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Conserved domains on  [gi|768000844|ref|XP_011525988|]
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mitotic interactor and substrate of PLK1 isoform X1 [Homo sapiens]

Protein Classification

AKAP2_C domain-containing protein( domain architecture ID 10633876)

AKAP2_C domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKAP2_C pfam15304
A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor ...
325-674 4.03e-150

A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.


:

Pssm-ID: 464630  Cd Length: 341  Bit Score: 438.79  E-value: 4.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  325 IPTRPLLTKLSLITAP-RRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAP 403
Cdd:pfam15304   1 IPVRPLLTKVSLGALPrRRERGRASLYVQRDIEQETQREEALRREGLQVGRASTPDWRSEDPQPGLRRALSSDSILSPVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  404 DARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQE 483
Cdd:pfam15304  81 DARAADPAPELREVNRIPPDAYQPYLSPGTPPLEFSAFGAAGKPAGLSTDEAKAVASPKATGSQRHLSESSGKPPSTKQE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  484 ASK-PPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVA 562
Cdd:pfam15304 161 GSPvPPRAPPQAQKGVVRWEYFRLRPLRFRVPDVPQQAEIPRVWGWEVAGGPALRLGRSQASELLEREVESVLERERELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  563 EERRNALfpEVFSPTPdensDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGIN 642
Cdd:pfam15304 241 EQRRNAL--EVFGPAP----FQDSRPSLTASGITGSYSVSESHLFTPIRLHSGLVWTAEAPAPSASGSHRKKEQWYAGIN 314
                         330       340       350
                  ....*....|....*....|....*....|..
gi 768000844  643 PSDGINsevleAIRVTRHKNAMAERWESRIYA 674
Cdd:pfam15304 315 PLDRVN-----ATRVTRHRNALAERWEAGIYS 341
 
Name Accession Description Interval E-value
AKAP2_C pfam15304
A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor ...
325-674 4.03e-150

A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.


Pssm-ID: 464630  Cd Length: 341  Bit Score: 438.79  E-value: 4.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  325 IPTRPLLTKLSLITAP-RRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAP 403
Cdd:pfam15304   1 IPVRPLLTKVSLGALPrRRERGRASLYVQRDIEQETQREEALRREGLQVGRASTPDWRSEDPQPGLRRALSSDSILSPVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  404 DARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQE 483
Cdd:pfam15304  81 DARAADPAPELREVNRIPPDAYQPYLSPGTPPLEFSAFGAAGKPAGLSTDEAKAVASPKATGSQRHLSESSGKPPSTKQE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  484 ASK-PPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVA 562
Cdd:pfam15304 161 GSPvPPRAPPQAQKGVVRWEYFRLRPLRFRVPDVPQQAEIPRVWGWEVAGGPALRLGRSQASELLEREVESVLERERELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  563 EERRNALfpEVFSPTPdensDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGIN 642
Cdd:pfam15304 241 EQRRNAL--EVFGPAP----FQDSRPSLTASGITGSYSVSESHLFTPIRLHSGLVWTAEAPAPSASGSHRKKEQWYAGIN 314
                         330       340       350
                  ....*....|....*....|....*....|..
gi 768000844  643 PSDGINsevleAIRVTRHKNAMAERWESRIYA 674
Cdd:pfam15304 315 PLDRVN-----ATRVTRHRNALAERWEAGIYS 341
 
Name Accession Description Interval E-value
AKAP2_C pfam15304
A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor ...
325-674 4.03e-150

A-kinase anchor protein 2 C-terminus; This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.


Pssm-ID: 464630  Cd Length: 341  Bit Score: 438.79  E-value: 4.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  325 IPTRPLLTKLSLITAP-RRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAP 403
Cdd:pfam15304   1 IPVRPLLTKVSLGALPrRRERGRASLYVQRDIEQETQREEALRREGLQVGRASTPDWRSEDPQPGLRRALSSDSILSPVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  404 DARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQE 483
Cdd:pfam15304  81 DARAADPAPELREVNRIPPDAYQPYLSPGTPPLEFSAFGAAGKPAGLSTDEAKAVASPKATGSQRHLSESSGKPPSTKQE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  484 ASK-PPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVA 562
Cdd:pfam15304 161 GSPvPPRAPPQAQKGVVRWEYFRLRPLRFRVPDVPQQAEIPRVWGWEVAGGPALRLGRSQASELLEREVESVLERERELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000844  563 EERRNALfpEVFSPTPdensDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGIN 642
Cdd:pfam15304 241 EQRRNAL--EVFGPAP----FQDSRPSLTASGITGSYSVSESHLFTPIRLHSGLVWTAEAPAPSASGSHRKKEQWYAGIN 314
                         330       340       350
                  ....*....|....*....|....*....|..
gi 768000844  643 PSDGINsevleAIRVTRHKNAMAERWESRIYA 674
Cdd:pfam15304 315 PLDRVN-----ATRVTRHRNALAERWEAGIYS 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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