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Conserved domains on  [gi|768040916|ref|XP_011529761|]
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histone demethylase UTY isoform X21 [Homo sapiens]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 11421451)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

CATH:  1.25.40.10|2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0005515|GO:0032452|GO:0031490|GO:0046872
PubMed:  26059336|21153002|10517866|30708253|22404999|11165500|14697267|19478949
SCOP:  4001344|3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1193-1301 3.23e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.89  E-value: 3.23e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  1193 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1265
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 768040916  1266 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1301
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 168-445 3.76e-26

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 109.82  E-value: 3.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  168 LRLGLMFKVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLpaqvKATVLQQLG 247
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD----RAEALLELA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  248 WMHHNMDLVgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Cdd:COG2956    84 QDYLKAGLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKrcSNTSTLAARIKFLQAQLCNLPQ--SS 405
Cdd:COG2956   157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalEL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 768040916  406 LQNKTKLLPSIEEAWSLpipAELTSRQGAMNTAQQAYRAH 445
Cdd:COG2956   235 LRKALELDPSDDLLLAL---ADLLERKEGLEAALALLERQ 271
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 95-230 4.05e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 4.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   95 QLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFcraKEIHLRLGLMF 174
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPD---NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE---PEARLNLGLAL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916  175 KVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQ 230
Cdd:COG4783    83 LKAGDYDEALALLEKAL-KLDP---EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1159-1223 6.98e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.98e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916   1159 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1223
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1193-1301 3.23e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.89  E-value: 3.23e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  1193 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1265
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 768040916  1266 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1301
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 168-445 3.76e-26

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 109.82  E-value: 3.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  168 LRLGLMFKVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLpaqvKATVLQQLG 247
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD----RAEALLELA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  248 WMHHNMDLVgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Cdd:COG2956    84 QDYLKAGLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKrcSNTSTLAARIKFLQAQLCNLPQ--SS 405
Cdd:COG2956   157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalEL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 768040916  406 LQNKTKLLPSIEEAWSLpipAELTSRQGAMNTAQQAYRAH 445
Cdd:COG2956   235 LRKALELDPSDDLLLAL---ADLLERKEGLEAALALLERQ 271
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 95-230 4.05e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 4.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   95 QLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFcraKEIHLRLGLMF 174
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPD---NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE---PEARLNLGLAL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916  175 KVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQ 230
Cdd:COG4783    83 LKAGDYDEALALLEKAL-KLDP---EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 84-419 4.74e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646

                          330       340
                   ....*....|....*....|..
gi 768040916   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1159-1223 6.98e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.98e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916   1159 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1223
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 167-231 5.22e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 40.80  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768040916  167 HLRLGLMFK-VNTDYKSSLKHFQLALIDCNPCTLS--NAE---IQFHIAHLYEtqrKYHSAKEAYEQLLQT 231
Cdd:cd24145    10 ILRKALYYEsDKPDPQKALKYYKEALEQADELGMDpfSDEvtgIRIKIAEMLE---KLGMYKAAYEVLERL 77
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 6.06e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 6.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 768040916   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_17 pfam13431
Tetratricopeptide repeat;
269-300 8.67e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.21  E-value: 8.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 768040916   269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1193-1301 3.23e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.89  E-value: 3.23e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  1193 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1265
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 768040916  1266 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1301
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 168-445 3.76e-26

