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Conserved domains on  [gi|768040358|ref|XP_011529516|]
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cyclin-Q isoform X1 [Homo sapiens]

Protein Classification

cyclin-like FAM58 family protein( domain architecture ID 15334275)

cyclin-like FAM58 family protein similar to Homo sapiens cyclin-related protein FAM58A/B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 98-201 5.95e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 172.83  E-value: 5.95e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLQNWLNRHSWQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPAEVEAEKPWWQ 177
Cdd:cd20535    1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                         90       100
                 ....*....|....*....|....
gi 768040358 178 VFNDDLTKPIIDNIVSDLIQIYTM 201
Cdd:cd20535   81 AFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 1-93 1.43e-50

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 159.26  E-value: 1.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   1 MRSIPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDSRFWELRDSIV 80
Cdd:cd20534   18 LSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDKPPLELDDEYWELRDSIV 97

                         90
                 ....*....|...
gi 768040358  81 QCELLMLRVLRFQ 93
Cdd:cd20534   98 NCELLLLRILKFD 110
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 98-201 5.95e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 172.83  E-value: 5.95e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLQNWLNRHSWQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPAEVEAEKPWWQ 177
Cdd:cd20535    1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                         90       100
                 ....*....|....*....|....
gi 768040358 178 VFNDDLTKPIIDNIVSDLIQIYTM 201
Cdd:cd20535   81 AFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 1-93 1.43e-50

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 159.26  E-value: 1.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   1 MRSIPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDSRFWELRDSIV 80
Cdd:cd20534   18 LSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDKPPLELDDEYWELRDSIV 97

                         90
                 ....*....|...
gi 768040358  81 QCELLMLRVLRFQ 93
Cdd:cd20534   98 NCELLLLRILKFD 110
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 7-166 6.75e-19

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 82.47  E-value: 6.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQhlrTRDIINVSNRYFNPSGEPLELDsrfwelRDSIVQCELLM 86
Cdd:COG5333   67 ATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT---PRDISIESFEARDLWSEEPKSS------RERILEYEFEL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  87 LRVLRFQVSFQHPHKYLLHYLVSLQNWLNRHSWQRtpvavtAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVP 166
Cdd:COG5333  138 LEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLLQI------AWKIINDALRTDLCLLYPPHIIALAALLIACEVLGMPII 211
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 7-88 5.31e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 48.36  E-value: 5.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358     7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFnpsgepleldsrfwelRDSIVQCELLM 86
Cdd:smart00385  18 NLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT----------------EEEILRMERLL 81


                   ..
gi 768040358    87 LR 88
Cdd:smart00385  82 LE 83
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 6-112 4.08e-06

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 46.37  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358    6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEqhlrtrdiINVSNRYF--NPSGEPLeldsrfwELRDSIVQCE 83
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEE--------FNVSIDQFvgNLKETPL-------KALEQVLEYE 143

                          90       100
                  ....*....|....*....|....*....
gi 768040358   84 LLMLRVLRFQVSFQHPHKYLLHYLVSLQN 112
Cdd:TIGR00569 144 LLLIQQLNFHLIVHNPYRPLEGFLIDIKT 172
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 98-201 5.95e-56

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 172.83  E-value: 5.95e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLQNWLNRHSWQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPAEVEAEKPWWQ 177
Cdd:cd20535    1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEKPWWQ 80

                         90       100
                 ....*....|....*....|....
gi 768040358 178 VFNDDLTKPIIDNIVSDLIQIYTM 201
Cdd:cd20535   81 AFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 1-93 1.43e-50

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 159.26  E-value: 1.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   1 MRSIPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDSRFWELRDSIV 80
Cdd:cd20534   18 LSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRILHPDKPPLELDDEYWELRDSIV 97

                         90
                 ....*....|...
gi 768040358  81 QCELLMLRVLRFQ 93
Cdd:cd20534   98 NCELLLLRILKFD 110
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 6-92 6.13e-21

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 83.76  E-value: 6.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINV----SNRYFNPSGEPLELD---SRFWELRDS 78
Cdd:cd20532   33 MATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEETPRRLRDVINVfhrlLQRRLGKPAEVLPLDigsAEYEELKND 112

                         90
                 ....*....|....
gi 768040358  79 IVQCELLMLRVLRF 92
Cdd:cd20532  113 IIKAERRILKELGF 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 7-166 6.75e-19

