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Conserved domains on  [gi|768004120|ref|XP_011526612|]
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podocan-like protein 1 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-425 2.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  77 QHLSLQNNqlqelpyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqpsdgDLPPHLwgeagTQLSNagl 156
Cdd:COG4886   99 TELDLSGN-------EELSNLTNLESLDLSGNQLT--------------------------DLPEEL-----ANLTN--- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 157 ppdafrgseaIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQHNQLTDSGldaTTFSK 234
Cdd:COG4886  138 ----------LKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 235 LHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSGLPagALRPLRGLHTL 312
Cdd:COG4886  204 LTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TDLP--PLANLTNLKTL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 313 HLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 392
Cdd:COG4886  278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768004120 393 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 425
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
328-530 6.16e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 6.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 328 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 405
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 406 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 483
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004120 484 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 530
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-425 2.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  77 QHLSLQNNqlqelpyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqpsdgDLPPHLwgeagTQLSNagl 156
Cdd:COG4886   99 TELDLSGN-------EELSNLTNLESLDLSGNQLT--------------------------DLPEEL-----ANLTN--- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 157 ppdafrgseaIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQHNQLTDSGldaTTFSK 234
Cdd:COG4886  138 ----------LKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 235 LHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSGLPagALRPLRGLHTL 312
Cdd:COG4886  204 LTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TDLP--PLANLTNLKTL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 313 HLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 392
Cdd:COG4886  278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768004120 393 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 425
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
165-454 4.35e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.38  E-value: 4.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 165 EAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQLTDsgLDATTFSKLHSleyLDLS 244
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA---TLPDTIQEMELSINRITE--LPERLPSALQS---LDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 245 HNQLTTVPAGLPRTLAILHLGRNRIRQVEAarlHGARGLRYLLLQHNQLgsSGLPAgALRPlrGLHTLHLYGNGLDRVPP 324
Cdd:PRK15370 271 HNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-TLPP--GLKTLEAGENALTSLPA 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 325 ALPRRLRALVLPHNHVAALGArdlVATPGLTElnlaynrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLPTGLRTL 404
Cdd:PRK15370 343 SLPPELQVLDVSKNQITVLPE---TLPPTITT--------------------------LDVSRNALTNLPENLPAALQIM 393

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768004120 405 QLQRNQLRMLePEPLAGL----DQLRELSLAHNrlrvgdigPGTWHELQALQML 454
Cdd:PRK15370 394 QASRNNLVRL-PESLPHFrgegPQPTRIIVEYN--------PFSERTIQNMQRL 438
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
328-530 6.16e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 6.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 328 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 405
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 406 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 483
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004120 484 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 530
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 170-358 5.52e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 170 LSLSNNQLSYLP-PSLPPSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQ 247
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 248 LTTVpAGL--PRTLAILHLGRNRIRQ-----VEAARLHG-ARGLRYLLLQHNQLGSSglpaGALRPLRGLHTLHLYGNGL 319
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAAlSNSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQI 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004120 320 DRVPPALP-----RRLRALVLPHNHVAAL-GARD--LVATPGLTELN 358
Cdd:cd21340  155 SDLEELLDllsswPSLRELDLTGNPVCKKpKYRDkiILASKSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
186-248 3.21e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.21e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004120  186 PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTdsGLDATTFSKLHSLEYLDLSHNQL 248
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
399-461 1.75e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.75e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004120  399 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 461
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 383-531 5.72e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 383 LDLAGNQLTRLPmGLP--TGLRTLQLQRNQLRMLEPepLAGLDQLRELSLAHNRLRV--GdigpgtWHELQALQMLDLSH 458
Cdd:cd21340   29 LYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveG------LENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 459 NELsfvPPDLP------------EALEELHLEGNRIGHVGPEAFLStpRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD 526
Cdd:cd21340  100 QRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISDLEELLDLLSSWPSLRELD 174


                 ....*
gi 768004120 527 TAGNP 531
Cdd:cd21340  175 LTGNP 179
PLN03150 PLN03150
hypothetical protein; Provisional
 404-523 3.79e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 404 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELS-FVPPDLPE--ALEELHLEGN 480
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR-GNI-PPSLGSITSLEVLDLSYNSFNgSIPESLGQltSLRILNLNGN 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768004120 481 RIGHVGPEAflstprLRALFLRANRLHMTSIAaeAFLGLPNLR 523
Cdd:PLN03150 501 SLSGRVPAA------LGGRLLHRASFNFTDNA--GLCGIPGLR 535
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-425 2.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  77 QHLSLQNNqlqelpyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqpsdgDLPPHLwgeagTQLSNagl 156
Cdd:COG4886   99 TELDLSGN-------EELSNLTNLESLDLSGNQLT--------------------------DLPEEL-----ANLTN--- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 157 ppdafrgseaIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQHNQLTDSGldaTTFSK 234
Cdd:COG4886  138 ----------LKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 235 LHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSGLPagALRPLRGLHTL 312
Cdd:COG4886  204 LTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TDLP--PLANLTNLKTL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 313 HLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTR 392
Cdd:COG4886  278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        330       340       350
                 ....*....|....*....|....*....|...
gi 768004120 393 LPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 425
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
165-454 4.35e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.38  E-value: 4.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 165 EAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQLTDsgLDATTFSKLHSleyLDLS 244
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA---TLPDTIQEMELSINRITE--LPERLPSALQS---LDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 245 HNQLTTVPAGLPRTLAILHLGRNRIRQVEAarlHGARGLRYLLLQHNQLgsSGLPAgALRPlrGLHTLHLYGNGLDRVPP 324
Cdd:PRK15370 271 HNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-TLPP--GLKTLEAGENALTSLPA 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 325 ALPRRLRALVLPHNHVAALGArdlVATPGLTElnlaynrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLPTGLRTL 404
Cdd:PRK15370 343 SLPPELQVLDVSKNQITVLPE---TLPPTITT--------------------------LDVSRNALTNLPENLPAALQIM 393

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768004120 405 QLQRNQLRMLePEPLAGL----DQLRELSLAHNrlrvgdigPGTWHELQALQML 454
Cdd:PRK15370 394 QASRNNLVRL-PESLPHFrgegPQPTRIIVEYN--------PFSERTIQNMQRL 438
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-317 4.86e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  57 TVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqp 134
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT----------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 135 sdgDLPPHLwgeagtqlsnAGLPpdafrgseAIATLSLSNNQLSYLPPSL--PPSLERLHLQNNLISKVPRgALSRQTQL 212
Cdd:COG4886  173 ---DLPEEL----------GNLT--------NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 213 RELYLQHNQLTdsglDATTFSKLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAARLHGARGLRYLLLQH 290
Cdd:COG4886  231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPplANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*..
gi 768004120 291 NQLGSSGLPAGALRPLRGLHTLHLYGN 317
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
169-462 3.21e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 3.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 169 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQltdsgldatTFSKLHSLEYLDLSHNQL 248
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 249 TTVPAGLPR--TLAILHLGRNRIRQVEAArLHGARGLRYLLLQHNQLgsSGLPAgALRPLRGLHTLHLYGNGLDRVPPAL 326
Cdd:COG4886  126 TDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDLPE-ELGNLTNLKELDLSNNQITDLPEPL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 327 --PRRLRALVLPHNHVAALGArDLVATPGLTELNLAYNRLASArvhhRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRT 403
Cdd:COG4886  202 gnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDLPPLANlTNLKT 276

