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Conserved domains on  [gi|767995685|ref|XP_011523456|]
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transcriptional adapter 2-alpha isoform X4 [Homo sapiens]

Protein Classification

transcriptional adapter( domain architecture ID 709052)

transcriptional adapter facilitates the assembly and activation of the transcriptional machinery at specific gene promoters or enhancer regions; similar to Homo sapiens transcriptional adapter 2-alpha, a component of the ATAC (Ada-Two-A-containing) complex, which is a protein complex involved in regulating chromatin accessibility and gene expression

Gene Ontology:  GO:0003677|GO:0008270

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5114 super family cl27155
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
2-377 1.87e-59

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5114:

Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 198.37  E-value: 1.87e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685   2 TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADT 79
Cdd:COG5114   56 TNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRAKEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685  80 AIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKER 155
Cdd:COG5114  136 RHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYMNEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFR 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 156 QRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFC 235
Cdd:COG5114  216 ARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARYLTKSDFNVFFRDILEGVYIEKRIHELQEWRNNGLTTLE 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 236 SARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSpsipmasnsgRRSAPPLNLTGLPGTEKLNE 315
Cdd:COG5114  296 AGLKYERDKFEKFGASTAASLSEGNSRYRSNSAHRSNAEYSQMDVKNILP----------SKNMTISDIQHAPDYALLSD 365
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995685 316 KEKELCQMVRLVPGAYLEYKSALLNECNKQGG-LRLAQARALIKIDVNKTRKIYDFLIREGYI 377
Cdd:COG5114  366 DEQRLCETLNISPKPYLELKKEVISCFLRTRGeFTKEDFNRLFGIDLGKADGLYDFFLERGWI 428
 
Name Accession Description Interval E-value
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
2-377 1.87e-59

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 198.37  E-value: 1.87e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685   2 TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADT 79
Cdd:COG5114   56 TNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRAKEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685  80 AIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKER 155
Cdd:COG5114  136 RHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYMNEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFR 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 156 QRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFC 235
Cdd:COG5114  216 ARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARYLTKSDFNVFFRDILEGVYIEKRIHELQEWRNNGLTTLE 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 236 SARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSpsipmasnsgRRSAPPLNLTGLPGTEKLNE 315
Cdd:COG5114  296 AGLKYERDKFEKFGASTAASLSEGNSRYRSNSAHRSNAEYSQMDVKNILP----------SKNMTISDIQHAPDYALLSD 365
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995685 316 KEKELCQMVRLVPGAYLEYKSALLNECNKQGG-LRLAQARALIKIDVNKTRKIYDFLIREGYI 377
Cdd:COG5114  366 DEQRLCETLNISPKPYLELKKEVISCFLRTRGeFTKEDFNRLFGIDLGKADGLYDFFLERGWI 428
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
11-55 5.06e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 5.06e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767995685  11 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 55
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
311-377 1.18e-09

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 54.49  E-value: 1.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995685  311 EKLNEKEKELCQMVR----LVPGAYLEYKSALLNE--CNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYI 377
Cdd:pfam04433   4 DKLHPIEKRLLPEFFngksKTPEVYLEIRNFILNLwrENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLI 76
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
11-55 2.24e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 52.61  E-value: 2.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767995685    11 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 55
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLL 47
 
Name Accession Description Interval E-value
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
2-377 1.87e-59

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 198.37  E-value: 1.87e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685   2 TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADT 79
Cdd:COG5114   56 TNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRAKEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQR 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685  80 AIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKER 155
Cdd:COG5114  136 RHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYMNEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFR 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 156 QRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFC 235
Cdd:COG5114  216 ARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARYLTKSDFNVFFRDILEGVYIEKRIHELQEWRNNGLTTLE 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995685 236 SARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSpsipmasnsgRRSAPPLNLTGLPGTEKLNE 315
Cdd:COG5114  296 AGLKYERDKFEKFGASTAASLSEGNSRYRSNSAHRSNAEYSQMDVKNILP----------SKNMTISDIQHAPDYALLSD 365
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995685 316 KEKELCQMVRLVPGAYLEYKSALLNECNKQGG-LRLAQARALIKIDVNKTRKIYDFLIREGYI 377
Cdd:COG5114  366 DEQRLCETLNISPKPYLELKKEVISCFLRTRGeFTKEDFNRLFGIDLGKADGLYDFFLERGWI 428
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
11-55 5.06e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 5.06e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767995685  11 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 55
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
311-377 1.18e-09

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 54.49  E-value: 1.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995685  311 EKLNEKEKELCQMVR----LVPGAYLEYKSALLNE--CNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYI 377
Cdd:pfam04433   4 DKLHPIEKRLLPEFFngksKTPEVYLEIRNFILNLwrENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLI 76
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
11-55 2.24e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 52.61  E-value: 2.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767995685    11 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 55
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLL 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
11-55 3.78e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.04  E-value: 3.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767995685   11 SWTAQEEMALLEAVMDCGfGNWQDVANQMCTKTKEECEKHYMKHF 55
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
9-65 1.47e-03

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 40.64  E-value: 1.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995685   9 DPSWTAQEEMALLEAVMDCGfGNWQDVANQMCTKTKEECekhyMKHFINNPLFASTL 65
Cdd:COG5259  279 DKNWSRQELLLLLEGIEMYG-DDWDKVARHVGTKTKEQC----ILHFLQLPIEDNYL 330
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
12-38 1.90e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 36.01  E-value: 1.90e-03
                         10        20
                 ....*....|....*....|....*..
gi 767995685  12 WTAQEEMALLEAVMDCGFGNWQDVANQ 38
Cdd:cd11660    3 WTDEEDEALVEGVEKYGVGNWAKILKD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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