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Conserved domains on  [gi|768020327|ref|XP_011527781|]
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coxsackievirus and adenovirus receptor isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
20-136 1.34e-65

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


:

Pssm-ID: 409552  Cd Length: 114  Bit Score: 199.21  E-value: 1.34e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADnqKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDlK 99
Cdd:cd20960    1 LLITSAQTEIKKVAGENVTLPCHHQLGLEDQGTLDIEWLLLPSD--KVEKVVITYSGDRVYNHYYPALKGRVAFTSND-L 77
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLV 136
Cdd:cd20960   78 SGDASLNISNLKLSDTGTYQCKVKKAPGYAWSKITLI 114
 
Name Accession Description Interval E-value
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
20-136 1.34e-65

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 199.21  E-value: 1.34e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADnqKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDlK 99
Cdd:cd20960    1 LLITSAQTEIKKVAGENVTLPCHHQLGLEDQGTLDIEWLLLPSD--KVEKVVITYSGDRVYNHYYPALKGRVAFTSND-L 77
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLV 136
Cdd:cd20960   78 SGDASLNISNLKLSDTGTYQCKVKKAPGYAWSKITLI 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
24-138 6.69e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 76.73  E-value: 6.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327   24 TPEEMIEKAKGETAYLPCKFTLSpEDQGPLDIEWLISPADNQKvDQVIILYSGDkiyDDYYPDlKGRVHFTSNDLKsGDA 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSS-MSEASTSVYWYRQPPGKGP-TFLIAYYSNG---SEEGVK-KGRFSGRGDPSN-GDG 73
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768020327  104 SINVTNLQLSDIGTYQCKV-KKAPGVANKKIHLVVL 138
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAViPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
29-137 2.45e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 2.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327    29 IEKAKGETAYLPCKFTLSPEDQgpldIEWLispadnqKVDQVIILYSGdkiyddyypdlkgRVHFTSNdlkSGDASINVT 108
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPE----VTWY-------KQGGKLLAESG-------------RFSVSRS---GSTSTLTIS 56
                           90       100
                   ....*....|....*....|....*....
gi 768020327   109 NLQLSDIGTYQCKVKKAPGVANKKIHLVV 137
Cdd:smart00410  57 NVTPEDSGTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
20-136 1.34e-65

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 199.21  E-value: 1.34e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADnqKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDlK 99
Cdd:cd20960    1 LLITSAQTEIKKVAGENVTLPCHHQLGLEDQGTLDIEWLLLPSD--KVEKVVITYSGDRVYNHYYPALKGRVAFTSND-L 77
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLV 136
Cdd:cd20960   78 SGDASLNISNLKLSDTGTYQCKVKKAPGYAWSKITLI 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
24-138 6.69e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 76.73  E-value: 6.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327   24 TPEEMIEKAKGETAYLPCKFTLSpEDQGPLDIEWLISPADNQKvDQVIILYSGDkiyDDYYPDlKGRVHFTSNDLKsGDA 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSS-MSEASTSVYWYRQPPGKGP-TFLIAYYSNG---SEEGVK-KGRFSGRGDPSN-GDG 73
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768020327  104 SINVTNLQLSDIGTYQCKV-KKAPGVANKKIHLVVL 138
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAViPSGEGVFGKGTRLTVL 109
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
20-137 1.04e-15

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 70.92  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEmIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPaDNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNdLK 99
Cdd:cd05715    1 MEVYTPRE-LNVLNGSDVRLTCTFTSCYTVGDAFSVTWTYQP-EGGNTTESMFHYSKGKPYILKVGRFKDRVSWAGN-PS 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKVKKAPGVANK--KIHLVV 137
Cdd:cd05715   78 KKDASIVISNLQFSDNGTYTCDVKNPPDIVGGhgEIRLYV 117
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
24-122 6.41e-10

