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Conserved domains on  [gi|768003324|ref|XP_011526462|]
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splicing factor Cactin isoform X1 [Homo sapiens]

Protein Classification

PTZ00266 and Cactin_mid domain-containing protein( domain architecture ID 10563362)

PTZ00266 and Cactin_mid domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-452 2.64e-71

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


:

Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 223.20  E-value: 2.64e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 768003324  423 GKIRAGGPnLDMGYWESLLQQLRAHMARAR 452
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKAR 181
 
Name Accession Description Interval E-value
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-452 2.64e-71

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 223.20  E-value: 2.64e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 768003324  423 GKIRAGGPnLDMGYWESLLQQLRAHMARAR 452
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKAR 181
 
Name Accession Description Interval E-value
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-452 2.64e-71

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 223.20  E-value: 2.64e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003324  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 768003324  423 GKIRAGGPnLDMGYWESLLQQLRAHMARAR 452
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKAR 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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