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Conserved domains on  [gi|767996413|ref|XP_011523755|]
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solute carrier family 13 member 2 isoform X4 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 6-542 6.45e-110

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 336.65  E-value: 6.45e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  326 LLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGLTQDPV-----------ENPG-----------KLKAPLG 383
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLfvlllllwifgGSLNidattvaiiglALMLLLR 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  384 LLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  461 LPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIP 538
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 767996413  539 LFSL 542
Cdd:pfam00939 469 LGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-542 6.45e-110

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 336.65  E-value: 6.45e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  326 LLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGLTQDPV-----------ENPG-----------KLKAPLG 383
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLfvlllllwifgGSLNidattvaiiglALMLLLR 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  384 LLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  461 LPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIP 538
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 767996413  539 LFSL 542
Cdd:pfam00939 469 LGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-536 3.01e-86

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 272.54  E-value: 3.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVI-----LLLLAWLWLQILFLGFNMVSDGTVAIFI 353
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIgllylWFIFRLAVLIITIVLLAALAAITGLLPV 213

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 354 GIIMFIIPSKFpgltqdpvenpgklkAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVP 432
Cdd:cd01115  214 SVAIAIGAIVL---------------VFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLP 278

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 433 APAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLD 512
Cdd:cd01115  279 PFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSD 358

                        490       500
                 ....*....|....*....|....
gi 767996413 513 MARAGFLLNIIGVLIIALAINSWG 536
Cdd:cd01115  359 FAKVGLPLSILSLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-535 1.42e-66

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 220.80  E-value: 1.42e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLWLQILFL-GFNMVSDGTVAIFIGIIMFIIPSK--------------- 363
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWLVLYRLLPpEIKEVPGSKEVIREELAELGPLSRrekialaifaltvll 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 364 --FPGLTQDPVENPGKLKAPL----GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAI 436
Cdd:COG0471  188 wiTGSLHGIPIAVVALLGAVLllltGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLL 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 437 AIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARA 516
Cdd:COG0471  268 LLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKV 347

                        410
                 ....*....|....*....
gi 767996413 517 GFLLNIIGVLIIALAINSW 535
Cdd:COG0471  348 GLPLNLIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 33-535 5.69e-36

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 139.79  E-value: 5.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGT 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEV 230

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  349 VAIFIGIIMFIIPSKF-----PGLTQDPV-----ENPGKLKAP------------LGLLDWKTVNQ-KMPWNIVLLLGGG 405
Cdd:TIGR00785 231 DLWAKEELEEMGPMSFrekalLGIFLLALllwifGGSLGINASvvallavvlmlfLGIVTWKDIQKnKVAWNTLILFGGL 310

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  406 YALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCT 483
Cdd:TIGR00785 311 IGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALA 390

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767996413  484 LATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 535
Cdd:TIGR00785 391 LSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-542 6.45e-110

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 336.65  E-value: 6.45e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  326 LLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGLTQDPV-----------ENPG-----------KLKAPLG 383
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLfvlllllwifgGSLNidattvaiiglALMLLLR 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  384 LLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  461 LPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIP 538
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 767996413  539 LFSL 542
Cdd:pfam00939 469 LGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-536 3.01e-86

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 272.54  E-value: 3.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVI-----LLLLAWLWLQILFLGFNMVSDGTVAIFI 353
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIgllylWFIFRLAVLIITIVLLAALAAITGLLPV 213

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 354 GIIMFIIPSKFpgltqdpvenpgklkAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVP 432
Cdd:cd01115  214 SVAIAIGAIVL---------------VFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLP 278

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 433 APAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLD 512
Cdd:cd01115  279 PFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSD 358

                        490       500
                 ....*....|....*....|....
gi 767996413 513 MARAGFLLNIIGVLIIALAINSWG 536
Cdd:cd01115  359 FAKVGLPLSILSLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-535 1.42e-66

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 220.80  E-value: 1.42e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLWLQILFL-GFNMVSDGTVAIFIGIIMFIIPSK--------------- 363
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWLVLYRLLPpEIKEVPGSKEVIREELAELGPLSRrekialaifaltvll 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 364 --FPGLTQDPVENPGKLKAPL----GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAI 436
Cdd:COG0471  188 wiTGSLHGIPIAVVALLGAVLllltGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLL 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 437 AIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARA 516
Cdd:COG0471  268 LLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKV 347

                        410
                 ....*....|....*....
gi 767996413 517 GFLLNIIGVLIIALAINSW 535
Cdd:COG0471  348 GLPLNLIGLVVLLLLGPLW 366
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 46-532 9.89e-37

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 140.85  E-value: 9.89e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  46 ALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpplshvstc 125
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--------------------------------------------- 35