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004120 404 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQMLDLSHNELS 462
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-506 1.28e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  77 QHLSLQNNQLQ-ELPYNELSRLSGLRTLNLHNNlissealsgpSVSAPVPpcRGSgcqpsdgdlpphLWGEAGTQLSN-- 153
Cdd:PLN00113  96 QTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN----------NFTGSIP--RGS------------IPNLETLDLSNnm 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 154 -AGLPPDAFRGSEAIATLSLSNNQLS-YLPPSLP--PSLERLHL-QNNLISKVPRgALSRQTQLRELYLQHNQLtdSGLD 228
Cdd:PLN00113 152 lSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTnlTSLEFLTLaSNQLVGQIPR-ELGQMKSLKWIYLGYNNL--SGEI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 229 ATTFSKLHSLEYLDLSHNQLT-TVPAGLP--RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgsSGLPAGALRP 305
Cdd:PLN00113 229 PYEIGGLTSLNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL--SGEIPELVIQ 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 306 LRGLHTLHLYGNGLD-RVPPALPR--RLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLaSARVHHRAFRRLRALrS 382
Cdd:PLN00113 307 LQNLEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL-TGEIPEGLCSSGNLF-K 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 383 LDLAGNQL-TRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIGPGTWhELQALQMLDLSHN 459
Cdd:PLN00113 385 LILFSNSLeGEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARN 462

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 768004120 460 ELSFVPPDL--PEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRL 506
Cdd:PLN00113 463 KFFGGLPDSfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
170-498 1.93e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.99  E-value: 1.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 170 LSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQLTdsgldattfsklhsleyldlshnqlt 249
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLT-------------------------- 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 250 TVPAGLPRTLAILHLGRNRIRQVeAARLHGArgLRYLLLQHNQLgsSGLPAGAlrPlRGLHTLHLYGNGLDRVPPALPRr 329
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRITEL-PERLPSA--LQSLDLFHNKI--SCLPENL--P-EELRYLSVYDNSIRTLPAHLPS- 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 330 lralvlphnhvaalgardlvatpGLTELNlaynrlasarvhhrafrrlralrsldLAGNQLTRLPMGLPTGLRTLQLQRN 409
Cdd:PRK15370 305 -----------------------GITHLN--------------------------VQSNSLTALPETLPPGLKTLEAGEN 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 410 QLRMLePEPLAglDQLRELSLAHNRLRV-GDIGPGTwhelqaLQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVgPE 488
Cdd:PRK15370 336 ALTSL-PASLP--PELQVLDVSKNQITVlPETLPPT------ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PE 405

                        330
                 ....*....|
gi 768004120 489 aflSTPRLRA 498
Cdd:PRK15370 406 ---SLPHFRG 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
328-530 6.16e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 6.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 328 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 405
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 406 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 483
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004120 484 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 530
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-507 4.89e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 4.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 164 SEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDL 243
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 244 SHNQlttvPAGLPRTLAILHLGRNRIRQVEAArLHGARGLRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVP 323
Cdd:COG4886  104 SGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPE-PLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 324 PALprrlralvlphnhvaalgardlvatPGLTELNlaynrlasarvhhrafrrlralrSLDLAGNQLTRLPMGL--PTGL 401
Cdd:COG4886  176 EEL-------------------------GNLTNLK-----------------------ELDLSNNQITDLPEPLgnLTNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 402 RTLQLQRNQLRMLePEPLAGLDQLRELSLAHNRLR-VGDIGpgtwhELQALQMLDLSHNELSFVPPDLP-EALEELHLEG 479
Cdd:COG4886  208 EELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTdLPELG-----NLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSN 281

                        330       340
                 ....*....|....*....|....*...
gi 768004120 480 NRIGHVGPEAFLSTPRLRALFLRANRLH 507
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLN 309
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-480 1.16e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  83 NNQLQELPYnELSRLSGLRTLNL-HNNLissealsgpsvSAPVPPcrgsgcqpSDGDLPPHLWGEAGTQLSNAGLPPDAF 161
Cdd:PLN00113 222 NNLSGEIPY-EIGGLTSLNHLDLvYNNL-----------TGPIPS--------SLGNLKNLQYLFLYQNKLSGPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 162 rGSEAIATLSLSNNQLSYLPPSLP---PSLERLHL-QNNLISKVPRgALSRQTQLRELYLQHNQLtdSGLDATTFSKLHS 237
Cdd:PLN00113 282 -SLQKLISLDLSDNSLSGEIPELViqlQNLEILHLfSNNFTGKIPV-ALTSLPRLQVLQLWSNKF--SGEIPKNLGKHNN 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 238 LEYLDLSHNQLT-TVPAGLPRT--LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgSSGLPAGALRpLRGLHTLHL 314
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTK-LPLVYFLDI 435