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 109.82  E-value: 3.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  168 LRLGLMFKVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLpaqvKATVLQQLG 247
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD----RAEALLELA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  248 WMHHNMDLVgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Cdd:COG2956    84 QDYLKAGLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKrcSNTSTLAARIKFLQAQLCNLPQ--SS 405
Cdd:COG2956   157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalEL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 768040916  406 LQNKTKLLPSIEEAWSLpipAELTSRQGAMNTAQQAYRAH 445
Cdd:COG2956   235 LRKALELDPSDDLLLAL---ADLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 127-377 8.56e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 105.58  E-value: 8.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  127 AAFLYG---LGLVYFYYNAFHWAIKAFQDVLYVDPSfcrAKEIHLRLGLMFKVNTDYKSSLKHFQlALIDCNPctlSNAE 203
Cdd:COG2956     5 VAAALGwyfKGLNYLLNGQPDKAIDLLEEALELDPE---TVEAHLALGNLYRRRGEYDRAIRIHQ-KLLERDP---DRAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  204 IQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLPAQVK-ATVLQQLG-WmhhnmdlvgDKatkesyAIQYLQKSLEADPN 279
Cdd:COG2956    78 ALLELAQDYLKAGLLDRAEELLEKLLELDpdDAEALRLlAEIYEQEGdW---------EK------AIEVLERLLKLGPE 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  280 SGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLY 359
Cdd:COG2956   143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                         250
                  ....*....|....*...
gi 768040916  360 ESCNQPQDAIKCYLNAAR 377
Cdd:COG2956   223 EKLGDPEEALELLRKALE 240
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
201-446 1.39e-24

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 104.32  E-value: 1.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  201 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQVKAtvLQQLGWMHHNMdlvGDKATkesyAIQYLQKSLEADPNS 280
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELD--PDDAEA--LYNLGLAYLRL---GRYEE----ALADYEQALELDPDD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  281 GQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  361 SCNQPQDAIKCYlNAARSKRCSNTSTLAARIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQ 440
Cdd:COG0457   156 KLGRYEEALELL-EKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALR 234


                  ....*.
gi 768040916  441 AYRAHD 446
Cdd:COG0457   235 LAALAL 240
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 266-372 8.66e-20

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 8.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG4235     2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                          90       100
                  ....*....|....*....|....*..
gi 768040916  346 HGHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:COG4235    82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 72-377 2.87e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 89.40  E-value: 2.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLILKAEGKVESDFfcQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG2956    26 KAIDLLEEALELDPETVEAHL--ALGNLYRRRGEYDRAIRIHQKLLERDPD---RAEALLELAQDYLKAGLLDRAEELLE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  152 DVLYVDPsfcrakeihlrlglmfkvntdyksslkhfqlalidcnpctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT 231
Cdd:COG2956   101 KLLELDP-----------------------------------------DDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  232 ENLPAQV---KATVLQQLgwmhhnmdlvGDKATkesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSI 308
Cdd:COG2956   140 GPENAHAyceLAELYLEQ----------GDYDE----AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERAL 205

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768040916  309 DKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGhAAAWMDLGTLYESCNQPQDAIKCYLNAAR 377
Cdd:COG2956   206 EQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLR 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
274-375 2.64e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.83  E-value: 2.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  274 LEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWM 353
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                          90       100
                  ....*....|....*....|..
gi 768040916  354 DLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457    81 NLGLALQALGRYEEALEDYDKA 102
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
125-316 3.23e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.83  E-value: 3.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  125 KNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKHFQLALiDCNPctlSNAEI 204
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA---LYNLGLAYLRLGRYEEALADYEQAL-ELDP---DDAEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  205 QFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQVKAtvLQQLGWMHHNMdlvGDKATkesyAIQYLQKSLEADPNSGQSW 284
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELD--PDDAEA--LYNLGLALLEL---GRYDE----AIEAYERALELDPDDADAL 147

                         170       180       190
                  ....*....|....*....|....*....|..
gi 768040916  285 YFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 316
Cdd:COG0457   148 YNLGIALEKLGRYEEALELLEKLEAAALAALL 179
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 186-421 7.42e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 89.28  E-value: 7.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  186 HFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVK--------ATVLQQLGWMHHNMDLVG 257
Cdd:COG3914     6 LLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALlalaageaAAAAAALLLLAALLELAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  258 DKATKESY---AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDA 334
Cdd:COG3914    86 LLLQALGRyeeALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  335 LQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAQLCNLPQSS-LQNKTKLL 413
Cdd:COG3914   166 IAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRAL--ELDPDNADAHSNLLFALRQACDWEVYDrFEELLAAL 243


