IGGV 260
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   412 ELATIcalcndsaLDYNEAKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacntVIKQLMRKEFTLEFSRDR 491
Cdd:TIGR01494  261 EEASL--------ALALLAASLEYLSGHPLERAIVKSAEGVIKSD-----------------EINVEYKILDVFPFSSVL 315
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   492 KSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltptsrEQILAKIRDWGSgsDTLRCLALATRDAPP 571
Cdd:TIGR01494  316 KRMGVIV-----EGANGSDLLFVKGAPEFVLERCNNE--------------NDYDEKVDEYAR--QGLRVLAFASKKLPD 374
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   572 rkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdtedvagk 651
Cdd:TIGR01494  375 ------------------DLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   652 aytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGtAVAKSAA 731
Cdd:TIGR01494  428 -----------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG-DVAKAAA 483
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992213   732 EMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAIlglpealipvqllwVNLVTDGLPATAL 807
Cdd:TIGR01494  484 DIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIV--------------IILLPPLLAALAL 545
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
35-807 1.07e-138

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 430.68  E-value: 1.07e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   35 RYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetTTAFVEPLVIMLILVANAIVGVWQERNAES 114
Cdd:cd07539    14 LPARNLALETATRSGILAVAAQLELPPVALLGLAAGASAS----------TGGGVDAVLIVGVLTVNAVIGGVQRLRAER 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  115 AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEAI 194
Cdd:cd07539    84 ALAALLAQQQQPARVVRAPAGRTQTVPAESLVPGDVIELRAGEVVPADARLLE--ADDLEVDESALTGESLPVDKQVAPT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  195 PdpRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSHAISVICVAVWvi 274
Cdd:cd07539   162 P--GAPLADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAPVETA-TGVQAQLRELTSQLLPLSLGGGAAVT-- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  275 nighfadpahGGSWLRGA--VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDK 352
Cdd:cd07539   237 ----------GLGLLRGAplRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  353 TGTLTTNQMSVcrmfvvaeadagscllheftisGTTYTPEGEVrqgdqPVRCGQfdglvelaticalcndsaldyNEAKG 432
Cdd:cd07539   307 TGTLTENRLRV----------------------VQVRPPLAEL-----PFESSR---------------------GYAAA 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  433 VYEKVGEATETAltclvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptgqgskm 512
Cdd:cd07539   339 IGRTGGGIPLLA-------------------------------------------------------------------- 350
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  513 fVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMeLDDCskfvqyETDLT 592
Cdd:cd07539   351 -VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNEL--LAGQGLRVLAVAYRTLDAGTTHA-VEAV------VDDLE 420
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  593 FVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVagkayTGREFDDLSPEQQRQACRT 672
Cdd:cd07539   421 LLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLPRDAEVV-----TGAELDALDEEALTGLVAD 495
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  673 ARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGR 751
Cdd:cd07539   496 IDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGArGSDAAREAADLVLTDDDLETLLDAVVEGR 575
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767992213  752 AIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATAL 807
Cdd:cd07539   576 TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALAL 631
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
23-861 4.29e-134

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 427.15  E-value: 4.29e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETttafvEP--------LVI 94
Cdd:cd02608     1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEE-----EPsndnlylgIVL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   95 MLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLR 174
Cdd:cd02608    76 AAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEK--MQINAEELVVGDLVEVKGGDRIPADIRIISAHG--CK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  175 VDQSILTGESVSVTKHTEAIPDpravNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKL 253
Cdd:cd02608   152 VDNSSLTGESEPQTRSPEFTHE----NPlETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREI 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  254 DEFgrqlSHAISVicVAVWvINIGHFA-DPAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVITTCLALGTRRMARKNAI 332
Cdd:cd02608   228 EHF----IHIITG--VAVF-LGVSFFIlSLILGYTWLEAVIFLI----GIIVANVPEGLLATVTVCLTLTAKRMARKNCL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  333 VRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYTPEGevrqgdqpvrcgqfDG 409
Cdd:cd02608   297 VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGASFDKSS--------------AT 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  410 LVELATICALCNDSALDYNEAKGVYEK---VGEATETALTCLVEkMNVFDTDLqalsrveragacntvIKQLMRKEFTLE 486
Cdd:cd02608   357 WLALSRIAGLCNRAEFKAGQENVPILKrdvNGDASESALLKCIE-LSCGSVME---------------MRERNPKVAEIP 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  487 F-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDtlRCLALA 565
Cdd:cd02608   421 FnSTNKYQLSIH---ENEDPGDPRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGE--RVLGFC 495
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  566 trdapprkeDMEL--DDCSKFVQYETD--------LTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:cd02608   496 ---------HLYLpdDKFPEGFKFDTDevnfptenLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI 566
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  636 CRRLGIFgdtedvagkaytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:cd02608   567 AKGVGII--------------------------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 614
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  716 IGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLW 794
Cdd:cd02608   615 IGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILC 694
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767992213  795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgwlfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:cd02608   695 IDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS----MAYGQIGM---IQALAGFFTYFVIMAE 760
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
5-861 1.02e-133

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 428.83  E-value: 1.02e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213     5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01106   18 HKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQASTEE 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    85 TTAFVE---PLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPA 161
Cdd:TIGR01106   98 EPQNDNlylGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEK--MSINAEQVVVGDLVEVKGGDRIPA 175
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   162 DLRLIEIKSttLRVDQSILTGESVsvtkhteaiPDPRAVN------QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01106  176 DLRIISAQG--CKVDNSSLTGESE---------PQTRSPEfthenpLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRI 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   236 RSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVI 315
Cdd:TIGR01106  245 ASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL------ILGYTWLEAVIFLI----GIIVANVPEGLLATV 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYtpe 392
Cdd:TIGR01106  315 TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGVSF--- 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   393 gevrqgDQPVRcgqfdGLVELATICALCNDSALDYN-EAKGVYEK--VGEATETALTCLVEKmnvfdtdlqalsrverag 469
Cdd:TIGR01106  386 ------DKSSA-----TWLALSRIAGLCNRAVFKAGqENVPILKRavAGDASESALLKCIEL------------------ 436
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   470 ACNTVIKqlMRKEFT----LEF-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQ 544
Cdd:TIGR01106  437 CLGSVME--MRERNPkvveIPFnSTNKYQLSIH---ENEDPRDPRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEA 511
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   545 I-LAKIRDWGSGSDTLR-CLALATRDAPPRKEDMELDDcskfVQYETD-LTFVGCVGMLDPPRPEVAACITRCYQAGIRV 621
Cdd:TIGR01106  512 FqNAYLELGGLGERVLGfCHLYLPDEQFPEGFQFDTDD----VNFPTDnLCFVGLISMIDPPRAAVPDAVGKCRSAGIKV 587
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   622 VMITGDNKGTAVAICRRLGIFGD----TEDVA--------------GKA--YTGREFDDLSPEQQRQACR--TARCFARV 679
Cdd:TIGR01106  588 IMVTGDHPITAKAIAKGVGIISEgnetVEDIAarlnipvsqvnprdAKAcvVHGSDLKDMTSEQLDEILKyhTEIVFART 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   680 EPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMK 758
Cdd:TIGR01106  668 SPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   759 QFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgw 832
Cdd:TIGR01106  748 KSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS-- 825
                          890       900
                   ....*....|....*....|....*....
gi 767992213   833 lfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:TIGR01106  826 --MAYGQIGM---IQALGGFFTYFVILAE 849
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
23-842 3.81e-133

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 416.84  E-value: 3.81e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafveplVIMLILVANA 102
Cdd:cd07538     1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREG-----------LILLIFVVVI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  103 IV-GVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILT 181
Cdd:cd07538    70 IAiEVVQEWRTERALEALKNLSSPRATVIRDGRE--RRIPSRELVPGDLLILGEGERIPADGRLLE--NDDLGVDESTLT 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  182 GESVSVTKhTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS 261
Cdd:cd07538   146 GESVPVWK-RIDGKAMSAPGGWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  262 HAISVIC---VAVWVINIGHFADPAHGGSWLRGAVyyfkiavalavaaIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd07538   225 LAALVFCaliVAVYGVTRGDWIQAILAGITLAMAM-------------IPEEFPVILTVFMAMGAWRLAKKNVLVRRAAA 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscLLHEFTisgttYTPEgevrqgdqpvrcgqfdglvelatica 418
Cdd:cd07538   292 VETLGSITVLCVDKTGTLTKNQMEVVELTS---------LVREYP-----LRPE-------------------------- 331
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  419 lcndsaldyneaKGVYEKVGEATETALTCLvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyc 498
Cdd:cd07538   332 ------------LRMMGQVWKRPEGAFAAA-------------------------------------------------- 349
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  499 tptrphptgqgskmfvKGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMEL 578
Cdd:cd07538   350 ----------------KGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAG--EGLRVLAVAACRIDESFLPDDL 401
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  579 DDCSkfvqyetdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdteDVAGKAYTGREF 658
Cdd:cd07538   402 EDAV--------FIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-----DNTDNVITGQEL 468
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  659 DDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSD 737
Cdd:cd07538   469 DAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDIVLLD 548
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  738 DNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDglPATALGF--NPPDLD 815
Cdd:cd07538   549 DNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIID--PTCSIVFeaEPAERD 626
                         810       820
                  ....*....|....*....|....*..
gi 767992213  816 IMEKLPRSPREALISGWLFFRYLAIGV 842
Cdd:cd07538   627 IMRRPPRPPDEPLFGPRLVIKAILQGA 653
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
24-980 3.85e-132

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 423.42  E-value: 3.85e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    24 LSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWF-----EEGEETTTAFVEPLVIML-I 97
Cdd:TIGR01517   62 LSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYvpsvgEDKADTETGWIEGVAILVsV 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    98 LVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLrlIEIKSTTLRVDQ 177
Cdd:TIGR01517  142 ILVVLVTAVNDYKKELQFRQLNREKSAQKIAVIRGGQ--EQQISIHDIVVGDIVSLSTGDVVPADG--VFISGLSLEIDE 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   178 SILTGESvsvtkhteaipDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFG 257
Cdd:TIGR01517  218 SSITGES-----------DPIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELA 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   258 RQLSHA---ISVICVAV----WVINI----GHFADPAHGGSWLrgaVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
Cdd:TIGR01517  287 GLIGKFgmgSAVLLFLVlslrYVFRIirgdGRFEDTEEDAQTF---LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKM 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftISGTTYTPEGEVRQGDQP--VRc 404
Cdd:TIGR01517  364 MKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY----------------IGEQRFNVRDEIVLRNLPaaVR- 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   405 gqfDGLVElatiCALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERagacntVIKqlmrkefT 484
Cdd:TIGR01517  427 ---NILVE----GISLNSSSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK------VVK-------I 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   485 LEFSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRdwGSGSDTLRCLA 563
Cdd:TIGR01517  487 YPFNSERKFMSVVVK----HSGGK-YREFRKGASEIVLKPCRKRLDSNGEAtPISEDDKDRCADVIE--PLASDALRTIC 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   564 LATRDAPPRKEDmelddcskFVQY-ETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:TIGR01517  560 LAYRDFAPEEFP--------RKDYpNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGIL 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   643 GDTedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
Cdd:TIGR01517  632 TFG----GLAMEGKEFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGi 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA--LIPVQLLWVNLVT 799
Cdd:TIGR01517  708 SGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISSSHTspLTAVQLLWVNLIM 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   800 DGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAaatwwfvydaegphINFYQLRNFLKCSED 879
Cdd:TIGR01517  788 DTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFI--------------LLFAGGSIFDVSGPD 853
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   880 N-PLFAGIDCEvfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVaMSMALHFLILLVPPLPLIFQ 958
Cdd:TIGR01517  854 EiTSHQQGELN--------TIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTI-MGFTFGFQVIIVEFGGSFFS 924
                          970       980
                   ....*....|....*....|....*
gi 767992213   959 VTPLSGRQW---VVVLQISLPVILL 980
Cdd:TIGR01517  925 TVSLSIEQWigcVLLGMLSLIFGVL 949
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
10-854 2.18e-131

