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Conserved domains on  [gi|768026033|ref|XP_011528732|]
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kremen protein 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 33-116 1.84e-26

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


:

Pssm-ID: 238056  Cd Length: 83  Bit Score: 100.92  E-value: 1.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108    3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75


                 ....*..
gi 768026033 110 YCEIPAC 116
Cdd:cd00108   76 YCDIPRC 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 123-229 5.34e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 5.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033 123 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 195
Cdd:cd00041    1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768026033 196 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 229
Cdd:cd00041   81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
 
Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 33-116 1.84e-26

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 100.92  E-value: 1.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108    3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75


                 ....*..
gi 768026033 110 YCEIPAC 116
Cdd:cd00108   76 YCDIPRC 82
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 33-116 8.66e-26

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 99.00  E-value: 8.66e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033    33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDVS-PWCYVAehEDGVYWK 109
Cdd:smart00130   2 ECYAGNGESYRGTVSVTK--SGKPCQRWDSQtpHLHRFTPESFPDL---GLEENYCRNPDGDSEgPWCYTT--DPNVRWE 74


                   ....*..
gi 768026033   110 YCEIPAC 116
Cdd:smart00130  75 YCDIPQC 81
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 123-229 5.34e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 5.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033 123 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 195
Cdd:cd00041    1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768026033 196 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 229
Cdd:cd00041   81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 34-116 8.24e-21

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 85.44  E-value: 8.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033   34 CFTANGADYRGTQNWTAlqGGKPCLFWNETFQH---PYNTLKYPNGegGLGEhNYCRNPDGDVSPWCYVAehEDGVYWKY 110
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE--SGRPCQAWDSQTPHrhsKYTPENFPAK--GLGE-NYCRNPDGDERPWCYTT--DPRVRWEY 73


                  ....*.
gi 768026033  111 CEIPAC 116
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
123-227 5.11e-19

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 81.57  E-value: 5.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033  123 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDS----ADMVELLDGY--THRVLARFHGrSR 196
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPsaSSPLLGRFCG-SG 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768026033  197 PPLSFNVSLDFVILYFFSDRINQAQGFAVLY 227
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 133-227 9.39e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 75.12  E-value: 9.39e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033   133 VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYT--HRVLARFHGRSRPPLSFNVSLD 206
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSasSPLLGRFCGSEAPPPVISSSSN 81

                           90       100
                   ....*....|....*....|.
gi 768026033   207 FVILYFFSDRINQAQGFAVLY 227
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
 
Name Accession Description Interval E-value
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 33-116 1.84e-26

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 100.92  E-value: 1.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033  33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDV-SPWCYVAehEDGVYWK 109
Cdd:cd00108    3 DCYWGNGESYRGTVSTTK--SGKPCQRWNSQlpHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYTT--DPNVRWE 75


                 ....*..
gi 768026033 110 YCEIPAC 116
Cdd:cd00108   76 YCDIPRC 82
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 33-116 8.66e-26

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 99.00  E-value: 8.66e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033    33 ECFTANGADYRGTQNWTAlqGGKPCLFWNET--FQHPYNTLKYPNGeggLGEHNYCRNPDGDVS-PWCYVAehEDGVYWK 109
Cdd:smart00130   2 ECYAGNGESYRGTVSVTK--SGKPCQRWDSQtpHLHRFTPESFPDL---GLEENYCRNPDGDSEgPWCYTT--DPNVRWE 74


                   ....*..
gi 768026033   110 YCEIPAC 116
Cdd:smart00130  75 YCDIPQC 81
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 123-229 5.34e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 5.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033 123 CGGNYSAMSS-VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYTH--RVLARFHGRS 195
Cdd:cd00041    1 CGGTLTASTSgTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTssPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768026033 196 RPPlSFNVSLDFVILYFFSDRINQAQGFAVLYQA 229
Cdd:cd00041   81 LPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 34-116 8.24e-21

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 85.44  E-value: 8.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033   34 CFTANGADYRGTQNWTAlqGGKPCLFWNETFQH---PYNTLKYPNGegGLGEhNYCRNPDGDVSPWCYVAehEDGVYWKY 110
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE--SGRPCQAWDSQTPHrhsKYTPENFPAK--GLGE-NYCRNPDGDERPWCYTT--DPRVRWEY 73


                  ....*.
gi 768026033  111 CEIPAC 116
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
123-227 5.11e-19

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 81.57  E-value: 5.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033  123 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDS----ADMVELLDGY--THRVLARFHGrSR 196
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPsaSSPLLGRFCG-SG 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768026033  197 PPLSFNVSLDFVILYFFSDRINQAQGFAVLY 227
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 133-227 9.39e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 75.12  E-value: 9.39e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026033   133 VVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSA----DMVELLDGYT--HRVLARFHGRSRPPLSFNVSLD 206
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSasSPLLGRFCGSEAPPPVISSSSN 81

                           90       100
                   ....*....|....*....|.
gi 768026033   207 FVILYFFSDRINQAQGFAVLY 227
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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