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 82.47  E-value: 6.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQhlrTRDIINVSNRYFNPSGEPLELDsrfwelRDSIVQCELLM 86
Cdd:COG5333   67 ATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT---PRDISIESFEARDLWSEEPKSS------RERILEYEFEL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  87 LRVLRFQVSFQHPHKYLLHYLVSLQNWLNRHSWQRtpvavtAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVP 166
Cdd:COG5333  138 LEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLLQI------AWKIINDALRTDLCLLYPPHIIALAALLIACEVLGMPII 211
CYCLIN_CCNL_rpt2 cd20533
second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 98-201 1.63e-14

second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410236 [Multi-domain]  Cd Length: 92  Bit Score: 66.09  E-value: 1.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLQNWLNRhswqrtPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPaeveAEKPWWQ 177
Cdd:cd20533    1 HPHKFILMYLQVLEGEDNK------KLAQTAWNYMNDSLRTDLCVRYPPEVIACACIYLAARELGIPLP----LPPPWWE 70

                         90       100
                 ....*....|....*....|....
gi 768040358 178 VFndDLTKPIIDNIVSDLIQIYTM 201
Cdd:cd20533   71 LF--DVSKEDIEEICLTILELYTR 92
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 1-92 7.94e-13

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 62.44  E-value: 7.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   1 MRSIPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPL--ELDSRFWELRDS 78
Cdd:cd20545   21 LPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKVEESGRKLRDIVIACAKVAQKNPNLVidEQSKEVWRWRDS 100

                         90
                 ....*....|....
gi 768040358  79 IVQCELLMLRVLRF 92
Cdd:cd20545  101 ILYNEEVLLETLCF 114
CYCLIN_CCNK_rpt2 cd20531
second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA ...
 97-199 1.33e-12

second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410234 [Multi-domain]  Cd Length: 101  Bit Score: 61.20  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  97 QHPHKYLLHYLVSLQNWLNrhswQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPAEV--EAEKP 174
Cdd:cd20531    1 EHPYKYLLKYAKQLKGDKN----KIQKLVQMAWTFVNDSLCTTLCLQWEPEIIAVALMYLAAKLSKFDLQDWTskPPGKR 76

                         90       100
                 ....*....|....*....|....*
gi 768040358 175 WWQVFNDDLTKPIIDNIVSDLIQIY 199
Cdd:cd20531   77 WWEQFVEDVSLEVLEDICHQVLDLY 101
CYCLIN_SpCG1C_ScCTK2-like_rpt2 cd20546
second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces ...
 98-200 1.23e-10

second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2), and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. This group also includes yeast RNA polymerase II holoenzyme cyclin-like subunit, a component of the SRB8-11 complex, a regulatory module of the Mediator complex which is involved in regulation of basal and activated RNA polymerase II-dependent transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410249 [Multi-domain]  Cd Length: 97  Bit Score: 56.22  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLqnwlNRHSWQRtpVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVP-AEVEAEKPWW 176
Cdd:cd20546    1 HPYQYLIKFAKKL----GVSDPKE--LAQLAWAFLNDSYRTPLCLLYPPHVIAAAAIYLAAKLLGIDLElSPNEKLNEWW 74

                         90       100
                 ....*....|....*....|....
gi 768040358 177 QVFndDLTKPIIDNIVSDLIQIYT 200
Cdd:cd20546   75 ELF--GVDEEEIADAINEILDLYS 96
CYCLIN_AcCycT_rpt2 cd20588
second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 97-199 2.04e-10

second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410291 [Multi-domain]  Cd Length: 93  Bit Score: 55.23  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  97 QHPHKYLLhylvslqNWLNRHSWQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPaeVEAEKPWW 176
Cdd:cd20588    1 EHPYKPLV-------AAIKKFNVAQNALAQAAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLP--CDGRKVWW 71

                         90       100
                 ....*....|....*....|...
gi 768040358 177 QVFndDLTKPIIDNIVSDLIQIY 199
Cdd:cd20588   72 QEF--DVTPRQLEEVSNQMLELY 92
CYCLIN_AcCycL_rpt2 cd20594
second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 97-199 1.34e-09

second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410297 [Multi-domain]  Cd Length: 101  Bit Score: 53.33  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  97 QHPHKYLLHYLVSLQnwlnrhswqrTPVAV--TAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPaeveAEKP 174
Cdd:cd20594    3 EHPHKFILNYLAMLM----------APPELrqEAWNLANDSLRTTLCVRFKSEVVACGVVYAAARRFQVPLP----ENPP 68

