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Conserved domains on  [gi|767996147|ref|XP_011523647|]
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nuclear speckle splicing regulatory protein 1 isoform X3 [Homo sapiens]

Protein Classification

nuclear speckle splicing regulatory protein 1 family protein( domain architecture ID 10560920)

nuclear speckle splicing regulatory protein 1 (NSRP1) family protein is a DUF2040 domain-containing protein similar to Schizosaccharomyces pombe NSRP1 homolog, also called coiled-coil domain-containing protein 55 homolog

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 272-449 1.66e-49

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


:

Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 168.48  E-value: 1.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  272 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 351
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  352 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 431
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 767996147  432 RKESSPNSRAKDKFLDQE 449
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 37-156 8.47e-31

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


:

Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 116.08  E-value: 8.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147   37 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 115
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767996147  116 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 156
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
 
Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 272-449 1.66e-49

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 168.48  E-value: 1.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  272 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 351
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  352 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 431
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 767996147  432 RKESSPNSRAKDKFLDQE 449
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 37-156 8.47e-31

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 116.08  E-value: 8.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147   37 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 115
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767996147  116 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 156
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 269-431 3.13e-06

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 49.90  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 269 RSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDShwKRHEQEDKPRARD 348
Cdd:PRK12678 133 RGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERG--RDGDDRDRRDRRE 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 349 QRERSDRvwKREKDREKYSQREQERDRQQNDQNRpSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 428
Cdd:PRK12678 211 QGDRREE--RGRRDGGDRRGRRRRRDRRDARGDD-NREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGGDGGNEREPEL 287


                 ...
gi 767996147 429 NQD 431
Cdd:PRK12678 288 RED 290
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 289-380 6.64e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 42.21  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  289 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 368
Cdd:TIGR01622   2 YRDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS---RSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90
                  ....*....|..
gi 767996147  369 REQERDRQQNDQ 380
Cdd:TIGR01622  79 RGDSYRRRRDDR 90
 
Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 272-449 1.66e-49

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 168.48  E-value: 1.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  272 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 351
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  352 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 431
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 767996147  432 RKESSPNSRAKDKFLDQE 449
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 37-156 8.47e-31

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 116.08  E-value: 8.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147   37 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 115
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767996147  116 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 156
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 269-431 3.13e-06

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 49.90  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 269 RSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDShwKRHEQEDKPRARD 348
Cdd:PRK12678 133 RGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERG--RDGDDRDRRDRRE 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 349 QRERSDRvwKREKDREKYSQREQERDRQQNDQNRpSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 428
Cdd:PRK12678 211 QGDRREE--RGRRDGGDRRGRRRRRDRRDARGDD-NREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGGDGGNEREPEL 287


                 ...
gi 767996147 429 NQD 431
Cdd:PRK12678 288 RED 290
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 289-380 6.64e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 42.21  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  289 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 368
Cdd:TIGR01622   2 YRDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS---RSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90
                  ....*....|..
gi 767996147  369 REQERDRQQNDQ 380
Cdd:TIGR01622  79 RGDSYRRRRDDR 90
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 225-383 1.02e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 225 ADSDFDAKSSADDEIEETRVNCRREkviETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQS 304
Cdd:PRK12678 137 ARRGAARKAGEGGEQPATEARADAA---ERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGD 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 305 RDQENHYTDRDYRKERDSHRHREASHRDshwkRHEQEDKPRARDQRE-RSDRVWKREKDREkysqREQERDRQQNDQNRP 383
Cdd:PRK12678 214 RREERGRRDGGDRRGRRRRRDRRDARGD----DNREDRGDRDGDDGEgRGGRRGRRFRDRD----RRGRRGGDGGNEREP 285
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 268-464 2.24e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 40.66  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 268 SRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDShrhREASHRDSHWKRHEQEDKPRAR 347
Cdd:PRK12678  79 RAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRER---GEAARRGAARKAGEGGEQPATE 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147 348 DQRERSDRvwKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYR--DREKREVGVQS 425
Cdd:PRK12678 156 ARADAAER--TEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRrdGGDRRGRRRRR 233

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767996147 426 SERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERN 464
Cdd:PRK12678 234 DRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRDRR 272
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 317-430 4.74e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 39.52  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  317 RKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAK 396
Cdd:TIGR01622   2 YRDRERERLRD---SSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767996147  397 EEHM--KVRKERYENNDKYRDREKREVGVQSSERNQ 430
Cdd:TIGR01622  79 RGDSyrRRRDDRRSRREKPRARDGTPEPLTEDERDR 114
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 256-365 5.65e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  256 ENDFKHHRSQNHSRSPSEERgHSTRHHTKGSRTSRGHEKRE------DQHQQKQSRDQENHYTDRDYRKERDSHRHREAS 329
Cdd:TIGR01642   4 EPDREREKSRGRDRDRSSER-PRRRSRDRSRFRDRHRRSRErsyredSRPRDRRRYDSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767996147  330 HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREK 365
Cdd:TIGR01642  83 RSVRSIEQHRRRLRDRSPSNQWRKDDKKRSLWDIKP 118
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 313-419 7.39e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.11  E-value: 7.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  313 DRDYRKERDSHRHRE-ASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEE 391
Cdd:TIGR01642   2 DEEPDREREKSRGRDrDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRDRPRRR 81

                          90       100
                  ....*....|....*....|....*...
gi 767996147  392 KSKAKeehmKVRKERYENNDKYRDREKR 419
Cdd:TIGR01642  82 SRSVR----SIEQHRRRLRDRSPSNQWR 105
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 335-444 7.85e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 38.72  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996147  335 WKRHEQEdKPRARDQRERSDRVWKREKDREkysqREQERDRQQNDQNRPSEKGEKEEKSKAKEehmKVRKERYENNDKYR 414
Cdd:TIGR01642   4 EPDRERE-KSRGRDRDRSSERPRRRSRDRS----RFRDRHRRSRERSYREDSRPRDRRRYDSR---SPRSLRYSSVRRSR 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767996147  415 DREKRE---VGVQSSERNQDRKESSPNSRAKDK 444
Cdd:TIGR01642  76 DRPRRRsrsVRSIEQHRRRLRDRSPSNQWRKDD 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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