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 424.04  E-value: 2.18e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    10 ADVLRHFSVTA-EGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFvlawfeegeeTTTAF 88
Cdd:TIGR01523   12 ADEAAEFIGTSiPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISF----------AMHDW 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    89 VEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:TIGR01523   82 IEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKS--DAIDSHDLVPGDICLLKTGDTIPADLRLIET 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   169 KSttLRVDQSILTGESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIR---------- 236
Cdd:TIGR01523  160 KN--FDTDEALLTGESLPVIKDAHATfgKEEDTPIGDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAaglqgdgglf 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   237 SQMAAVEPER-------------------------TPLQRKLDEFgrqlshAISVICVAVWVINIGHFADPAHGGSwlRG 291
Cdd:TIGR01523  238 QRPEKDDPNKrrklnkwilkvtkkvtgaflglnvgTPLHRKLSKL------AVILFCIAIIFAIIVMAAHKFDVDK--EV 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   292 AVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV--- 368
Cdd:TIGR01523  310 AIY----AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIprf 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   369 ----VAEAD-------AGSCLLHEFTISGTTYTPEG----------EVRQGDQP--VRCGQFDGLVElatICALCNDSAL 425
Cdd:TIGR01523  386 gtisIDNSDdafnpneGNVSGIPRFSPYEYSHNEAAdqdilkefkdELKEIDLPedIDMDLFIKLLE---TAALANIATV 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   426 DYNEAKGVYEKVGEATETALTCLVEKMNVFDTDL-------QALSRVERAGACNTVIKQLMRKEFTLEFSRDR--KSMSV 496
Cdd:TIGR01523  463 FKDDATDCWKAHGDPTEIAIHVFAKKFDLPHNALtgeedllKSNENDQSSLSQHNEKPGSAQFEFIAEFPFDSeiKRMAS 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   497 YCTPTRphptGQGSKMFVKGAPESVIERCSSV--RVGSRTAPLTPTSREQILAKIrdWGSGSDTLRCLALATR--DAPPR 572
Cdd:TIGR01523  543 IYEDNH----GETYNIYAKGAFERIIECCSSSngKDGVKISPLEDCDRELIIANM--ESLAAEGLRVLAFASKsfDKADN 616
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   573 KEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDT------E 646
Cdd:TIGR01523  617 NDDQLKNETLNRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIPPNfihdrdE 696
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   647 DVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 725
Cdd:TIGR01523  697 IMDSMVMTGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGiNGSD 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIfltaILGL-----------PeaLIPVQLLW 794
Cdd:TIGR01523  777 VAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILL----IIGLafrdengksvfP--LSPVEILW 850
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLatVAAATW 854
Cdd:TIGR01523  851 CIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFFLGG--SCLASF 908
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
23-800 2.30e-116

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 376.20  E-value: 2.30e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTtaFVEPLVIMLILVANA 102
Cdd:cd02077     1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--LVGALIILLMVLISG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02077    79 LLDFIQEIRSLKAAEKLKKMVKNTATVIR-DGSKYMEIPIDELVPGDIVYLSAGDMIPADVRIIQ--SKDLFVSQSSLTG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSH 262
Cdd:cd02077   156 ESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSITEKRPE-TSFDKGINKVSKLLIR 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  263 AISVICVAVWVINIghfadpAHGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02077   235 FMLVMVPVVFLING------LTKGDWLEALLF----ALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNF 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  343 GCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISgttYTPEGevrqgdqpvrcgqFDGLVELATICALCND 422
Cdd:cd02077   305 GAMDILCTDKTGTLTQDKIVLERHLDVNGKESERVLRLAYLNS---YFQTG-------------LKNLLDKAIIDHAEEA 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  423 SaldYNEAKGVYEKVGEatetaltclvekmnvfdtdlqalsrveragacntvikqlmrkeftLEFSRDRKSMSVYCTPTR 502
Cdd:cd02077   369 N---ANGLIQDYTKIDE---------------------------------------------IPFDFERRRMSVVVKDND 400
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  503 phptgQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMELDDcs 582
Cdd:cd02077   401 -----GKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEE--LNREGLRVLAIAYKKLPAPEGEYSVKD-- 471
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  583 kfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgDTEDVagkaYTGREFDDLS 662
Cdd:cd02077   472 -----EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINRV----LTGSEIEALS 540
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  663 PEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFAS 742
Cdd:cd02077   541 DEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLEKDLMV 620
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767992213  743 IVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILgLP-EALIPVQLLWVNLVTD 800
Cdd:cd02077   621 LEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASAF-LPfLPMLPIQLLLQNLLYD 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
23-793 7.50e-107

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 351.14  E-value: 7.50e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEgKSLWELVLEQFEDLLVRILLLAALVSFVLA-WfeegeetttafVEPLVIMLILVAN 101
Cdd:cd02076     1 GLTSEEAAKRLKEYGPNELPEKK-ENPILKFLSFFWGPIPWMLEAAAILAAALGdW-----------VDFAIILLLLLIN 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILT 181
Cdd:cd02076    69 AGIGFIEERQAGNAVAALKKSLAPKARVLRDGQ--WQEIDAKELVPGDIVSLKIGDIVPADARLLTGD--ALQVDQSALT 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  182 GESVSVTKHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPeRTPLQRKLDEFGRQLS 261
Cdd:cd02076   145 GESLPVTKHPGD-------------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEE-QGHLQKVLNKIGNFLI 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  262 HAISVICVAVWVINIGHFADPAHGgswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVET 341
Cdd:cd02076   211 LLALILVLIIVIVALYRHDPFLEI---LQFVLVLL-------IASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEE 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCN 421
Cdd:cd02076   281 LAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKDELLLL------------------------------------AALAS 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  422 DsaldyneakgvyEKVGEATETALtclvekmnvfdtdLQALSRVERAGACntvIKQLMRKEFTLEfsrDRKSMSVYCTPT 501
Cdd:cd02076   325 D------------TENPDAIDTAI-------------LNALDDYKPDLAG---YKQLKFTPFDPV---DKRTEATVEDPD 373
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  502 rphptgqGSKMFV-KGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGS-GsdtLRCLALAtrdappRKEDMELD 579
Cdd:cd02076   374 -------GERFKVtKGAPQVILELVG----------NDEAIRQAVEEKIDELASrG---YRSLGVA------RKEDGGRW 427
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  580 DcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfGDTEDVAGKAYTGREFD 659
Cdd:cd02076   428 E------------LLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGM-GTNILSAERLKLGGGGG 494
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  660 DLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDN 739
Cdd:cd02076   495 GMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATDAARAAADIVLTAPG 574
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767992213  740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLL 793
Cdd:cd02076   575 LSVIIDAIKTSRQIFQRMKSYVIYRIAETL-RILVFFTLGILILNFYPLPLIMI 627
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
23-874 3.54e-105

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 345.85  E-value: 3.54e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    23 GLSPAQVTGARERYGPNELPsEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafvepLVIMLILVANA 102
Cdd:TIGR01647    1 GLTSAEAKKRLAKYGPNELP-EKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDF----------VIILGLLLLNA 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQrIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:TIGR01647   70 TIGFIEENKAGNAVEALKQSLAPKARVLR-DGKWQE-IPASELVPGDVVRLKIGDIVPADCRLFE--GDYIQVDQAALTG 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   183 ESVSVTKHTEAIPdpravnqdkknmlFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:TIGR01647  146 ESLPVTKKTGDIA-------------YSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIV 212
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   263 AISVICVAVWVINIGHFadpahGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:TIGR01647  213 LIGVLVLIELVVLFFGR-----GESFREGLQF----ALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEEL 283
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   343 GCTSVICSDKTGTLTTNQMSvcrmfvvaeadagsclLHEFTISGTTYTPEgevrqgdqpvrcgqfDGLVELATICALCND 422
Cdd:TIGR01647  284 AGMDILCSDKTGTLTLNKLS----------------IDEILPFFNGFDKD---------------DVLLYAALASREEDQ 332
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   423 SALDyneaKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacnTVIKqlmRKEFTLEFSRDRKSMSVyctptr 502
Cdd:TIGR01647  333 DAID----TAVLGSAKDLKEARDGYKVLEFVPFD----------------PVDK---RTEATVEDPETGKRFKV------ 383
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   503 phptgqgskmfVKGAPESVIERCSSVRvgsrtapltpTSREQILAKIRDWGSGSdtLRCLALATRDAPPRKEdmelddcs 582
Cdd:TIGR01647  384 -----------TKGAPQVILDLCDNKK----------EIEEKVEEKVDELASRG--YRALGVARTDEEGRWH-------- 432
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   583 kfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--TEDVAGKAYTGrefdD 660
Cdd:TIGR01647  433 ----------FLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNR----D 498
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF 740
Cdd:TIGR01647  499 DLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAVAGATDAARSAADIVLTEPGL 578
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   741 ASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLLWVNLVTDGlPATALGFN---PPDLDIM 817
Cdd:TIGR01647  579 SVIVDAILESRKIFQRMKSYVIYRIAETI-RIVFFFGLLILILNFYFPPIMVVIIAILNDG-TIMTIAYDnvkPSKLPQR 656
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767992213   818 EKLPRSPREALISGWlffrYLAIGVYVGLATVAAATWWfvYDAEGPHINFYQLRNFL 874
Cdd:TIGR01647  657 WNLREVFTMSTVLGI----YLVISTFLLLAIALDTTFF--IDKFGLQLLHGNLQSFI 707
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
483-807 1.47e-103

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 326.72  E-value: 1.47e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  483 FTLEFSRDRKSMSVYCTPTRPHptgqgsKMFVKGAPESVIERCSSvrvgsrtaPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:cd01431    23 EEIPFNSTRKRMSVVVRLPGRY------RAIVKGAPETILSRCSH--------ALTEEDRNKIEKAQEESAR--EGLRVL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  563 ALATRdapprkedmELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:cd01431    87 ALAYR---------EFDPETSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGID 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  643 GDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd01431   158 TKASGV----ILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGS 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  723 -GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:cd01431   234 tGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDL 313

                  ....*.
gi 767992213  802 LPATAL 807
Cdd:cd01431   314 IPALAL 319
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 2.04e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 2.04e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517   52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517  121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517  197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517  271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517  338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517  400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517  436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517  508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517  579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517  653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992213  789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517  731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
1-863 2.04e-91

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 311.42  E-value: 2.04e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213     1 MEAAHLlPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfee 80
Cdd:TIGR01524   13 LKESQM-GKETLLRKLGVHETG-LTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYL------ 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    81 geetTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQRIRARD-IVPGDIVEVAVG 156
Cdd:TIGR01524   85 ----TDDLEATVIIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinENGNGSMDEVPIDaLVPGDLIELAAG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   157 DKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEaIPDPRAVNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01524  161 DIIPADARVIS--ARDLFINQSALTGESLPVEKFVE-DKRARDPEIlERENLCFMGTNVLSGHAQAVVLATGSSTWFGSL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   236 rSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINiGHFAdpahgGSWLRGAVYyfkiAVALAVAAIPEGLPAVI 315
Cdd:TIGR01524  238 -AIAATERRGQTAFDKGVKSVSKLLIRFMLVMVPVVLMIN-GLMK-----GDWLEAFLF----ALAVAVGLTPEMLPMIV 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmfvvaeadagscLLHEFTISGTTytpegev 395
Cdd:TIGR01524  307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQDKIE---------------LEKHIDSSGET------- 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   396 rqgdqpvrcgqfdglVELATICALCNDSaldyneakgvyekvgeaTETALTclvekmNVFDTDLqaLSRVERAGACNTVI 475
Cdd:TIGR01524  365 ---------------SERVLKMAWLNSY-----------------FQTGWK------NVLDHAV--LAKLDESAARQTAS 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   476 KQLMRKEFTLEFSRDRKSMSVyctPTRPHPTgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSG 555
Cdd:TIGR01524  405 RWKKVDEIPFDFDRRRLSVVV---ENRAEVT----RLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSELQDMTAEMNRQ 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   556 SdtLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:TIGR01524  478 G--IRVIAVATKTLKVGEADFTKTD-------EEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARI 548
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   636 CRRLGIfgDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:TIGR01524  549 CQEVGI--DANDF----LLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKAD 622
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTA--ILGLPeaLIPVQLL 793
Cdd:TIGR01524  623 VGISVDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASafIPFLP--MLSLHLL 700
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992213   794 WVNLVTDgLPATALGFNPPDLDIMEKlprsPREALISGWLFFrYLAIGVYVGLATVAA-ATWWFVYDAEGP 863
Cdd:TIGR01524  701 IQNLLYD-FSQLTLPWDKMDREFLKK----PHQWEQKGMGRF-MLCIGPVSSIFDIATfLLMWFVFSANTV 765
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
23-813 2.50e-80

