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Conserved domains on  [gi|767996241|ref|XP_011523689|]
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coronin-6 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-484 3.49e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 284.09  E-value: 3.49e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAF--------------IVL----PLAKV-- 138
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVlkhtdygklasnppILLgqegPIIDVaf 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 139 -------------------WQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLS 199
Cdd:PTZ00421  84 npfdpqklftasedgtimgWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 200 LDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQRELGL 278
Cdd:PTZ00421 164 IKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 279 WDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGLDV 358
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 359 SKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP------ 427
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmgas 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 428 -------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQAQ 483
Cdd:PTZ00421 400 alspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQKK 479


                 .
gi 767996241 484 E 484
Cdd:PTZ00421 480 E 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-484 3.49e-90

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 284.09  E-value: 3.49e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAF--------------IVL----PLAKV-- 138
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVlkhtdygklasnppILLgqegPIIDVaf 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 139 -------------------WQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLS 199
Cdd:PTZ00421  84 npfdpqklftasedgtimgWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 200 LDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQRELGL 278
Cdd:PTZ00421 164 IKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 279 WDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGLDV 358
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 359 SKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP------ 427
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmgas 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 428 -------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQAQ 483
Cdd:PTZ00421 400 alspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQKK 479


                 .
gi 767996241 484 E 484
Cdd:PTZ00421 480 E 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-138 1.17e-32

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 118.76  E-value: 1.17e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996241   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKV 138
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQT 64
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-326 1.49e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 106 WDSSFCAVNPKFLAiiveaGGGGAFIvlplaKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNV 185
Cdd:cd00200   55 RDVAASADGTYLAS-----GSSDKTI-----RLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 186 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHI 263
Cdd:cd00200  117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKL 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996241 264 FTTGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 326
Cdd:cd00200  193 LSSS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
136-328 4.36e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 4.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 136 AKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNS 215
Cdd:COG2319  144 VRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDT 295
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG---SADGTVRLWDLATGELLRTLT--GH 287

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767996241 296 SNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 328
Cdd:COG2319  288 SGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-233 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767996241   193 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 233
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-484 3.49e-90

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 284.09  E-value: 3.49e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAF--------------IVL----PLAKV-- 138
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVlkhtdygklasnppILLgqegPIIDVaf 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 139 -------------------WQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLS 199
Cdd:PTZ00421  84 npfdpqklftasedgtimgWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 200 LDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQRELGL 278
Cdd:PTZ00421 164 IKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 279 WDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGLDV 358
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 359 SKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP------ 427
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmgas 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 428 -------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQAQ 483
Cdd:PTZ00421 400 alspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQKK 479


                 .
gi 767996241 484 E 484
Cdd:PTZ00421 480 E 480
PTZ00420 PTZ00420
coronin; Provisional
 137-438 1.42e-54

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 192.47  E-value: 1.42e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 137 KVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDVIHSVCWNS 215
Cdd:PTZ00420 100 RVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKKLSSLKWNI 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPRKgQVVAERFAAHEGMRPMRAVFT-----RQGHIFTTGFTRMSQRELGLWDPNNFEEPVAL 290
Cdd:PTZ00420 178 KGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLKNTTSALVT 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 291 QEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYK-L 369
Cdd:PTZ00420 257 MSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnE 334

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 370 HERKCEPIIMTVPRK-SDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLRDgyvpPKHRELRVTKR 438
Cdd:PTZ00420 335 NNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-138 1.17e-32

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 118.76  E-value: 1.17e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996241   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKV 138
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQT 64
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-326 1.49e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 106 WDSSFCAVNPKFLAiiveaGGGGAFIvlplaKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNV 185
Cdd:cd00200   55 RDVAASADGTYLAS-----GSSDKTI-----RLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 186 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHI 263
Cdd:cd00200  117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKL 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996241 264 FTTGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 326
Cdd:cd00200  193 LSSS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 374-416 3.25e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 83.72  E-value: 3.25e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767996241  374 CEPIIMTVPRKS-DLFQDDLYPDTPGPEPALEADEWLSGQDAEP 416
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
136-328 4.36e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 4.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 136 AKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNS 215
Cdd:COG2319  144 VRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDT 295
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG---SADGTVRLWDLATGELLRTLT--GH 287

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767996241 296 SNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 328
Cdd:COG2319  288 SGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-322 2.02e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 2.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 153 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 232
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 233 DPRKGQVVAErFAAHEGmrPMRAV-FTRQGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIV 311
Cdd:cd00200   79 DLETGECVRT-LTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                        170
                 ....*....|.
gi 767996241 312 YlCGKGDSSIR 322
Cdd:cd00200  151 A-SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
136-322 7.63e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 7.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 136 AKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNS 215
Cdd:COG2319  228 VRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSP 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPNNFEEPVALQemDT 295
Cdd:COG2319  299 DGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLASGS---DDGTVRLWDLATGELLRTLT--GH 371

                        170       180
                 ....*....|....*....|....*..
gi 767996241 296 SNGVLLPFYDPDSSIVYLCGkGDSSIR 322
Cdd:COG2319  372 TGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-325 5.26e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 5.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 136 AKVWQIPDYtpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNS 215
Cdd:cd00200  117 IKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSP 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPNNFEEPVALQEmdT 295
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHEN-GVNSVAFSPDGYLLASGS---EDGTIRVWDLRTGECVQTLSG--H 260

                        170       180       190
                 ....*....|....*....|....*....|
gi 767996241 296 SNGVLLPFYDPDSSIVYLCGKgDSSIRYFE 325
Cdd:cd00200  261 TNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
136-235 1.56e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 136 AKVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNS 215
Cdd:COG2319  312 VRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSP 382

                         90       100
                 ....*....|....*....|
gi 767996241 216 NGSLLATTCKDKTLRIIDPR 235
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
151-322 1.01e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 151 TEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLR 230
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 231 IIDPRKGQVVAErFAAHEGmrPMRAV-FTRQGHIFTTGFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSS 309
Cdd:COG2319  146 LWDLATGKLLRT-LTGHSG--AVTSVaFSPDGKLLASGS---DDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK 217

                        170
                 ....*....|...
gi 767996241 310 IVYLCGkGDSSIR 322
Cdd:COG2319  218 LLASGS-ADGTVR 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-328 4.81e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 4.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 204 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV-FTRQGH-IFTTGFTRMSQrelgLWDP 281
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGSSDKTIR----LWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767996241 282 NNFEEPVALqEMDTSnGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 328
Cdd:cd00200   81 ETGECVRTL-TGHTS-YVSSVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-233 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767996241   193 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 233
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-190 9.30e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 9.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767996241   152 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 190
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
152-190 6.87e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767996241  152 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 190
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
204-233 7.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.35e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 767996241  204 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 233
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
136-193 1.61e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767996241 136 AKVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGT 193
Cdd:COG2319  354 VRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
148-283 1.89e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241 148 RNITEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDK 227
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996241 228 TLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGftrmSQ-RELGLWDPNN 283
Cdd:COG2319  101 TVRLWDLATGLLLR-TLTGHTG-AVRSVAFSPDGKTLASG----SAdGTVRLWDLAT 151
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 208-240 4.37e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.37e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767996241  208 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV 240
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 137-216 6.34e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996241  137 KVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLdDMHPDVIHSVCWNSN 216
Cdd:pfam12894  28 RVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHHF-SAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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