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 55.41  E-value: 6.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  24 TPEEMIEKAKGETAYLPCKFTLSPEDQGP--LDIEWLISPADNQKvDQVIILYSGD--KIYDDYypdlKGRVHFTSNDlk 99
Cdd:cd05877    2 TVQAKVFSHRGGNVTLPCRYHYEPELSAPrkIRVKWTKLEVDYAK-EEDVLVAIGTrhKSYGSY----QGRVFLRRAD-- 74
                         90       100
                 ....*....|....*....|...
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKV 122
Cdd:cd05877   75 DLDASLVITDLRLEDYGRYRCEV 97
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
34-133 3.82e-09

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 52.99  E-value: 3.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTLSPEDQGpLDIEWLiSPADNQKVDQviiLYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLS 113
Cdd:cd20984   12 GEDGILSCTFTPDIKLSD-IVIQWL-KEGDSGLVHE---FKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRLKNVQLT 86
                         90       100
                 ....*....|....*....|
gi 768020327 114 DIGTYQCKVKKAPGVANKKI 133
Cdd:cd20984   87 DAGTYLCIISNSKGTGNANM 106
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
21-120 1.38e-07

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 48.73  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  21 SITTPEEMIEKAKGETAYLPCKftLSPE-DQGPLDIEWLISpadnqKVDQVIILY-SGDKIYDDYYPDLKGRVHFTSNDL 98
Cdd:cd05713    2 SVIGPTEPILALVGEDAELPCH--LSPKmSAEHMEVRWFRS-----QFSPVVHLYrDGQDQEEEQMPEYRGRTELLKDAI 74
                         90       100
                 ....*....|....*....|..
gi 768020327  99 KSGDASINVTNLQLSDIGTYQC 120
Cdd:cd05713   75 AEGSVALRIHNVRPSDEGQYTC 96
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
29-122 1.47e-07

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 49.13  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  29 IEKAKGETAYLPCKFTLSPEDQGP----LDIEWLISPADNQKVDQVIILYSGD---KIYDDYypdlKGRVHFTSNDLKSG 101
Cdd:cd05714    7 VFSHLGGNVTLPCKFYRDPTAFGSgihkIRIKWTKLTSDSGYLKEVDVLVAMGnvvYHKKTY----GGRVSVPLKPGSDS 82
                         90       100
                 ....*....|....*....|.
gi 768020327 102 DASINVTNLQLSDIGTYQCKV 122
Cdd:cd05714   83 DASLVITDLTASDYGLYRCEV 103
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
20-128 3.35e-07

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 47.90  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEmIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQKvDQVIILYsgdkiYDDYYPDL----KGRVHFTS 95
Cdd:cd05880    1 IEVYTSKE-VEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGR-EESVFYY-----HKRPYPPPdgrfKGRVVWDG 73
                         90       100       110
                 ....*....|....*....|....*....|...
gi 768020327  96 NDLKSgDASINVTNLQLSDIGTYQCKVKKAPGV 128
Cdd:cd05880   74 NIMRR-DASILIWQLQPTDNGTYTCQVKNPPDV 105
IgV_CD80 cd16086
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here ...
29-136 7.02e-07

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 80). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as cluster of differentiation 152/CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 319335  Cd Length: 105  Bit Score: 46.67  E-value: 7.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  29 IEKAKGETAYLPCKFTLSPEDQGPLDIEWlispadnQKVDQVII-LYSGDKiydDYYPDLKGRvhfTSNDLkSGDASINV 107
Cdd:cd16086    4 VTKSVKEKALLSCDYNVSVDELAQVRIYW-------QKDDKMVLtIISGDV---KVWPEYKNR---TLFDI-TNNLSIVI 69
                         90       100
                 ....*....|....*....|....*....
gi 768020327 108 TNLQLSDIGTYQCKVKKAPGVANKKIHLV 136
Cdd:cd16086   70 LALRLSDRGTYTCVVQKKERGAYKREHLA 98
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
58-138 1.10e-06

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 45.80  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  58 LISPADNQKVDQVIILYSGDKIYD-------DYYPDLKGRVHFtsnDLKSGDASInvTNLQLSDIGTYQCKVKKAPG-VA 129
Cdd:cd05775   15 LTISSLQDDIDEIKWKKTKDKIVEwennigpTYFGSFKDRVLL---DKESGSLTI--KNLTKEDSGTYELEITSTNGkVL 89