                  ....*...
gi 768040916  414 PSIEEAWS 421
Cdd:COG3914   244 ARGPSELS 251
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 266-377 3.83e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 73.69  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG4783    23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                          90       100       110
                  ....*....|....*....|....*....|..
gi 768040916  346 HGHAAAWMDLGTLYESCNQPQDAIKCYLNAAR 377
Cdd:COG4783   103 PEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 202-345 1.13e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.45  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  202 AEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQVKAtvLQQLGWMHHNMdlvGDKATkesyAIQYLQKSLEADPNSG 281
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELD--PDNPEA--FALLGEILLQL---GDLDE----AIVLLHEALELDPDEP 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768040916  282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG4783    73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
72-277 1.23e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLILKAEGKVESdfFCQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG0457    26 EAIEDYEKALELDPDDAEA--LYNLGLAYLRLGRYEEALADYEQALELDPD---DAEALNNLGLALQALGRYEEALEDYD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  152 DVLYVDPSFCRAK----EIHLRLGlmfkvntDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQ 227
Cdd:COG0457   101 KALELDPDDAEALynlgLALLELG-------RYDEAIEAYERAL-ELDP---DDADALYNLGIALEKLGRYEEALELLEK 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 768040916  228 LLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD 277
Cdd:COG0457   170 LEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 72-277 5.54e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLILKAEGKVESdfFCQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG2956    94 RAEELLEKLLELDPDDAEA--LRLLAEIYEQEGDWEKAIEVLERLLKLGPE---NAHAYCELAELYLEQGDYDEAIEALE 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  152 DVLYVDPSFCRAK----EIHLRLGlmfkvntDYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQ 227
Cdd:COG2956   169 KALKLDPDCARALlllaELYLEQG-------DYEEAIAALE-RALEQDP---DYLPALPRLAELYEKLGDPEEALELLRK 237

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 768040916  228 LLQTENLPAQV--KATVLQQLGwmhhnmdlvGDKAtkesyAIQYLQKSLEAD 277
Cdd:COG2956   238 ALELDPSDDLLlaLADLLERKE---------GLEA-----ALALLERQLRRH 275
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
266-345 1.52e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.03  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAfISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG3063    11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 95-230 4.05e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 4.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   95 QLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFcraKEIHLRLGLMF 174
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPD---NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE---PEARLNLGLAL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916  175 KVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQ 230
Cdd:COG4783    83 LKAGDYDEALALLEKAL-KLDP---EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-370 2.80e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.77  E-value: 2.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  275 EADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMD 354
Cdd:COG4785    67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                          90
                  ....*....|....*.
gi 768040916  355 LGTLYESCNQPQDAIK 370
Cdd:COG4785   147 RGIALYYLGRYELAIA 162
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 95-191 5.03e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   95 QLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMF 174
Cdd:COG4235    22 LLGRAYLRLGRYDEALAAYEKALRLDPD---NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEA---LYLLGLAA 95

                          90
                  ....*....|....*..
gi 768040916  175 KVNTDYKSSLKHFQLAL 191
Cdd:COG4235    96 FQQGDYAEAIAAWQKLL 112
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 266-345 5.36e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 56.51  E-value: 5.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG5010    73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 282-377 6.84e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 6.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYES 361
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90
                  ....*....|....*.
gi 768040916  362 CNQPQDAIKCYLNAAR 377
Cdd:COG4783    85 AGDYDEALALLEKALK 100
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 266-378 2.39e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG5010    39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                          90       100       110
                  ....*....|....*....|....*....|...
gi 768040916  346 HGHAAAWMDLGTLYESCNQPQDAIKCYLNAARS 378
Cdd:COG5010   119 PDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 201-316 2.73e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.86  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  201 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAqvKATVLQQLGWMhhnmdLVGDKATKEsyAIQYLQKSLEADPNS 280
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLD--PD--NADALLDLAEA-----LLAAGDTEE--AEELLERALALDPDN 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768040916  281 GQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 316
Cdd:COG4235    85 PEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 283-448 3.11e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 3.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESC 362
Cdd:COG2956    10 GWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  363 NQPQDAIKCYLNAARSKRcSNTSTLAARIKFLQAQlcNLPQSSLQNKTKLLPSI-EEAWSLPIPAELTSRQGAMNTAQQA 441
Cdd:COG2956    90 GLLDRAEELLEKLLELDP-DDAEALRLLAEIYEQE--GDWEKAIEVLERLLKLGpENAHAYCELAELYLEQGDYDEAIEA 166