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 315 YGNGL----DRVPPALPRrLRALVLPHNHVAAlGARDLVATPGLTELNLAYNRLASArvhhrafrrlralrsldlagnqL 390
Cdd:PLN00113 436 SNNNLqgriNSRKWDMPS-LQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGA----------------------V 491

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 391 TRLPMGLPTgLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELSF-VPPDLP 469
Cdd:PLN00113 492 PRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS-GQI-PASFSEMPVLSQLDLSQNQLSGeIPKNLG 568

                        410
                 ....*....|...
gi 768004120 470 --EALEELHLEGN 480
Cdd:PLN00113 569 nvESLVQVNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
241-551 1.01e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 241 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVeAARLHGarglrylllqhnqlgssglpagalrplrGLHTLHLYGNGLD 320
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG----------------------------NIKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 321 RVPPALPRRLRALVLPHNHVaalgardlvatpglTELNlayNRLASArvhhrafrrlraLRSLDLAGNQLTRLPMGLPTG 400
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRI--------------TELP---ERLPSA------------LQSLDLFHNKISCLPENLPEE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 401 LRTLQLQRNQLRMLePEPLAglDQLRELSLAHNRLRV--GDIGPGtwhelqaLQMLDLSHNELSFVPPDLPEALEELHLE 478
Cdd:PRK15370 285 LRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNSLTAlpETLPPG-------LKTLEAGENALTSLPASLPPELQVLDVS 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768004120 479 GNRIGhVGPEAFlsTPRLRALFLRANrlhmtsiaaeAFLGLPN-----LRVVDTAGNPeqvLIRLPPTTPRGpRAGGP 551
Cdd:PRK15370 355 KNQIT-VLPETL--PPTITTLDVSRN----------ALTNLPEnlpaaLQIMQASRNN---LVRLPESLPHF-RGEGP 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 170-358 5.52e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 170 LSLSNNQLSYLP-PSLPPSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQ 247
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 248 LTTVpAGL--PRTLAILHLGRNRIRQ-----VEAARLHG-ARGLRYLLLQHNQLGSSglpaGALRPLRGLHTLHLYGNGL 319
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAAlSNSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQI 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004120 320 DRVPPALP-----RRLRALVLPHNHVAAL-GARD--LVATPGLTELN 358
Cdd:cd21340  155 SDLEELLDllsswPSLRELDLTGNPVCKKpKYRDkiILASKSLEVLD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-291 2.57e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 2.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  39 LQPLPRACPlrcscPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYN-----ELSRLSGLRTLNLHNNLISse 113
Cdd:PRK15370 190 LTTIPACIP-----EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATlpdtiQEMELSINRITELPERLPS-- 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 114 ALSGPSVSapvppCRGSGCQPSdgDLPPHLWGEAGTQLSNAGLPPDAFRGseaIATLSLSNNQLSYLPPSLPPSLERLHL 193
Cdd:PRK15370 263 ALQSLDLF-----HNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALPETLPPGLKTLEA 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 194 QNNLISKVPRgalSRQTQLRELYLQHNQLT--DSGLDATtfsklhsLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQ 271
Cdd:PRK15370 333 GENALTSLPA---SLPPELQVLDVSKNQITvlPETLPPT-------ITTLDVSRNALTNLPENLPAALQIMQASRNNLVR 402