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 275.31  E-value: 2.50e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVleqFEDLLVRI----LLLAALVSFVLAWfeegeetttafvEPLVIMLIL 98
Cdd:cd02609     1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIV---RENVFTLFnlinFVIAVLLILVGSY------------SNLAFLGVI 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   99 VANAIVGVWQERNAESAIEALKEYEPEMGKVIRsDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQS 178
Cdd:cd02609    66 IVNTVIGIVQEIRAKRQLDKLSILNAPKVTVIR-DGQ-EVKIPPEELVLDDILILKPGEQIPADGEVVE--GGGLEVDES 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  179 ILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGR 258
Cdd:cd02609   142 LLTGESDLIPK-------------KAGDKLLSGSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILK 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  259 QLSHAISVICVAVWVINIghfadPAHGGSWLRGAVyyfkIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd02609   209 FTSFIIIPLGLLLFVEAL-----FRRGGGWRQAVV----STVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYS 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelatica 418
Cdd:cd02609   280 IETLARVDVLCLDKTGTITEGKMKVERVEPLDEANE-------------------------------------------- 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  419 lcndsaldyneakgvyekvgEATETALTCLVEKMNVFDTDLQALsrverAGACNTVIKQLMRKEftLEFSRDRKSMSVyc 498
Cdd:cd02609   316 --------------------AEAAAALAAFVAASEDNNATMQAI-----RAAFFGNNRFEVTSI--IPFSSARKWSAV-- 366
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  499 tptrphpTGQGSKMFVKGAPESVIercssvrvgsRTAPltptsrEQILAKIRDwgSGSDTLRCLALATRDAPPRKEdmel 578
Cdd:cd02609   367 -------EFRDGGTWVLGAPEVLL----------GDLP------SEVLSRVNE--LAAQGYRVLLLARSAGALTHE---- 417
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  579 ddcskfvQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGRef 658
Cdd:cd02609   418 -------QLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLEGAESYIDASTLTTD-- 488
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  659 ddlspEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDD 738
Cdd:cd02609   489 -----EELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVVLLDS 563
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992213  739 NFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD 813
Cdd:cd02609   564 DFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNK 638
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
19-800 3.06e-78

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 274.98  E-value: 3.06e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   19 TAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL-AWF--EEGEETTTAFVEPLVIM 95
Cdd:PRK15122   41 THRQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdYWLplRRGEETDLTGVIIILTM 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   96 LILvaNAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIEikST 171
Cdd:PRK15122  121 VLL--SGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghAGAEPVRReIPMRELVPGDIVHLSAGDMIPADVRLIE--SR 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  172 TLRVDQSILTGESVSVTK-------HTEAIPDPRAVNQ---DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAA 241
Cdd:PRK15122  197 DLFISQAVLTGEALPVEKydtlgavAGKSADALADDEGsllDLPNICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVG 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  242 VEPErTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGLPAVITTC 318
Cdd:PRK15122  277 TRAQ-TAFDRGVNSVSWLLIRFMLVMVPVVLLIN---------GftkGDWLEALLF----ALAVAVGLTPEMLPMIVSSN 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  319 LALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMsvcrmfvvaeadagsCLLHEFTISGttytpegevrQG 398
Cdd:PRK15122  343 LAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRI---------------ILEHHLDVSG----------RK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  399 DQPVrcgqfdglVELATicalcndsaLDYNEAKGVyekvgeatetaltclvekMNVFDtdlQA-LSRVERAGAcnTVIKQ 477
Cdd:PRK15122  398 DERV--------LQLAW---------LNSFHQSGM------------------KNLMD---QAvVAFAEGNPE--IVKPA 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  478 LMRK--EFTLEFSRDRKSMSVyctptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWgsG 555
Cdd:PRK15122  438 GYRKvdELPFDFVRRRLSVVV-------EDAQGQHLLICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAY--N 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  556 SDTLRCLALATRDAPPRKEDMEL--DDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV 633
Cdd:PRK15122  509 ADGFRVLLVATREIPGGESRAQYstAD-------ERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTA 581
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  634 AICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKK 713
Cdd:PRK15122  582 KICREVGL------EPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRD 655
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  714 AEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMkqfIRYL---ISSNVGEVVCIfLTAILGLP-EALIP 789
Cdd:PRK15122  656 ADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNI---IKYLnmtASSNFGNVFSV-LVASAFIPfLPMLA 731
                         810
                  ....*....|.
gi 767992213  790 VQLLWVNLVTD 800
Cdd:PRK15122  732 IHLLLQNLMYD 742
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
59-759 2.97e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 211.15  E-value: 2.97e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVAnaiVGVWQE----RNAESAIEALKEYEPEMGKVIRSDR 134
Cdd:COG2217   149 DVLV---ALGTLAAFLYSLYATLFGAGHVYFEAAAMIIFLLL---LGRYLEarakGRARAAIRALLSLQPKTARVLRDGE 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  135 kgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAIpdpravnqdkknmLFSGTNI 214
Cdd:COG2217   223 --EVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS---VDESMLTGESLPVEKTPGDE-------------VFAGTIN 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  215 TSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL---SHAISVICVAVWVINIGHFADpahggsWLRG 291
Cdd:COG2217   285 LDGSLRVRVTKVGSDTTLARIIRLVEEAQSSKAPIQRLADRIARYFvpaVLAIAALTFLVWLLFGGDFST------ALYR 358
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  292 AVyyfkiavalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 359
Cdd:COG2217   359 AV-------------------AVlVIACpcaLGLatptaimvGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEG 419
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  360 QMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELATicalcndSALDYNE---AKGVYEK 436
Cdd:COG2217   420 KPEVTDVVPLDGLDE---------------------------------DELLALAA-------ALEQGSEhplARAIVAA 459
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  437 VGEATETALTClvekmnvfdTDLQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKG 516
Cdd:COG2217   460 AKERGLELPEV---------EDFEAI-------------------------------------------PGKGVEATVDG 487
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  517 ApesviercsSVRVGSRT--APLTPTSREQILAKIRDWGSGSDTLRCLALATRdapprkedmelddcskfvqyetdltFV 594
Cdd:COG2217   488 K---------RVLVGSPRllEEEGIDLPEALEERAEELEAEGKTVVYVAVDGR-------------------------LL 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  595 GCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtAR 674
Cdd:COG2217   534 GLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI-------------------------------DE 582
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  675 CFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIY 754
Cdd:COG2217   583 VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMGSGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM 662

                  ....*
gi 767992213  755 SNMKQ 759
Cdd:COG2217   663 RIIRQ 667
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
59-788 1.13e-55

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 202.86  E-value: 1.13e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    59 DLLVrilLLAALVSFVLAWFEEGeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgVQ 138
Cdd:TIGR01525    2 DTLM---ALAAIAAYAMGLVLEG----------ALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQGDGS-EE 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGK 218
Cdd:TIGR01525   68 EVPVEELQVGDIVIVRPGERIPVDGVVISGESE---VDESALTGESMPVEKKE----------GDE---VFAGTINGDGS 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVInighfadPAHGGSWLRGAVYYFki 298
Cdd:TIGR01525  132 LTIRVTKLGEDSTLAQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVV-------WLALGALWREALYRA-- 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   299 aVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAGSCL 378
Cdd:TIGR01525  203 -LTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVD-IEPLDDASEEEL 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   379 LHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvfdTD 458
Cdd:TIGR01525  281 LA------------------------------------LAAALEQSSSHPLARAIVRYAKERGLELPP----------ED 314
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   459 LQALSrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptGQGSKMFVKGAPESVIERCSSvrVGSRTAPLT 538
Cdd:TIGR01525  315 VEEVP-------------------------------------------GKGVEATVDGGREVRIGNPRF--LGNRELAIE 349
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   539 PTSREQILakIRDWGSGSDTLRCLALatrdapprkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAG 618
Cdd:TIGR01525  350 PISASPDL--LNEGESQGKTVVFVAV-------------------------DGELLGVIALRDQLRPEAKEAIAALKRAG 402
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   619 -IRVVMITGDNKGTAVAICRRLGIfgdTEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEI 697
Cdd:TIGR01525  403 gIKLVMLTGDNRSAAEAVAAELGI---DDEV---------------------------HAELLPEDKLAIVKKLQEEGGP 452
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   698 TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVcIFL 777
Cdd:TIGR01525  453 VAMVGDGINDAPALAAADVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIP-LAA 531
                          730
                   ....*....|.
gi 767992213   778 TAILGLPEALI 788
Cdd:TIGR01525  532 GGLLPLWLAVL 542
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
59-788 5.05e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 181.64  E-value: 5.05e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEmgKVIRSDRKGVQ 138
Cdd:cd02079    62 DVLV---SLAAIGAFVASLLTPLLGGIGYFEEAAMLLFLFLLGRYLEERARSRARSALKALLSLAPE--TATVLEDGSTE 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAipdprAVnqdkknmlFSGTNITSGK 218
Cdd:cd02079   137 EVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS---VDESSLTGESLPVEKGAGD-----TV--------FAGTINLNGP 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHggsWLRGAVyyfki 298
Cdd:cd02079   201 LTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSL---ALYRAL----- 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  299 avalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRM 366
Cdd:cd02079   273 --------------AVlVVACpcaLGLatptaivaGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEI 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  367 FVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekvgeatetalt 446
Cdd:cd02079   339 EPLEGFSE------------------------------------------------------------------------ 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  447 clvekmnvfDTDLQALSRVERAgacntvikqlmrkeftlefsrdrksmsvyctptRPHPTGQGskmFVKGAPESVIErcs 526
Cdd:cd02079   347 ---------DELLALAAALEQH---------------------------------SEHPLARA---IVEAAEEKGLP--- 378
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  527 svrvgsrtaPLTPTSREQILAK-IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSK--FVQYETDLTFVGCVGMLDPP 603
Cdd:cd02079   379 ---------PLEVEDVEEIPGKgISGEVDGREVLIGSLSFAEEEGLVEAADALSDAGKtsAVYVGRDGKLVGLFALEDQL 449
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAH 683
Cdd:cd02079   450 RPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------------DEVHAGLLPED 498
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  684 KSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRY 763
Cdd:cd02079   499 KLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAW 578
                         730       740
                  ....*....|....*....|....*
gi 767992213  764 LISSNvgeVVCIFLtAILGLPEALI 788
Cdd:cd02079   579 ALGYN---AIALPL-AALGLLTPWI 599
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
23-857 1.75e-47

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 184.49  E-value: 1.75e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    23 GLSPAQVTGARERYGPNEL----PSEEgKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetttafVEPLVIMLIL 98
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIeipvPSFL-ELLKEEVLHPFYVFQVFSVILWLLDEYY--------------YYSLCIVFMS 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    99 VANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAV--GDKVPADLRLIeikSTTLRVD 176
Cdd:TIGR01657  204 STSISLSVYQIRKQMQRLRDMV-HKPQSVIVIRNGKW--VTIASDELVPGDIVSIPRpeEKTMPCDSVLL---SGSCIVN 277
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   177 QSILTGESVSVTKhtEAIPDPRAVNQD-------KKNMLFSGTNI-------TSGKAVGVAVATGLHTELGKIRSQMaaV 242
Cdd:TIGR01657  278 ESMLTGESVPVLK--FPIPDNGDDDEDlflyetsKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQLVRSI--L 353
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   243 EPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHfadpahggswLRGAVYYFKIAVALA--VAAIPEGLPAVITTCLA 320
Cdd:TIGR01657  354 YPKPRVFKFYKDSFKFILFLAVLALIGFIYTIIELI----------KDGRPLGKIILRSLDiiTIVVPPALPAELSIGIN 423
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   321 LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrMFVVAEADAGSCLLHEFTISGTTytpegevrqgdq 400
Cdd:TIGR01657  424 NSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDL--RGVQGLSGNQEFLKIVTEDSSLK------------ 489
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   401 pvrcgqfdgLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQlmr 480
Cdd:TIGR01657  490 ---------PSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEEDDESAEPTSILAVVRTDDPPQELSIIRR--- 557
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   481 keftLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSSVRVgsrtapltPTSREQILAKIRDWGSgsdtlR 560
Cdd:TIGR01657  558 ----FQFSSALQRMSVIVS----TNDERSPDAFVKGAPETIQSLCSPETV--------PSDYQEVLKSYTREGY-----R 616
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   561 CLALATRDAPPRKEDmELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:TIGR01657  617 VLALAYKELPKLTLQ-KAQDLSR-DAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECG 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   641 I-----------FGDTEDVAGK--------------------------------------AYTGREFDDL---SPEQQRQ 668
Cdd:TIGR01657  695 IvnpsntlilaeAEPPESGKPNqikfevidsipfastqveipyplgqdsvedllasryhlAMSGKAFAVLqahSPELLLR 774
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAksAAEMVLSDDNFASIVAAVE 748
Cdd:TIGR01657  775 LLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASV--AAPFTSKLASISCVPNVIR 852
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   749 EGRA-------IYSNMKQ---------FIRYLISSNVGEvvcifltailglpealipVQLLWVNLVTDGLPATALGFNPP 812
Cdd:TIGR01657  853 EGRCalvtsfqMFKYMALysliqfysvSILYLIGSNLGD------------------GQFLTIDLLLIFPVALLMSRNKP 914
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767992213   813 dldiMEKLPRS-PREALISGWLFFR-----YLAIGVYVGLATVAAATWWFV 857
Cdd:TIGR01657  915 ----LKKLSKErPPSNLFSVYILTSvliqfVLHILSQVYLVFELHAQPWYK 961
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 9.04e-47