                         170
                  ....*....|
gi 768040916  442 YR---AHDPN 448
Cdd:COG2956   167 LEkalKLDPD 176
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 84-419 4.74e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646

                          330       340
                   ....*....|....*....|..
gi 768040916   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
290-377 6.07e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 6.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  290 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQaYICAVQLDHGHAAAWMDLGTLYESCNQPQDAI 369
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                  ....*...
gi 768040916  370 KCYLNAAR 377
Cdd:COG3063    80 AYLERALE 87
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 1159-1223 6.98e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.98e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768040916   1159 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1223
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 72-191 4.56e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 4.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLIlkAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG4783    22 EAEALLEKAL--ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD---EPEARLNLGLALLKAGDYDEALALLE 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 768040916  152 DVLYVDPSFcraKEIHLRLGLMFKVNTDYKSSLKHFQLAL 191
Cdd:COG4783    97 KALKLDPEH---PEAYLRLARAYRALGRPDEAIAALEKAL 133
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 266-338 4.35e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 4.35e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768040916  266 AIQYLQKSLEADPNS---GQSWYFLGRCYSSIGKVQDAFISYRQSID---KSEASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG1729    12 AIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELGDYDKARATL 90
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 127-280 5.10e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKHFQLALIDcNPctlSNAEIQF 206
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEA---FALLGEILLQLGDLDEAIVLLHEALEL-DP---DEPEARL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768040916  207 HIAHLYETQRKYHSAKEAYEQLLQTEnlPAQvkATVLQQLGWMHHNMdlvGDKAtkesYAIQYLQKSLEADPNS 280
Cdd:COG4783    77 NLGLALLKAGDYDEALALLEKALKLD--PEH--PEAYLRLARAYRAL---GRPD----EAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 108-278 8.63e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.26  E-value: 8.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  108 KALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGlmfkvntDYKSSLKHF 187
Cdd:COG5010     5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLG-------DFEESLALL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  188 QLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQVKAtvlqqlgwmHHNMDLVGDKATKESYAI 267
Cdd:COG5010    78 EQAL-QLDP---NNPELYYNLALLYSRSGDKDEAKEYYEKALALS--PDNPNA---------YSNLAALLLSLGQDDEAK 142

                         170
                  ....*....|.
gi 768040916  268 QYLQKSLEADP 278
Cdd:COG5010   143 AALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 100-234 1.75e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  100 NLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHW------AIKAFQDVLYVDPSFcraKEIHLRLGLM 173
Cdd:COG5010    21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKlgdfeeSLALLEQALQLDPNN---PELYYNLALL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768040916  174 FKVNTDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENL 234
Cdd:COG5010    98 YSRSGDKDEAKEYYEKAL-ALSP---DNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 162-372 1.79e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.31  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   162 RAKEIHLRLGLMFKVNTDYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLPAQVk 239
Cdd:TIGR02917  599 DSPEAWLMLGRAQLAAGDLNKAVSSFK-KLLALQP---DSALALLLLADAYAVMKNYAKAITSLKRALELKpdNTEAQI- 673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   240 atVLQQLgwmhhnmdLVGDKATKESYAI-QYLQKsleADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIdKSEASADTW 318
Cdd:TIGR02917  674 --GLAQL--------LLAAKRTESAKKIaKSLQK---QHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL-KRAPSSQNA 739

