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Conserved domains on  [gi|768024674|ref|XP_011528453|]
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radial spoke head 14 homolog isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 10453181)

armadillo/beta-catenin-like repeat-containing protein; similar to human armadillo repeat-containing protein 1, human radial spoke head 14 homolog, and Bos taurus Rap1 GTPase-GDP dissociation stimulator 1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 4.65e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 4.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024674  220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
PDS5 super family cl48339
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 28-120 1.69e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


The actual alignment was detected with superfamily member pfam20168:

Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 40.65  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674    28 LPKLKEELQSEDLQTRQKALMALCDLMHDPECI-----YKAMnigcmenLKALLK---DSNSMVRIKTTEVL-HITASHS 98
Cdd:pfam20168  244 IPQLEEELKADDVDIRLLATETLGRMFSEPGGSdlakqYPSL-------WKAWLGrfnDKSVAVRIAWVEAAkQILLNHP 316

                           90       100
                   ....*....|....*....|..
gi 768024674    99 vgryaFLEHDIVLALSFLLNDP 120
Cdd:pfam20168  317 -----DLRSEILEALKDRLLDP 333
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 4.65e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 4.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024674  220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 7.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 7.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024674   220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 28-120 1.69e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 40.65  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674    28 LPKLKEELQSEDLQTRQKALMALCDLMHDPECI-----YKAMnigcmenLKALLK---DSNSMVRIKTTEVL-HITASHS 98
Cdd:pfam20168  244 IPQLEEELKADDVDIRLLATETLGRMFSEPGGSdlakqYPSL-------WKAWLGrfnDKSVAVRIAWVEAAkQILLNHP 316

                           90       100
                   ....*....|....*....|..
gi 768024674    99 vgryaFLEHDIVLALSFLLNDP 120
Cdd:pfam20168  317 -----DLRSEILEALKDRLLDP 333
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 26-136 5.11e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 38.94  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674  26 RALPKLKEELQSEDLQTRQKALMALCdLMHDPECIYKAMNIgcmenLKALLKDSNSMVRikTTEVLHITASHSVGRYAFL 105
Cdd:COG5096   92 LAVNTIQKDLQDPNEEIRGFALRTLS-LLRVKELLGNIIDP-----IKKLLTDPHAYVR--KTAALAVAKLYRLDKDLYH 163

                         90       100       110
                 ....*....|....*....|....*....|.
gi 768024674 106 EHDIVLALSFLLNDPSPVCRGNLYKAYMQLV 136
Cdd:COG5096  164 ELGLIDILKELVADSDPIVIANALASLAEID 194
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 4.65e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 4.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024674  220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 7.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 7.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024674   220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 28-120 1.69e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 40.65  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674    28 LPKLKEELQSEDLQTRQKALMALCDLMHDPECI-----YKAMnigcmenLKALLK---DSNSMVRIKTTEVL-HITASHS 98
Cdd:pfam20168  244 IPQLEEELKADDVDIRLLATETLGRMFSEPGGSdlakqYPSL-------WKAWLGrfnDKSVAVRIAWVEAAkQILLNHP 316

                           90       100
                   ....*....|....*....|..
gi 768024674    99 vgryaFLEHDIVLALSFLLNDP 120
Cdd:pfam20168  317 -----DLRSEILEALKDRLLDP 333
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 192-256 2.04e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 2.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768024674  192 VLVLKQKLL-SANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALM 256
Cdd:pfam13646   1 LPALLQALLrDPDPEVRAAAIRAL----------GRIGDPEAVPALLELLKDEDPAVRRAAAEALG 56
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 26-136 5.11e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 38.94  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674  26 RALPKLKEELQSEDLQTRQKALMALCdLMHDPECIYKAMNIgcmenLKALLKDSNSMVRikTTEVLHITASHSVGRYAFL 105
Cdd:COG5096   92 LAVNTIQKDLQDPNEEIRGFALRTLS-LLRVKELLGNIIDP-----IKKLLTDPHAYVR--KTAALAVAKLYRLDKDLYH 163

                         90       100       110
                 ....*....|....*....|....*....|.
gi 768024674 106 EHDIVLALSFLLNDPSPVCRGNLYKAYMQLV 136
Cdd:COG5096  164 ELGLIDILKELVADSDPIVIANALASLAEID 194
HEAT COG1413
HEAT repeat [General function prediction only];
26-135 5.67e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.92  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024674  26 RALPKLKEELQSEDLQTRQKALMALCDLmHDPECIykamnigcmENLKALLKDSNSMVRIKTTEVLhitashsvgrYAFL 105
Cdd:COG1413   47 RAVPALLEALKDPDPEVRAAAAEALGRI-GDPEAV---------PALIAALKDEDPEVRRAAAEAL----------GRLG 106

                         90       100       110
                 ....*....|....*....|....*....|
gi 768024674 106 EHDIVLALSFLLNDPSPVCRGNLYKAYMQL 135
Cdd:COG1413  107 DPAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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