                         90       100
                 ....*....|....*....|....*
gi 768040358 175 WWQVFndDLTKPIIDNIVSDLIQIY 199
Cdd:cd20594   69 WWKVF--DAEKAEIDVVCKVLADLY 91
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 6-92 1.65e-09

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 53.69  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYF----NPSGEPLELDSR-FWELRDSIV 80
Cdd:cd20591   36 MATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEESPRKIRQVLMVFHRMEcrreNLPLEPLEPESKkYDEMKEDLI 115

                         90
                 ....*....|..
gi 768040358  81 QCELLMLRVLRF 92
Cdd:cd20591  116 RTERHLLKEMGF 127
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 6-92 2.19e-09

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 53.01  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDsrfwELRDSIVQCELL 85
Cdd:cd20530   32 IATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKCKDIIKTARSLLNDKQFAQFGD----DPKEEVMVLERI 107


                 ....*..
gi 768040358  86 MLRVLRF 92
Cdd:cd20530  108 LLQTIKF 114
CYCLIN_CCNL2_rpt2 cd20593
second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 98-200 3.14e-08

second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410296 [Multi-domain]  Cd Length: 123  Bit Score: 50.35  E-value: 3.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLVSLQNWLNRHSWQrtpvavTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPaeveaEKP-WW 176
Cdd:cd20593    1 HPHKIIVMYLQVLECERNRHLVQ------TSWNYMNDSLRTDVFVRFNPETIACACIYLAARTLEIPLP-----NRPhWF 69

                         90       100
                 ....*....|....*....|....
gi 768040358 177 QVFNddLTKPIIDNIVSDLIQIYT 200
Cdd:cd20593   70 LLFG--ATEEEIQEICLKILQLYT 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 7-88 5.31e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 48.36  E-value: 5.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358     7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFnpsgepleldsrfwelRDSIVQCELLM 86
Cdd:smart00385  18 NLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT----------------EEEILRMERLL 81


                   ..
gi 768040358    87 LR 88
Cdd:smart00385  82 LE 83
CYCLIN_CCNL1_rpt1 cd20589
first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 4-92 5.83e-08

first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410292 [Multi-domain]  Cd Length: 124  Bit Score: 49.36  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   4 IPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINV----SNRYFNPSGEPLELDSRFWELRDSI 79
Cdd:cd20589   31 VAMATGQVLFQRFFYSKSFVKHSMEIVAMACINLASKIEEAPRRIRDVINVfhhiKQVRGKRTISPLILDQNYINLKNQV 110

                         90
                 ....*....|...
gi 768040358  80 VQCELLMLRVLRF 92
Cdd:cd20589  111 IKAERRVLKELGF 123
CYCLIN_CCNL2_rpt1 cd20590
first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 4-92 6.86e-08

first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410293 [Multi-domain]  Cd Length: 156  Bit Score: 50.00  E-value: 6.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   4 IPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFN----PSGEPLELDSRFWELRDSI 79
Cdd:cd20590   63 VAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQlrekKKPVPLILDQEYVNLKNQI 142

                         90
                 ....*....|...
gi 768040358  80 VQCELLMLRVLRF 92
Cdd:cd20590  143 IKAERRVLKELGF 155
CYCLIN_CCNL1_rpt2 cd20592
second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 97-200 8.30e-08

second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410295 [Multi-domain]  Cd Length: 123  Bit Score: 49.22  E-value: 8.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  97 QHPHKYLLHYLVSLQnwlnrhsWQRTPVAV-TAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVPaeveaEKP- 174
Cdd:cd20592    1 KHPHKIIVMYLQVLE-------CERNQTLVqTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLP-----NRPh 68

                         90       100
                 ....*....|....*....|....*.
gi 768040358 175 WWQVFNddLTKPIIDNIVSDLIQIYT 200
Cdd:cd20592   69 WFLLFG--ATEEEIQEICITTLKLYT 92
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 6-56 1.33e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 47.41  E-value: 1.33e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSN 56
Cdd:cd00043   20 LELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSG 70
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 6-92 8.14e-07

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 46.36  E-value: 8.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFN---PSG-EPLELDSRFWELRDSIVQ 81
Cdd:cd20587   33 IATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKDVIVVSYEIIFkkdPSAaQRIKQKEVYEQQKELVLN 112

