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Conserved domains on  [gi|768012222|ref|XP_011525833|]
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myeloid cell surface antigen CD33 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 75-193 6.49e-64

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


:

Pssm-ID: 409377  Cd Length: 119  Bit Score: 200.69  E-value: 6.49e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  75 FWLQVQESVTVQEGLCVLVPCTFFHPIPYYDkNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNN 154
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWV-SNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768012222 155 CSLSIVDARRRDNGSYFFRMERG-STKYSYKSPQLSVHVT 193
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 199-284 1.66e-37

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


:

Pssm-ID: 409579  Cd Length: 94  Bit Score: 131.54  E-value: 1.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222 199 PKILIPGTLEPGHSKNLTCSVSWACEQGtPPIFSWLSAAPTSLGPR---------TTHSSVLIITPRPQDHGTNLTCQVK 269
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLPPVlgrleeegtTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 768012222 270 FAGAGVTTERTIQLN 284
Cdd:cd20987   80 FPGATVTTERTIQLN 94
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 75-193 6.49e-64

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 200.69  E-value: 6.49e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  75 FWLQVQESVTVQEGLCVLVPCTFFHPIPYYDkNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNN 154
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWV-SNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768012222 155 CSLSIVDARRRDNGSYFFRMERG-STKYSYKSPQLSVHVT 193
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 199-284 1.66e-37

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 131.54  E-value: 1.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222 199 PKILIPGTLEPGHSKNLTCSVSWACEQGtPPIFSWLSAAPTSLGPR---------TTHSSVLIITPRPQDHGTNLTCQVK 269
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLPPVlgrleeegtTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 768012222 270 FAGAGVTTERTIQLN 284
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 78-193 1.42e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.63  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222   78 QVQESVTVQEGLCVLVPCTFfhpipyydKNSPVHG----YWFREGAIISRDSPVATNKlDQEVQEETQGRFRLLGDPSRN 153
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY--------SSSMSEAstsvYWYRQPPGKGPTFLIAYYS-NGSEEGVKKGRFSGRGDPSNG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 768012222  154 NCSLSIVDARRRDNGSYFFRMerGSTKYSYKSPQLSVHVT 193
Cdd:pfam07686  72 DGSLTIQNLTLSDSGTYTCAV--IPSGEGVFGKGTRLTVL 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 200-281 1.46e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 48.73  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  200 KILIPGTLEPGHSKNLTCSVSwacEQGTPPIFSWLSAAPTSLGP--------RTTHSSVLIITPRPQDHGTnLTCQVKFA 271
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSAS---TGSPGPDVTWSKEGGTLIESlkvkhdngRTTQSSLLISNVTKEDAGT-YTCVVNNP 76

                          90
                  ....*....|
gi 768012222  272 GAGVTTERTI 281
Cdd:pfam00047  77 GGSATLSTSL 86
IGv smart00406
Immunoglobulin V-Type;
93-171 2.59e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.59  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222    93 VPCTFfhpipYYDKNSPVHGYWFREGA-----IISRDSPVATNKLDQEVQeetqGRFRLLGDPSRNNCSLSIVDARRRDN 167
Cdd:smart00406   4 LSCKF-----SGSTFSSYYVSWVRQPPgkgleWLGYIGSNGSSYYQESYK----GRFTISKDTSKNDVSLTISNLRVEDT 74


                   ....
gi 768012222   168 GSYF 171
Cdd:smart00406  75 GTYY 78
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 75-193 6.49e-64

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 200.69  E-value: 6.49e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  75 FWLQVQESVTVQEGLCVLVPCTFFHPIPYYDkNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNN 154
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWV-SNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768012222 155 CSLSIVDARRRDNGSYFFRMERG-STKYSYKSPQLSVHVT 193
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 199-284 1.66e-37

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 131.54  E-value: 1.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222 199 PKILIPGTLEPGHSKNLTCSVSWACEQGtPPIFSWLSAAPTSLGPR---------TTHSSVLIITPRPQDHGTNLTCQVK 269
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLPPVlgrleeegtTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 768012222 270 FAGAGVTTERTIQLN 284
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 78-193 1.42e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.63  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222   78 QVQESVTVQEGLCVLVPCTFfhpipyydKNSPVHG----YWFREGAIISRDSPVATNKlDQEVQEETQGRFRLLGDPSRN 153
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY--------SSSMSEAstsvYWYRQPPGKGPTFLIAYYS-NGSEEGVKKGRFSGRGDPSNG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 768012222  154 NCSLSIVDARRRDNGSYFFRMerGSTKYSYKSPQLSVHVT 193
Cdd:pfam07686  72 DGSLTIQNLTLSDSGTYTCAV--IPSGEGVFGKGTRLTVL 109
IgC1_CD22_d2 cd20938
Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 ...
 199-285 3.60e-08

Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains; The members here are composed of the second immunoglobulin domain of clusters of differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C1-set of IgSF domains.


