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Conserved domains on  [gi|768013639|ref|XP_011527516|]
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lysophosphatidylserine lipase ABHD12 isoform X2 [Homo sapiens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-354 2.44e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 143.52  E-value: 2.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 158 MWYEDALAS-SHPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073   26 DLYLPAGASkKYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073  104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 768013639 311 -KFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSF 354
Cdd:COG1073  178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKEL 222
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-354 2.44e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 143.52  E-value: 2.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 158 MWYEDALAS-SHPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073   26 DLYLPAGASkKYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073  104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 768013639 311 -KFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSF 354
Cdd:COG1073  178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKEL 222
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 165-352 6.86e-17

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 79.18  E-value: 6.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  165 ASSHPIILYLHGnagtrGGDH--R-VELYKVLSSLGYHVVTFDYRGWGDSVGT----PSERGMTYDALHVFDWIKARSGD 237
Cdd:pfam12146   1 GEPRAVVVLVHG-----LGEHsgRyAHLADALAAQGFAVYAYDHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  238 NPVYIWGHSLGTGVATNLVRRlceRETPPDALILESPFTNIREE-------------AKSHP---------FSVIYRYFP 295
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALR---YPDKVDGLILSAPALKIKPYlappilkllakllGKLFPrlrvpnnllPDSLSRDPE 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768013639  296 GFDWFFLDPITSSGI--KFAND---------ENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPAR 352
Cdd:pfam12146 153 VVAAYAADPLVHGGIsaRTLYElldagerllRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTD 220
PLN02511 PLN02511
hydrolase
 156-337 1.73e-06

hydrolase


Pssm-ID: 215282 [Multi-domain]  Cd Length: 388  Bit Score: 49.78  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 156 DQMWYED-ALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDS-VGTPS--ERGMTYDALHVFDWI 231
Cdd:PLN02511  87 DWVSGDDrALPADAPVLILLPGLTGGSDDSYVRHMLLRARSKGWRVVVFNSRGCADSpVTTPQfySASFTGDLRQVVDHV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 232 KARSGDNPVYIWGHSLGtgvATNLVRRLCER-ETPP--DALILESPFT-NIREEAKSHPFSVIY---------RYF---- 294
Cdd:PLN02511 167 AGRYPSANLYAAGWSLG---ANILVNYLGEEgENCPlsGAVSLCNPFDlVIADEDFHKGFNNVYdkalakalrKIFakha 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768013639 295 ------PG---------------FDwfflDPIT--SSGIKFAND--------ENVKHISCPLLILHAEDDPVVP 337
Cdd:PLN02511 244 llfeglGGeyniplvanaktvrdFD----DGLTrvSFGFKSVDAyysnssssDSIKHVRVPLLCIQAANDPIAP 313
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-354 2.44e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 143.52  E-value: 2.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 158 MWYEDALAS-SHPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073   26 DLYLPAGASkKYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073  104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 768013639 311 -KFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSF 354
Cdd:COG1073  178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKEL 222
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
168-377 2.64e-26

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 105.48  E-value: 2.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 168 HPIILYLHGNAGTRGgDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSeRGMTYDALHVFDWIKARSGDNP--VYIWGH 245
Cdd:COG1506   23 YPVVVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWG-GDEVDDVLAAIDYLAARPYVDPdrIGIYGH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 246 SLGTGVATNLvrrLCERETPPDALILESPFTNIREEAK-SHPFSVIYRYFPGFDWFFLDpitssgiKFANDENVKHISCP 324
Cdd:COG1506  101 SYGGYMALLA---AARHPDRFKAAVALAGVSDLRSYYGtTREYTERLMGGPWEDPEAYA-------ARSPLAYADKLKTP 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768013639 325 LLILHAEDDPVVPFQLGRKLYSiaapARSFRDFKVQFVPF----HSDLGYRHKYIYK 377
Cdd:COG1506  171 LLLIHGEADDRVPPEQAERLYE----ALKKAGKPVELLVYpgegHGFSGAGAPDYLE 223
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
128-372 1.14e-22

