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Conserved domains on  [gi|767995704|ref|XP_011523464|]
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hepatocyte nuclear factor 1-beta isoform X4 [Homo sapiens]

Protein Classification

HTH_XRE and homeodomain domain-containing protein( domain architecture ID 11153336)

HTH_XRE and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-174 1.49e-93

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461440  Cd Length: 178  Bit Score: 277.47  E-value: 1.49e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704    8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKLETLPLSPGSGaePDTKPVFHTLTNGHAK---------GRLSGD 77
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdPEFGVKLESLPLSPGSS--CDSKPVFPTLANGHGPsssssssstSKLSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704   78 EGSEDGDDYDTPPIL---KELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHL 154
Cdd:pfam04814  79 EGSSDGNSYDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHL 158

                         170       180
                  ....*....|....*....|
gi 767995704  155 NKGTPMKTQKRAALYTWYVR 174
Cdd:pfam04814 159 NKGTPMKTQKRAALYTWYVR 178
HNF-1B_C super family cl04770
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 314-350 1.50e-10

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


The actual alignment was detected with superfamily member pfam04812:

Pssm-ID: 461438  Cd Length: 258  Bit Score: 61.17  E-value: 1.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767995704  314 AMDAYSSNQTHSLNPLLSHGSPHH-QPSSSPPNKLSGV 350
Cdd:pfam04812   1 AMDAYSGPQPHSANPLLPHSSPHHpQPSASPPSKVQGV 38
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 232-305 1.09e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 45.31  E-value: 1.09e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995704 232 RRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRRK 305
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-174 1.49e-93

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 277.47  E-value: 1.49e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704    8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKLETLPLSPGSGaePDTKPVFHTLTNGHAK---------GRLSGD 77
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdPEFGVKLESLPLSPGSS--CDSKPVFPTLANGHGPsssssssstSKLSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704   78 EGSEDGDDYDTPPIL---KELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHL 154
Cdd:pfam04814  79 EGSSDGNSYDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHL 158

                         170       180
                  ....*....|....*....|
gi 767995704  155 NKGTPMKTQKRAALYTWYVR 174
Cdd:pfam04814 159 NKGTPMKTQKRAALYTWYVR 178
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 314-350 1.50e-10

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 61.17  E-value: 1.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767995704  314 AMDAYSSNQTHSLNPLLSHGSPHH-QPSSSPPNKLSGV 350
Cdd:pfam04812   1 AMDAYSGPQPHSANPLLPHSSPHHpQPSASPPSKVQGV 38
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 232-305 1.09e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 45.31  E-value: 1.09e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995704 232 RRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRRK 305
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 231-305 1.79e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.55  E-value: 1.79e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767995704   231 MRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRRK 305
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
232-304 3.34e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.25  E-value: 3.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767995704  232 RRNRfkWGPASQQI--LYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRR 304
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-174 1.49e-93

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 277.47  E-value: 1.49e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704    8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKLETLPLSPGSGaePDTKPVFHTLTNGHAK---------GRLSGD 77
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdPEFGVKLESLPLSPGSS--CDSKPVFPTLANGHGPsssssssstSKLSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995704   78 EGSEDGDDYDTPPIL---KELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHL 154
Cdd:pfam04814  79 EGSSDGNSYDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHL 158

                         170       180
                  ....*....|....*....|
gi 767995704  155 NKGTPMKTQKRAALYTWYVR 174
Cdd:pfam04814 159 NKGTPMKTQKRAALYTWYVR 178
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 314-350 1.50e-10

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 61.17  E-value: 1.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767995704  314 AMDAYSSNQTHSLNPLLSHGSPHH-QPSSSPPNKLSGV 350
Cdd:pfam04812   1 AMDAYSGPQPHSANPLLPHSSPHHpQPSASPPSKVQGV 38
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 232-305 1.09e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 45.31  E-value: 1.09e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995704 232 RRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRRK 305
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 231-305 1.79e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.55  E-value: 1.79e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767995704   231 MRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRRK 305
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
232-304 3.34e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.25  E-value: 3.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767995704  232 RRNRfkWGPASQQI--LYQAYDRQKNPSKEEREALVEECNraeclqrgvspskahglgsnlVTEVRVYNWFANRR 304
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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