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.44  E-value: 9.04e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122    1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122   66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 767992213   281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122  139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
66-759 2.86e-45

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 172.46  E-value: 2.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILvanaIVGVWQERNAES----AIEALKEYEPEMGKVIRSDrKGVQRIR 141
Cdd:TIGR01511   32 YGYSLVALLANQVLTGLHVHTFFDASAMLITFI----LLGRWLEMLAKGrasdALSKLAKLQPSTATLLTKD-GSIEEVP 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   142 ARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGKAVG 221
Cdd:TIGR01511  107 VALLQPGDIVKVLPGEKIPVDGTVIEGESE---VDESLVTGESLPVPKKV----------GDP---VIAGTVNGTGSLVV 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   222 VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAISVICVAVWVinighFAdpahggswLRGAVYYFki 298
Cdd:TIGR01511  171 RATATGEDTTLAQIVRLVRQAQQSKAPIQRLADKVAGYFVpvvIAIALITFVIWL-----FA--------LEFAVTVL-- 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   299 avalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscl 378
Cdd:TIGR01511  236 -----IIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTV--------------- 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   379 lheftisgTTYTPEGEVRQGDQpvrcgqfdglveLATICALCNDSalDYNEAKGVYEKVGEATETALTClvekmnvfdTD 458
Cdd:TIGR01511  296 --------TDVHVFGDRDRTEL------------LALAAALEAGS--EHPLAKAIVSYAKEKGITLVTV---------SD 344
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   459 LQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKGApesviercsSVRVGSrtaplt 538
Cdd:TIGR01511  345 FKAI-------------------------------------------PGIGVEGTVEGT---------KIQLGN------ 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   539 ptsreqilakiRDWgsgsdtlrCLALATRDAPPRKEDMElddcSKFVQYETDLTFVGCVGmlDPPRPEVAACITRCYQAG 618
Cdd:TIGR01511  367 -----------EKL--------LGENAIKIDGKAGQGST----VVLVAVNGELAGVFALE--DQLRPEAKEVIQALKRRG 421
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   619 IRVVMITGDNKGTAVAICRRLGIfgdteDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEIT 698
Cdd:TIGR01511  422 IEPVMLTGDNRKTAKAVAKELGI-----DV---------------------------RAEVLPDDKAALIKKLQEKGPVV 469
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992213   699 AMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:TIGR01511  470 AMVGDGINDAPALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQ 530
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
784-987 7.00e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 159.71  E-value: 7.00e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   784 PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGP 863
Cdd:pfam00689    1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   864 HINFYqlrnflkcsednplfagidcevfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMAL 943
Cdd:pfam00689   81 SQNAQ-----------------------------TMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLL 131
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 767992213   944 HFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL 987
Cdd:pfam00689  132 QLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
33-770 8.77e-45

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 173.97  E-value: 8.77e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   33 RERYGPNELPSEEgKSLWEL----VLEQFedllvrilLLAALVSfVLAWFEEGeetttaFVE-PLVIMLILVANAIVGVW 107
Cdd:cd07542     7 RLIYGPNEIDVPL-KSILKLlfkeVLNPF--------YVFQLFS-VILWSSDD------YYYyAACIVIISVISIFLSLY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  108 QERNAESAIEALKEYePEMGKVIRsdRKGVQRIRARDIVPGDIVEVAVGDKV-PADLRLIeikSTTLRVDQSILTGESVS 186
Cdd:cd07542    71 ETRKQSKRLREMVHF-TCPVRVIR--DGEWQTISSSELVPGDILVIPDNGTLlPCDAILL---SGSCIVNESMLTGESVP 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  187 VTK-----HTEAIPDPRAVNQD-KKNMLFSGTNI------TSGKAVGVAVATGLHTELGK-IRSQMAavePERTPLQRKL 253
Cdd:cd07542   145 VTKtplpdESNDSLWSIYSIEDhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILY---PKPVDFKFYR 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  254 DefgrqlshAISVICVAVWVINIGHFADpahggswlrgAVYYFKIAVALAVA----------AIPEGLPAVITTCLALGT 323
Cdd:cd07542   222 D--------SMKFILFLAIIALIGFIYT----------LIILILNGESLGEIiiraldiitiVVPPALPAALTVGIIYAQ 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagSCLLhefTISGTtytpegevRQGDQPVr 403
Cdd:cd07542   284 SRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDL------------WGVR---PVSGN--------NFGDLEV- 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  404 cgqfdglvelaTICALCNDSALDYneakgvyekvGEATETALTC----LVEkmNVFDTDLQALSRVERAGACNTVIKQLm 479
Cdd:cd07542   340 -----------FSLDLDLDSSLPN----------GPLLRAMATChsltLID--GELVGDPLDLKMFEFTGWSLEILRQF- 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  480 rkeftlEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERC--SSVrvgsrtapltPTSREQILAKIRDWGsgsd 557
Cdd:cd07542   396 ------PFSSALQRMSVIVK----TPGDDSMMAFTKGAPEMIASLCkpETV----------PSNFQEVLNEYTKQG---- 451
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  558 tLRCLALATRDAPprKEDMELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICR 637
Cdd:cd07542   452 -FRVIALAYKALE--SKTWLLQKLSR-EEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVAR 527
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  638 RLGIFGDTEdvagKAYTGR---EFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:cd07542   528 ECGMISPSK----KVILIEavkPEDDDSASLTWTLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAA 603
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767992213  715 EIGIAMGSgtAVAKSAAEMVLSDDNFASIVAAVEEGRA-------------IYSnMKQFIR----YLISSNVG 770
Cdd:cd07542   604 DVGISLSE--AEASVAAPFTSKVPDISCVPTVIKEGRAalvtsfscfkymaLYS-LIQFISvlilYSINSNLG 673
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
58-788 2.13e-44

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 169.81  E-value: 2.13e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    58 EDLLVRILLLAALvsFVLAWFEEgeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrkGV 137
Cdd:TIGR01512    1 VDLLMALAALGAV--AIGEYLEG-----------ALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGD--SL 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   138 QRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSG 217
Cdd:TIGR01512   66 EEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS---VDESALTGESVPVEKAPG----------DE---VFAGAINLDG 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   218 KAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadPAHGGSWLRGAVYYFk 297
Cdd:TIGR01512  130 VLTIEVTKLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVP------PLLGAGPFLEWIYRA- 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   298 iaVALAVAAIPEGLpaVITTCLAL--GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAG 375
Cdd:TIGR01512  203 --LVLLVVASPCAL--VISAPAAYlsAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD-VHPADGHSE 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   376 SCLLHEFTISGTTYTpegevrqgdQPVrcgqfdglvelaticalcNDSALDYNEAKGVYEKVGEATEtaltclvekmnvf 455
Cdd:TIGR01512  278 SEVLRLAAAAEQGST---------HPL------------------ARAIVDYARARELAPPVEDVEE------------- 317
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   456 dtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphPTGQGSKMFVKGApesviercsSVRVGSRTA 535
Cdd:TIGR01512  318 -------------------------------------------------VPGEGVRAVVDGG---------EVRIGNPRS 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   536 pltptSREQILAKIRDWGSGSDTlrcLALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCY 615
Cdd:TIGR01512  340 -----LSEAVGASIAVPESAGKT---IVLVARDG----------------------TLLGYIALSDELRPDAAEAIAELK 389
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   616 QAGI-RVVMITGDNKGTAVAICRRLGIfgdTEDVAgkaytgrefdDLSPEQqrqacrtarcfarvepahKSRIVENLQSF 694
Cdd:TIGR01512  390 ALGIkRLVMLTGDRRAVAEAVARELGI---DEVHA----------ELLPED------------------KLEIVKELREK 438
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   695 NEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGeVV 773
Cdd:TIGR01512  439 AGPVAMVGDGINDAPALAAADVGIAMGaSGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILV-LI 517
                          730
                   ....*....|....*
gi 767992213   774 CIFLTAILGLPEALI 788
Cdd:TIGR01512  518 LLALFGVLPLWLAVL 532
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
92-759 1.92e-41

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 162.65  E-value: 1.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVanaivGVWQE----RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIE 167
Cdd:cd02094   107 VIITFILL-----GKYLEarakGKTSEAIKKLLGLQPKTARVIRDG--KEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVE 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  168 IKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSGKAVGVAVATGLHTELGKIrsqMAAVEpE-- 245
Cdd:cd02094   180 GESS---VDESMLTGESLPVEKKPG----------DK---VIGGTINGNGSLLVRATRVGADTTLAQI---IRLVE-Eaq 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  246 --RTPLQRKLDefgrQLS-------HAISVICVAVWVInIGHFADPAHGgswLRGAVyyfkiavalavaaipeglpAV-I 315
Cdd:cd02094   240 gsKAPIQRLAD----RVSgvfvpvvIAIAILTFLVWLL-LGPEPALTFA---LVAAV-------------------AVlV 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  316 TTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGscllhefti 384
Cdd:cd02094   293 IACpcaLGLatptaimvGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--------- 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  385 sgttytpegevrqgdqpvrcgqfdglvELATICAlcndSALDYNE---AKGVYEKVGEATETALTClvekmnvfdTDLQA 461
Cdd:cd02094   364 ---------------------------ELLRLAA----SLEQGSEhplAKAIVAAAKEKGLELPEV---------EDFEA 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  462 LsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGskmfVKGAPESViercsSVRVGSRtapltpts 541
Cdd:cd02094   404 I-------------------------------------------PGKG----VRGTVDGR-----RVLVGNR-------- 423
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  542 reqilAKIRDWG--SGSDTLRCLALATRDAPPrkedmelddcskfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGI 619
Cdd:cd02094   424 -----RLMEENGidLSALEAEALALEEEGKTV-------------VLVAVDGELAGLIAVADPLKPDAAEAIEALKKMGI 485
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  620 RVVMITGDNKGTAVAICRRLGIfgdtEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITA 699
Cdd:cd02094   486 KVVMLTGDNRRTARAIAKELGI----DEV---------------------------IAEVLPEDKAEKVKKLQAQGKKVA 534
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  700 MTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02094   535 MVGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKQ 594
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
92-846 3.40e-38

