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Conserved domains on  [gi|768024096|ref|XP_011528336|]
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melanoma antigen preferentially expressed in tumors isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
333-421 1.06e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 333 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 412
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                 ....*....
gi 768024096 413 HLIGLSNLT 421
Cdd:COG5238  371 YLEGNTTLR 379
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
216-422 2.63e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 216 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 294
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 295 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 373
Cdd:COG4886  133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768024096 374 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 422
Cdd:COG4886  194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
333-421 1.06e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 333 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 412
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                 ....*....
gi 768024096 413 HLIGLSNLT 421
Cdd:COG5238  371 YLEGNTTLR 379
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-422 2.63e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 216 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 294
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 295 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 373
Cdd:COG4886  133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768024096 374 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 422
Cdd:COG4886  194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
307-420 4.20e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 307 PLETLSITNCRLSEGDVMHLSQS--PSVSQLSVLSLSGVMLTDVSPEPLqALLERASATLQDLVFDECGITDDQLLALLP 384
Cdd:cd00116  109 SLQELKLNNNGLGDRGLRLLAKGlkDLPPALEKLVLGRNRLEGASCEAL-AKALRANRDLKELNLANNGIGDAGIRALAE 187
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768024096 385 SLSHCSQLTTLSFYGNSIS---ISALQSLLQHLIGLSNL 420
Cdd:cd00116  188 GLKANCNLEVLDLNNNGLTdegASALAETLASLKSLEVL 226
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
333-421 1.06e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 333 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 412
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                 ....*....
gi 768024096 413 HLIGLSNLT 421
Cdd:COG5238  371 YLEGNTTLR 379
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
325-421 1.25e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 325 HLSQSPSVSQLSvlsLSGVMLTDVSPEPL-QALLERASATLQDLVfDECgITDDQLLALLPSLSHCSQLTTLSFYGNSIS 403
Cdd:COG5238  203 ALTQNTTVTTLW---LKRNPIGDEGAEILaEALKGNKSLTTLDLS-NNQ-IGDEGVIALAEALKNNTTVETLYLSGNQIG 277
                         90
                 ....*....|....*...
gi 768024096 404 ISALQSLLQHLIGLSNLT 421
Cdd:COG5238  278 AEGAIALAKALQGNTTLT 295
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-422 2.63e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 216 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 294
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 295 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 373
Cdd:COG4886  133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 768024096 374 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 422
Cdd:COG4886  194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
307-420 4.20e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 307 PLETLSITNCRLSEGDVMHLSQS--PSVSQLSVLSLSGVMLTDVSPEPLqALLERASATLQDLVFDECGITDDQLLALLP 384
Cdd:cd00116  109 SLQELKLNNNGLGDRGLRLLAKGlkDLPPALEKLVLGRNRLEGASCEAL-AKALRANRDLKELNLANNGIGDAGIRALAE 187
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768024096 385 SLSHCSQLTTLSFYGNSIS---ISALQSLLQHLIGLSNL 420
Cdd:cd00116  188 GLKANCNLEVLDLNNNGLTdegASALAETLASLKSLEVL 226
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
308-459 7.82e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 7.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 308 LETLSITNCRLSEGDvMHLSQSPSvsqLSVLSLSGVMLTDVsPEPLQAL--LE--RASAT-------------LQDLVFD 370
Cdd:COG4886  184 LKELDLSNNQITDLP-EPLGNLTN---LEELDLSGNQLTDL-PEPLANLtnLEtlDLSNNqltdlpelgnltnLEELDLS 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 371 ECGITDdqllalLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHAR 450
Cdd:COG4886  259 NNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                 ....*....
gi 768024096 451 LRELLCELG 459
Cdd:COG4886  333 LLVTLTTLA 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
278-403 9.09e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 9.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024096 278 SLQCLQALYVD--SLFFLRGrLDQLlrhvmNPLETLSITNCRLSEGDVMH------LSQSPSvsqLSVLSLSGVMLTDVS 349
Cdd:cd21340   66 NLVNLKKLYLGgnRISVVEG-LENL-----TNLEELHIENQRLPPGEKLTfdprslAALSNS---LRVLNISGNNIDSLE 136
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768024096 350 P-EPLQALlerasatlQDLVFDECGITDdqLLALLPSLSHCSQLTTLSFYGNSIS 403
Cdd:cd21340  137 PlAPLRNL--------EQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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