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Conserved domains on  [gi|767994135|ref|XP_011522859|]
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G patch domain-containing protein 8 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 40-82 1.43e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 1.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767994135    40 SDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82
Cdd:pfam01585    1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 136-163 4.31e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 4.31e-05
                           10        20
                   ....*....|....*....|....*...
gi 767994135   136 FYCELCDKQYQKHQEFDNHINSydHAHK 163
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1085-1345 2.83e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1085 DDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKllleKIQSRKVERKPSVSEEVQATpNKAGPKLKDPPQGYfgpkl 1164
Cdd:PTZ00449  503 DSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSK----ESDEPKEGGKPGETKEGEVG-KKPGPAKEHKPSKI----- 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1165 pPSLGNKPVLPLIGKLPatRKPnKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPsEETTGPLLDPPPEESKSGEA 1244
Cdd:PTZ00449  573 -PTLSKKPEFPKDPKHP--KDP-EEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRP-ESPKSPKRPPPPQRPSSPER 647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1245 TADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDG-------DTLESLDSSSQ----------PGPVESSLLPIAPDLEH 1307
Cdd:PTZ00449  648 PEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAaaksketKTTVVLDESFEsilketlpetPGTPFTTPRPLPPKLPR 727

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767994135 1308 FPSYA-PPSGDPSIESTDGAEDASLAPLESQPITFTPEE 1345
Cdd:PTZ00449  728 DEEFPfEPIGDPDAEQPDDIEFFTPPEEERTFFHETPAD 766
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 40-82 1.43e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 1.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767994135    40 SDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82
Cdd:pfam01585    1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 38-82 5.29e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 59.10  E-value: 5.29e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 767994135     38 IESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82
Cdd:smart00443    1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 136-163 4.31e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 4.31e-05
                           10        20
                   ....*....|....*....|....*...
gi 767994135   136 FYCELCDKQYQKHQEFDNHINSydHAHK 163
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1085-1345 2.83e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1085 DDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKllleKIQSRKVERKPSVSEEVQATpNKAGPKLKDPPQGYfgpkl 1164
Cdd:PTZ00449  503 DSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSK----ESDEPKEGGKPGETKEGEVG-KKPGPAKEHKPSKI----- 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1165 pPSLGNKPVLPLIGKLPatRKPnKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPsEETTGPLLDPPPEESKSGEA 1244
Cdd:PTZ00449  573 -PTLSKKPEFPKDPKHP--KDP-EEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRP-ESPKSPKRPPPPQRPSSPER 647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1245 TADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDG-------DTLESLDSSSQ----------PGPVESSLLPIAPDLEH 1307
Cdd:PTZ00449  648 PEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAaaksketKTTVVLDESFEsilketlpetPGTPFTTPRPLPPKLPR 727

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767994135 1308 FPSYA-PPSGDPSIESTDGAEDASLAPLESQPITFTPEE 1345
Cdd:PTZ00449  728 DEEFPfEPIGDPDAEQPDDIEFFTPPEEERTFFHETPAD 766
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 40-82 1.43e-12

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.30  E-value: 1.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767994135    40 SDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82
Cdd:pfam01585    1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 38-82 5.29e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 59.10  E-value: 5.29e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 767994135     38 IESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82
Cdd:smart00443    1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 136-163 4.31e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 4.31e-05
                           10        20
                   ....*....|....*....|....*...
gi 767994135   136 FYCELCDKQYQKHQEFDNHINSydHAHK 163
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1085-1345 2.83e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1085 DDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKllleKIQSRKVERKPSVSEEVQATpNKAGPKLKDPPQGYfgpkl 1164
Cdd:PTZ00449  503 DSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSK----ESDEPKEGGKPGETKEGEVG-KKPGPAKEHKPSKI----- 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1165 pPSLGNKPVLPLIGKLPatRKPnKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPsEETTGPLLDPPPEESKSGEA 1244
Cdd:PTZ00449  573 -PTLSKKPEFPKDPKHP--KDP-EEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRP-ESPKSPKRPPPPQRPSSPER 647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994135 1245 TADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDG-------DTLESLDSSSQ----------PGPVESSLLPIAPDLEH 1307
Cdd:PTZ00449  648 PEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAaaksketKTTVVLDESFEsilketlpetPGTPFTTPRPLPPKLPR 727

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767994135 1308 FPSYA-PPSGDPSIESTDGAEDASLAPLESQPITFTPEE 1345
Cdd:PTZ00449  728 DEEFPfEPIGDPDAEQPDDIEFFTPPEEERTFFHETPAD 766
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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