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Conserved domains on  [gi|768001873|ref|XP_011526204|]
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tetraspanin-16 isoform X2 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992924)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

CATH:  1.10.1450.10
Gene Ontology:  GO:0016020
PubMed:  11756464|19709882|16024509|12575999
SCOP:  4001512
TCDB:  8.A.40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 115-179 3.30e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03156:

Pssm-ID: 351888  Cd Length: 114  Bit Score: 68.71  E-value: 3.30e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768001873 115 LKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD----VSPNVIHQKGCFHKLLKITKTQS 179
Cdd:cd03156   42 LKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDcpklGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
19-204 3.98e-08

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTLLFCILSMVIVL 98
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   99 IMEVTAATVVLLffpilkccgvnnYTDFSGSSFEMTTGHTYPRSCCKSIGSVSCDGRDVSPnvIHQ-----KGCFHKLLK 173
Cdd:pfam00335  86 LAELAAGILAFV------------YRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDS--LQSefgccGGCKEKLLE 151

                         170       180       190
                  ....*....|....*....|....*....|.
gi 768001873  174 ITKTQSFTLSGSSLGAAVIQLPGILATLLLF 204
Cdd:pfam00335 152 WLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 115-179 3.30e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 68.71  E-value: 3.30e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768001873 115 LKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD----VSPNVIHQKGCFHKLLKITKTQS 179
Cdd:cd03156   42 LKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDcpklGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
19-204 3.98e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTLLFCILSMVIVL 98
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   99 IMEVTAATVVLLffpilkccgvnnYTDFSGSSFEMTTGHTYPRSCCKSIGSVSCDGRDVSPnvIHQ-----KGCFHKLLK 173
Cdd:pfam00335  86 LAELAAGILAFV------------YRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDS--LQSefgccGGCKEKLLE 151

                         170       180       190
                  ....*....|....*....|....*....|.
gi 768001873  174 ITKTQSFTLSGSSLGAAVIQLPGILATLLLF 204
Cdd:pfam00335 152 WLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 115-179 3.30e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 68.71  E-value: 3.30e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768001873 115 LKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD----VSPNVIHQKGCFHKLLKITKTQS 179
Cdd:cd03156   42 LKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDcpklGSPNSYNKKGCYEKLSNPIERYA 114
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 115-178 1.76e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 58.51  E-value: 1.76e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768001873 115 LKCCGVNNYTDFSGSSFE---MTTGHTYPRSCCKSIgSVSCDGRDVSPNVIHQ--KGCFHKLLKITKTQ 178
Cdd:cd03155   42 FKCCGSNNYTDWQDSEWInsnEANGRLVPDSCCKTV-VDRCGCLRDHPSNIYKveGGCIPKLEDFLYDH 109
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 115-167 1.11e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 56.33  E-value: 1.11e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768001873 115 LKCCGVNNYTDFSGssFEMTTGHTYPRSCCKSIgSVSCdGRDVSPNVIHQKGC 167
Cdd:cd03166   39 LKCCGANNYTDWEN--IPSLDTDSVPDSCCINV-TKGC-GINFDEKVIHLEGC 87
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 115-173 5.45e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 54.74  E-value: 5.45e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873 115 LKCCGVNNYTDFSGSS-FEMTTGHTYPRSCCKSIGSvSCDGRDVSPNVIHQKGCFHKLLK 173
Cdd:cd03163   40 LQCCGIHNYTDWENTPwFKESKNNSVPLSCCKETFT-SCTGSLTQPKDLYQEGCEAKLVK 98
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 115-172 3.68e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 49.67  E-value: 3.68e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768001873 115 LKCCGVNNYTDFSGSSFemTTGHTYPRSCCKSigSVSCDGRD-----VSPNVIHQKGCFHKLL 172
Cdd:cd03161   39 LHCCGVENYTDWLNSPY--FLEKGIPLSCCKN--RSDCSPQDlknltKAATKVYQQGCFTLVT 97
Tetraspanin pfam00335
Tetraspanin family;
19-204 3.98e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 51.17  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTLLFCILSMVIVL 98
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768001873   99 IMEVTAATVVLLffpilkccgvnnYTDFSGSSFEMTTGHTYPRSCCKSIGSVSCDGRDVSPnvIHQ-----KGCFHKLLK 173
Cdd:pfam00335  86 LAELAAGILAFV------------YRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDS--LQSefgccGGCKEKLLE 151

                         170       180       190
                  ....*....|....*....|....*....|.
gi 768001873  174 ITKTQSFTLSGSSLGAAVIQLPGILATLLLF 204
Cdd:pfam00335 152 WLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 115-171 2.06e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 47.11  E-value: 2.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768001873 115 LKCCGVNNYTDFsgssfeMTTGHTYPRSCCKsigsvSCDGRDVSPnvIHQKGCFHKL 171
Cdd:cd03127   39 FECCGVNGPTDY------LDLRLLVPSSCCK-----GTDGNCGLN--LYTEGCLEKL 82
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 114-171 2.32e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 47.36  E-value: 2.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768001873 114 ILKCCGVNNYTDFsgssFEMTTGHTYPRSCCKSIgSVSCdGRDvSPNVIHQKGCFHKL 171
Cdd:cd03165   40 EFRCCGVTNYTDW----YEVLGENRVPDSCCQED-SQDC-GRN-PTELWWKTGCYEKV 90
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 115-171 1.23e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 42.76  E-value: 1.23e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768001873 115 LKCCGVNNYTDFSGSSFEMT-TGHTYPRSCCKSIGSVS--------CDGRDVSPNVIHQKGCFHKL 171
Cdd:cd03160   43 LQCCGWTGPQDWTDNSLIKNsSEPLYPCSCCNSSATADsprpskgfCEAPASLDWPVYQEGCMEKL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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