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 153.90  E-value: 3.40e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgVQRIRARDIVPGDIVEVAV-GDKVPADLRLIEiks 170
Cdd:cd02082    54 ITVVFMTTINSLSCIYIRGVMQKELKDAC-LNNTSVIVQRHGYQ-EITIASNMIVPGDIVLIKRrEVTLPCDCVLLE--- 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  171 TTLRVDQSILTGESVSVTKhtEAIPDP----RAVNQD--KKNMLFSGTNI------TSGKAVGVAVATGLHTELGKIRsq 238
Cdd:cd02082   129 GSCIVTEAMLTGESVPIGK--CQIPTDshddVLFKYEssKSHTLFQGTQVmqiippEDDILKAIVVRTGFGTSKGQLI-- 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  239 maavepeRTPLQRKLDEFGRQLSHAISVICVAVwvinighFADPAHGGSWLRG------AVYYFKIAVALAVAAIPEGLP 312
Cdd:cd02082   205 -------RAILYPKPFNKKFQQQAVKFTLLLAT-------LALIGFLYTLIRLldielpPLFIAFEFLDILTYSVPPGLP 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  313 AVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAdagscllHEFTisgttytpe 392
Cdd:cd02082   271 MLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQN-------QTFD--------- 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  393 gevrqgdqPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvFDTDLQALSRVERAGACN 472
Cdd:cd02082   335 --------PIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWD--------LDYDHEAKQHYSKSGTKR 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  473 TVIKQlmrkefTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDW 552
Cdd:cd02082   399 FYIIQ------VFQFHSALQRMSVVAKEVDMITKDFKHYAFIKGAPEKIQSLFSHV----------PSDEKAQLSTLINE 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  553 GSgsdtlRCLALATRDAPPRKEDMELDdcSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTA 632
Cdd:cd02082   463 GY-----RVLALGYKELPQSEIDAFLD--LSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTA 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  633 VAICRRLGIFGdtedvagKAYTGREFDDLSPEQQRQACRTAR------CFARVEPAHKSRIVENLQSFNEITAMTGDGVN 706
Cdd:cd02082   536 LKVAQELEIIN-------RKNPTIIIHLLIPEIQKDNSTQWIliihtnVFARTAPEQKQTIIRLLKESDYIVCMCGDGAN 608
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  707 DAPALKKAEIGIAMGSGTavAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA 786
Cdd:cd02082   609 DCGALKEADVGISLAEAD--ASFASPFTSKSTSISCVKRVILEGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYS 686
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767992213  787 LIPVQLLWVNLVTDGLPATALGFNPPdLDIMEKLPR---SPREALISGWLFFRYLA-IGVYVGL 846
Cdd:cd02082   687 SSGQMDWQLLAAGYFLVYLRLGCNTP-LKKLEKDDNlfsIYNVTSVLFGFTLHILSiVGCVESL 749
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
124-720 4.76e-37

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 150.61  E-value: 4.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  124 PEMGKVIRsDRKGVQrIRARDIVPGDIVEV---AVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHT-EAIPDPRA 199
Cdd:cd07543    85 PYTIQVYR-DGKWVP-ISSDELLPGDLVSIgrsAEDNLVPCDLLLL---RGSCIVNEAMLTGESVPLMKEPiEDRDPEDV 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  200 V---NQDKKNMLFSGTNI-------------TSGKAVGVAVATGLHTELGK-IRSQMAAVEpERTPLQRKldefgrqlsh 262
Cdd:cd07543   160 LdddGDDKLHVLFGGTKVvqhtppgkgglkpPDGGCLAYVLRTGFETSQGKlLRTILFSTE-RVTANNLE---------- 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  263 aiSVICVAVWVInighFADPAHGGSWLRGA----VYY--FKIAVALAVAAIPEGLPavittclalgtrrMARKNAIVRSL 336
Cdd:cd07543   229 --TFIFILFLLV----FAIAAAAYVWIEGTkdgrSRYklFLECTLILTSVVPPELP-------------MELSLAVNTSL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  337 PSVETLG--CT-----------SVICSDKTGTLTTNQMSVcrmfvvaeadAGscllheftISGTTYTPEGEVRQGDQPVR 403
Cdd:cd07543   290 IALAKLYifCTepfripfagkvDICCFDKTGTLTSDDLVV----------EG--------VAGLNDGKEVIPVSSIEPVE 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  404 CGQfdglvelatICALCNdSALDYNEAKGVYEKVGEATETALTCLVEKMNVFdtdlqalsrVERAGACNTVikQLMRKef 483
Cdd:cd07543   352 TIL---------VLASCH-SLVKLDDGKLVGDPLEKATLEAVDWTLTKDEKV---------FPRSKKTKGL--KIIQR-- 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  484 tLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDWGSgsdtlRCLA 563
Cdd:cd07543   409 -FHFSSALKRMSVVASYKDPGSTDLKYIVAVKGAPETLKSMLSDV----------PADYDEVYKEYTRQGS-----RVLA 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  564 LATRD----APPRKEDMELDDcskfvqYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRL 639
Cdd:cd07543   473 LGYKElghlTKQQARDYKRED------VESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKEL 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  640 GIfgdtedvAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07543   547 GI-------VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVA 619

                  .
gi 767992213  720 M 720
Cdd:cd07543   620 L 620
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
50-783 8.36e-36

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 144.70  E-value: 8.36e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   50 WELVLEQFEDLL------VRIL-LLAALVSFVLAWFEEGeetttafvePLVIMLILVANAIVGVWQERnAESAIEALKEY 122
Cdd:cd07551    40 YASAKEGIEATLrkktlnVDLLmILAAIGAAAIGYWAEG---------ALLIFIFSLSHALEDYAMGR-SKRAITALMQL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  123 EPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHteaIPDPravnq 202
Cdd:cd07551   110 APETARRIQRD-GEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSSS---IDEASITGESIPVEKT---PGDE----- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  203 dkknmLFSGTnITSGKAVGVAVaTGLHTE--LGKIRSQMAAVEPERTPLQRKLDEFGRQlsHAISVICVAVWVINIGHFA 280
Cdd:cd07551   178 -----VFAGT-INGSGALTVRV-TKLSSDtvFAKIVQLVEEAQSEKSPTQSFIERFERI--YVKGVLLAVLLLLLLPPFL 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  281 DpahGGSW----LRGAVYyfkiavalAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTL 356
Cdd:cd07551   249 L---GWTWadsfYRAMVF--------LVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  357 TTNQMSVcrmfvvaeadagscllheftisgTTYTPEGEVRQgdqpvrcgqfdglvelaticalcndsaldyneakgvyEK 436
Cdd:cd07551   318 TEGKPRV-----------------------TDVIPAEGVDE-------------------------------------EE 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  437 VgeatetaltclvekmnvfdtdLQALSRVERAGacNTVIKQLMRKEFTLEFSRDRKSMSVyctptrPHPTGQGSKMFVKG 516
Cdd:cd07551   338 L---------------------LQVAAAAESQS--EHPLAQAIVRYAEERGIPRLPAIEV------EAVTGKGVTATVDG 388
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  517 ApesviercsSVRVGSrtapltPTSREQILakirdwgsgsDTLRCLALATRDAPPRKEDMelddcskFVQyeTDLTFVGC 596
Cdd:cd07551   389 Q---------TYRIGK------PGFFGEVG----------IPSEAAALAAELESEGKTVV-------YVA--RDDQVVGL 434
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  597 VGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddLSPEQqrqacrtarcf 676
Cdd:cd07551   435 IALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI---DEVVAN----------LLPED----------- 490
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  677 arvepahKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRaiysN 756
Cdd:cd07551   491 -------KVAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMGAGTDVALETADVVLMKDDLSKLPYAIRLSR----K 559
                         730       740
                  ....*....|....*....|....*..
gi 767992213  757 MKQFIRYLISSNVGEVVCIFLTAILGL 783
Cdd:cd07551   560 MRRIIKQNLIFALAVIALLIVANLFGL 586
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
92-807 6.86e-33

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 135.61  E-value: 6.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07546    67 MVLLLFLVGELLEGYAASR-ARSGVKALMALVPETALREENG--ERREVPADSLRPGDVIEVAPGGRLPADGELLSGFAS 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKA-VGVAVATGLHTeLGKIRSQMAAVEPERTPLQ 250
Cdd:cd07546   144 ---FDESALTGESIPVEK-------------AAGDKVFAGSINVDGVLrIRVTSAPGDNA-IDRILHLIEEAEERRAPIE 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  251 RKLDEFGRQLSHAISVICVAVWVInighfadP--AHGGSW----LRGavyyfkiaVALAVAAIPEGL----PAVITTCLA 320
Cdd:cd07546   207 RFIDRFSRWYTPAIMAVALLVIVV-------PplLFGADWqtwiYRG--------LALLLIGCPCALvistPAAITSGLA 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  321 LGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPegevrqgdq 400
Cdd:cd07546   272 AAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDVVPLTGISEAELLALAAAVEMGSSHP--------- 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  401 pvrcgqfdglveLATicALcndsaldyneakgvyekVGEATETALtclvekmnvfdTDLQALSRVERAgacntvikqlmr 480
Cdd:cd07546   339 ------------LAQ--AI-----------------VARAQAAGL-----------TIPPAEEARALV------------ 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  481 keftlefsrdrksmsvyctptrphptGQGSKMFVKGAPesvIERCSSVRVGSRtapLTPTSREQILAkIRDWGsgsdtlR 560
Cdd:cd07546   365 --------------------------GRGIEGQVDGER---VLIGAPKFAADR---GTLEVQGRIAA-LEQAG------K 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  561 CLALATRDAPPrkedmelddcskfvqyetdltfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:cd07546   406 TVVVVLANGRV----------------------LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELG 463
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  641 IfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAM 720
Cdd:cd07546   464 L---------------DFR-----------------AGLLPEDKVKAVRELAQ-HGPVAMVGDGINDAPAMKAASIGIAM 510
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  721 GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISsnvgeVVCIFL-TAILGLPEalipvqlLWVNLVT 799
Cdd:cd07546   511 GSGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALG-----LKAVFLvTTLLGITG-------LWLAVLA 578

                  ....*...
gi 767992213  800 DGlPATAL 807
Cdd:cd07546   579 DT-GATVL 585
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
92-800 3.99e-29

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 124.07  E-value: 3.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07545    64 MVVFLFAISEALEAYSMDR-ARRSIRSLMDIAPKTALVRRDGQE--REVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGkAVGVAV-ATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:cd07545   141 ---VNQAAITGESLPVEK-------------GVGDEVFAGTLNGEG-ALEVRVtKPAEDSTIARIIHLVEEAQAERAPTQ 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  251 RKLDEFGRQLSHAISVICVAVWVINIGHFadpahGGSWLrGAVYyfkIAVALAVAAIPEGLpaVITTCL----ALGTrrM 326
Cdd:cd07545   204 AFVDRFARYYTPVVMAIAALVAIVPPLFF-----GGAWF-TWIY---RGLALLVVACPCAL--VISTPVsivsAIGN--A 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADagscllheftisgttytpEGEVrqgdqpvrcgq 406
Cdd:cd07545   271 ARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQT------------------EKEL----------- 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  407 fdglveLATICALcnDSALDYNEAKGVyekVGEATETALTclvekmnvfdtdlqaLSRVEragacntvikqlmrkEFTle 486
Cdd:cd07545   322 ------LAIAAAL--EYRSEHPLASAI---VKKAEQRGLT---------------LSAVE---------------EFT-- 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  487 fsrdrkSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSR------TAPLTPTSREQILAkIRDWGSGSdtlr 560
Cdd:cd07545   359 ------AL-----------TGRGVRGVVNG---------TTYYIGSPrlfeelNLSESPALEAKLDA-LQNQGKTV---- 407
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  561 cLALATRDapprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRL 639
Cdd:cd07545   408 -MILGDGE-----------------------RILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQV 463
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  640 GIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07545   464 GV-------------------------------SDIRAELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIA 512
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  720 MGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQfirylissNVGEVVCIFLTAILglpeALIPVQL-LWVNL 797
Cdd:cd07545   513 MGAaGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQ--------NIAFALGIKLIALL----LVIPGWLtLWMAV 580

                  ...
gi 767992213  798 VTD 800
Cdd:cd07545   581 FAD 583
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
93-759 2.21e-28