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 1.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 128 YYLQPEEDVTIGVWHTVPAvwwknaqgkdqmwyedalASSHPIILYLHGnagtrGGDHRVELYKV---LSSLGYHVVTFD 204
Cdd:COG2267    6 VTLPTRDGLRLRGRRWRPA------------------GSPRGTVVLVHG-----LGEHSGRYAELaeaLAAAGYAVLAFD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 205 YRGWGDSVGT----PSERGMTYDALHVFDWIKARSGDnPVYIWGHSLGTGVATNLVRRlceRETPPDALILESPftnire 280
Cdd:COG2267   63 LRGHGRSDGPrghvDSFDDYVDDLRAALDALRARPGL-PVVLLGHSMGGLIALLYAAR---YPDRVAGLVLLAP------ 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 281 eakshpfsviyryfpgfdWFFLDPITSSGIKFAND----ENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRD 356
Cdd:COG2267  133 ------------------AYRADPLLGPSARWLRAlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVL 194

                        250
                 ....*....|....*.
gi 768013639 357 FKvqfvpfhsdlGYRH 372
Cdd:COG2267  195 LP----------GARH 200
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 165-352 6.86e-17

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 79.18  E-value: 6.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  165 ASSHPIILYLHGnagtrGGDH--R-VELYKVLSSLGYHVVTFDYRGWGDSVGT----PSERGMTYDALHVFDWIKARSGD 237
Cdd:pfam12146   1 GEPRAVVVLVHG-----LGEHsgRyAHLADALAAQGFAVYAYDHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  238 NPVYIWGHSLGTGVATNLVRRlceRETPPDALILESPFTNIREE-------------AKSHP---------FSVIYRYFP 295
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALR---YPDKVDGLILSAPALKIKPYlappilkllakllGKLFPrlrvpnnllPDSLSRDPE 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768013639  296 GFDWFFLDPITSSGI--KFAND---------ENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPAR 352
Cdd:pfam12146 153 VVAAYAADPLVHGGIsaRTLYElldagerllRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTD 220
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 157-352 1.63e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 1.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 157 QMWYEDALASSHPIILyLHGNAGTrgGDHRVELYKVLSSlGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARsG 236
Cdd:COG0596   13 RLHYREAGPDGPPVVL-LHGLPGS--SYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDAL-G 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 237 DNPVYIWGHSLGTGVATNLVRRLCERetpPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITssgikfandE 316
Cdd:COG0596   88 LERVVLVGHSMGGMVALELAARHPER---VAGLVLVDEVLAALAEPLRRPGLAPEALAALLRALARTDLR---------E 155

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 768013639 317 NVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPAR 352
Cdd:COG0596  156 RLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
168-344 3.92e-16

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 76.35  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 168 HPiilyLHGnaGTRggDHRV--ELYKVLSSLGYHVVTFDYRGWGDSVGTPSE-RGMTYDALHVFDWIKARsgdNPVYIW- 243
Cdd:COG2945   32 HP----LFG--GTM--DNKVvyTLARALVAAGFAVLRFNFRGVGRSEGEFDEgRGELDDAAAALDWLRAQ---NPLPLWl 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 244 -GHSLGTGVATNLVRRLCEretpPDALILESPFTNIreeakshpfsviyryfpgFDWFFLDPITssgikfandenvkhis 322
Cdd:COG2945  101 aGFSFGAYVALQLAMRLPE----VEGLILVAPPVNR------------------YDFSFLAPCP---------------- 142

                        170       180
                 ....*....|....*....|..
gi 768013639 323 CPLLILHAEDDPVVPFQLGRKL 344
Cdd:COG2945  143 APTLVIHGEQDEVVPPAEVLDW 164
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
164-345 5.75e-12