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 126 qvavEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIvGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:cd00625   36 ----AIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 206 DQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhlTQCMSLCVCYSASIGGIAT 285
Cdd:cd00625  111 RKLGLSP------------------------------------------------------PVPLLLALAFAANIGGAAT 136

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 286 LTGTAPNLVLQGQINslfpqngnvVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFP 365
Cdd:cd00625  137 PIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKK 207

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 366 GLT---------------QDPVENPGKLKAPLGLL------DWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNK 424
Cdd:cd00625  208 FLLlallllllfvllfffLIPLGLIALLGALLLLLllvrglDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAEL 287

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 425 LTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASM-----AQAICLHPLYVMLPCTLATSLAFMLPVATPPN 499
Cdd:cd00625  288 LVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAEN 367

                        490       500       510
                 ....*....|....*....|....*....|...
gi 767996413 500 AIVfsfgDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:cd00625  368 AGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 33-535 5.69e-36

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 139.79  E-value: 5.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGT 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEV 230

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  349 VAIFIGIIMFIIPSKF-----PGLTQDPV-----ENPGKLKAP------------LGLLDWKTVNQ-KMPWNIVLLLGGG 405
Cdd:TIGR00785 231 DLWAKEELEEMGPMSFrekalLGIFLLALllwifGGSLGINASvvallavvlmlfLGIVTWKDIQKnKVAWNTLILFGGL 310

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  406 YALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCT 483
Cdd:TIGR00785 311 IGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALA 390

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767996413  484 LATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 535
Cdd:TIGR00785 391 LSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
CitMHS pfam03600
Citrate transporter;
137-480 1.09e-22

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 99.31  E-value: 1.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassn 216
Cdd:pfam03600  43 LLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP----- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  217 veegsnnptfelqePSPqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQ 296
Cdd:pfam03600 118 --------------PSP------------------------------------LLIALAFAANIGGTATPIGDPPNIIIA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  297 GQINSLFPQngnvvnfaswFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGL--------- 367
Cdd:pfam03600 148 SALGLSFGD----------FGFFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLlaisalvla 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  368 --------TQDPVENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLqsVPAPAIAII 439
Cdd:pfam03600 218 lvilgfllLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALAL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 767996413  440 LSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVML 480
Cdd:pfam03600 296 ILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
381-532 2.27e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 62.33  E-value: 2.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  381 PLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam03600  24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996413  461 LPILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
382-532 8.38e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 54.75  E-value: 8.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 382 LGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFL 461
Cdd:COG1055   39 LGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLT 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996413 462 PILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:COG1055  119 PVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVL 190
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 397-539 2.04e-07

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 53.36  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 397 NIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL 476
Cdd:cd01115   47 PAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPS 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 477 YVMLPCTLATSLAFML-PVATPPNAIV------FSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPL 539
Cdd:cd01115  127 RLLMPLAFAASIGGMLtLIGTPPNLVAsgylesLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAVLII 196
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
137-209 5.46e-04

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 42.45  E-value: 5.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996413 137 LLFFGGLL-VAIAVEHWNLHKRIALRVL-LIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLH 209
Cdd:COG0471  229 LLLFGGGLaLGAALEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
392-532 6.12e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 42.42  E-value: 6.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 392 QKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAI 471
Cdd:COG1055  266 KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATG 345

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996413 472 CLHPLY--VMLPCTLATSLafmLPVATPPNAIV----------FSFGDLkvldmARAGFLLNIIGVLIIALAI 532
Cdd:COG1055  346 NPEPLWlaLALGATLGGNL---TPIGSAANVIVlgiaekkgikISFGEF-----LKVGLPLTLLTLLIALLYL 410
CitMHS pfam03600
Citrate transporter;
54-214 1.45e-03

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 41.14  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413   54 LPLAVTALFPLILF----PMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAV 129
Cdd:pfam03600 167 VALLLVGLLPLLLIfrklLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413  130 EYLKD---SNLLFFGGLL-VAIAVEHWNLHKRIAlrVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:pfam03600 247 EALKAvdwSTLLFFAGLFiLVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324


                  ....*....
gi 767996413  206 DQLHSSQAS 214
Cdd:pfam03600 325 PAAGLGDPD 333
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
137-208 4.64e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 39.73  E-value: 4.64e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996413 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 208
Cdd:COG1055   57 LFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 383-532 8.57e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 38.77  E-value: 8.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 383 GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLP 462
Cdd:cd01116   34 LSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVP 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996413 463 ILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDmaragFLLNIIGVLIIALAI 532
Cdd:cd01116  114 VTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFND-----FLLHMLPSVVLALVV 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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