                 ....*....
gi 768020327 130 NKKIHLVVL 138
Cdd:cd05775   90 SSKFTLEVL 98
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
29-137 2.45e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 2.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327    29 IEKAKGETAYLPCKFTLSPEDQgpldIEWLispadnqKVDQVIILYSGdkiyddyypdlkgRVHFTSNdlkSGDASINVT 108
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPE----VTWY-------KQGGKLLAESG-------------RFSVSRS---GSTSTLTIS 56
                           90       100
                   ....*....|....*....|....*....
gi 768020327   109 NLQLSDIGTYQCKVKKAPGVANKKIHLVV 137
Cdd:smart00410  57 NVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
34-122 7.35e-06

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 44.15  E-value: 7.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTLSPEDQGP------LDIEWLISPADNQKVDQVIILYSGD---KIYDDYypdlKGRVHFTSNDLKSGDAS 104
Cdd:cd05878   12 GTSVTLPCYFIDPPHPVTPstaplaPRIKWSKVSVDGKKEKEVVLLVATEgrvRVNSAY----QGRVSLPNYPAIPSDAT 87
                         90
                 ....*....|....*...
gi 768020327 105 INVTNLQLSDIGTYQCKV 122
Cdd:cd05878   88 LEVQSLRASDSGLYRCEV 105
IGv smart00406
Immunoglobulin V-Type;
36-122 8.15e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 43.14  E-value: 8.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327    36 TAYLPCKFTLSpeDQGPLDIEWLISPADNQkvdqVIILYSGDKIYDDYYPD-LKGRVHFtSNDLKSGDASINVTNLQLSD 114
Cdd:smart00406   1 SVTLSCKFSGS--TFSSYYVSWVRQPPGKG----LEWLGYIGSNGSSYYQEsYKGRFTI-SKDTSKNDVSLTISNLRVED 73

                   ....*...
gi 768020327   115 IGTYQCKV 122
Cdd:smart00406  74 TGTYYCAV 81
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
20-137 9.54e-06

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 43.71  E-value: 9.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  20 LSITTPEEmIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPaDNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDlK 99
Cdd:cd05879    1 IVVYTDRE-VYGTVGSDVTLSCSFWSSEWISDDISFTWHYQP-DGSRDAISIFHYGKGQPYIDNVGPFKERIEWVGNP-S 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768020327 100 SGDASINVTNLQLSDIGTYQCKVKKAPGVANK--KIHLVV 137
Cdd:cd05879   78 RKDGSIVIHNLDYTDNGTFTCDVKNPPDIVGKssQVTLYV 117
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
34-134 1.40e-05

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 43.08  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTlSPEDqgpLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLksgdaSINVTNLQLS 113
Cdd:cd16087    8 NETAYLPCQFK-NPQN---ISLSELVVFWQDQKKLVLYELYLGKEKLDNVNSKYIGRTSFDQENW-----TLQLHNVQIK 78
                         90       100
                 ....*....|....*....|.
gi 768020327 114 DIGTYQCKVKKAPGVANKKIH 134
Cdd:cd16087   79 DQGTYQCFIHHKSPKGLVLIH 99
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
39-137 1.67e-05

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 42.76  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  39 LPCKFTLSPEDQgpldIEWlISPADNQKVDqviILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTY 118
Cdd:cd16091   17 LPCSFTPGSEVV----IHW-YKQDSDIKVH---SYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRVQLQDEGRY 88
                         90
                 ....*....|....*....
gi 768020327 119 QCKVKKAPGVANKKIHLVV 137
Cdd:cd16091   89 KCYTSTIIGNQESFVNLKV 107
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
34-137 2.19e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 42.43  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTlSPEDQGPLDIEWLISPADNQkvdQVIILYS---GDKIYDDYypdlKGRVHFTSNDLKSGDASINVTNL 110
Cdd:cd05718   14 GGSVTLPCSLT-SPGTTKITQVTWMKIGAGSS---QNVAVFHpqyGPSVPNPY----AERVEFLAARLGLRNATLRIRNL 85
                         90       100
                 ....*....|....*....|....*...
gi 768020327 111 QLSDIGTYQCKVKKAP-GVANKKIHLVV 137
Cdd:cd05718   86 RVEDEGNYICEFATFPqGNRQGTTWLRV 113
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
28-122 2.65e-05