                         90
                 ....*....|.
gi 768040358  82 CELLMLRVLRF 92
Cdd:cd20587  113 GEKLVLSTLGF 123
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 4-93 9.40e-07

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 46.58  E-value: 9.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   4 IPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDSR-FWELRDSIVQC 82
Cdd:cd20596   49 LTINTAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEEQPRKLEHVIKVAHACLNPLEPQLDTKSDaYLQQAQELVIL 128

                         90
                 ....*....|.
gi 768040358  83 ELLMLRVLRFQ 93
Cdd:cd20596  129 ETIMLQTLGFE 139
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 6-90 1.14e-06

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 45.28  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATAcTIYHK-FFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDsrfwelRDSIVQCEL 84
Cdd:cd20513   23 IATA-IVYFKrFYARNSFKDIDPRLVAPTCLYLASKVEECPSHARLIVAEAKVLKTKFSYEFPYR------VNDILECEF 95


                 ....*.
gi 768040358  85 LMLRVL 90
Cdd:cd20513   96 YLLEAL 101
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 4-92 3.13e-06

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 45.07  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   4 IPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDS-RFWELRDSIVQC 82
Cdd:cd20538   47 LCINTAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKVEEQPRKLEHVIKVAHACLHRGEPDLDTKSeAYLQQAQELVIN 126

                         90
                 ....*....|
gi 768040358  83 ELLMLRVLRF 92
Cdd:cd20538  127 ENILLQTLGF 136
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 6-112 4.08e-06

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 46.37  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358    6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEqhlrtrdiINVSNRYF--NPSGEPLeldsrfwELRDSIVQCE 83
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEE--------FNVSIDQFvgNLKETPL-------KALEQVLEYE 143

                          90       100
                  ....*....|....*....|....*....
gi 768040358   84 LLMLRVLRFQVSFQHPHKYLLHYLVSLQN 112
Cdd:TIGR00569 144 LLLIQQLNFHLIVHNPYRPLEGFLIDIKT 172
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 6-92 1.66e-05

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 42.33  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPLELDSrFWELRDSIVQCELL 85
Cdd:cd20547   23 LGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQKKSKDILAASYNLRHPDKISVDDQM-LEEFRKAILGLERL 101


                 ....*..
gi 768040358  86 MLRVLRF 92
Cdd:cd20547  102 LLETICF 108
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 4-93 1.99e-04

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 40.04  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   4 IPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSgEPLElDSR---FWELRDSIV 80
Cdd:cd20595   48 LTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQ-ESLP-DTRseaYLQQVQDLV 125

                         90
                 ....*....|...
gi 768040358  81 QCELLMLRVLRFQ 93
Cdd:cd20595  126 ILESIILQTLGFE 138
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 7-93 6.36e-04

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 38.73  E-value: 6.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINvsnrYFNPSGEPLEldsrfwelrdSIVQCELLM 86
Cdd:cd20524   77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVG----NIKESEKTAE----------IILEYELLL 142


                 ....*..
gi 768040358  87 LRVLRFQ 93
Cdd:cd20524  143 LQGLNFH 149
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 7-51 9.06e-04

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 38.66  E-value: 9.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 768040358   7 ATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDI 51
Cdd:cd20585  100 ATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEEL 144
CYCLIN_CCNC_rpt2 cd20514
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 98-199 1.24e-03

second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410218 [Multi-domain]  Cd Length: 92  Bit Score: 36.83  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358  98 HPHKYLLHYLvslqnwlnRHSWQRTPVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVEVpaeveaeKPWWQ 177
Cdd:cd20514    1 HPYRPLTQYV--------QDAGLDDELLPLAWRIVNDSYRTDVCLLYPPYLIALACLHMACVLLQKDA-------RQWFA 65

                         90       100
                 ....*....|....*....|..
gi 768040358 178 VFNDDLTKpiIDNIVSDLIQIY 199
Cdd:cd20514   66 ELNVDMDK--ILEITREILSLY 85
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 6-92 1.44e-03

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 36.76  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040358   6 IATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQHLRTRDIINVSNRYFNPSGEPleldsrfWELRDsIVQCELL 85
Cdd:cd20571   28 VATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLLVFYMKRLYADEYHR-------YEIKD-ILEMEMK 99


                 ....*..
gi 768040358  86 MLRVLRF 92
Cdd:cd20571  100 LLEALDY 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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