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Conserved domains on  [gi|767993695|ref|XP_011522685|]
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schlafen family member 13 isoform X2 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 1009293)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase

Gene Ontology:  GO:0005524

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3972 super family cl28313
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
226-565 1.07e-09

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG3972:

Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 61.00  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 226 VLLGFRSLLSDQLGCEVLNLLTAQQyEIFSRSLRKNRELfVHGLPGSGKT-IMAMKIMEKIRNvfHCEAhRILYVCEN-- 302
Cdd:COG3972  140 ALRLLNLVSLEDFFLPLIAVLDLQQ-ERIARSIPDGPQR-IRGVAGSGKTvLLAAKAAYLALK--HPGW-RILVTCFNrs 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 303 --QPLRNFISDRNICRAE-------------------------TRETFLREK----------FEHIQH---------IVI 336
Cdd:COG3972  215 laDHLRDLIPRFLRRFSNgepednvklivfhawggkllkqygiPPLTFSQPNeafdeackalLEAIQGeiippiydaILI 294
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 337 DEAQNFRTEdgdWYRkakTITQREKDCPGVLWIFLDYFQ----TSHLGHSGLPPLSAQypREELTRVVRN-------ADE 405
Cdd:COG3972  295 DEAQDFEPE---FLR---LLYQLLKPPKKRLIWAYDEAQniygRKIPSAGGIPAGIGR--DTILKKNYRNtrpiltfAHA 366
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 406 IAEYIQQEMQLIIENPP--INIPHGYLAILSEAKWVPGVPGNTKIIKNF-TLEQIVTYVADTC-RCFFERGYSPKDVAVL 481
Cdd:COG3972  367 FGMGLLRPPGLLQGDAEdyEVERPGDKVTLIRPPEPAGRKGPLPEFKKYdDRAEELEAIAEEIkKNLRDEGLRPSDIAVI 446
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 482 VSTVTEVEQYQSKLLKAMRKKMVvqlsdACDMLGV-----------HIVLDSVRRFSGLERSIVF--GIH--PRTADPAI 546
Cdd:COG3972  447 YLGNNEAKELGDRLAAALERQGI-----DSYIAGArsdpnffwkdgGVTISTIHRAKGLEAPVVIivGLDqlAKGESLER 521
                        410
                 ....*....|....*....
gi 767993695 547 LPNILICLASRAKQHLYIF 565
Cdd:COG3972  522 LRNLLYVAMTRARGWLVVS 540
 
Name Accession Description Interval E-value
COG3972 COG3972
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
226-565 1.07e-09

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 61.00  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 226 VLLGFRSLLSDQLGCEVLNLLTAQQyEIFSRSLRKNRELfVHGLPGSGKT-IMAMKIMEKIRNvfHCEAhRILYVCEN-- 302
Cdd:COG3972  140 ALRLLNLVSLEDFFLPLIAVLDLQQ-ERIARSIPDGPQR-IRGVAGSGKTvLLAAKAAYLALK--HPGW-RILVTCFNrs 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 303 --QPLRNFISDRNICRAE-------------------------TRETFLREK----------FEHIQH---------IVI 336
Cdd:COG3972  215 laDHLRDLIPRFLRRFSNgepednvklivfhawggkllkqygiPPLTFSQPNeafdeackalLEAIQGeiippiydaILI 294
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 337 DEAQNFRTEdgdWYRkakTITQREKDCPGVLWIFLDYFQ----TSHLGHSGLPPLSAQypREELTRVVRN-------ADE 405
Cdd:COG3972  295 DEAQDFEPE---FLR---LLYQLLKPPKKRLIWAYDEAQniygRKIPSAGGIPAGIGR--DTILKKNYRNtrpiltfAHA 366
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 406 IAEYIQQEMQLIIENPP--INIPHGYLAILSEAKWVPGVPGNTKIIKNF-TLEQIVTYVADTC-RCFFERGYSPKDVAVL 481
Cdd:COG3972  367 FGMGLLRPPGLLQGDAEdyEVERPGDKVTLIRPPEPAGRKGPLPEFKKYdDRAEELEAIAEEIkKNLRDEGLRPSDIAVI 446
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 482 VSTVTEVEQYQSKLLKAMRKKMVvqlsdACDMLGV-----------HIVLDSVRRFSGLERSIVF--GIH--PRTADPAI 546
Cdd:COG3972  447 YLGNNEAKELGDRLAAALERQGI-----DSYIAGArsdpnffwkdgGVTISTIHRAKGLEAPVVIivGLDqlAKGESLER 521
                        410
                 ....*....|....*....
gi 767993695 547 LPNILICLASRAKQHLYIF 565
Cdd:COG3972  522 LRNLLYVAMTRARGWLVVS 540
AAA_22 pfam13401
AAA domain;
264-345 3.38e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695  264 LFVHGLPGSGKTIMAMKIMEKIRNVfhcEAHRILYVCENQP-LRNFIsdRNICRA-------ETRETFLREKFEHI---- 331
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEV---RDSVVFVDLPSGTsPKDLL--RALLRAlglplsgRLSKEELLAALQQLllal 82
                          90
                  ....*....|....*..
gi 767993695  332 ---QHIVIDEAQNFRTE 345
Cdd:pfam13401  83 avaVVLIIDEAQHLSLE 99
 
