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Conserved domains on  [gi|767997923|ref|XP_011524058|]
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gamma-soluble NSF attachment protein isoform X2 [Homo sapiens]

Protein Classification

soluble NSF attachment family protein( domain architecture ID 581131)

soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) is involved in intracellular membrane trafficking; may contain TPR repeats

CATH:  1.25.40.10
Gene Ontology:  GO:0005483|GO:0000149
PubMed:  11536358|17634982
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNAP super family cl24038
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-196 4.44e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


The actual alignment was detected with superfamily member cd15832:

Pssm-ID: 451671 [Multi-domain]  Cd Length: 278  Bit Score: 141.18  E-value: 4.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQL 156
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAKDYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDL 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767997923 157 LEGYDQQDQDQVSDVCNSPLfKYMDNDYAKLGLSLVVPGG 196
Cdd:cd15832  239 LEAVEEGDVEAFTDAVKEYD-SISKLDKWKTTMLLKIKKS 277
 
Name Accession Description Interval E-value
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-196 4.44e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 141.18  E-value: 4.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQL 156
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAKDYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDL 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767997923 157 LEGYDQQDQDQVSDVCNSPLfKYMDNDYAKLGLSLVVPGG 196
Cdd:cd15832  239 LEAVEEGDVEAFTDAVKEYD-SISKLDKWKTTMLLKIKKS 277
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 11-161 1.72e-06

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 47.56  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   11 EAVQLIEKASMMYLENGTPDTAAMALERAGKLIEN--VDPEKAVQLYQQTANVFENEERLRQAVELLGKAsrllvrgrrf 88
Cdd:pfam14938  84 EAVRALEKAIEIYTEMGRFRRAAKHKKEIAELYEQelGDLEKAIEAYEQAADWYEGEGASALANKCYLKV---------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   89 deAALSIQKEkNIYKEIENYPTCYK--------KTIAQ------VLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAAL 153
Cdd:pfam14938 154 --ADLSAELE-DYPKAIEIYEKVAKnslennllKYSVKeyflkaGLCHLAAGDLVAAQRALERYEELdPSFADTREYKLL 230


                  ....*...
gi 767997923  154 EQLLEGYD 161
Cdd:pfam14938 231 NDLLEAVE 238
 
Name Accession Description Interval E-value
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-196 4.44e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 141.18  E-value: 4.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQL 156
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAKDYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDL 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767997923 157 LEGYDQQDQDQVSDVCNSPLfKYMDNDYAKLGLSLVVPGG 196
Cdd:cd15832  239 LEAVEEGDVEAFTDAVKEYD-SISKLDKWKTTMLLKIKKS 277
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 11-161 1.72e-06

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 47.56  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   11 EAVQLIEKASMMYLENGTPDTAAMALERAGKLIEN--VDPEKAVQLYQQTANVFENEERLRQAVELLGKAsrllvrgrrf 88
Cdd:pfam14938  84 EAVRALEKAIEIYTEMGRFRRAAKHKKEIAELYEQelGDLEKAIEAYEQAADWYEGEGASALANKCYLKV---------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997923   89 deAALSIQKEkNIYKEIENYPTCYK--------KTIAQ------VLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAAL 153
Cdd:pfam14938 154 --ADLSAELE-DYPKAIEIYEKVAKnslennllKYSVKeyflkaGLCHLAAGDLVAAQRALERYEELdPSFADTREYKLL 230


                  ....*...
gi 767997923  154 EQLLEGYD 161
Cdd:pfam14938 231 NDLLEAVE 238
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 8-71 2.50e-04

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 41.01  E-value: 2.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767997923    8 KLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDPEKAVQLYQQTANVFENEERLRQA 71
Cdd:pfam14938  42 NWEEAGEAFEKAAECQLKLGSKDEAANAYVEAAKCYKKVDPEEAVRALEKAIEIYTEMGRFRRA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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