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 122.03  E-value: 2.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   93 VIMLIlvanaivGVWQERN----AESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:cd07552   102 VIMLL-------GHWIEMKavmgAGDALKKLAELLPKTAHLVTDG--SIEDVPVSELKVGDVVLVRAGEKIPADGTILEG 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  169 KSttlRVDQSILTGESvsvtkhteaipdpRAVNQDKKNMLFSGTnITSGKAVGVAV-ATGLHTELGKIRSQMAAVEPERT 247
Cdd:cd07552   173 ES---SVNESMVTGES-------------KPVEKKPGDEVIGGS-VNGNGTLEVKVtKTGEDSYLSQVMELVAQAQASKS 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  248 PLQRKLDEFGRQLSHA---ISVICVAVWVInIGHFADPahggswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTR 324
Cdd:cd07552   236 RAENLADKVAGWLFYIalgVGIIAFIIWLI-LGDLAFA------LERAVTVL-------VIACPHALGLAIPLVVARSTS 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadagscllheftisgttytpegevrqgdqpvrc 404
Cdd:cd07552   302 IAAKNGLLIRNREALERARDIDVVLFDKTGTLTE---------------------------------------------- 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  405 GQFdGLVELATICALCNDSALDYNEAkgvyekvgeatetaltclvekmnvfdtdLQALSRVERAGACNTVIKQlmrKEFT 484
Cdd:cd07552   336 GKF-GVTDVITFDEYDEDEILSLAAA----------------------------LEAGSEHPLAQAIVSAAKE---KGIR 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  485 LEFSRDRKSMSvyctptrphptGQGSKMFVKGapesviercSSVRVGSR--TAPLTPTSREQILAKIRDWGSgsdTLrcl 562
Cdd:cd07552   384 PVEVENFENIP-----------GVGVEGTVNG---------KRYQVVSPkyLKELGLKYDEELVKRLAQQGN---TV--- 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  563 alatrdapprkedmelddcsKFVQYETDLtfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIf 642
Cdd:cd07552   438 --------------------SFLIQDGEV--IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI- 494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  643 gdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd07552   495 ------------------------------DEYFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIGA 544
                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 767992213  723 GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd07552   545 GTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQ 581
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
84-787 2.91e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 121.23  E-value: 2.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   84 TTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADL 163
Cdd:cd07550    59 LTGDYLAANTIAFLLELGELLEDYTARKSEKALLDLLSPQERTVWVERDGV--EVEVPADEVQPGDTVVVGAGDVIPVDG 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  164 RLIEIKSTtlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:cd07550   137 TVLSGEAL---IDQASLTGESLPVEK-------------REGDLVFASTVVEEGQLVIRAERVGRETRAARIAELIEQSP 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  244 PERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahgGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTClalgt 323
Cdd:cd07550   201 SLKARIQNYAERLADRLVPPTLGLAGLVYALT----------GDISRAAAVLLVDFSCGIRLSTPVAVLSALNHA----- 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  324 rrmARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgttytpegevrqgdQPVR 403
Cdd:cd07550   266 ---ARHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEV------------------------------------TAII 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  404 CgqFDGLVELATICALcndsaldyneAKGVYEKVGEATETALtclvekmnvfdtdlqaLSRVERAGacntvIKQLMRKEf 483
Cdd:cd07550   307 T--FDGRLSEEDLLYL----------AASAEEHFPHPVARAI----------------VREAEERG-----IEHPEHEE- 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  484 tLEFSrdrksmsvyctptrphpTGQGSKMFVKGAPesviercssVRVGSR------TAPLTPTsreqILAKIRDWGSGSD 557
Cdd:cd07550   353 -VEYI-----------------VGHGIASTVDGKR---------IRVGSRhfmeeeEIILIPE----VDELIEDLHAEGK 401
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  558 TLRCLALATRdapprkedmelddcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAG-IRVVMITGDNKGTAVAIC 636
Cdd:cd07550   402 SLLYVAIDGR-------------------------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA 456
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  637 RRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEI 716
Cdd:cd07550   457 EQLGI-------------------------------DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADV 505
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992213  717 GIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGevvCIFLTAILGLPEAL 787
Cdd:cd07550   506 GISMRGGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTA---VLAGGVFGLLSPIL 573
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
418-528 3.14e-28

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 108.85  E-value: 3.14e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   418 ALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtdlqalsrveraGACNTVIKQLMRKEFTLEFSRDRKSMSVY 497
Cdd:pfam13246    1 ALCNSAAFDENEEKGKWEIVGDPTESALLVFAEKM----------------GIDVEELRKDYPRVAEIPFNSDRKRMSTV 64
                           90       100       110
                   ....*....|....*....|....*....|.
gi 767992213   498 CTPtrphPTGQGSKMFVKGAPESVIERCSSV 528
Cdd:pfam13246   65 HKL----PDDGKYRLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
128-728 1.47e-26

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 117.27  E-value: 1.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  128 KVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02073    84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLlsssepdglcyVETANldgeTNLKIRQALPETALLLSEEDLA 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  193 A----------------------IPDPRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTEL----GKIRSQmaavepe 245
Cdd:cd02073   164 RfsgeieceqpnndlytfngtleLNGGRELPLSPDNLLLRGCTLrNTEWVYGVVVYTGHETKLmlnsGGTPLK------- 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  246 RTPLQRKLDE-----FGRQLSHA-ISVICVAVWVINIGHFA---DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVIT 316
Cdd:cd02073   237 RSSIEKKMNRfiiaiFCILIVMClISAIGKGIWLSKHGRDLwylLPKEERSPALEFFFDFLTFIILYNNLIPISLYVTIE 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  317 TCLALGTRRMA----------RKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVvaeadagscllhEFTISG 386
Cdd:cd02073   317 VVKFLQSFFINwdldmydeetDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIME----FK------------KCSING 380
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  387 TTYtpegevrqgdqpvrcgQFdgLVELAticaLCNdsaldyneakgvyekvgeatetalTCLVEKMNVFDTDL-QALSRV 465
Cdd:cd02073   381 VDY----------------GF--FLALA----LCH------------------------TVVPEKDDHPGQLVyQASSPD 414
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  466 ERA---GACN-----------TVIKQLM--RKEF----TLEFSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERC 525
Cdd:cd02073   415 EAAlveAARDlgfvflsrtpdTVTINALgeEEEYeilhILEFNSDRKRMSVIVR----DPDGR-ILLYCKGADSVIFERL 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  526 SSvrvgsRTAPLtptsREQILAKIRDWGSgsDTLRCLALATRDAPP-------------------RKEdmELDDCSKFVq 586
Cdd:cd02073   490 SP-----SSLEL----VEKTQEHLEDFAS--EGLRTLCLAYREISEeeyeewnekydeastalqnREE--LLDEVAEEI- 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  587 yETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAIC------------RRLGIFGDTEDVAGKAYT 654
Cdd:cd02073   556 -EKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGyscrllsedmenLALVIDGKTLTYALDPEL 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  655 GREFDDLSpeqqrQACRTARCfARVEPAHKSRIVENLQSF-NEITAMTGDGVNDAPALKKAEIGI----------AMGSG 723
Cdd:cd02073   635 ERLFLELA-----LKCKAVIC-CRVSPLQKALVVKLVKKSkKAVTLAIGDGANDVSMIQEAHVGVgisgqegmqaARASD 708

                  ....*
gi 767992213  724 TAVAK 728
Cdd:cd02073   709 YAIAQ 713
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
92-807 4.69e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.01  E-value: 4.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVANAIVGvWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIeikST 171
Cdd:PRK11033  211 MVLLLFLIGERLEG-YAASRARRGVSALMALVPETATRLRDGER--EEVAIADLRPGDVIEVAAGGRLPADGKLL---SP 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  172 TLRVDQSILTGESVSVTKHT-EAIPdPRAVNQDKKNMLfsgtNITSGKAvgvavatglHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK11033  285 FASFDESALTGESIPVERATgEKVP-AGATSVDRLVTL----EVLSEPG---------ASAIDRILHLIEEAEERRAPIE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPahggsWLrGAVYyfkiavalavaaipEGL---------------PAVI 315
Cdd:PRK11033  351 RFIDRFSRIYTPAIMLVALLVILVPPLLFAAP-----WQ-EWIY--------------RGLtllligcpcalvistPAAI 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  316 TTCLALGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEadagscllheftisgttytpegev 395
Cdd:PRK11033  411 TSGLAAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATG------------------------ 462
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  396 rqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekVGEATETALTCLVEkmnVFDTDLQALSRVERAGAcntvi 475
Cdd:PRK11033  463 -----------------------------------------ISESELLALAAAVE---QGSTHPLAQAIVREAQV----- 493
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  476 kqlmrKEFTLEFSRDRKSMSvyctptrphptGQGSKMFVKGapeSVIERCSSvrvgSRTAPLTPtsreQILAKIRDWGSG 555
Cdd:PRK11033  494 -----RGLAIPEAESQRALA-----------GSGIEGQVNG---ERVLICAP----GKLPPLAD----AFAGQINELESA 546
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  556 SDTLrclALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:PRK11033  547 GKTV---VLVLRND----------------------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAI 601
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  636 CRRLGIfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAE 715
Cdd:PRK11033  602 AGELGI---------------DFR-----------------AGLLPEDKVKAVTELNQ-HAPLAMVGDGINDAPAMKAAS 648
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNmkqfIRYLISSNVGeVVCIFL-TAILGLPEalipvqlLW 794
Cdd:PRK11033  649 IGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRATHAN----IRQNITIALG-LKAIFLvTTLLGITG-------LW 716
                         730
                  ....*....|...
gi 767992213  795 VNLVTDGlPATAL 807
Cdd:PRK11033  717 LAVLADS-GATAL 728
copA PRK10671
copper-exporting P-type ATPase CopA;
601-759 8.30e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 101.74  E-value: 8.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddlspeqqrqacrtarcfarVE 680
Cdd:PRK10671  649 DPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI---DEVIAG----------------------------VL 697
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767992213  681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:PRK10671  698 PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQ 776
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
117-753 9.91e-22

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 101.18  E-value: 9.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  117 EALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIE-IKSttlrVDQSILTGESVSVTKhtEAI 194
Cdd:cd02078    86 DSLRKTKTEtQAKRLRNDGK-IEKVPATDLKKGDIVLVEAGDIIPADGEVIEgVAS----VDESAITGESAPVIR--ESG 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  195 PDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVI 274
Cdd:cd02078   159 GDRSSVT--------GGTKVLSDRIKVRITANPGETFLDRMIALVEGASRQKTPNEIALTILLVGLTLIFLIVVATLPPF 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  275 nighfadpahggswlrgAVYYfkiavalavaaipeGLPAVITTCLAL-------------------GTRRMARKNAIVRS 335
Cdd:cd02078   231 -----------------AEYS--------------GAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKS 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  336 LPSVETLGCTSVICSDKTGTLTT-NQMSvcrmfvvaeadagscllheftisgTTYTPEGEVRqgdqpvrcgqfdgLVELA 414
Cdd:cd02078   280 GRAVEAAGDVDTLLLDKTGTITLgNRQA------------------------TEFIPVGGVD-------------EKELA 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  415 TICALCndSALDYN-EAKGVYEkvgeatetaltcLVEKMNVFDTDLQalsrveRAGAcntvikqlmrkEFtLEFSRDRKs 493
Cdd:cd02078   323 DAAQLA--SLADETpEGRSIVI------------LAKQLGGTERDLD------LSGA-----------EF-IPFSAETR- 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  494 MSVYCTPtrphptgqGSKMFVKGAPESVIERCSSvRVGSrtaplTPTSREQILAKIRDWGSGSdtlrcLALATRDapprk 573
Cdd:cd02078   370 MSGVDLP--------DGTEIRKGAVDAIRKYVRS-LGGS-----IPEELEAIVEEISKQGGTP-----LVVAEDD----- 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  574 edmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkay 653
Cdd:cd02078   426 ------------------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV------------ 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  654 tgrefDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEM 733
Cdd:cd02078   476 -----DDF--------------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAGNM 536
                         650       660
                  ....*....|....*....|
gi 767992213  734 VLSDDNFASIVAAVEEGRAI 753
Cdd:cd02078   537 VDLDSDPTKLIEVVEIGKQL 556
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
110-794 1.28e-20