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 42.51  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  28 MIEKAKGETAYLPCKFTLSPEDQGPLD---IEWL-ISPADNQKvdQVIILYSGDKIYDdYYPDLKGRVHFTSNDLKSGDA 103
Cdd:cd05902    6 PVRRPLSSSVLLPCVFTLPPSASSPPEgprIKWTkLSTSGGQQ--QRPVLVARDNVVR-VAKAFQGRVSLPGYPKNRYNA 82
                         90
                 ....*....|....*....
gi 768020327 104 SINVTNLQLSDIGTYQCKV 122
Cdd:cd05902   83 SLVLSRLRYSDSGTYRCEV 101
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
39-122 5.35e-05

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 41.87  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  39 LPCKFTLSPEDQGP-------LDIEWLISPADNQKVDQ----VIILYSGD-KIYDDYypdlKGRVHFTSNDLKSGDASIN 106
Cdd:cd05901   17 LPCRFSTLPTLPPSynitsefLRIKWTKIQVDKNGKDHkettVLVAQNGIiKIGQEY----MGRVSVPSHPEDQGDASLT 92
                         90
                 ....*....|....*.
gi 768020327 107 VTNLQLSDIGTYQCKV 122
Cdd:cd05901   93 IVKLRASDAGVYRCEV 108
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
22-137 9.10e-05

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 40.69  E-value: 9.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  22 ITTPEEMIEKAKGETAYLPCKFTLSPE-DQGPLDIEWlispadNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKS 100
Cdd:cd20947    1 VTVPKDLYVVEYGSNMTIECKFPVEKQlDLAALIVYW------EMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSL 74
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768020327 101 GDASINVTNLQLSDIGTYQCKVKKApGVANKKIHLVV 137
Cdd:cd20947   75 GNAALQITDVKLQDAGVYRCMISYG-GADYKRITVKV 110
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
22-122 1.27e-04

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 40.59  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  22 ITTPEEMIEKAKGETAyLPCkfTLSPE-DQGPLDIEWLISpadnQKVDQVIILY---SGDKIYDDYYpdlKGRVHFTSNd 97
Cdd:cd16089    3 LEGPESITGPWKGSVN-LPC--TYVPEeGYTQVLVKWLVQ----RDSDPVTIFLrdsSGDHIQQAKY---RGRLEVSKD- 71
                         90       100
                 ....*....|....*....|....*
gi 768020327  98 lKSGDASINVTNLQLSDIGTYQCKV 122
Cdd:cd16089   72 -TPGDVSLQLDTLEMDDRGHYTCQV 95
I-set pfam07679
Immunoglobulin I-set domain;
21-137 3.83e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327   21 SITTPEEMIEKAKGETAYLPCKFTLSPedqgPLDIEWLispadnqKVDQVIIlysgdkiyddyyPDLKGRVHFtsndlKS 100
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTGTP----DPEVSWF-------KDGQPLR------------SSDRFKVTY-----EG 53
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 768020327  101 GDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVV 137
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVATNSAGEAEASAELTV 90
IgV_VCBP cd20963
Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set ...
34-122 3.91e-04

Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set domain; The members here are composed of the immunoglobulin variable (IgV) region-containing chitin-binding proteins (VCBPs). VCBPs are secreted, immune-type molecules that have been identified in both amphioxus and sea squirt (Ciona intestinalis). VCBPs, which consist of a leader peptide, two tandem N-terminal immunoglobulin V-type domains and a single C-terminal chitin-binding domain, belong to a multigene family encoding secreted proteins. The VCBPs were identified first in the cephalochordate Branchiostoma floridae and show structural similarities with V-type domains of immunoglobulins and T cell receptors, suggesting that VCBPs represent a unique gut-associated form of innate immune proteins. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other.


