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Conserved domains on  [gi|767930847|ref|XP_011529820|]
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protein FAM13A isoform X11 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-40 1.17e-17

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04393:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 189  Bit Score: 81.74  E-value: 1.17e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767930847   1 MNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILEN 40
Cdd:cd04393  150 MTAENLAAVFGPDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-40 1.17e-17

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 81.74  E-value: 1.17e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767930847   1 MNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILEN 40
Cdd:cd04393  150 MTAENLAAVFGPDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-41 5.18e-05

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 44.56  E-value: 5.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767930847     1 MNVHNLATVFGPNCFHVPPG-LEGMKEQDLCNKIMAKILENY 41
Cdd:smart00324 133 MTARNLAIVFGPTLLRPPDGeVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1-19 4.94e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 38.29  E-value: 4.94e-03
                          10
                  ....*....|....*....
gi 767930847    1 MNVHNLATVFGPNCFHVPP 19
Cdd:pfam00620 130 MNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-40 1.17e-17

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 81.74  E-value: 1.17e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767930847   1 MNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILEN 40
Cdd:cd04393  150 MTAENLAAVFGPDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-41 5.18e-05

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 44.56  E-value: 5.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767930847     1 MNVHNLATVFGPNCFHVPPG-LEGMKEQDLCNKIMAKILENY 41
Cdd:smart00324 133 MTARNLAIVFGPTLLRPPDGeVASLKDIRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-40 7.75e-05

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 44.21  E-value: 7.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767930847   1 MNVHNLATVFGPNCFHVP-PGLEGMKEQDLCNKIMAKILEN 40
Cdd:cd00159  129 MTASNLAIVFAPTLLRPPdSDDELLEDIKKLNEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1-19 4.94e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 38.29  E-value: 4.94e-03
                          10
                  ....*....|....*....
gi 767930847    1 MNVHNLATVFGPNCFHVPP 19
Cdd:pfam00620 130 MNAHNLAIVFGPTLLRPPD 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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