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 97.39  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  110 RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTK 189
Cdd:cd07544    95 RRASRELTALLDRAPRIAHRLVGG--QLEEVPVEEVTVGDRLLVRPGEVVPVDGEVV---SGTATLDESSLTGESKPVSK 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  190 HteaipdpravnqdkknmlfSGTNITSGKAVG------VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHA 263
Cdd:cd07544   170 R-------------------PGDRVMSGAVNGdsaltmVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYAVPFTLL 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  264 ISVICVAVWVINighfADPAHGGSWLRGAvyyfkiavalavaaIPegLPAVITTCLAL--GTRRMARKNAIVRSLPSVET 341
Cdd:cd07544   231 ALAIAGVAWAVS----GDPVRFAAVLVVA--------------TP--CPLILAAPVAIvsGMSRSSRRGILVKDGGVLEK 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELAticalcn 421
Cdd:cd07544   291 LARAKTVAFDKTGTLTYGQPKVVDVVPAPGVDA---------------------------------DEVLRLA------- 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  422 dSALDYNEAKGVYEKVGEATETALTclvekmnvfdtDLQALSRVERagacntvikqlmrkeftlefsrdrksmsvyctpt 501
Cdd:cd07544   331 -ASVEQYSSHVLARAIVAAAREREL-----------QLSAVTELTE---------------------------------- 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  502 rphPTGQGSKMFVKGApesviercsSVRVGSRTapltptsreqiLAKIRDWGSgsdtlrclalatrdapPRKEDMELDDC 581
Cdd:cd07544   365 ---VPGAGVTGTVDGH---------EVKVGKLK-----------FVLARGAWA----------------PDIRNRPLGGT 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  582 SKFVQyeTDLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtEDVAGkaytgrefdD 660
Cdd:cd07544   406 AVYVS--VDGKYAGAITLRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI----DEVRA---------E 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  661 LSPEQqrqacrtarcfarvepahKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKS-AAEMVLSDDN 739
Cdd:cd07544   471 LLPED------------------KLAAVKEAPK-AGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASeAADVVILVDD 531
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992213  740 FASIVAAVeegrAIYSNMKQFIryLISSNVGEVVCI---------FLTAILG--LPEALIPVQLLW 794
Cdd:cd07544   532 LDRVVDAV----AIARRTRRIA--LQSVLIGMALSIigmliaafgLIPPVAGalLQEVIDVVSILN 591
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
4-71 2.90e-19

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 82.61  E-value: 2.90e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767992213     4 AHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALV 71
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
97-751 1.55e-18

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 91.10  E-value: 1.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    97 ILVANAIVGVWQERNAESAiEALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrV 175
Cdd:TIGR01497   77 VLFANFAEAVAEGRGKAQA-DSLKGTKKTtFAKLLRDDGA-IDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGVAS---V 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   176 DQSILTGESVSVTKhtEAIPDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDE 255
Cdd:TIGR01497  152 DESAITGESAPVIK--ESGGDFASVT--------GGTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTI 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   256 FGRQLSHAISVICVAVWVinighFAdpAHGGSWLRGAVyyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRS 335
Cdd:TIGR01497  222 LLIALTLVFLLVTATLWP-----FA--AYGGNAISVTV-----LVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATS 289
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   336 LPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQFDGLVELAT 415
Cdd:TIGR01497  290 GRAVEACGDVDTLLLDKTGTITL----------------GNRLASEFI-----------------PAQGVDEKTLADAAQ 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   416 ICALCNDSAldynEAKGVYEkvgeatetaltcLVEKMNVFDTDLQALSrveragacntvikqlmrKEFtLEFSRDRKsMS 495
Cdd:TIGR01497  337 LASLADDTP----EGKSIVI------------LAKQLGIREDDVQSLH-----------------ATF-VEFTAQTR-MS 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   496 VYCTPtrphptgqGSKMFVKGAPESvIERcssvRVGSRTAPLtPTSREQILAKIRDWGsGSDTLRCLalatrdapprked 575
Cdd:TIGR01497  382 GINLD--------NGRMIRKGAVDA-IKR----HVEANGGHI-PTDLDQAVDQVARQG-GTPLVVCE------------- 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   576 melddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytg 655
Cdd:TIGR01497  434 --------------DNRIYGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV-------------- 485
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   656 refDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVL 735
Cdd:TIGR01497  486 ---DDF--------------IAEATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAANMVD 548
                          650
                   ....*....|....*.
gi 767992213   736 SDDNFASIVAAVEEGR 751
Cdd:TIGR01497  549 LDSDPTKLIEVVHIGK 564
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
110-759 6.09e-18

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 88.95  E-value: 6.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  110 RNAESAIEALKEYEPEMGKVIRSDrkGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVT 188
Cdd:cd02092   111 GRARSAAEELAALEARGAQRLQAD--GSREyVPVAEIRPGDRVLVAAGERIPVDGTVV---SGTSELDRSLLTGESAPVT 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  189 KHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAIS 265
Cdd:cd02092   186 VAPGD-------------LVQAGAMNLSGPLRLRATAAGDDTLLAEIARLMEAAEQGRSRYVRLADRAARLYApvvHLLA 252
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  266 VICVAVWVInighfadpaHGGSWlRGAVyyfkiavalavaaipegLPAV---ITTC-LALG----------TRRMARKNA 331
Cdd:cd02092   253 LLTFVGWVA---------AGGDW-RHAL-----------------LIAVavlIITCpCALGlavpavqvvaSGRLFRRGV 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftISGTTYTPEgevrqgdqpvrcgqfdglv 411
Cdd:cd02092   306 LVKDGTALERLAEVDTVVFDKTGTLTLGSPRL--------------------VGAHAISAD------------------- 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  412 ELATICALCNDSAldyneakgvyekvgeatetaltclvekmnvfdtdlQALSR--VERAGACNTVIKQLmrKEftlefsr 489
Cdd:cd02092   347 LLALAAALAQASR-----------------------------------HPLSRalAAAAGARPVELDDA--RE------- 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  490 drksmsvycTPtrphptGQGSKMFVKGAPesviercssVRVGSR----TAPLTPTSREqilakirdwgsgsdtlrcLALA 565
Cdd:cd02092   383 ---------VP------GRGVEGRIDGAR---------VRLGRPawlgASAGVSTASE------------------LALS 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  566 TRDAPPrkedmelddcskfvqyetdltfvGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdt 645
Cdd:cd02092   421 KGGEEA-----------------------ARFPFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI---- 473
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  646 edvagkaytgrefDDLSpeqqrqacrtarcfARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTA 725
Cdd:cd02092   474 -------------EDWR--------------AGLTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASAVD 526
                         650       660       670
                  ....*....|....*....|....*....|....
gi 767992213  726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02092   527 ASRSAADIVFLGDSLAPVPEAIEIARRARRLIRQ 560
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
67-743 1.79e-17

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 87.18  E-value: 1.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   67 LAALVSFVLAWFEEGEETTTAFVEPL--VIMLILVANAIVGVWQERNAEsaiEALKEYEPEMGKVIRSDRKGVQRIRARD 144
Cdd:cd07553    69 LGIVIGFVVSWYGLIKGDGLVYFDSLsvLVFLMLVGRWLQVVTQERNRN---RLADSRLEAPITEIETGSGSRIKTRADQ 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  145 IVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHteaipdpravnqdKKNMLFSGTNITSGKAVGVAV 224
Cdd:cd07553   146 IKSGDVYLVASGQRVPVDGKLL---SEQASIDMSWLTGESLPRIVE-------------RGDKVPAGTSLENQAFEIRVE 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  225 ATGLHTELGKIRSQMAAVEPERTPLqrklDEFGRQLSHAISVICVAVWVinighfadpAHGGSWLR-GAVYYFKIAVALA 303
Cdd:cd07553   210 HSLAESWSGSILQKVEAQEARKTPR----DLLADKIIHYFTVIALLIAV---------AGFGVWLAiDLSIALKVFTSVL 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  304 VAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheft 383
Cdd:cd07553   277 IVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSF-------------------- 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  384 isgTTYTPEGEVRQgdqpvrcgqfdGLVELATICALCNdsaldyneakgvyekvgeatetaltclvekmnvfdtdlQALS 463
Cdd:cd07553   337 ---VMVNPEGIDRL-----------ALRAISAIEAHSR--------------------------------------HPIS 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  464 RveragacnTVIKQLMRKEFTLEFSRDRKSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSrtapltptsre 543
Cdd:cd07553   365 R--------AIREHLMAKGLIKAGASELVEI-----------VGKGVSGNSSG---------SLWKLGS----------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  544 qilakirdwgsgsdtlrclalatrdapprkedmELDDC---SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIR 620
Cdd:cd07553   406 ---------------------------------APDACgiqESGVVIARDGRQLLDLSFNDLLRPDSNREIEELKKGGLS 452
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  621 VVMITGDNKGTAVAICRRLGIfGDTEDVAGkaytgrefddLSPEQqrqacrtarcfarvepahKSRIVENLQSFNeiTAM 700
Cdd:cd07553   453 IAILSGDNEEKVRLVGDSLGL-DPRQLFGN----------LSPEE------------------KLAWIESHSPEN--TLM 501
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 767992213  701 TGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:cd07553   502 VGDGANDALALASAFVGIAVAGEVGVSLEAADIYYAGNGIGGI 544
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
92-780 3.17e-17

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 86.68  E-value: 3.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   92 LVIMLILVANAIVGVWQERNAESAIEALKEYEPEM-GKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKS 170
Cdd:PRK14010   70 IILLLTLVFANFSEALAEGRGKAQANALRQTQTEMkARRIKQD-GSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLA 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  171 TtlrVDQSILTGESVSVTKHTEAipdpravnqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK14010  149 T---VDESAITGESAPVIKESGG----------DFDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNE 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  251 RKLdeFGRQLSHAISVICVAVWVINIGHFadpahggswlrgavYYFKIAVALAVAAIPEGLPAVITTCLAL----GTRRM 326
Cdd:PRK14010  216 IAL--FTLLMTLTIIFLVVILTMYPLAKF--------------LNFNLSIAMLIALAVCLIPTTIGGLLSAigiaGMDRV 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQ 406
Cdd:PRK14010  280 TQFNILAKSGRSVETCGDVNVLILDKTGTITY----------------GNRMADAFI-----------------PVKSSS 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  407 FDGLVELATICALCNDSALdyneakgvyekvgeatetaltclvekmnvfdtdlqalsrveragacNTVIKQLMRKEFtLE 486
Cdd:PRK14010  327 FERLVKAAYESSIADDTPE----------------------------------------------GRSIVKLAYKQH-ID 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  487 FSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERcssvrvgsrtapltptsreqilakIRDWGSGSdtlrclalat 566
Cdd:PRK14010  360 LPQEVGEYIPFTAETRMSGVKFTTREVYKGAPNSMVKR------------------------VKEAGGHI---------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  567 rdapPRKEDMELDDCSK-----FVQYETDLtFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI 641
Cdd:PRK14010  406 ----PVDLDALVKGVSKkggtpLVVLEDNE-ILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV 480
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  642 fgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG 721
Cdd:PRK14010  481 -------------------------------DRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAMN 529
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767992213  722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCI----FLTAI 780
Cdd:PRK14010  530 SGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAIlpamFMAAM 592
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.55e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992213      5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
590-751 1.81e-15

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 80.74  E-value: 1.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  590 DLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtedvaGKAYTgrefdDLSPEQQRQ 668
Cdd:cd07548   417 DGKYVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSVAEKVAKKLGI--------DEVYA-----ELLPEDKVE 483
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  669 AcrtarcFARVEPAHKSRIvenlqsfneitAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAV 747
Cdd:cd07548   484 K------VEELKAESKGKV-----------AFVGDGINDAPVLARADVGIAMGGlGSDAAIEAADVVLMNDEPSKVAEAI 546

                  ....
gi 767992213  748 EEGR 751
Cdd:cd07548   547 KIAR 550
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
47-718 3.61e-14

