BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGK 104
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILDFIYTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768023960 105 LLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGK 144
Cdd:cd18334   81 LLTSDQPGEQNFNALLTAASYLQLHDLAALCRKKLKRNGK 120

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 768023960  533 FPCNICGKMFTQRGTMTRHMRSH 555
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768023960 503 RPFkCSVCEKTYKDPATLRQHEK-THwltrpFPCNICGKMFTQRGTMTRHM 552
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHC 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGK 104
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILDFIYTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768023960 105 LLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGK 144
Cdd:cd18334   81 LLTSDQPGEQNFNALLTAASYLQLHDLAALCRKKLKRNGK 120

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960    47 DVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDT----DMVSSTVFQQILDFIYTGKLLPSDQPAEPnfstLLTA 122
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSeiylDDVSPEDFRALLNFLYTGKLDLPEENVEE----LLEL 76

                           90
                   ....*....|....*....
gi 768023960   123 ASYLQLPELAALCRRKLKR 141
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLK 95

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 768023960  575 RLTEHMRVHSGEKPYECQLCGGKFTQ 600
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768023960 559 KPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLIS--HLRMHTS 613
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHN 88

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 768023960  561 FACDECGMRFTRQYRLTEHMRVH 583
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 768023960   533 FPCNICGKMFTQRGTMTRHMRSH 555
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGK 104
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILDFIYTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768023960 105 LLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGK 144
Cdd:cd18334   81 LLTSDQPGEQNFNALLTAASYLQLHDLAALCRKKLKRNGK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGK 104
Cdd:cd18333    1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768023960 105 LLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGK 144
Cdd:cd18333   81 LSEGDPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRNGK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  23 MELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYF----KSLVLHDNLINLDTDMVSSTVFQQILD 98
Cdd:cd18324    1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFhlfyKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768023960  99 FIYTGKLLPSDQPAEpnfsTLLTAASYLQLPELAALCRRKLKR 141
Cdd:cd18324   81 FMYEGKLQFKDLPIE----DVLAAASYLHMYDIVKVCKKKLKE 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  23 MELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKsLVLHDNL-----INLDTDMVSSTVFQQIL 97
Cdd:cd18325    1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLdkrdiVHLNSDIVTAPAFSLLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768023960  98 DFIYTGKLLPSDQPAEpnfsTLLTAASYLQLPELAALCRRKLK 140
Cdd:cd18325   80 EFMYEGKLEFSSLPVE----DVLAAASYLHMYDIVKVCKGKLK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  23 MELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKsLVLHD-----NLINLDTDMVSSTVFQQIL 97
Cdd:cd18194    1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDrldkrDLVRLNSDIVTAPAFGLLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768023960  98 DFIYTGKLLPSDQPAEpnfsTLLTAASYLQLPELAALCRRKLK 140
Cdd:cd18194   80 DFMYEGRLALRDLPVE----DVLAAASYLHMYDIVKVCKGRLQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  45 LCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHD------NLINLdtDMVSSTVFQQILDFIYTGKLLPSDQpaepNFST 118
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkesssSEIEL--DDVSPEAFEALLDYIYTGELELSEE----NVEE 74

                 ....*...
gi 768023960 119 LLTAASYL 126
Cdd:cd18186   75 LLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDT------DMVSSTVFQQILDFIYTGKLLPSDQpae 113
Cdd:cd18201   16 RKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQttvthlDVVAVQGFSVILDFMYSGNLVLTSQ--- 92

                         90       100
                 ....*....|....*....|....*....
gi 768023960 114 pNFSTLLTAASYLQLPELAALCRRKLKRA 142
Cdd:cd18201   93 -NAIEVMSVASYLQMTEVVQSCRNFIKDA 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLH-----DNLINLDTDMVSSTVFQQILDF 99
Cdd:cd18230    1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvqktsDQATVTHLDIVTAQGFKAIIDF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768023960 100 IYTGKLLPSDQpaepNFSTLLTAASYLQLPELAALCRRKLKRA 142
Cdd:cd18230   81 MYSAHLALTSK----NVIEVMSAASYLQMTDIVQACHNFIKAA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHD-----NLINLDTDMVSSTVFQQILDFIYTGKLLPSDQpaep 114
Cdd:cd18329   16 RKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNaketgQPTVATFDVFSPDTFTIILDFVYSGKLSLTSQ---- 91

