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fms-related tyrosine kinase 3 ligand isoform X3 [Homo sapiens]
Flt3_lig domain-containing protein( domain architecture ID 10502990)
Flt3_lig domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Flt3_lig | pfam02947 | flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. |
29-159 | 1.54e-90 | |||
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. : Pssm-ID: 460760 Cd Length: 131 Bit Score: 262.79 E-value: 1.54e-90
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Atrophin-1 super family | cl38111 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
156-245 | 3.70e-03 | |||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. The actual alignment was detected with superfamily member pfam03154: Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 38.21 E-value: 3.70e-03
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Name | Accession | Description | Interval | E-value | |||
Flt3_lig | pfam02947 | flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. |
29-159 | 1.54e-90 | |||
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. Pssm-ID: 460760 Cd Length: 131 Bit Score: 262.79 E-value: 1.54e-90
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Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
156-245 | 3.70e-03 | |||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 38.21 E-value: 3.70e-03
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Name | Accession | Description | Interval | E-value | |||
Flt3_lig | pfam02947 | flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. |
29-159 | 1.54e-90 | |||
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold. Pssm-ID: 460760 Cd Length: 131 Bit Score: 262.79 E-value: 1.54e-90
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Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
156-245 | 3.70e-03 | |||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 38.21 E-value: 3.70e-03
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Blast search parameters | ||||
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