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 77.42  E-value: 3.61e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213    47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVIMLILVAnaivgvwqernAESAIEALK------ 120
Cdd:TIGR01652   19 KNLFE----QFKRFANLYFLVVALLQQVPILSPTYRGTSIV---PLAFVLIVTA-----------IKEAIEDIRrrrrdk 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   121 EYEPEMGKVIRSDRKGVqRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSI------ 179
Cdd:TIGR01652   81 EVNNRLTEVLEGHGQFV-EIPWKDLRVGDIVKVKKDERIPADLLLlsssepdgvcyVETANldgeTNLKLRQALeetqkm 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   180 --------LTGESVSVTKH--------TEAIPDPRAVNQDKKNMLFSGTNITSGK-AVGVAVATGLHTELGKIRSQmaav 242
Cdd:TIGR01652  160 ldeddiknFSGEIECEQPNaslysfqgNMTINGDRQYPLSPDNILLRGCTLRNTDwVIGVVVYTGHDTKLMRNATQ---- 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   243 eperTPLQRKLDEfgRQLSHAISVICVAVWVINI-----GHFADPAHGGSwlrgaVYYFKIAVALAVAAIPEGLPavITT 317
Cdd:TIGR01652  236 ----APSKRSRLE--KELNFLIIILFCLLFVLCLissvgAGIWNDAHGKD-----LWYIRLDVSERNAAANGFFS--FLT 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   318 CLAL-------------------------GTRRMARKN----AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFV 368
Cdd:TIGR01652  303 FLILfsslipislyvslelvksvqayfinSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIME----FK 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   369 VAeadagscllhefTISGTTYTpEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVY--EKVGEATETALT 446
Cdd:TIGR01652  379 KC------------SIAGVSYG-DGFTEIKDGIRERLGSYVENENSMLVESKGFTFVDPRLVDLLKtnKPNAKRINEFFL 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   447 CL---------VEKMNVFDTDLQALSRVERA-------------GACNTVIKQLMR-----KEF----TLEFSRDRKSMS 495
Cdd:TIGR01652  446 ALalchtvvpeFNDDGPEEITYQAASPDEAAlvkaardvgfvffERTPKSISLLIEmhgetKEYeilnVLEFNSDRKRMS 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   496 VYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTApltpTSREqiLAKIrdwgsGSDTLRCLALATRDAPP---- 571
Cdd:TIGR01652  526 VIVR----NPDGR-IKLLCKGADTVIFKRLSSGGNQVNEE----TKEH--LENY-----ASEGLRTLCIAYRELSEeeye 589
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   572 -------------RKEDMELDDCSKFVqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI--- 635
Cdd:TIGR01652  590 ewneeyneastalTDREEKLDVVAESI--EKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIgys 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   636 CRRLGI-----------FGDTEDVA-----GKAYTGREFDD-------------------LSPEQQRQ------ACRTAR 674
Cdd:TIGR01652  668 CRLLSRnmeqivitsdsLDATRSVEaaikfGLEGTSEEFNNlgdsgnvalvidgkslgyaLDEELEKEflqlalKCKAVI 747
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 767992213   675 CfARVEPAHKSRIVENLQ-SFNEITAMTGDGVNDAPALKKAEIGI 718
Cdd:TIGR01652  748 C-CRVSPSQKADVVRLVKkSTGKTTLAIGDGANDVSMIQEADVGV 791
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
47-720 1.76e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 68.40  E-value: 1.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVImlILVANAIVGVWQERNAESAIEALKEYEPem 126
Cdd:cd07536    17 GVLYE----QFKRFLNLYFLVIACLQFVPALKPGYLYTTWA---PLIF--ILAVTMTKEAIDDFRRFQRDKEVNKKQL-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  127 gKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI--KSTTLRVDQSILTGES-------VSVTKHTEAI--- 194
Cdd:cd07536    86 -YSKLTGRK--VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTsePQGSCYVETAQLDGETdlklrvaVSCTQQLPALgdl 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  195 -----------PD-----------------PRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTELGKIRSQmaaVEPE 245
Cdd:cd07536   163 mkisayvecqkPQmdihsfegnftledsdpPIHESLSIENTLLRASTLrNTGWVIGVVVYTGKETKLVMNTSN---AKNK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  246 RTPLQRKLDefgrQLSHAISVICVAVWVINI--GHFADPAHG-GSW----LRGAVYYFKIAVALAVAAIPEGLPAVITTC 318
Cdd:cd07536   240 VGLLDLELN----RLTKALFLALVVLSLVMVtlQGFWGPWYGeKNWyikkMDTTSDNFGRNLLRFLLLFSYIIPISLRVN 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  319 LAL--------------------GTRRMARKNAIVrslpsvETLGCTSVICSDKTGTLTTNQMSVCRMfvvaeadagscl 378
Cdd:cd07536   316 LDMvkavyawfimwdenmyyignDTGTVARTSTIP------EELGQVVYLLTDKTGTLTQNEMIFKRC------------ 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  379 lhefTISGTTYtpegevrqGDQPVRCGqfdglvelaticalcndsaldyneakgvyekvgeatetaltclvekmnvfdtd 458
Cdd:cd07536   378 ----HIGGVSY--------GGQVLSFC----------------------------------------------------- 392
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  459 lqalsrveragacntvIKQLmrkeftLEFSRDRKSMSVYctpTRPHPTGQgSKMFVKGAPESVIERcssVRVGSRTaplt 538
Cdd:cd07536   393 ----------------ILQL------LEFTSDRKRMSVI---VRDESTGE-ITLYMKGADVAISPI---VSKDSYM---- 439
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  539 ptsrEQILAKIRDWGSgsDTLRCLALATRDApprKEDMELDDCSKFVQ------------------YETDLTFVGCVGML 600
Cdd:cd07536   440 ----EQYNDWLEEECG--EGLRTLCVAKKAL---TENEYQEWESRYTEaslslhdrslrvaevvesLERELELLGLTAIE 510
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-------------------------------CRRLGI-FGDTEDV 648
Cdd:cd07536   511 DRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIakschlvsrtqdihllrqdtsrgeraaitqhAHLELNaFRRKHDV 590
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  649 A----GKA------YTGREFDDLSPEqqrqaCRTARCfARVEPAHKSRIVENLQSFNE-ITAMTGDGVNDAPALKKAEIG 717
Cdd:cd07536   591 AlvidGDSlevalkYYRHEFVELACQ-----CPAVIC-CRVSPTQKARIVTLLKQHTGrRTLAIGDGGNDVSMIQAADCG 664

                  ...
gi 767992213  718 IAM 720
Cdd:cd07536   665 VGI 667
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
601-714 3.14e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 63.37  E-value: 3.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGrefddlspeqqrqacrtarcFARVE 680
Cdd:pfam00702   97 LKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVG--------------------VGKPK 156
                           90       100       110
                   ....*....|....*....|....*....|....
gi 767992213   681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:pfam00702  157 PEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAA 190
PLN03190 PLN03190
aminophospholipid translocase; Provisional
334-720 2.02e-08

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 58.76  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  334 RSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVVAeadagscllhefTISGTTYTPEGEVRQGDQPVRCGQFDGL--- 410
Cdd:PLN03190  442 RALNINEDLGQIKYVFSDKTGTLTENKME----FQCA------------SIWGVDYSDGRTPTQNDHAGYSVEVDGKilr 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  411 ----VELATICALCNDSALDYNEAKGVYE--KVGEATETALTCLVE-----KMNVFD-----TDLQALSR---------V 465
Cdd:PLN03190  506 pkmkVKVDPQLLELSKSGKDTEEAKHVHDffLALAACNTIVPIVVDdtsdpTVKLMDyqgesPDEQALVYaaaaygfmlI 585
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  466 ERAGACNTVIKQLMRKEFTL----EFSRDRKSMSVY--CtptrPHPTgqgSKMFVKGAPES---VIERCSSVRV------ 530
Cdd:PLN03190  586 ERTSGHIVIDIHGERQRFNVlglhEFDSDRKRMSVIlgC----PDKT---VKVFVKGADTSmfsVIDRSLNMNViratea 658
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  531 --------GSRTapLTPTSREQILAKIRDWGSGSDTLRClALATRDAPPRKEDMELddcskfvqyETDLTFVGCVGMLDP 602
Cdd:PLN03190  659 hlhtysslGLRT--LVVGMRELNDSEFEQWHFSFEAAST-ALIGRAALLRKVASNV---------ENNLTILGASAIEDK 726
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  603 PRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-----------------------CRR-----------LGIFGDTEDV 648
Cdd:PLN03190  727 LQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqiiinsnskesCRKsledalvmskkLTTVSGISQN 806
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  649 AGKAYTGRE---------------FDDLSPEQQRQ---ACRTARCfARVEPAHKSRIVENLQS-FNEITAMTGDGVNDAP 709
Cdd:PLN03190  807 TGGSSAAASdpvaliidgtslvyvLDSELEEQLFQlasKCSVVLC-CRVAPLQKAGIVALVKNrTSDMTLAIGDGANDVS 885
                         490
                  ....*....|.
gi 767992213  710 ALKKAEIGIAM 720
Cdd:PLN03190  886 MIQMADVGVGI 896
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
685-734 2.99e-05

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 46.88  E-value: 2.99e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767992213   685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMV 734
Cdd:TIGR00099  194 QSLAEALGiSLEDVIAF-GDGMNDIEMLEAAGYGVAMGNADEELKALADYV 243
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
589-749 7.24e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.74  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  589 TDL--TFVGCVGMLDPprpEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--------TEDVAGKAYTGRef 658
Cdd:COG0561     7 LDLdgTLLNDDGEISP---RTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDPlitsngalIYDPDGEVLYER-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  659 dDLSPEQQRQACRTAR-------CFARVEP---------AHKSRIVENLQ-----SFNEITAMtGDGVNDAPALKKAEIG 717
Cdd:COG0561    82 -PLDPEDVREILELLRehglhlqVVVRSGPgfleilpkgVSKGSALKKLAerlgiPPEEVIAF-GDSGNDLEMLEAAGLG 159
                         170       180       190
                  ....*....|....*....|....*....|..
gi 767992213  718 IAMGSGTAVAKSAAEMVLSDDNFASIVAAVEE 749
Cdd:COG0561   160 VAMGNAPPEVKAAADYVTGSNDEDGVAEALEK 191
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
685-743 1.67e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 44.54  E-value: 1.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:pfam08282  193 KALAKHLNiSLEEVIAF-GDGENDIEMLEAAGLGVAMGNASPEVKAAADYVTDSNNEDGV 251
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
619-737 4.97e-04

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 443263 [Multi-domain]  Cd Length: 156  Bit Score: 41.69  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  619 IRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrEFDDLSPEQQRQAcrtarcfarvepahKSRIVENLQSfnEIT 698
Cdd:COG4087    46 LEIHVLTADTFGTVAKELAGLPV---------------ELHILPSGDQAEE--------------KLEFVEKLGA--ETT 94
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767992213  699 AMTGDGVNDAPALKKAEIGIA-MGS-GTAV-AKSAAEMVLSD 737
Cdd:COG4087    95 VAIGNGRNDVLMLKEAALGIAvIGPeGASVkALLAADIVVKS 136
HAD pfam12710
haloacid dehalogenase-like hydrolase;
604-712 6.54e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 6.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG---IFGDTEDVAGKAYTGREFDDLSPEQQRQACR--TARCFAR 678
Cdd:pfam12710   86 HPGALELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRrlRAWLAAR 165
                           90       100       110
                   ....*....|....*....|....*....|....
gi 767992213   679 VEPAHKSRIVenlqsfneitAMtGDGVNDAPALK 712
Cdd:pfam12710  166 GLGLDLADSV----------AY-GDSPSDLPMLR 188
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
604-719 1.13e-03

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 41.75  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213  604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI---FGDTEDVAGKAYTGREFDDLspeqqrqacrtarcfarVE 680
Cdd:COG0560    90 YPGARELIAEHRAAGHKVAIVSGGFTFFVEPIAERLGIdhvIANELEVEDGRLTGEVVGPI-----------------VD 152
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767992213  681 PAHKSRIVENL-----QSFNEITAMtGDGVNDAPALKKAEIGIA 719
Cdd:COG0560   153 GEGKAEALRELaaelgIDLEQSYAY-GDSANDLPMLEAAGLPVA 195
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
702-760 2.34e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 40.67  E-value: 2.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767992213  702 GDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVlSDDNFasivaavEEGraIYSNMKQF 760
Cdd:cd07517   164 GDGLNDIEMLEAVGIGIAMGNAHEELKEIADYV-TKDVD-------EDG--ILKALKHF 212
HAD_Pase cd07514
phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), ...
695-748 6.27e-03

phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), and Pyrococcus horikoshii PH1421, a magnesium-dependent phosphatase; belongs to the haloacid dehalogenase-like superfamily; Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PGPase) catalyzes the magnesium-dependent dephosphorylation of phosphoglycolate. This family also includes Pyrococcus horikoshii OT3 PH1421, a magnesium-dependent phosphatase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319816 [Multi-domain]  Cd Length: 139  Bit Score: 37.95  E-value: 6.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767992213  695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd07514    84 EEVLAI-GDSENDIEMFKVAGFKVAVANADEELKEAADYVTDASYGDGVLEAID 136
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
695-749 6.82e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 6.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767992213  695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEmVLSDDNFASIVA-AVEE 749
Cdd:cd07516   200 EEVIAF-GDNENDLSMLEYAGLGVAMGNAIDEVKEAAD-YVTLTNNEDGVAkAIEK 253
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
679-744 9.08e-03

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 38.88  E-value: 9.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992213   679 VEPAHKSRIVENLQSFNEI----TAMTGDGVNDAPALKKAEIGIAMGSGTAVaKSAAEMVLSDDNFASIV 744
Cdd:TIGR00338  148 VDASYKGKTLLILLRKEGIspenTVAVGDGANDLSMIKAAGLGIAFNAKPKL-QQKADICINKKDLTDIL 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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