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 768040916   319 CSIGVLYQQQNQPMDALQAYIcAVQLDH-GHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  740 IKLHRALLASGNTAEAVKTLE-AWLKTHpNDAVLRTALAELYLAQKDYDKAIKHY 793
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 108-246 3.37e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  108 KALSAYQRYysLQADYwKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFcraKEIHLRLGLMFKVNTDYKSSLKHF 187
Cdd:COG4235     1 EAIARLRQA--LAANP-NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDN---ADALLDLAEALLAAGDTEEAEELL 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768040916  188 QLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLqtENLPAQVKATVLQQL 246
Cdd:COG4235    75 ERAL-ALDP---DNPEALYLLGLAAFQQGDYAEAIAAWQKLL--ALLPADAPARLLEAS 127
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 105-372 5.21e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 5.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   105 DYSKALSAYQRYYSLQADYWkNAAFLygLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKE----IHLRLGLMfkvnTDY 180
Cdd:TIGR02917  276 NYEDARETLQDALKSAPEYL-PALLL--AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRllasIQLRLGRV----DEA 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   181 KSSLKHFqLALIDCNPCTLSNAEIqfhiAHLyeTQRKYHSAKEAYEQLlqTENLPAQVKATVLQQLGWMHHNmdlvgdka 260
Cdd:TIGR02917  349 IATLSPA-LGLDPDDPAALSLLGE----AYL--ALGDFEKAAEYLAKA--TELDPENAAARTQLGISKLSQG-------- 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   261 tKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Cdd:TIGR02917  412 -DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEK 490

                          250       260       270
                   ....*....|....*....|....*....|..
gi 768040916   341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  491 ALSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 82-317 5.92e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 5.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916    82 LKAEGKVESDFF-CQLGHFNLLLEDySKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:TIGR02917  658 LKRALELKPDNTeAQIGLAQLLLAA-KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSS 736

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   161 CRAKEIHLRLGLmfkvNTDYKSSLKHFQLALIDcNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTenlpAQVKA 240
Cdd:TIGR02917  737 QNAIKLHRALLA----SGNTAEAVKTLEAWLKT-HP---NDAVLRTALAELYLAQKDYDKAIKHYQTVVKK----APDNA 804

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768040916   241 TVLQQLGWMHHNMdlvgdkatKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  805 VVLNNLAWLYLEL--------KDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAI 873
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 72-158 1.17e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLILKAEGkvESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG5010    72 ESLALLEQALQLDPN--NPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---NPNAYSNLAALLLSLGQDDEAKAALQ 146


                  ....*..
gi 768040916  152 DVLYVDP 158
Cdd:COG5010   147 RALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
136-230 1.30e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  136 VYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKhFQLALiDCNPctlSNAEIQFHIAHLYETQ 215
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADA---LNNLGLLLLEQGRYDEAIA-LEKAL-KLDP---NNAEALLNLAELLLEL 72

                          90
                  ....*....|....*
gi 768040916  216 RKYHSAKEAYEQLLQ 230
Cdd:COG3063    73 GDYDEALAYLERALE 87
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 105-191 2.63e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.90  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  105 DYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSL 184
Cdd:COG1729     8 DYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLELGDYDKAR 87


                  ....*..
gi 768040916  185 KHFQLAL 191
Cdd:COG1729    88 ATLEELI 94
TPR COG0790
TPR repeat [General function prediction only];
202-377 3.96e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 43.76  E-value: 3.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  202 AEIQFHIAHLYE----TQRKYHSAKEAYEQLLQTENLPAQVkatvlqQLGWMHHNmdlvGdKATKESY--AIQYLQKSle 275
Cdd:COG0790    63 AEAQYNLGLMYAegrgVPKDYEKALEWFEKAAEQGDAEAQY------NLGLMYEE----G-LGVPQDYakALEWYEKA-- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  276 ADPNSGQSWYFLGRCYSS-IGKVQD---AFISYRQSIDKSEASADTwcSIGVLYQQ-QNQPMD---ALQAYICAVqlDHG 347
Cdd:COG0790   130 AEQGDADAQYNLGLLYLNgEGVPKDpakAAEWYRKAAEQGDADAQY--NLGVLYENgRGVPKDpakALEWYRKAA--EQG 205