                        250       260
                 ....*....|....*....|....
gi 768004120 272 VEAARLH----GARGLRyLLLQHN 291
Cdd:PRK15370 403 LPESLPHfrgeGPQPTR-IIVEYN 425
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 169-317 2.34e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 169 TLSLSNNQLSYLPP-SLPPSLERLHLQNNLISKVPRgaLSRQTQLRELYLQHNQLTD-SGLDattfsKLHSLEYLDLSHN 246
Cdd:cd21340   28 VLYLYDNKITKIENlEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGLE-----NLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 247 QLttvPAGL-----PRTLA-------ILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHL 314
Cdd:cd21340  101 RL---PPGEkltfdPRSLAalsnslrVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDL 175


                 ...
gi 768004120 315 YGN 317
Cdd:cd21340  176 TGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
167-435 2.41e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 66.72  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 167 IATLSLSNNQLSYLPpSLPPSLERLHLQNNLISKVPrgalSRQTQLRELYLQHNQLTDSGLDATTFSKLHsleyldLSHN 246
Cdd:PRK15387 224 ITTLVIPDNNLTSLP-ALPPELRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLW------IFGN 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 247 QLTTVPAgLPRTLAILHLGRNRIRQVEAArlhgARGLRYLLLQHNQLGS-SGLPAgalrplrGLHTLHLYGNGLDRVpPA 325
Cdd:PRK15387 293 QLTSLPV-LPPGLQELSVSDNQLASLPAL----PSELCKLWAYNNQLTSlPTLPS-------GLQELSVSDNQLASL-PT 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 326 LPRRLRALVLPHNHVAALGArdlvATPGLTELNLAYNRLASARVhhrafrRLRALRSLDLAGNQLTRLPMgLPTGLRTLQ 405
Cdd:PRK15387 360 LPSELYKLWAYNNRLTSLPA----LPSGLKELIVSGNRLTSLPV------LPSELKELMVSGNRLTSLPM-LPSGLLSLS 428

                        250       260       270
                 ....*....|....*....|....*....|
gi 768004120 406 LQRNQLRMLePEPLAGLDQLRELSLAHNRL 435
Cdd:PRK15387 429 VYRNQLTRL-PESLIHLSSETTVNLEGNPL 457
LRR_8 pfam13855
Leucine rich repeat;
186-248 3.21e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.21e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004120  186 PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTdsGLDATTFSKLHSLEYLDLSHNQL 248
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-256 1.19e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  38 SLQPLPRACPlrcscprvDTVDCDGLDL-RV--FPDNITRAAQHLSLQNNQLQELPYNelsRLSGLRTLNLHNNLISSEA 114
Cdd:PRK15370 231 QLTSIPATLP--------DTIQEMELSInRIteLPERLPSALQSLDLFHNKISCLPEN---LPEELRYLSVYDNSIRTLP 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 115 LSGPSVSAPVPPCRGS-GCQPSDgdLPPHL----WGEAGTQLSNAGLPPdafrgseAIATLSLSNNQLSYLPPSLPPSLE 189
Cdd:PRK15370 300 AHLPSGITHLNVQSNSlTALPET--LPPGLktleAGENALTSLPASLPP-------ELQVLDVSKNQITVLPETLPPTIT 370

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768004120 190 RLHLQNNLISKVPRgalsrqtqlrelylqhnqltdsGLDAttfsklhSLEYLDLSHNQLTTVPAGLP 256
Cdd:PRK15370 371 TLDVSRNALTNLPE----------------------NLPA-------ALQIMQASRNNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
399-461 1.75e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.75e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004120  399 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 461
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 187-364 2.38e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.42  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 187 SLERLHLQNNLIS----KVPRGALSRQTQLRELYLQHNQLTDSGLD--ATTFSKLHSLEYLDLSHNQLTTvpAGL----- 255
Cdd:COG5238  181 SVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIGDEGAEilAEALKGNKSLTTLDLSNNQIGD--EGVialae 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 256 ----PRTLAILHLGRNRIrQVEAAR-----LHGARGLRYLLLQHNQLGSSGLPAGA--LRPLRGLHTLHLYGNGLD---- 320
Cdd:COG5238  259 alknNTTVETLYLSGNQI-GAEGAIalakaLQGNTTLTSLDLSVNRIGDEGAIALAegLQGNKTLHTLNLAYNGIGaqga 337