Pssm-ID: 409555  Cd Length: 123  Bit Score: 39.14  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTLSPEDQGPLdIEWL--ISPADNQKV---DQVIILYSGDkiYDDYYPDLKGRVhfTSNDLKSgdASINVT 108
Cdd:cd20963   17 GNRVELPCSYTISPAAQPPT-ITWLkgISVDRAEVVfkgFKYWNETSSS--GEVYFGDYAGRA--SVASLTQ--PTLVLT 89
                         90
                 ....*....|....
gi 768020327 109 NLQLSDIGTYQCKV 122
Cdd:cd20963   90 DLKFDDWGRYWCRV 103
IgV_B7-H6 cd20981
Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the ...
98-137 1.02e-03

Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H6 (also known as NCR3LG1). B7-H6 contains one IgV domain and one IgC domain (IgV-IgC) and belongs to the B7-family, which consists of structurally related cell-surface protein ligands which bind to receptors on lymphocytes that regulate immune responses. B7-H6 is a ligand of NKp30, which is a member of CD28 family and an activating receptor of natural killer (NK) cells. The expression of NKp30 has been found in most of NK cells, which is involved in the process of tumor cell killing and interaction with antigen presenting cells (APCs) such as dendritic cells. Studies showed that NK cells eliminate B7-H6-expressing tumor cells either directly via cytotoxicity or indirectly by cytokine secretion. For instance, chimeric NKp30-expressing T cells responded to B7-H6(+) tumor cells and those T cells produced IFN-gamma and killed B7-H6-expressing tumor cells in vivo. B7-H6 mRNA is not found in normal cells, while high expression of B7-H6 is found in certain type tumor cells, such as lymphoma, leukemia, ovarian cancer, brain tumors, breast cancers, and various sarcomas. Since B7-H6 can bind NKp30 to exert anti-tumor effects by NK cells, which are able to recognize the difference between cancer cells and normal cells, B7-H6 may serve as a promising target for cancer immunotherapy.


Pssm-ID: 409573  Cd Length: 114  Bit Score: 37.98  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768020327  98 LKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVV 137
Cdd:cd20981   75 LKSGDASLQLPGVQLEEAGEYRCEVVVTPLKAQGTVQLEV 114
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
85-136 1.72e-03

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 37.15  E-value: 1.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768020327  85 PDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKVKKAP-GVANKKIHLV 136
Cdd:cd05889   57 KPYAGRVYFLNSTMASNNMSLSFRNASEDDVGYYSCSLYTYPqGSWEKVIQVV 109
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
85-138 2.39e-03

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 36.84  E-value: 2.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768020327  85 PDLKGRVHFTSNDLKsgDASINVTNLQLSDIGTYQCKVKKAP-GVANKKIHLVVL 138
Cdd:cd05887   58 GEYQGRVSFKNYSLN--DATITLHNVGFSDSGKYICKAVTFPlGNAQSSTTVTVL 110
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
34-137 4.30e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 35.57  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  34 GETAYLPCKFTLSPEDQgpldIEWLiSPAdnqkvdqviilysGDKIYDDYYPDLKGR----VHFTSNDLksgdaSINVTN 109
Cdd:cd05717   11 GETLTLKCQVSLRDDSS----LQWL-NPN-------------GQTIYFNDKRALRDSryqlLNHSASEL-----SISVSN 67
                         90       100
                 ....*....|....*....|....*...
gi 768020327 110 LQLSDIGTYQCKVKKAPgVANKKIHLVV 137
Cdd:cd05717   68 VTLSDEGVYTCLHYTDP-VSTKKVTVTV 94
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
25-123 4.52e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 36.04  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020327  25 PEEMIEKAKGETAYLPCKFTLSPE-DQGPLDIEWLISpadNQKvDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDA 103
Cdd:cd20934    3 PEDPVVALVGTDATLRCSFSPEPGfSLAQLSVFWQLT---DTK-QLVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNA 78
                         90       100
                 ....*....|....*....|
gi 768020327 104 SINVTNLQLSDIGTYQCKVK 123
Cdd:cd20934   79 SLRLQRVRVADEGSYTCFVS 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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