Name Accession Description Interval E-value
COG3972 COG3972
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
226-565 1.07e-09

Superfamily I DNA and RNA helicases [Replication, recombination and repair];


Pssm-ID: 443172 [Multi-domain]  Cd Length: 565  Bit Score: 61.00  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 226 VLLGFRSLLSDQLGCEVLNLLTAQQyEIFSRSLRKNRELfVHGLPGSGKT-IMAMKIMEKIRNvfHCEAhRILYVCEN-- 302
Cdd:COG3972  140 ALRLLNLVSLEDFFLPLIAVLDLQQ-ERIARSIPDGPQR-IRGVAGSGKTvLLAAKAAYLALK--HPGW-RILVTCFNrs 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 303 --QPLRNFISDRNICRAE-------------------------TRETFLREK----------FEHIQH---------IVI 336
Cdd:COG3972  215 laDHLRDLIPRFLRRFSNgepednvklivfhawggkllkqygiPPLTFSQPNeafdeackalLEAIQGeiippiydaILI 294
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 337 DEAQNFRTEdgdWYRkakTITQREKDCPGVLWIFLDYFQ----TSHLGHSGLPPLSAQypREELTRVVRN-------ADE 405
Cdd:COG3972  295 DEAQDFEPE---FLR---LLYQLLKPPKKRLIWAYDEAQniygRKIPSAGGIPAGIGR--DTILKKNYRNtrpiltfAHA 366
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 406 IAEYIQQEMQLIIENPP--INIPHGYLAILSEAKWVPGVPGNTKIIKNF-TLEQIVTYVADTC-RCFFERGYSPKDVAVL 481
Cdd:COG3972  367 FGMGLLRPPGLLQGDAEdyEVERPGDKVTLIRPPEPAGRKGPLPEFKKYdDRAEELEAIAEEIkKNLRDEGLRPSDIAVI 446
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 482 VSTVTEVEQYQSKLLKAMRKKMVvqlsdACDMLGV-----------HIVLDSVRRFSGLERSIVF--GIH--PRTADPAI 546
Cdd:COG3972  447 YLGNNEAKELGDRLAAALERQGI-----DSYIAGArsdpnffwkdgGVTISTIHRAKGLEAPVVIivGLDqlAKGESLER 521
                        410
                 ....*....|....*....
gi 767993695 547 LPNILICLASRAKQHLYIF 565
Cdd:COG3972  522 LRNLLYVAMTRARGWLVVS 540
Zot COG4128
Zona occludens toxin, predicted ATPase [General function prediction only];
265-342 1.99e-04

Zona occludens toxin, predicted ATPase [General function prediction only];


Pssm-ID: 443304 [Multi-domain]  Cd Length: 276  Bit Score: 43.55  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695 265 FVHGLPGSGKTIMAMKIM-----EKIRNVF-HCEAHRILYVCENQPLRNFISDRNICRAETRETFLREK----FEHIQH- 333
Cdd:COG4128    5 LITGVPGSGKSYEAVWFLiipalKKGRRVItNIPGLKILERIAEHLGLAVPDTAELINVDTDDPDGLEKmarwFHWAPDg 84
                         90
                 ....*....|.
gi 767993695 334 --IVIDEAQNF 342
Cdd:COG4128   85 alIVIDEAQRV 95
AAA_22 pfam13401
AAA domain;
264-345 3.38e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993695  264 LFVHGLPGSGKTIMAMKIMEKIRNVfhcEAHRILYVCENQP-LRNFIsdRNICRA-------ETRETFLREKFEHI---- 331
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEV---RDSVVFVDLPSGTsPKDLL--RALLRAlglplsgRLSKEELLAALQQLllal 82
                          90
                  ....*....|....*..
gi 767993695  332 ---QHIVIDEAQNFRTE 345
Cdd:pfam13401  83 avaVVLIIDEAQHLSLE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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