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768004120 321 -RVPPALP--RRLRALVLPHNHVAALGARDL----VATPGLTELNLAYNRL 364
Cdd:COG5238  338 iALAKALQenTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNI 388
LRR_8 pfam13855
Leucine rich repeat;
210-269 2.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768004120  210 TQLRELYLQHNQLTDsgLDATTFSKLHSLEYLDLSHNQLTTVP----AGLPRtLAILHLGRNRI 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLPS-LRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
241-523 3.56e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 241 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAArlhgARGLRYLLLQHNQLGSsgLPAgaLRPlrGLHTLHLYGNGLD 320
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL----PPELRTLEVSGNQLTS--LPV--LPP--GLLELSIFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 321 RVPpALPRRLRALVLPHNHVAALGardlVATPGLTELNLAYNRLASarvhhrAFRRLRALRSLDLAGNQLTRLPMgLPTG 400
Cdd:PRK15387 276 HLP-ALPSGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLAS------LPALPSELCKLWAYNNQLTSLPT-LPSG 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 401 LRTLQLQRNQLRMLEPEPlaglDQLRELSLAHNRLRVgdigpgtwhelqalqmldlshnelsfvPPDLPEALEELHLEGN 480
Cdd:PRK15387 344 LQELSVSDNQLASLPTLP----SELYKLWAYNNRLTS---------------------------LPALPSGLKELIVSGN 392

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 768004120 481 RIGHVGpeafLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLR 523
Cdd:PRK15387 393 RLTSLP----VLPSELKELMVSGNRLTSLPMLPSGLLSLSVYR 431
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 383-531 5.72e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 383 LDLAGNQLTRLPmGLP--TGLRTLQLQRNQLRMLEPepLAGLDQLRELSLAHNRLRV--GdigpgtWHELQALQMLDLSH 458
Cdd:cd21340   29 LYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveG------LENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 459 NELsfvPPDLP------------EALEELHLEGNRIGHVGPEAFLStpRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD 526
Cdd:cd21340  100 QRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISDLEELLDLLSSWPSLRELD 174


                 ....*
gi 768004120 527 TAGNP 531
Cdd:cd21340  175 LTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
472-531 3.94e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  472 LEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLhmTSIAAEAFLGLPNLRVVDTAGNP 531
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 134-506 1.96e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 134 PSDGDLPPHLWGEAGTQlsnaglPPDAFRGSEAIATLSLSNNQLSYLPPSlppslerlhlqnNLISKVPRGALSRQTQLR 213
Cdd:COG5238   98 EEVSPVALAETATAVAT------PPPDLRRIMAKTLEDSLILYLALPRRI------------NLIQVLKDPLGGNAVHLL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 214 elYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA-------GLPRTLAILHLGRNRI--RQVE--AARLHGARG 282
Cdd:COG5238  160 --GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQNTTVTTLWLKRNPIgdEGAEilAEALKGNKS 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 283 LRYLLLQHNQLGSSGLP--AGALRPLRGLHTLHLYGNGLDrvppalprrlralvlpHNHVAALgARDLVATPGLTELNLA 360
Cdd:COG5238  238 LTTLDLSNNQIGDEGVIalAEALKNNTTVETLYLSGNQIG----------------AEGAIAL-AKALQGNTTLTSLDLS 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 361 YNRLASArvhhrafrrlralrsldlagnqltrlpmglptGLRTLQlqrnqlrmlepEPLAGLDQLRELSLAHNRlrvgdI 440
Cdd:COG5238  301 VNRIGDE--------------------------------GAIALA-----------EGLQGNKTLHTLNLAYNG-----I 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 441 GPGTWHEL-QALQM------LDLSHNELSFVPPD-LPEALE------ELHLEGNRIGHVGPEAF---LSTPRLRALFLRA 503
Cdd:COG5238  333 GAQGAIALaKALQEnttlhsLDLSDNQIGDEGAIaLAKYLEgnttlrELNLGKNNIGKQGAEALidaLQTNRLHTLILDG 412


