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Conserved domains on  [gi|768009247|ref|XP_011525273|]
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phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 34-113 7.72e-19

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467102  Cd Length: 80  Bit Score: 74.39  E-value: 7.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009247  34 NGLMCPACTASFRDKCMGP-MTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVlFLHHIEC 112
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSV-NITTATC 79


                 .
gi 768009247 113 T 113
Cdd:cd23572   80 T 80
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 1-24 3.36e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23571:

Pssm-ID: 480272  Cd Length: 89  Bit Score: 34.31  E-value: 3.36e-03
                         10        20
                 ....*....|....*....|....
gi 768009247   1 MGPKDHMVTSSFCCQSDGCNSAFL 24
Cdd:cd23571   66 FFPKIRMRRNSKCCQTDGCNSGAV 89
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 34-113 7.72e-19

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 74.39  E-value: 7.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009247  34 NGLMCPACTASFRDKCMGP-MTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVlFLHHIEC 112
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSV-NITTATC 79


                 .
gi 768009247 113 T 113
Cdd:cd23572   80 T 80
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 38-88 2.64e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 34.05  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768009247   38 CPACTASFRDKCMGPMThCTGKENHCVSLSGHVQAGIFKPRFAMRGCATES 88
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT-CPLSDGQCVTTTLELPEGNLRGTVVSKGCARSS 50
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 1-24 3.36e-03

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 34.31  E-value: 3.36e-03
                         10        20
                 ....*....|....*....|....
gi 768009247   1 MGPKDHMVTSSFCCQSDGCNSAFL 24
Cdd:cd23571   66 FFPKIRMRRNSKCCQTDGCNSGAV 89
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 34-113 7.72e-19

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 74.39  E-value: 7.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009247  34 NGLMCPACTASFRDKCMGP-MTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVlFLHHIEC 112
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSV-NITTATC 79


                 .
gi 768009247 113 T 113
Cdd:cd23572   80 T 80
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 30-90 3.17e-05

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 39.69  E-value: 3.17e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768009247  30 NLTENGLMCPACTASFRDKCMG---PMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMC 90
Cdd:cd23558    2 DLPPNGIQCYSCNGNSTHGCSSeetSKVRCRGPQTQCLEATGTTAHGGKNQSYMVKGCATPSMC 65
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 38-88 2.64e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 34.05  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768009247   38 CPACTASFRDKCMGPMThCTGKENHCVSLSGHVQAGIFKPRFAMRGCATES 88
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT-CPLSDGQCVTTTLELPEGNLRGTVVSKGCARSS 50
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 1-24 3.36e-03

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 34.31  E-value: 3.36e-03
                         10        20
                 ....*....|....*....|....
gi 768009247   1 MGPKDHMVTSSFCCQSDGCNSAFL 24
Cdd:cd23571   66 FFPKIRMRRNSKCCQTDGCNSGAV 89
TFP_LU_ECD_LYPD9 cd23570
extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) ...
 34-90 8.88e-03

extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) and similar proteins; LYPD9 is a testis-specific secreted protein dispensable for spermatogenesis in mouse. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467100  Cd Length: 86  Bit Score: 32.93  E-value: 8.88e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768009247  34 NGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMC 90
Cdd:cd23570    8 NGLKCPTCFAVMGRKCNPELKWCSADKIKCVEFSGIINTGLKDIAIELKKCIQAELC 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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