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Conserved domains on  [gi|767996416|ref|XP_011523756|]
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solute carrier family 13 member 2 isoform X5 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 6-396 1.92e-72

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 236.50  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996416  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTRE 396
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG 287
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-396 1.92e-72

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 236.50  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996416  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTRE 396
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG 287
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-324 8.50e-40

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 147.35  E-value: 8.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767996416 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGnvvNFASWFSFAFPTMV 324
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGF---SFFEFTPIGLPLLI 179
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-395 1.42e-33

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 129.89  E-value: 1.42e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 300 NSLFPQNgnvVNFASWFSFAFPTMVillllAWLWLQILFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 379
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVAL-----VGLLLLWLVLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                        250
                 ....*....|....*.
gi 767996416 380 AISILFVILVLLWFTR 395
Cdd:COG0471  176 IALAIFALTVLLWITG 191
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 33-394 6.38e-19

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 88.94  E-value: 6.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILF---LGFNFRK 345
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFppeLKLKDEV 230

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 767996416  346 NFGIGEKMQEqqqaaycviqtehrlLGPMTFAEKAISILFVILVLLWFT 394
Cdd:TIGR00785 231 DLWAKEELEE---------------MGPMSFREKALLGIFLLALLLWIF 264
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-396 1.92e-72

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 236.50  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996416  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTRE 396
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG 287
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-324 8.50e-40

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 147.35  E-value: 8.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767996416 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGnvvNFASWFSFAFPTMV 324
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGF---SFFEFTPIGLPLLI 179
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-395 1.42e-33

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 129.89  E-value: 1.42e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 300 NSLFPQNgnvVNFASWFSFAFPTMVillllAWLWLQILFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 379
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVAL-----VGLLLLWLVLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                        250
                 ....*....|....*.
gi 767996416 380 AISILFVILVLLWFTR 395
Cdd:COG0471  176 IALAIFALTVLLWITG 191
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 33-394 6.38e-19

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 88.94  E-value: 6.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILF---LGFNFRK 345
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFppeLKLKDEV 230

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 767996416  346 NFGIGEKMQEqqqaaycviqtehrlLGPMTFAEKAISILFVILVLLWFT 394
Cdd:TIGR00785 231 DLWAKEELEE---------------MGPMSFREKALLGIFLLALLLWIF 264
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 46-324 3.62e-15

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 76.90  E-value: 3.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  46 ALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpplshvstc 125
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--------------------------------------------- 35

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 126 qvavEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIvGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:cd00625   36 ----AIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALL 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 206 DQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhlTQCMSLCVCYSASIGGIAT 285
Cdd:cd00625  111 RKLGLSP------------------------------------------------------PVPLLLALAFAANIGGAAT 136

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767996416 286 LTGTAPNLVlqgqINSLFPqngnvVNFASWFSFAFPTMV 324
Cdd:cd00625  137 PIGNPPNLI----IASLSG-----LGFLDFLAFMAPPAL 166
CitMHS pfam03600
Citrate transporter;
137-394 4.62e-13

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 70.03  E-value: 4.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassn 216
Cdd:pfam03600  43 LLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP----- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  217 veegsnnptfelqePSPqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQ 296
Cdd:pfam03600 118 --------------PSP------------------------------------LLIALAFAANIGGTATPIGDPPNIIIA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  297 GQINSLFPQNGNVVNFASWFSFAFPTMVillllawlwlqilFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTF 376
Cdd:pfam03600 148 SALGLSFGDFGFFMFPPVGVALLLVGLL-------------PLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISAL 214

                         250
                  ....*....|....*...
gi 767996416  377 AEKAISILFVILVLLWFT 394
Cdd:pfam03600 215 VLALVILGFLLLSVLALA 232
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 137-203 2.86e-05

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 46.09  E-value: 2.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996416 137 LLFFGGLLV-AIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHA 203
Cdd:cd00625  262 LLFFAGLFVlVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAAS 329
CitMHS pfam03600
Citrate transporter;
54-214 5.16e-05

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 45.38  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416   54 LPLAVTALFPLILF----PMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAV 129
Cdd:pfam03600 167 VALLLVGLLPLLLIfrklLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  130 EYLKD---SNLLFFGGLL-VAIAVEHWNLHKRIAlrVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:pfam03600 247 EALKAvdwSTLLFFAGLFiLVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324


                  ....*....
gi 767996416  206 DQLHSSQAS 214
Cdd:pfam03600 325 PAAGLGDPD 333
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
42-209 5.49e-05

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 45.15  E-value: 5.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416  42 IILMALFWCTEA---LPLAVTALFPLILFPMMGIVDASEIIQrpfpssfespgecqSVGMSVtashnlggtvgdsrvfpp 118
Cdd:COG0471  181 FALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYK--------------SIPWGV------------------ 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996416 119 lshvstcqvaveylkdsnLLFFGGLL-VAIAVEHWNLHKRIALRVL-LIVGVRPAPLILGFMLVTAFLSMWISNTATSAM 196
Cdd:COG0471  229 ------------------LLLFGGGLaLGAALEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAAL 290

                        170
                 ....*....|...
gi 767996416 197 MVPIAHAVLDQLH 209
Cdd:COG0471  291 LLPIAISLAQALG 303
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 137-201 1.49e-04

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 43.73  E-value: 1.49e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996416 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILG-FMLVTAFLSMWISNTATSAMMVPIA 201
Cdd:cd01115  245 FLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLlLCLLTLVLTNFISNTATAVLLAPIA 310
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
137-208 9.01e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 41.65  E-value: 9.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996416 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 208
Cdd:COG1055   57 LFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 137-208 6.87e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 38.77  E-value: 6.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996416 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 208
Cdd:cd01116   51 ALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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