                         90       100
                 ....*....|....*....|..
gi 768023960 115 NFSTLLTAASYLQLPELAALCR 136
Cdd:cd18329   92 NVIEVMSAASYLQMTDVISVCK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  23 MELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKsLVLHD------NLINLDTDMVSSTVFQQI 96
Cdd:cd18956    1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDrpaggrDTVRLNGDIVTAPAFGRL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768023960  97 LDFIYTGKLLPSDQPAEpnfsTLLTAASYLQLPELAALCRRKLKRAGKP 145
Cdd:cd18956   80 LDFMYEGRLDLRSLPVE----DVLAAASYLHMYDIVKVCKGRLREKDPA 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLH------DNLINLDTdmVSSTVFQQILDFIYTGKLLPSdqpae 113
Cdd:cd18264   23 RAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytqeskARVIHLPV--VSAAGLQRVLDFIYTSWLSLS----- 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 768023960 114 pnFSTL---LTAASYLQLPELAALCRRKLKR 141
Cdd:cd18264   96 --LDTLedtLEAASYLQVTEAIGLCSQYLIN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVL-HDNLIN---LDTDMVSSTVFQQILDFIYTGKL 105
Cdd:cd18223   13 RIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSsQEIWISshvLELPDLKAEVFAEILNFIYSSKV 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  45 LCDV-IIMV-ENSIFRAHKNVLAASSIYFKSLVLHD---NLINLDTDMVSSTVFQQILDFIYTGKLLPSDQpaepNFSTL 119
Cdd:cd18231   14 LCDVdIVLVrQRSTFPAHKGVLAAYSQFFHSLFTQNkqlQRVELSLEALTSQGLQQILNFIYTSKLLVNSC----NVQDV 89

                         90
                 ....*....|....*..
gi 768023960 120 LTAASYLQLPELAALCR 136
Cdd:cd18231   90 LNAAAVLQMNDIAASCQ 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  25 LPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSL------VLHDNLINLdtDMVSSTVFQQILD 98
Cdd:cd18326    5 FPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLftsgavVDQQNVYEI--DFVSAEALTALLD 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768023960  99 FIYTGKLLPSDQpaepNFSTLLTAASYLQLPELAALC 135
Cdd:cd18326   83 FAYTATLTVSTS----NVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  47 DVIIMVENSIFRAHKNVLAASSIYFKSLVLHD----NLINLDTDMVSSTVFQQILDFIYTGKLLPSDQpaepNFSTLLTA 122
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSmiesNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEE----NVLDLLML 83

                         90
                 ....*....|...
gi 768023960 123 ASYLQLPELAALC 135
Cdd:cd18314   84 ASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  27 SHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSL----VLHDNLINLDTDMVSSTVFQQILDFIYT 102
Cdd:cd18261   10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNLHGVTSLGLKQALDFAYT 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 768023960 103 GKLLpsdqpAEPN-FSTLLTAASYLQLPELAALCRRKL 139
Cdd:cd18261   90 GQIL-----LEPGvIQDVLAAGSHLQLLELLSLCSHYL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLH-----DNLINLDTDMVSStvFQQILDFIYTGKLlpsdQPAEP 114
Cdd:cd18233   13 RIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNsssqkNDVFHLDIKNVGG--IGQILDFMYTSHL----DLNQD 86

                         90       100
                 ....*....|....*....|....*.
gi 768023960 115 NFSTLLTAASYLQLPELAALCRRKLK 140
Cdd:cd18233   87 NVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  24 ELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVL-HDNLINLDTDMVSStvFQQILDFIYT 102
Cdd:cd18206    1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVdQKDVVHLDISNAAG--LGQVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 768023960 103 GKLLPSDQpaepNFSTLLTAASYLQLPELAALC 135
Cdd:cd18206   79 AKLSLSPE----NVDDVLAVATFLQMQDIVTAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  22 DMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSS-TVFQQILDFI 100
Cdd:cd18220    2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNpNVFEQLLSFC 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768023960 101 YTGKLLPSDQpaepNFSTLLTAASYLQLPELAALCRRKLK 140
Cdd:cd18220   82 YTGRMSLQLK----DVVSFLTAASFLQMQCVIDKCTQILE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  28 HSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLP 107
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 768023960 108 SdqpaEPNFSTLLTAASYLQLPELAALCRR 137
Cdd:cd18232   81 T----RENRDRVLLAAKELRVPEAVELCQR 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  23 MELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLD-TDMVSSTVFQQILDFIY 101
Cdd:cd18290    5 MEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVElPAAVQPQSFQQILSFCY 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 768023960 102 TGKLLPS--DQpaepnfSTLLTAASYLQLPEL 131
Cdd:cd18290   85 TGRLSMNvgDQ------FLLMYTAGFLQIQEI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023960  40 RTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHD------NLINLDtDMVSSTVfQQILDFIYTGKLLPSDQpae 113
Cdd:cd18247   14 RRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmveskqDEITMQ-GIEPSAL-EALINFAYSGRIAIDTS--- 88

                         90       100
                 ....*....|....*....|....*...
gi 768023960 114 pNFSTLLTAASYLQLPELAALCRRKLKR 141
Cdd:cd18247   89 -NVQSLLVGASFLQLQSVKDACCEFLKE 115