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Conserved domains on  [gi|767998643|ref|XP_011524256|]
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coiled-coil domain-containing protein 178 isoform X3 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000037)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
96-407 2.11e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643    96 VNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRdekcpelKQEMETLLSEAIRLIK 175
Cdd:TIGR02169  182 VEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQ-------KEAIERQLASLEEELE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   176 SLETDRADAEEALKQQRSRKNMINMKIDSwsvwKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEA 255
Cdd:TIGR02169  255 KLTEEISELEKRLEEIEQLLEELNKKIKD----LGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   256 NAKIQADIDYMNEHgpllDSKQNQELQDLKNHYKKKMEVMDLHRkvneeLEEALEACENARLKAQQIKEEIDKDIYQDEk 335
Cdd:TIGR02169  331 IDKLLAEIEELERE----IEEERKRRDKLTEEYAELKEELEDLR-----AELEEVDKEFAETRDELKDYREKLEKLKRE- 400
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998643   336 tIEAYKREIYQLNSLFDHYSSSVINVNTNIEEK-------EEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQ 407
Cdd:TIGR02169  401 -INELKRELDRLQEELQRLSEELADLNAAIAGIeakinelEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEY 478
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
96-407 2.11e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643    96 VNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRdekcpelKQEMETLLSEAIRLIK 175
Cdd:TIGR02169  182 VEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQ-------KEAIERQLASLEEELE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   176 SLETDRADAEEALKQQRSRKNMINMKIDSwsvwKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEA 255
Cdd:TIGR02169  255 KLTEEISELEKRLEEIEQLLEELNKKIKD----LGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   256 NAKIQADIDYMNEHgpllDSKQNQELQDLKNHYKKKMEVMDLHRkvneeLEEALEACENARLKAQQIKEEIDKDIYQDEk 335
Cdd:TIGR02169  331 IDKLLAEIEELERE----IEEERKRRDKLTEEYAELKEELEDLR-----AELEEVDKEFAETRDELKDYREKLEKLKRE- 400
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998643   336 tIEAYKREIYQLNSLFDHYSSSVINVNTNIEEK-------EEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQ 407
Cdd:TIGR02169  401 -INELKRELDRLQEELQRLSEELADLNAAIAGIeakinelEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEY 478
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
158-351 5.13e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.37  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643 158 ELKQEMETLlSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQElplavqkEHEAYLSDVIELQWHLED 237
Cdd:COG4717   82 EAEEKEEEY-AELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELE-------ALEAELAELPERLEELEE 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643 238 KANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLldsKQNQELQDLKNHYKkkmevmDLHRKVNEELeealeaceNARL 317
Cdd:COG4717  154 RLEELRELEEELEELEAELAELQEELEELLEQLSL---ATEEELQDLAEELE------ELQQRLAELE--------EELE 216
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767998643 318 KAQQIKEEIDKDI--YQDEKTIEAYKREIYQLNSLF 351
Cdd:COG4717  217 EAQEELEELEEELeqLENELEAAALEERLKEARLLL 252
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
96-407 2.11e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643    96 VNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRdekcpelKQEMETLLSEAIRLIK 175
Cdd:TIGR02169  182 VEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQ-------KEAIERQLASLEEELE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   176 SLETDRADAEEALKQQRSRKNMINMKIDSwsvwKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEA 255
Cdd:TIGR02169  255 KLTEEISELEKRLEEIEQLLEELNKKIKD----LGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   256 NAKIQADIDYMNEHgpllDSKQNQELQDLKNHYKKKMEVMDLHRkvneeLEEALEACENARLKAQQIKEEIDKDIYQDEk 335
Cdd:TIGR02169  331 IDKLLAEIEELERE----IEEERKRRDKLTEEYAELKEELEDLR-----AELEEVDKEFAETRDELKDYREKLEKLKRE- 400
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998643   336 tIEAYKREIYQLNSLFDHYSSSVINVNTNIEEK-------EEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQ 407
Cdd:TIGR02169  401 -INELKRELDRLQEELQRLSEELADLNAAIAGIeakinelEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEY 478
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
158-417 2.21e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   158 ELKQEMETLLSEAIRL---IKSLETDRADAEEALKQQRSRKNMINMKIDSwsvwkLQELPLAVQKEHEAYLSDVIELQWH 234
Cdd:TIGR02168  681 ELEEKIEELEEKIAELekaLAELRKELEELEEELEQLRKELEELSRQISA-----LRKDLARLEAEVEQLEERIAQLSKE 755
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   235 LEDKANQLqhfEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
Cdd:TIGR02168  756 LTELEAEI---EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643   315 ARLKAQQIkEEIDKDIYQDEKTIEAYKREIYQLNslfdhysssvinvnTNIEEKEEevteairETKSSKNELHSLSKMLE 394
Cdd:TIGR02168  833 IAATERRL-EDLEEQIEELSEDIESLAAEIEELE--------------ELIEELES-------ELEALLNERASLEEALA 890
                          250       260
                   ....*....|....*....|...
gi 767998643   395 DLRRVYDQLTWKQKSHENQYLEA 417
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSEL 913
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
158-351 5.13e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.37  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643 158 ELKQEMETLlSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQElplavqkEHEAYLSDVIELQWHLED 237
Cdd:COG4717   82 EAEEKEEEY-AELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELE-------ALEAELAELPERLEELEE 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998643 238 KANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLldsKQNQELQDLKNHYKkkmevmDLHRKVNEELeealeaceNARL 317
Cdd:COG4717  154 RLEELRELEEELEELEAELAELQEELEELLEQLSL---ATEEELQDLAEELE------ELQQRLAELE--------EELE 216
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767998643 318 KAQQIKEEIDKDI--YQDEKTIEAYKREIYQLNSLF 351
Cdd:COG4717  217 EAQEELEELEEELeqLENELEAAALEERLKEARLLL 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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