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Conserved domains on  [gi|768011423|ref|XP_011525674|]
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zinc finger protein 541 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1060-1115 8.78e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 61.09  E-value: 8.78e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 768011423  1060 INIGSRFQAEIPELQERSLAGTDEHVA--SLVWKPWGDMmisseTQDRVTELCNVACS 1115
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEdeLLVWDPNHNL-----PDRKLDEYLVVARS 53
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 1140-1158 1.93e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11661:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.93e-03
                          10
                  ....*....|....*....
gi 768011423 1140 QIQTKTVAQCVEYYYIWKK 1158
Cdd:cd11661    28 FLPWKSVGELVEFYYMWKK 46
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
150-324 5.60e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  150 SSASSLSKHYLTHSQERKHVCKICSKAFKRQDHlyvgvWTGHMLTHQKTKPFVCIEQGCSKSYCD----YRSLRRHYEVH 225
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEH-----LTRHIRSHTGEKPSQCSYSGCDKSFSRplelSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  226 HGLCILKEAPPEEEACGDSPHAH----------ESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLRRIVSSIVHQKTPSP 295
Cdd:COG5048    91 SDLNSKSLPLSNSKASSSSLSSSssnsndnnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPP 170

                         170       180
                  ....*....|....*....|....*....
gi 768011423  296 GPAPAGASDSEGRNTACPCPASSGSSSCT 324
Cdd:COG5048   171 LPANSLSKDPSSNLSLLISSNVSTSIPSS 199
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1060-1115 8.78e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 61.09  E-value: 8.78e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 768011423  1060 INIGSRFQAEIPELQERSLAGTDEHVA--SLVWKPWGDMmisseTQDRVTELCNVACS 1115
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEdeLLVWDPNHNL-----PDRKLDEYLVVARS 53
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 1140-1158 1.93e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.93e-03
                          10
                  ....*....|....*....
gi 768011423 1140 QIQTKTVAQCVEYYYIWKK 1158
Cdd:cd11661    28 FLPWKSVGELVEFYYMWKK 46
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
150-324 5.60e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  150 SSASSLSKHYLTHSQERKHVCKICSKAFKRQDHlyvgvWTGHMLTHQKTKPFVCIEQGCSKSYCD----YRSLRRHYEVH 225
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEH-----LTRHIRSHTGEKPSQCSYSGCDKSFSRplelSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  226 HGLCILKEAPPEEEACGDSPHAH----------ESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLRRIVSSIVHQKTPSP 295
Cdd:COG5048    91 SDLNSKSLPLSNSKASSSSLSSSssnsndnnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPP 170

                         170       180
                  ....*....|....*....|....*....
gi 768011423  296 GPAPAGASDSEGRNTACPCPASSGSSSCT 324
Cdd:COG5048   171 LPANSLSKDPSSNLSLLISSNVSTSIPSS 199
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1060-1115 8.78e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 61.09  E-value: 8.78e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 768011423  1060 INIGSRFQAEIPELQERSLAGTDEHVA--SLVWKPWGDMmisseTQDRVTELCNVACS 1115
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEdeLLVWDPNHNL-----PDRKLDEYLVVARS 53
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 1140-1158 1.93e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.93e-03
                          10
                  ....*....|....*....
gi 768011423 1140 QIQTKTVAQCVEYYYIWKK 1158
Cdd:cd11661    28 FLPWKSVGELVEFYYMWKK 46
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
150-324 5.60e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  150 SSASSLSKHYLTHSQERKHVCKICSKAFKRQDHlyvgvWTGHMLTHQKTKPFVCIEQGCSKSYCD----YRSLRRHYEVH 225
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEH-----LTRHIRSHTGEKPSQCSYSGCDKSFSRplelSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011423  226 HGLCILKEAPPEEEACGDSPHAH----------ESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLRRIVSSIVHQKTPSP 295
Cdd:COG5048    91 SDLNSKSLPLSNSKASSSSLSSSssnsndnnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPP 170

                         170       180
                  ....*....|....*....|....*....
gi 768011423  296 GPAPAGASDSEGRNTACPCPASSGSSSCT 324
Cdd:COG5048   171 LPANSLSKDPSSNLSLLISSNVSTSIPSS 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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