                 ...
gi 768004120 504 NRL 506
Cdd:COG5238  413 NLI 415
LRR_8 pfam13855
Leucine rich repeat;
451-506 4.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 4.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004120  451 LQMLDLSHNELSFVPPDL---PEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRL 506
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
139-326 5.03e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 5.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 139 LPPHL--WGEAGTQLSNAG-LPPdafrgseAIATLSLSNNQLSYLP-------------------PSLPPSLERLHLQNN 196
Cdd:PRK15387 240 LPPELrtLEVSGNQLTSLPvLPP-------GLLELSIFSNPLTHLPalpsglcklwifgnqltslPVLPPGLQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 197 LISKVPrgalSRQTQLRELYLQHNQLtdsgldaTTFSKLHS-LEYLDLSHNQLTTVPAgLPRTLAILHLGRNRIRQVEAA 275
Cdd:PRK15387 313 QLASLP----ALPSELCKLWAYNNQL-------TSLPTLPSgLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPAL 380

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768004120 276 rlhgARGLRYLLLQHNQLGSSGLPAGALRPL--------------RGLHTLHLYGNGLDRVPPAL 326
Cdd:PRK15387 381 ----PSGLKELIVSGNRLTSLPVLPSELKELmvsgnrltslpmlpSGLLSLSVYRNQLTRLPESL 441
LRR_8 pfam13855
Leucine rich repeat;
169-222 5.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768004120  169 TLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 222
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 74-297 3.65e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  74 RAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEALSGPSVSAPVPPCRGSgcqPSDGDLPPH--LWGEAGTQL 151
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRS---SSLQELKLNnnGLGDRGLRL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 152 SNAGLPPDafrgSEAIATLSLSNNQLSY-----LPPSLP--PSLERLHLQNNLISkvPRG------ALSRQTQLRELYLQ 218
Cdd:cd00116  128 LAKGLKDL----PPALEKLVLGRNRLEGasceaLAKALRanRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLN 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 219 HNQLTDSG--LDATTFSKLHSLEYLDLSHNQLTTVPAglpRTLAilhlgrnrirqveAARLHGARGLRYLLLQHNQLGSS 296
Cdd:cd00116  202 NNGLTDEGasALAETLASLKSLEVLNLGDNNLTDAGA---AALA-------------SALLSPNISLLTLSLSCNDITDD 265