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 64.96  E-value: 5.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 164 LASSHPIILYLHGNAGTRGgDHRvELYKVLSSLGYHVVTFDYRGWGDSVGTPseRGMTYDalhvfDWIKA--------RS 235
Cdd:COG1647   11 LEGGRKGVLLLHGFTGSPA-EMR-PLAEALAKAGYTVYAPRLPGHGTSPEDL--LKTTWE-----DWLEDveeayeilKA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 236 GDNPVYIWGHSLGTGVATnlvrRLCERETPPDALILESPftNIREEAKSHPFSVIYRYF-------------PGFDWFFL 302
Cdd:COG1647   82 GYDKVIVIGLSMGGLLAL----LLAARYPDVAGLVLLSP--ALKIDDPSAPLLPLLKYLarslrgigsdiedPEVAEYAY 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768013639 303 DPITSSGI----KFAND--ENVKHISCPLLILHAEDDPVVPFQLGRKLY 345
Cdd:COG1647  156 DRTPLRALaelqRLIREvrRDLPKITAPTLIIQSRKDEVVPPESARYIY 204
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 169-301 9.71e-12

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 64.45  E-value: 9.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  169 PIILYLHGNAGTRGGDHrvELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDAL-HVFDWIKARSGDNPVYIWGHSL 247
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWR--KLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLaEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 768013639  248 GTGVATNLvrrLCERETPPDALILESPFTNireeaKSHPFSVIYRYFPGFDWFF 301
Cdd:pfam00561  79 GGLIALAY---AAKYPDRVKALVLLGALDP-----PHELDEADRFILALFPGFF 124
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
159-337 2.96e-10

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 60.93  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 159 WYEDAlASSHPIILYLHGnagtRGGDHR----VELYKVLSSLGYHVVTFDYRGWGdsvGTP--SER----GMTYDALHVF 228
Cdd:COG0429   53 WSDPP-APSKPLVVLLHG----LEGSSDshyaRGLARALYARGWDVVRLNFRGCG---GEPnlLPRlyhsGDTEDLVWVL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 229 DWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALI-------LESPFTNIreeakSHPFSVIY---------- 291
Cdd:COG0429  125 AHLRARYPYAPLYAVGFSLGGNLLLKYLGEQGDDAPPLKAAVavsppldLAASADRL-----ERGFNRLYqryflrslkr 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768013639 292 ------RYFPG---------------FDWFFLDPIT-----------SSGIKFandenVKHISCPLLILHAEDDPVVP 337
Cdd:COG0429  200 klrrklALFPGlidlealkrirtlreFDDAYTAPLHgfkdaedyyqrASALPF-----LPQIRVPTLILNAADDPFLP 272
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
193-248 5.90e-10

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 59.51  E-value: 5.90e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768013639 193 LSSLGYHVVTFDYRGWGDSVGTPSeRGMTYDALH--------VFDWIKARSGDNPVYIWGHSLG 248
Cdd:COG4757   55 LAERGFAVLTYDYRGIGLSRPGSL-RGFDAGYRDwgeldlpaVLDALRARFPGLPLLLVGHSLG 117
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
162-337 1.23e-08

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 54.49  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 162 DALASSHPIILYLHGNAGTRGG--DHRVELYKVLSSLGYHVVTFDYR-----GWGDSVgtpsergmtYDALHVFDWIKAR 234
Cdd:COG0657    7 AGAKGPLPVVVYFHGGGWVSGSkdTHDPLARRLAARAGAAVVSVDYRlapehPFPAAL---------EDAYAALRWLRAN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 235 SGD-----NPVYIWGHSLGTGVATNLVRRLCERETP-PDALILESPFTNIReeakshpFSVIYRYFPGFdwffldpitss 308
Cdd:COG0657   78 AAElgidpDRIAVAGDSAGGHLAAALALRARDRGGPrPAAQVLIYPVLDLT-------ASPLRADLAGL----------- 139

