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Conserved domains on  [gi|768002754|ref|XP_011526368|]
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zinc finger protein 44 isoform X5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-563 5.77e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 152 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 228
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 229 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 304
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 305 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 384
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 385 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 450
Cdd:COG5048  263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 451 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 519
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002754 520 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 563
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-563 5.77e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 152 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 228
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 229 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 304
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 305 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 384
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 385 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 450
Cdd:COG5048  263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 451 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 519
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002754 520 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 563
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-388 7.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.97e-04
                          10        20
                  ....*....|....*....|....*
gi 768002754  364 FQRHERTHTGEKPYECKQCGKAFRT 388
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-563 5.77e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 152 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 228
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 229 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 304
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 305 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 384
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 385 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 450
Cdd:COG5048  263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 451 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 519
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002754 520 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 563
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-566 1.03e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 179 KPYECKQCSKAFPVYSSYLRHEKIHTGEKPYEC--KQCSKAFPDYSSYLRHERTHTGEKPYKC-KQCGKAFSVSGSLRVH 255
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 256 ERIHTGEKPYTCKQCGKAFCHLGSFQRHMIMHSGDGPHKCKIC-GKGFDFPGSARIHEGTHTLEKPyeckqcgKLLSHRS 334
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 335 SFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLR-------KHETTHTGEQPYKC 407
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslssSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 408 KCGKAFSDLFSFQSHETTHS-EEEPYECKECGKAFSSFKYFCRHERT--HSEEKSYECQ----ICGKAFSRFSYLKTHER 480
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFScpysLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 481 THTAEKPYECKQCR-------KAFFWPSFLLRHERTHTGERPYECKH--CGKAFSRSSFCREHERTHTGEKPYECK--EC 549
Cdd:COG5048  345 LHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410
                 ....*....|....*..
gi 768002754 550 GKAFSSLSSFNRHKRTH 566
Cdd:COG5048  425 SKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
69-272 5.22e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 5.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754  69 MGHSSLNCYIRVDTGHKHRecHEYAEKSYTHKQCGKGLSYRHSFQTCERPHTGK-KPYDCKECGKTFSSPGNLRRHM--- 144
Cdd:COG5048  235 LSPKSLLSQSPSSLSSSDS--SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsv 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 145 -VVKGGDGPYKC--ELCGKAFFWPSLLRMHERTHTGEKPYECK--QCSKAFPVYS-----SYLRHEKIHTGEKPYEC--K 212
Cdd:COG5048  313 nHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsN 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768002754 213 QCSKAFPDYSSYLRHERTHTGEKP--YKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGK 272
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-569 9.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 235 KPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTC--KQCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKG--FDFPGSARI 310
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 311 HEGTHTLEKPYECkQCGKLLSHRSSFRRHMMAHTGDGPHKCTVC-GKAFDSPSVFQRHERTHTGEkpyeckQCGKAFRTS 389
Cdd:COG5048  112 SSSSNSNDNNLLS-SHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 390 SSLRKHETTHTGEQPYKCKCGKAFSDLFSFQSHETTHSEEEPYECkecgkafssfkyfcrHERTHSEEKSYECQicgkaf 469
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSLLSQ------ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002754 470 sRFSYLKTHERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTGER-PYECKHCGKAFSRSSFCREHERT--HTGE--KPY 544
Cdd:COG5048  244 -SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                        330       340
                 ....*....|....*....|....*..
gi 768002754 545 ECKE--CGKAFSSLSSFNRHKRTHWKD 569
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-388 7.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.97e-04
                          10        20
                  ....*....|....*....|....*
gi 768002754  364 FQRHERTHTGEKPYECKQCGKAFRT 388
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*
gi 768002754  503 LLRHERTHTGERPYECKHCGKAFSR 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
168-190 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|...
gi 768002754  168 LRMHERTHTGEKPYECKQCSKAF 190
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-555 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....
gi 768002754  532 REHERTHTGEKPYECKECGKAFSS 555
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-247 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|..
gi 768002754  226 RHERTHTGEKPYKCKQCGKAFS 247
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-274 2.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|....
gi 768002754  251 SLRVHERIHTGEKPYTCKQCGKAF 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-218 7.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.34e-03
                          10        20
                  ....*....|....*....|.
gi 768002754  198 RHEKIHTGEKPYECKQCSKAF 218
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-497 7.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.41e-03
                          10        20
                  ....*....|....*....|....
gi 768002754  474 YLKTHERTHTAEKPYECKQCRKAF 497
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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