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N-acylethanolamine-hydrolyzing acid amidase isoform X9 [Homo sapiens]
NAAA-beta and Ntn_AC_NAAA domain-containing protein( domain architecture ID 10634631)
NAAA-beta and Ntn_AC_NAAA domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
Ntn_AC_NAAA | cd01903 | AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ... |
117-323 | 2.15e-124 | ||||
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC. : Pssm-ID: 238886 Cd Length: 231 Bit Score: 355.81 E-value: 2.15e-124
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NAAA-beta | pfam15508 | beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ... |
32-91 | 2.99e-12 | ||||
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275. : Pssm-ID: 464754 Cd Length: 63 Bit Score: 60.72 E-value: 2.99e-12
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Name | Accession | Description | Interval | E-value | ||||
Ntn_AC_NAAA | cd01903 | AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ... |
117-323 | 2.15e-124 | ||||
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC. Pssm-ID: 238886 Cd Length: 231 Bit Score: 355.81 E-value: 2.15e-124
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NAAA-beta | pfam15508 | beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ... |
32-91 | 2.99e-12 | ||||
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275. Pssm-ID: 464754 Cd Length: 63 Bit Score: 60.72 E-value: 2.99e-12
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C45_proenzyme | NF040521 | C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases ... |
59-266 | 3.07e-11 | ||||
C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases and N-acyltransferases, and belong to the Ntn (N-terminal nucleophile) hydrolase family. Members have an invariant Cys residue (Cys-103 in XP_002569112.1) required both for autoproteolytic processing into alpha and beta chains and for activity. The family is described by MEROPs as a cysteine protease, family C45, because of its autoproteolytic activity. Characterized members include TAN from Drosophila, which removes beta-alanine from both carcinine and N-beta-alanyl dopamine, and isopenicillin-N N-acyltransferase from various fungi. The latter has been heavily studied because of its role in penicillin biosynthesis. Pssm-ID: 468523 [Multi-domain] Cd Length: 312 Bit Score: 63.08 E-value: 3.07e-11
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CBAH | pfam02275 | Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several ... |
126-316 | 7.41e-09 | ||||
Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, pfam15508. Pssm-ID: 396726 Cd Length: 316 Bit Score: 55.98 E-value: 7.41e-09
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Name | Accession | Description | Interval | E-value | ||||
Ntn_AC_NAAA | cd01903 | AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ... |
117-323 | 2.15e-124 | ||||
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC. Pssm-ID: 238886 Cd Length: 231 Bit Score: 355.81 E-value: 2.15e-124
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Ntn_CGH_like | cd01935 | Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins ... |
126-325 | 1.35e-41 | ||||
Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which cleave non-peptide carbon-nitrogen bonds in bile salt constituents. These enzymes have an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which they belong. This nucleophilic cysteine is exposed by post-translational prossessing of the precursor protein. Pssm-ID: 238910 Cd Length: 229 Bit Score: 144.42 E-value: 1.35e-41
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NAAA-beta | pfam15508 | beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ... |
32-91 | 2.99e-12 | ||||
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275. Pssm-ID: 464754 Cd Length: 63 Bit Score: 60.72 E-value: 2.99e-12
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C45_proenzyme | NF040521 | C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases ... |
59-266 | 3.07e-11 | ||||
C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases and N-acyltransferases, and belong to the Ntn (N-terminal nucleophile) hydrolase family. Members have an invariant Cys residue (Cys-103 in XP_002569112.1) required both for autoproteolytic processing into alpha and beta chains and for activity. The family is described by MEROPs as a cysteine protease, family C45, because of its autoproteolytic activity. Characterized members include TAN from Drosophila, which removes beta-alanine from both carcinine and N-beta-alanyl dopamine, and isopenicillin-N N-acyltransferase from various fungi. The latter has been heavily studied because of its role in penicillin biosynthesis. Pssm-ID: 468523 [Multi-domain] Cd Length: 312 Bit Score: 63.08 E-value: 3.07e-11
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CBAH | pfam02275 | Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several ... |
126-316 | 7.41e-09 | ||||
Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, pfam15508. Pssm-ID: 396726 Cd Length: 316 Bit Score: 55.98 E-value: 7.41e-09
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Blast search parameters | ||||
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