                 .
gi 768004120 297 G 297
Cdd:cd00116  266 G 266
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 210-250 2.88e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768004120  210 TQLRELYLQHNQLTDSGLdattFSKLHSLEYLDLSHNQLTT 250
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNKIT 37
PLN03150 PLN03150
hypothetical protein; Provisional
 404-523 3.79e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 404 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELS-FVPPDLPE--ALEELHLEGN 480
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR-GNI-PPSLGSITSLEVLDLSYNSFNgSIPESLGQltSLRILNLNGN 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768004120 481 RIGHVGPEAflstprLRALFLRANRLHMTSIAaeAFLGLPNLR 523
Cdd:PLN03150 501 SLSGRVPAA------LGGRLLHRASFNFTDNA--GLCGIPGLR 535
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-220 3.83e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  78 HLSLQNNQLQELPYneLSRLSGLRTLNLHNNLISS-EALSGPS------VSapvppcrgsgCQpsdgDLPPhlwgeaGTQ 150
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGLENLTnleelhIE----------NQ----RLPP------GEK 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768004120 151 L-----SNAGLppdafrgSEAIATLSLSNNQLSYLPPSLP-PSLERLHLQNNLISKVPR--GALSRQTQLRELYLQHN 220
Cdd:cd21340  108 LtfdprSLAAL-------SNSLRVLNISGNNIDSLEPLAPlRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
257-319 4.24e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 4.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004120  257 RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgsSGLPAGALRPLRGLHTLHLYGNGL 319
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 214-530 8.89e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 214 ELYLQHNQLTDSGLdATTFSKLHSLEYLDLSHNQLTTVpaglprtlailhlgrnRIRQVeAARLHGARGLRYLLLQHNQL 293
Cdd:cd00116    2 QLSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEE----------------AAKAL-ASALRPQPSLKELCLSLNET 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 294 GSS----GLPAGALRPLRGLHTLHLYGNGLDrvpPALPRRLRALVLphnhvaalgardlvaTPGLTELNLAYNRLAsarv 369
Cdd:cd00116   64 GRIprglQSLLQGLTKGCGLQELDLSDNALG---PDGCGVLESLLR---------------SSSLQELKLNNNGLG---- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 370 hhrafrrlralrslDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQ----LRELSLAHNRLRvgdiGPGTW 445
Cdd:cd00116  122 --------------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRanrdLKELNLANNGIG----DAGIR 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 446 H------ELQALQMLDLSHN--------ELSFVPPDLPeALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSI 511
Cdd:cd00116  184 AlaeglkANCNLEVLDLNNNgltdegasALAETLASLK-SLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDI 262

                        330       340
                 ....*....|....*....|....*.
gi 768004120 512 AAEAFLGL-------PNLRVVDTAGN 530
Cdd:cd00116  263 TDDGAKDLaevlaekESLLELDLRGN 288
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 389-531 8.89e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 389 QLTRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQ---LRELSLAHNRL--RVGDIGPGTWHELQ-ALQMLDLSHNE 460
Cdd:cd00116   69 GLQSLLQGLTKgcGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdRGLRLLAKGLKDLPpALEKLVLGRNR 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 461 LSFVP-PDLPEA------LEELHLEGNRIGHVG----PEAFLSTPRLRALFLRANRLHMT--SIAAEAFLGLPNLRVVDT 527
Cdd:cd00116  149 LEGAScEALAKAlranrdLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDEgaSALAETLASLKSLEVLNL 228


                 ....
gi 768004120 528 AGNP 531
Cdd:cd00116  229 GDNN 232
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 25-248 3.87e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120  25 AGLEDAAFPHLGESLQPL-PRACPLRCSCPRVDTVDCDGLdLRVFPDNitRAAQHLSLQNNQLQE--LPY--NELSRLSG 99
Cdd:cd00116  118 NGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEAL-AKALRAN--RDLKELNLANNGIGDagIRAlaEGLKANCN 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 100 LRTLNLHNNLISSEalsgpsvsapvppcrgsGCQpsdgdlpphlwgeagtQLSnaglppDAFRGSEAIATLSLSNNQLSY 179
Cdd:cd00116  195 LEVLDLNNNGLTDE-----------------GAS----------------ALA------ETLASLKSLEVLNLGDNNLTD 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004120 180 LP--------PSLPPSLERLHLQNNLI----SKVPRGALSRQTQLRELYLQHNQLTDSG---LDATTFSKLHSLEYLDLS 244
Cdd:cd00116  236 AGaaalasalLSPNISLLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGNKFGEEGaqlLAESLLEPGNELESLWVK 315


                 ....
gi 768004120 245 HNQL 248
Cdd:cd00116  316 DDSF 319
LRR_8 pfam13855
Leucine rich repeat;
155-198 4.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 768004120  155 GLPPDAFRGSEAIATLSLSNNQLSYLPP---SLPPSLERLHLQNNLI 198
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 186-225 7.66e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768004120  186 PSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTDS 225
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-112 8.18e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 8.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768004120  50 CSCPRVDTVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPynELSRLSGLRTLNLHNNLISS 112
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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