                         170       180       190
                  ....*....|....*....|....*....|....
gi 768040916  348 HAAAWMDLGTLYESCNQ-PQD---AIKCYLNAAR 377
Cdd:COG0790   206 DADAQYNLGRLYLNGEGvEKDlekALRWLRKAAE 239
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 146-231 4.35e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.13  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  146 AIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQlALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAY 225
Cdd:COG1729    12 AIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFE-KLLKRYPDSPKAPDALLKLGLSYLELGDYDKARATL 90


                  ....*.
gi 768040916  226 EQLLQT 231
Cdd:COG1729    91 EELIKK 96
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
93-163 5.07e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.98  E-value: 5.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768040916   93 FCQLGHFNLLLEDYSKALSAYQRYYSLQADYwknAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRA 163
Cdd:COG4785   110 YNNRGLAYLLLGDYDAALEDFDRALELDPDY---AYAYLNRGIALYYLGRYELAIADLEKALELDPNDPER 177
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 201-347 5.40e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 43.75  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  201 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQtenlpAQVKATVLQQLGwmhhnmDLVGDKATKesyAIQYLQKSLEADPNS 280
Cdd:COG3071   192 DPELAAAYARALIALGDHDEAERLLREALK-----RQWDPRLVRLYG------RLQGGDPAK---QLKRAEKWLKKHPND 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  281 GQSWYFLGR-CYSS--IGKVQDAFisyRQSIdKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHG 347
Cdd:COG3071   258 PDLLLALGRlCLRNqlWGKAREYL---EAAL-ALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 179-280 1.24e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  179 DYKSSLKHFQlALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQVKA-TVLQQLGWMHHNMdlvG 257
Cdd:COG1729     8 DYDEAIAAFK-AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRY--PDSPKApDALLKLGLSYLEL---G 81

                          90       100
                  ....*....|....*....|...
gi 768040916  258 DKATkesyAIQYLQKSLEADPNS 280
Cdd:COG1729    82 DYDK----ARATLEELIKKYPDS 100
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
101-191 1.55e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  101 LLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIkAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDY 180
Cdd:COG3063     3 LKLGDLEEAEEYYEKALELDPD---NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEA---LLNLAELLLELGDY 75

                          90
                  ....*....|.
gi 768040916  181 KSSLKHFQLAL 191
Cdd:COG3063    76 DEALAYLERAL 86
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 215-310 2.51e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.20  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  215 QRKYHSAKEAYEQLLQtENLPAQVKATVLQQLGWMHHNMdlvGDKATkesyAIQYLQKSLEADPNS---GQSWYFLGRCY 291
Cdd:COG1729     6 AGDYDEAIAAFKAFLK-RYPNSPLAPDALYWLGEAYYAL---GDYDE----AAEAFEKLLKRYPDSpkaPDALLKLGLSY 77

                          90
                  ....*....|....*....
gi 768040916  292 SSIGKVQDAFISYRQSIDK 310
Cdd:COG1729    78 LELGDYDKARATLEELIKK 96
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 133-317 2.60e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 41.17  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   133 LGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKHFQLALidcnpcTLSNAEIQFHI---A 209
Cdd:TIGR02521   37 LALGYLEQGDLEVAKENLDKALEHDPDDYLA---YLALALYYQQLGELEKAEDSFRRAL------TLNPNNGDVLNnygT 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   210 HLYEtQRKYHSAKEAYEQLLQTENLPAQVKAtvlqqlgwmHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Cdd:TIGR02521  108 FLCQ-QGKYEQAMQQFEQAIEDPLYPQPARS---------LENAGLCALKAGDFDKAEKYLTRALQIDPQRPESLLELAE 177

