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Conserved domains on  [gi|767998587|ref|XP_011524233|]
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cadherin-19 isoform X2 [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 495-554 2.05e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 115.71  E-value: 2.05e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  495 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 554
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-255 1.64e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 164 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 238
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 767998587 239 QISSIPLYVQVLNINDH 255
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-155 5.63e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 5.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  50 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 128
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998587 129 HVPEQlmkyhteASTTFIKIQVEDVDE 155
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 263-361 1.29e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 263 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 342
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*....
gi 767998587 343 DNGIPSLTSTNTLTIHVCD 361
Cdd:cd11304   76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.11e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 3.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767998587     2 DRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSDVNDNKP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 495-554 2.05e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 115.71  E-value: 2.05e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  495 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 554
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-255 1.64e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 164 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 238
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 767998587 239 QISSIPLYVQVLNINDH 255
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-155 5.63e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 5.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  50 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 128
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998587 129 HVPEQlmkyhteASTTFIKIQVEDVDE 155
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 263-361 1.29e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 263 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 342
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*....
gi 767998587 343 DNGIPSLTSTNTLTIHVCD 361
Cdd:cd11304   76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-257 1.44e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   182 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 256
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 767998587   257 P 257
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
164-250 2.46e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  164 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYN 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 767998587  237 IEQISSIPLYVQVL 250
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
50-151 3.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 3.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   50 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 128
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 767998587  129 HVPEQlmkyhteASTTFIKIQVE 151
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.11e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 3.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767998587     2 DRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSDVNDNKP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 69-157 4.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 4.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587    69 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 147
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 767998587   148 IQVEDV-DEPP 157
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
263-360 6.92e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 6.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  263 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNssFTIidnQDNTAVILTNRtgfNLQEEPV-FY-ISIL 340
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRI---DPDTGDISTTK---PLDRESIgEYeLTVE 72

                          90       100
                  ....*....|....*....|
gi 767998587  341 IADNGIPSLTSTNTLTIHVC 360
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-41 1.47e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 1.47e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767998587   1 MDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSDVNDN 41
Cdd:cd11304   60 LDREEQSSYTLTVTATDGGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 281-364 3.16e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 3.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   281 SAVDRDeSIEEHHFYFNLsVEDTNNSSFTIidnQDNTAVILTNRTgFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 360
Cdd:smart00112   1 SATDAD-SGENGKVTYSI-LSGNDDGLFSI---DPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 767998587   361 DCGD 364
Cdd:smart00112  75 DVND 78
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 495-554 2.05e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 115.71  E-value: 2.05e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  495 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 554
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-255 1.64e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 164 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 238
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 767998587 239 QISSIPLYVQVLNINDH 255
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-155 5.63e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 5.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  50 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 128
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998587 129 HVPEQlmkyhteASTTFIKIQVEDVDE 155
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 263-361 1.29e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587 263 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 342
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*....
gi 767998587 343 DNGIPSLTSTNTLTIHVCD 361
Cdd:cd11304   76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-257 1.44e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   182 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 256
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 767998587   257 P 257
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
164-250 2.46e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  164 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYN 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 767998587  237 IEQISSIPLYVQVL 250
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
50-151 3.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 3.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   50 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 128
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 767998587  129 HVPEQlmkyhteASTTFIKIQVE 151
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.11e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 3.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767998587     2 DRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSDVNDNKP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 69-157 4.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 4.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587    69 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 147
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 767998587   148 IQVEDV-DEPP 157
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
263-360 6.92e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 6.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587  263 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNssFTIidnQDNTAVILTNRtgfNLQEEPV-FY-ISIL 340
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRI---DPDTGDISTTK---PLDRESIgEYeLTVE 72

                          90       100
                  ....*....|....*....|
gi 767998587  341 IADNGIPSLTSTNTLTIHVC 360
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-41 1.47e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 1.47e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767998587   1 MDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSDVNDN 41
Cdd:cd11304   60 LDREEQSSYTLTVTATDGGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 281-364 3.16e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 3.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998587   281 SAVDRDeSIEEHHFYFNLsVEDTNNSSFTIidnQDNTAVILTNRTgFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 360
Cdd:smart00112   1 SATDAD-SGENGKVTYSI-LSGNDDGLFSI---DPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 767998587   361 DCGD 364
Cdd:smart00112  75 DVND 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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