                        170       180
                 ....*....|....*....|....*....
gi 768013639 309 gikfandenvkhisCPLLILHAEDDPVVP 337
Cdd:COG0657  140 --------------PPTLIVTGEADPLVD 154
PLN02511 PLN02511
hydrolase
 156-337 1.73e-06

hydrolase


Pssm-ID: 215282 [Multi-domain]  Cd Length: 388  Bit Score: 49.78  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 156 DQMWYED-ALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDS-VGTPS--ERGMTYDALHVFDWI 231
Cdd:PLN02511  87 DWVSGDDrALPADAPVLILLPGLTGGSDDSYVRHMLLRARSKGWRVVVFNSRGCADSpVTTPQfySASFTGDLRQVVDHV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 232 KARSGDNPVYIWGHSLGtgvATNLVRRLCER-ETPP--DALILESPFT-NIREEAKSHPFSVIY---------RYF---- 294
Cdd:PLN02511 167 AGRYPSANLYAAGWSLG---ANILVNYLGEEgENCPlsGAVSLCNPFDlVIADEDFHKGFNNVYdkalakalrKIFakha 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768013639 295 ------PG---------------FDwfflDPIT--SSGIKFAND--------ENVKHISCPLLILHAEDDPVVP 337
Cdd:PLN02511 244 llfeglGGeyniplvanaktvrdFD----DGLTrvSFGFKSVDAyysnssssDSIKHVRVPLLCIQAANDPIAP 313
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 171-363 4.44e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 47.08  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  171 ILYLHGnagtrGGDHRVELYKVLSSlGYHVVTFDYRGWGDSVGTPSErgmTYDALHVFDWIKARSGDNPVYIWGHSLGTG 250
Cdd:pfam12697   1 VVLVHG-----AGLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLD---LADLADLAALLDELGAARPVVLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  251 VATNLVRR-------LCERETPPDALILESPFTNIREEAKSHP-FSVIYRYFPGF--------DWFFLDPITS---SGIK 311
Cdd:pfam12697  72 VALAAAAAalvvgvlVAPLAAPPGLLAALLALLARLGAALAAPaWLAAESLARGFlddlpadaEWAAALARLAallAALA 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 768013639  312 FANDENVKHISCPLLILHAEDDPVVPFqlgrklysIAAPARSFRDFKVQFVP 363
Cdd:pfam12697 152 LLPLAAWRDLPVPVLVLAEEDRLVPEL--------AQRLLAALAGARLVVLP 195
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 165-259 2.12e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 43.28  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639 165 ASSHPIILyLHGNAGTRGGDHRveLYKVLSSLGYHVVTFDYRGWGDSVgtpSERGmtyDALHVF-DWIKARSGDNPVYIW 243
Cdd:COG1075    3 ATRYPVVL-VHGLGGSAASWAP--LAPRLRAAGYPVYALNYPSTNGSI---EDSA---EQLAAFvDAVLAATGAEKVDLV 73

                         90
                 ....*....|....*.
gi 768013639 244 GHSLGTGVATNLVRRL 259
Cdd:COG1075   74 GHSMGGLVARYYLKRL 89
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
192-345 1.19e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 39.91  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  192 VLSSLGYHVVTFDYRGWGdsvgtpsERGmtyDALHvfDWIKARSGDNP---------------------VYIWGHSLGtG 250
Cdd:pfam00326   9 LLADRGYVVAIANGRGSG-------GYG---EAFH--DAGKGDLGQNEfddfiaaaeylieqgytdpdrLAIWGGSYG-G 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013639  251 VATNLVrrLCERETPPDALILESPFTNIR--EEAKSHPFSVIYRYFPGFDWfflDPITSSGIKFANDENVKHISCPLLIL 328
Cdd:pfam00326  76 YLTGAA--LNQRPDLFKAAVAHVPVVDWLayMSDTSLPFTERYMEWGNPWD---NEEGYDYLSPYSPADNVKVYPPLLLI 150

                         170
                  ....*....|....*..
gi 768013639  329 HAEDDPVVPFQLGRKLY 345
Cdd:pfam00326 151 HGLLDDRVPPWQSLKLV 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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