Pssm-ID: 409532  Cd Length: 98  Bit Score: 51.10  E-value: 3.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222 199 PKILIPGTLEPGHSKNLTCSVSWACeQGTPPIFSW-LSAAPTSLGPRTTHS---------SVLIITPRPQDHGTNLTCQV 268
Cdd:cd20938    3 PHIQLPPEIQESQEVTLTCLLNFSC-YGYPIQLQWlLEGSPMRQAAVTSTSltiksvftrSELKFQPKWSHHGKIVTCQL 81

                         90
                 ....*....|....*..
gi 768012222 269 KFAGAGVTTERTIQLNV 285
Cdd:cd20938   82 QDADGKVLSEDTVQLNV 98
IgV_CD22_d1 cd20929
First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF ...
 81-181 7.27e-08

First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains.


Pssm-ID: 409523  Cd Length: 114  Bit Score: 50.39  E-value: 7.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  81 ESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREgAIISRDSPVATNKLDQEVQEETQGRFRLLGDpSRNNCSLSIV 160
Cdd:cd20929    7 ETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNK-ATSKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIH 84

                         90       100
                 ....*....|....*....|.
gi 768012222 161 DARRRDNGSYFFRMERGSTKY 181
Cdd:cd20929   85 PVHLNDSGQLGLRMESKTEKW 105
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 200-281 1.46e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 48.73  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  200 KILIPGTLEPGHSKNLTCSVSwacEQGTPPIFSWLSAAPTSLGP--------RTTHSSVLIITPRPQDHGTnLTCQVKFA 271
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSAS---TGSPGPDVTWSKEGGTLIESlkvkhdngRTTQSSLLISNVTKEDAGT-YTCVVNNP 76

                          90
                  ....*....|
gi 768012222  272 GAGVTTERTI 281
Cdd:pfam00047  77 GGSATLSTSL 86
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 78-171 2.90e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 39.95  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  78 QVQESVTVQEGLCVLVPCTFFHPIPYYDknspvhgYWFRegaIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSL 157
Cdd:cd04983    3 QSPQSLSVQEGENVTLNCNYSTSTFYYL-------FWYR---QYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSL 72

                         90
                 ....*....|....
gi 768012222 158 SIVDARRRDNGSYF 171
Cdd:cd04983   73 HISAAQLSDSAVYF 86
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 199-272 6.63e-04

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 38.55  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222  199 PKILIPGTLE--PGHSKNLTCSVswaCEQGTPPIFSW------LSAAPTSLGPRT-----THSSVLIITPRPQDHGTNLT 265
Cdd:pfam08205   1 PTIEPPASLLegEGPEVVATCSS---AGGKPAPRITWyldgkpLEAAETSSEQDPesglvTVTSELKLVPSRSDHGQSLT 77


                  ....*..
gi 768012222  266 CQVKFAG 272
Cdd:pfam08205  78 CQVSYGA 84
IGv smart00406
Immunoglobulin V-Type;
93-171 2.59e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.59  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222    93 VPCTFfhpipYYDKNSPVHGYWFREGA-----IISRDSPVATNKLDQEVQeetqGRFRLLGDPSRNNCSLSIVDARRRDN 167
Cdd:smart00406   4 LSCKF-----SGSTFSSYYVSWVRQPPgkgleWLGYIGSNGSSYYQESYK----GRFTISKDTSKNDVSLTISNLRVEDT 74


                   ....
gi 768012222   168 GSYF 171
Cdd:smart00406  75 GTYY 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 80-182 3.26e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012222    80 QESVTVQEGLCVLVPCTFFHpipyydkNSPVHGYWFREGaiisrdspvatnklDQEVQEetQGRFRLlgDPSRNNCSLSI 159
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-------SPPPEVTWYKQG--------------GKLLAE--SGRFSV--SRSGSTSTLTI 55

                           90       100
                   ....*....|....*....|...
gi 768012222   160 VDARRRDNGSYFFRMERGSTKYS 182
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSAS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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