                          170       180
                   ....*....|....*....|....*...
gi 768040916   290 CYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02521  178 LYYLRGQYKDARAYLERYQQTYNQTAES 205
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
166-279 2.87e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  166 IHLRLGlmfkvntDYKSSLKHFQLALiDCNPctlSNAEIQFHIAHLYETQRKYHSAkEAYEQLLQTEnlPAQVKAtvLQQ 245
Cdd:COG3063     1 LYLKLG-------DLEEAEEYYEKAL-ELDP---DNADALNNLGLLLLEQGRYDEA-IALEKALKLD--PNNAEA--LLN 64

                          90       100       110
                  ....*....|....*....|....*....|....
gi 768040916  246 LGWMHHNMdlvGDKATkesyAIQYLQKSLEADPN 279
Cdd:COG3063    65 LAELLLEL---GDYDE----ALAYLERALELDPS 91
TPR COG0790
TPR repeat [General function prediction only];
215-377 3.94e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 40.68  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  215 QRKYHSAKEAYEQLLQTENLPAQVkatvlqQLGWMHHNMDLVgDKATKEsyAIQYLQKSleADPNSGQSWYFLGRCYSS- 293
Cdd:COG0790    44 AAGAAAAAAAAAAAAAAGGAEAQY------NLGLMYAEGRGV-PKDYEK--ALEWFEKA--AEQGDAEAQYNLGLMYEEg 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  294 IGKVQD---AFISYRQSIDKSEASAdtWCSIGVLYQQ-QNQPMDALQA---YICAVqlDHGHAAAWMDLGTLYES---CN 363
Cdd:COG0790   113 LGVPQDyakALEWYEKAAEQGDADA--QYNLGLLYLNgEGVPKDPAKAaewYRKAA--EQGDADAQYNLGVLYENgrgVP 188

                         170
                  ....*....|....*
gi 768040916  364 Q-PQDAIKCYLNAAR 377
Cdd:COG0790   189 KdPAKALEWYRKAAE 203
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
72-162 4.53e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   72 KAVRCYESLILKAEGkvESDFFCQLGHFNLLLEDYSKALsAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKAFQ 151
Cdd:COG3063    10 EAEEYYEKALELDPD--NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPN---NAEALLNLAELLLELGDYDEALAYLE 83

                          90
                  ....*....|.
gi 768040916  152 DVLYVDPSFCR 162
Cdd:COG3063    84 RALELDPSALR 94
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 70-238 4.93e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916   70 LGKAVRCYESLILKAEGKVEsdFFCQLGHFNLLLEDYSKALSAYQRYYSLQADywkNAAFLYGLGLVYFYYNAFHWAIKA 149
Cdd:COG3914   128 LEEALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPD---NAEALNNLGNALQDLGRLEEAIAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040916  150 FQDVLYVDPSFCRAkeIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNaeiqFHIAHLY----ETQRKYHsakEAY 225
Cdd:COG3914   203 YRRALELDPDNADA--HSNLLFALRQACDWEVYDRFEELLAALARGPSELSP----FALLYLPdddpAELLALA---RAW 273

                         170
                  ....*....|...
gi 768040916  226 EQLLQTENLPAQV 238
Cdd:COG3914   274 AQLVAAAAAPELP 286
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 167-231 5.22e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 40.80  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768040916  167 HLRLGLMFK-VNTDYKSSLKHFQLALIDCNPCTLS--NAE---IQFHIAHLYEtqrKYHSAKEAYEQLLQT 231
Cdd:cd24145    10 ILRKALYYEsDKPDPQKALKYYKEALEQADELGMDpfSDEvtgIRIKIAEMLE---KLGMYKAAYEVLERL 77
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 6.06e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 6.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 768040916   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_17 pfam13431
Tetratricopeptide repeat;
269-300 8.67e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.21  E-value: 8.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 768040916   269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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