NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|768023984|ref|XP_011528316|]
View 

GRAM domain-containing protein 4 isoform X8 [Homo sapiens]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11494998)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Gene Ontology:  GO:0016020

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
tolA super family cl35847
cell envelope integrity inner membrane protein TolA; Provisional
 96-151 2.60e-04

cell envelope integrity inner membrane protein TolA; Provisional


The actual alignment was detected with superfamily member PRK09510:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 2.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768023984  96 EELRKLREETNAEMLRQELDRERQRRMELEQ-KVQEVLKARTEEQMAQQPPKGQAQA 151
Cdd:PRK09510  78 EEQRKKKEQQQAEELQQKQAAEQERLKQLEKeRLAAQEQKKQAEEAAKQAALKQKQA 134
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 95-213 1.66e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023984   95 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQAsngAERRSQGLSSRLQKWFYERF 174
Cdd:TIGR02794  65 KEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQA---EEAKAKQAAEAKAKAEAEAE 141

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768023984  175 GEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAK 213
Cdd:TIGR02794 142 RKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAK 180
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 96-151 2.60e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 2.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768023984  96 EELRKLREETNAEMLRQELDRERQRRMELEQ-KVQEVLKARTEEQMAQQPPKGQAQA 151
Cdd:PRK09510  78 EEQRKKKEQQQAEELQQKQAAEQERLKQLEKeRLAAQEQKKQAEEAAKQAALKQKQA 134
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 95-213 1.66e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023984   95 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQAsngAERRSQGLSSRLQKWFYERF 174
Cdd:TIGR02794  65 KEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQA---EEAKAKQAAEAKAKAEAEAE 141

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768023984  175 GEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAK 213
Cdd:TIGR02794 142 RKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAK 180
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 96-151 2.60e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 2.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768023984  96 EELRKLREETNAEMLRQELDRERQRRMELEQ-KVQEVLKARTEEQMAQQPPKGQAQA 151
Cdd:PRK09510  78 EEQRKKKEQQQAEELQQKQAAEQERLKQLEKeRLAAQEQKKQAEEAAKQAALKQKQA 134
PTZ00121 PTZ00121
MAEBL; Provisional
 96-201 5.94e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023984   96 EELRKLREETNAEMLRQEldrERQRRMELEQKVQEVLKArtEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFG 175
Cdd:PTZ00121 1525 DEAKKAEEAKKADEAKKA---EEKKKADELKKAEELKKA--EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMK 1599

                          90       100
                  ....*....|....*....|....*.
gi 768023984  176 EYVEDFRFQPEENTVETEEPLSARRL 201
Cdd:PTZ00121 1600 LYEEEKKMKAEEAKKAEEAKIKAEEL 1625
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 95-213 1.66e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023984   95 QEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQAsngAERRSQGLSSRLQKWFYERF 174
Cdd:TIGR02794  65 KEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQA---EEAKAKQAAEAKAKAEAEAE 141

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768023984  175 GEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAK 213
Cdd:TIGR02794 142 RKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAK 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH