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Conserved domains on  [gi|767932467|ref|XP_011530476|]
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relaxin receptor 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
432-718 0e+00

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


:

Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 558.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15965    1 IVQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd15965   81 QLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15965  161 LHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEISNHIKKEMTLAKRFFFIVFTDALCWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 672 VVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15965  241 ILKLLSLLQVEIPGTISSWVVIFILPINSALNPILYTLTTRPFKEMI 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-384 1.23e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLLEGIEISNI 384
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
27-62 2.69e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.69e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932467  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
432-718 0e+00

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 558.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15965    1 IVQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd15965   81 QLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15965  161 LHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEISNHIKKEMTLAKRFFFIVFTDALCWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 672 VVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15965  241 ILKLLSLLQVEIPGTISSWVVIFILPINSALNPILYTLTTRPFKEMI 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-384 1.23e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLLEGIEISNI 384
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
448-707 2.54e-22

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 96.98  E-value: 2.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  448 GNIFVI---CMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMESTH-CQLVGSLAILSTE 523
Cdd:pfam00001   1 GNLLVIlviLRNKKLRTPTNIF---LLNLAVADLLFSL-------LTLPFWLVYYLNHGDWPFGSAlCKIVGALFVVNGY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  524 VSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPL--SNKEFFKNyyGTNGVCFPLHSEDTESI 600
Cdd:pfam00001  71 ASILLLTAISIDRYLAIVHPLRYkRRRTPRRAKVLILVIWVLALLLSLPPLlfGWTLTVPE--GNVTVCFIDFPEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  601 gaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT-ATEIRNQVKKEMilAKRFFFIVFTDALCWIPIFVVKFLSLL 679
Cdd:pfam00001 149 --VSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKqKSSERTQRRRKA--LKTLAVVVVVFILCWLPYHIVNLLDSL 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 767932467  680 --QVEIPGTITSWVVIFIL--PINSALNPILY 707
Cdd:pfam00001 225 alDCELSRLLDKALSVTLWlaYVNSCLNPIIY 256
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
154-362 4.56e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 4.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 154 NVTAMSLQWNLIRKLppDCFKNYHDLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRITFLKPgvFEDLHRLEWLIIE 233
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 234 DNHLSRISppTFYGLNSLILLVLMNNVLTrlPDKPLCQhmprlhwldlegnhihNLRNLTFISCSnLTVLVMRKNKINHL 313
Cdd:cd21340   77 GNRISVVE--GLENLTNLEELHIENQRLP--PGEKLTF----------------DPRSLAALSNS-LRVLNISGNNIDSL 135
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 314 NEntFAPLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKIQ 362
Cdd:cd21340  136 EP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
179-237 9.04e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.17  E-value: 9.04e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467  179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
27-62 2.69e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.69e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932467  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
153-383 5.42e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 232
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 233 EDNHLS-RISPPTfYGLNSLILLVL-MNNVLTRLPDKPLCQhmpRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKI 310
Cdd:PLN00113 436 SNNNLQgRINSRK-WDMPSLQMLSLaRNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 311 NHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQANqfdyLVKLKSLLEgIEISN 383
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN----LGNVESLVQ-VNISH 580
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
26-59 6.36e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767932467    26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 2.04e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 2.04e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932467   25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
511-714 5.78e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 42.84  E-value: 5.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV-RPGKCRTITVLILIWITGfIVAFIPLSNKEFFKNYYGTNgVC 589
Cdd:PHA03087 111 CKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNkINTVKYGYIVSLVIWIIS-IIETTPILFVYTTKKDHETL-IC 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQSAItateirNQVKKEMIlaKRFFFIVFTDALCWIP 669
Cdd:PHA03087 189 CMFYNNKTMNWKLFINFEINIIGM-LIPLTILLYCYSKILITLKGINK------SKKNKKAI--KLVLIIVILFVIFWLP 259
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 670 IFVVKFLSLLQV--EIPGTITSWVVIFILPI-------NSALNPILYTLTTRPF 714
Cdd:PHA03087 260 FNVSVFVYSLHIlhFKSGCKAVKYIQYALHVteiislsHCCINPLIYAFVSEFF 313
 
Name Accession Description Interval E-value
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
432-718 0e+00

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 558.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15965    1 IVQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd15965   81 QLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15965  161 LHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEISNHIKKEMTLAKRFFFIVFTDALCWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 672 VVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15965  241 ILKLLSLLQVEIPGTISSWVVIFILPINSALNPILYTLTTRPFKEMI 287
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
433-718 1.45e-147

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 433.55  E-value: 1.45e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 433 IQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 512
Cdd:cd15137    2 VLRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWLCT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPL 592
Cdd:cd15137   82 FAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNFYGRSGVCLPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 593 HSEDtESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATeiRNQVKKEMILAKRFFFIVFTDALCWIPIFV 672
Cdd:cd15137  162 HITD-ERPAGWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAA--SRKSKRDMAVAKRFFLIVLTDFLCWIPIIV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 673 VKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15137  239 IGILALSGVPIPGEVYAWVAVFVLPINSALNPILYTLSTPKFRKKL 284
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
432-716 1.50e-146

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 431.13  E-value: 1.50e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15966    1 NILRVFVWVMAFITCFGNLFVIGMRSFIRAENKTHAMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd15966   81 RIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFSNIRPGKCQTLIILISIWLVGFIIAVIPFWNEDFFGNYYGKNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15966  161 LHSDQTEKIGAKGYSTGIFLGLNLLAFIIIVFSYSSMFCSIQKTGLQTTEVRSHIHRDVAVANRFFFIVFSDAICWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767932467 672 VVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15966  241 LLKILSLFQVEIPGTITSWIVIFILPINSALNPILYTLTTSFFKE 285
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
432-718 1.34e-101

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 314.95  E-value: 1.34e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENK-LYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTH 510
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKkVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNY---YGTNG 587
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDnrlYGYSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHSEDTesigAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATeiRNQVKKEMILAKRFFFIVFTDALCW 667
Cdd:cd14980  161 ICMPSNVSNP----YYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSAR--RSSSKRDKRIAIRLALILITDLICW 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 668 IPIFVVKFLSLLQV-EIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd14980  235 LPYYIVIFSGLLTStEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
435-715 5.41e-51

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 179.72  E-value: 5.41e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLV 514
Cdd:cd15136    4 RIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGCKTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAFIPLsnkeFFKNYYGTNGVCFPLh 593
Cdd:cd15136   84 GFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGgWIFALIMALLPL----VGVSSYSKTSICLPF- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 594 seDTESIGAQIYsVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEirnqvkKEMILAKRFFFIVFTDALCWIPI--- 670
Cdd:cd15136  159 --ETETPVSKAY-VIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANS------NDTRIAKRMALLVFTDFLCWAPIaff 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 671 -----FVVKFLSLLQVEIpgtitswVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15136  230 gltaaFGLPLISVSNAKI-------LLVFFYPLNSCANPFLYAIFTKQFR 272
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
436-710 2.85e-33

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 129.33  E-value: 2.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDLKFRGeynkhaqLWMESTHCQ 512
Cdd:cd00637    3 VLYILIFVVGLVGNllvILVILRNRRLRTVTNYF---ILNLAVADLLVGLLVIPFSLVSLLLGR-------WWFGDALCK 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGVCFP 591
Cdd:cd00637   73 LLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYrRRFTRRRAKLLIALIWLLSLLLALPPL----LGWGVYDYGGYCCC 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTESIgAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAI------TATEIRNQVKKEMILAKRFFFIVFTDAL 665
Cdd:cd00637  149 CLCWPDLTL-SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRrirsssSNSSRRRRRRRERKVTKTLLIVVVVFLL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 666 CWIPIFVVKFLSLLQVEIPGT--ITSWVVIFILPINSALNPILYTLT 710
Cdd:cd00637  228 CWLPYFILLLLDVFGPDPSPLprILYFLALLLAYLNSAINPIIYAFF 274
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
435-715 2.41e-32

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 126.94  E-value: 2.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICMrpYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 512
Cdd:cd15964    4 RIVVWFVNLLAILGNVFVLLI--LLTSHYKLTVPRFLmcNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAFIPLSNkeffKNYYGTNGVCFP 591
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLgGWVFCFLLALLPLVG----VSSYAKVSICLP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LhseDTESIGAQIYSVAIfLGINLAAFIIIVFSYGSMFYSVHQSAITATEirnqvkKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15964  158 M---DTETPLAQAYIVFV-LMLNIIAFVIICACYIKIYITVRNPQYKSGD------KDTKIAKRMAVLIFTDFICMAPIS 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 672 VVKFLSLLQVEIPgTITSWVVIFIL--PINSALNPILYTLTTRPFK 715
Cdd:cd15964  228 FYALSAILNKPLI-TVSNSKILLVLfyPLNSCANPFLYAIFTKAFR 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-384 1.23e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLLEGIEISNI 384
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
435-715 2.36e-29

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 118.04  E-value: 2.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICMrpYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 512
Cdd:cd15359    4 RVLIWFINILAIAGNLIVLFV--LLTSRYKLTVPRFLmcNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAFIPLSNkefFKNYYGTNgVCFP 591
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRhAILIMLGGWVFSLLIAVLPLVG---VSNYMKVS-ICLP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LhseDTESIGAQIYsVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATeirnqvKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15359  158 M---DIETLLSQAY-ILLILVLNVIAFLVICACYIKIYLAVQNPELVAK------NKDTKIAKRMAILIFTDFTCMAPIS 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 672 VVKFLSLLQVEIPgTITSWVVIFIL--PINSALNPILYTLTTRPFK 715
Cdd:cd15359  228 FFAISAAFKVPLI-TVTNSKILLVLfyPINSCANPFLYAIFTKAFR 272
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
433-715 2.95e-29

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 117.65  E-value: 2.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 433 IQRVFVWVVSAVTCFGNIFVICMrpYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTH 510
Cdd:cd15360    2 ILRVLIWFINILAITGNIVVLAI--LLTSQYKLTVPRFLmcNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAFIPLsnkeFFKNYYGTNGVC 589
Cdd:cd15360   80 CAAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGgWIFAFTVALLPI----FGISSYMKVSIC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLhseDTESIGAQIYSVAIFLgINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVkkemilAKRFFFIVFTDALCWIP 669
Cdd:cd15360  156 LPM---DIESPLSQAYIIFILV-LNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKI------AKRMAVLIFTDFLCMAP 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 670 IFVVKFLSLLQVEIPgTITSWVVIFIL--PINSALNPILYTLTTRPFK 715
Cdd:cd15360  226 ISFFAISASLKVPLI-TVSKSKILLVLfyPINSCANPFLYAIFTKTFR 272
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
436-716 1.01e-27

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 113.04  E-value: 1.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVIC---MRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMESTHCQ 512
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILavyRNRRLRTVTNYF---IVSLAVADLLVAL-------LVMPFSAVYTLLGYWPFGPVLCR 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPG-KCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd14967   74 FWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMtKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSedtesigaQIYSVAIFLGINLAAFIIIVFSYGSMFYsvhqsaITATEIRNqvkkemilAKRFFFIVFTDALCWIPIF 671
Cdd:cd14967  154 TPN--------KIYVLVSSVISFFIPLLIMIVLYARIFR------VARRELKA--------AKTLAIIVGAFLLCWLPFF 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 672 VVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd14967  212 IIYLVSAFCPPDCVPPILYAVFFWLGyLNSALNPIIYALFNRDFRR 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
137-405 6.14e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 6.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 137 ELDCDETNLRAVPSV---SSNVTAMSLQWNLIRKLPPDcFKNYHDLQKLYLQNNKITSISiYAFRGLNSLTKLYLSHNRI 213
Cdd:COG4886  140 ELDLSNNQLTDLPEPlgnLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 214 TFLkPGVFEDLHRLEWLIIEDNHLSRIspPTFYGLNSLILLVLMNNVLTRLPDkplCQHMPRLHWLDLEGNHIHNLRNLT 293
Cdd:COG4886  218 TDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQLTDLKLKE 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 294 FISCSNLTVLVMRKNKINhlNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLK 373
Cdd:COG4886  292 LELLLGLNSLLLLLLLLN--LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
                        250       260       270
                 ....*....|....*....|....*....|..
gi 767932467 374 SLLEGIEISNIQQRMFRPLMNLSHIYFKKFQY 405
Cdd:COG4886  370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
448-707 2.54e-22

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 96.98  E-value: 2.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  448 GNIFVI---CMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMESTH-CQLVGSLAILSTE 523
Cdd:pfam00001   1 GNLLVIlviLRNKKLRTPTNIF---LLNLAVADLLFSL-------LTLPFWLVYYLNHGDWPFGSAlCKIVGALFVVNGY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  524 VSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPL--SNKEFFKNyyGTNGVCFPLHSEDTESI 600
Cdd:pfam00001  71 ASILLLTAISIDRYLAIVHPLRYkRRRTPRRAKVLILVIWVLALLLSLPPLlfGWTLTVPE--GNVTVCFIDFPEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  601 gaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT-ATEIRNQVKKEMilAKRFFFIVFTDALCWIPIFVVKFLSLL 679
Cdd:pfam00001 149 --VSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKqKSSERTQRRRKA--LKTLAVVVVVFILCWLPYHIVNLLDSL 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 767932467  680 --QVEIPGTITSWVVIFIL--PINSALNPILY 707
Cdd:pfam00001 225 alDCELSRLLDKALSVTLWlaYVNSCLNPIIY 256
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
436-716 7.57e-22

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 96.51  E-value: 7.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMrpYIRSENKLYAMS--IISLCCADCLMGIYlfvigGFDLKFRGEYNKHaqlWMESTH-CQ 512
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIV--FLKKKKLRTPLNlfLLNLALADLLMSVV-----GYPLSFYSNLSGR---WSFGDPgCV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGV---C 589
Cdd:cd14969   75 IYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPL----FGWSSYVPEGGgtsC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPlhSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQV------KKEMILAKRFFFIVFTD 663
Cdd:cd14969  151 SV--DWYSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAitkrtkKAEKKVAKMVLVMIVAF 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 664 ALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSAL-NPILYTLTTRPFKE 716
Cdd:cd14969  229 LIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIyNPIIYVFMNKQFRR 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
154-362 4.56e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 4.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 154 NVTAMSLQWNLIRKLppDCFKNYHDLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRITFLKPgvFEDLHRLEWLIIE 233
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 234 DNHLSRISppTFYGLNSLILLVLMNNVLTrlPDKPLCQhmprlhwldlegnhihNLRNLTFISCSnLTVLVMRKNKINHL 313
Cdd:cd21340   77 GNRISVVE--GLENLTNLEELHIENQRLP--PGEKLTF----------------DPRSLAALSNS-LRVLNISGNNIDSL 135
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 314 NEntFAPLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKIQ 362
Cdd:cd21340  136 EP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCKKP 184
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
440-716 9.31e-18

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 84.23  E-value: 9.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVI---CMRPYIRSENKLYamsIISLCCADCLMGIY-----LFVIGGFDLKFRGeynkhaqlwmesthC 511
Cdd:cd14968    9 LIAVLSVLGNVLVIwavKLNRALRTVTNYF---IVSLAVADILVGALaiplaILISLGLPTNFHG--------------C 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAFIPLSNKEFFKNYYGTnGVCF 590
Cdd:cd14968   72 LFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVcWVLSFLVGLTPMFGWNNGAPLESG-CGEG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQ------SAITATEIRNQVKKEMILAKRFFFIVFTDA 664
Cdd:cd14968  151 GIQCLFEEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKqlrqieSLLRSRRSRSTLQKEVKAAKSLAIILFLFA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 665 LCWIPIFVVKFLSLLQVE--IPGTITSWvVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd14968  231 LCWLPLHIINCITLFCPEckVPKILTYI-AILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
440-715 1.47e-17

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 84.19  E-value: 1.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVI---CMRPYIRSENKLYamsIISLCCADCLmgIYLFVIggfDLKFRGEYNKhaqLWMESTH-CQLVG 515
Cdd:cd14993    9 VVFLLALVGNSLVIavvLRNKHMRTVTNYF---LVNLAVADLL--VSLFCM---PLTLLENVYR---PWVFGEVlCKAVP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVaFIPL--SNKEFFKNYYGTNGVCFPL 592
Cdd:cd14993   78 YLQGVSVSASVLTLVAISIDRYLAICYPLKArRVSTKRRARIIIVAIWVIAIII-MLPLlvVYELEEIISSEPGTITIYI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 593 HSED-TESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT-ATEIRNQVKKEMILAKR------FFFIVFTDA 664
Cdd:cd14993  157 CTEDwPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPgDRGSANSTSSRRILRSKkkvarmLIVVVVLFA 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 665 LCWIPIFVVKFLSLLQVEIPGTITSWvVIFILPI-------NSALNPILYTLTTRPFK 715
Cdd:cd14993  237 LSWLPYYVLSILLDFGPLSSEESDEN-FLLILPFaqllgysNSAINPIIYCFMSKKFR 293
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
152-384 4.33e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 152 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLI 231
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 232 IEDNhlsrispPTFYGLNSLILLVLMNNVLTRLPDKplCQHMPRLHWLDLEGNHIHNLRNlTFISCSNLTVLVMRKNKIN 311
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 312 HLNENtFAPLQKLDELDLGSNKIENLPPLIFKdLKELSQLNLSYNPIQKIqANQFDYLVKLKSL-LEGIEISNI 384
Cdd:COG4886  173 DLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLdLSNNQLTDL 243
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
138-328 5.91e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 5.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 138 LDCDETNLRAVPSVSS--NVTAMSLQWNLIRKLPP-DCFKNyhdLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRIT 214
Cdd:cd21340    7 LYLNDKNITKIDNLSLckNLKVLYLYDNKITKIENlEFLTN---LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 215 FLKpGvFEDLHRLEWLIIEDNHLSR-----ISPPTFYGL-NSLILLVLMNNVLTRLpdKPLcQHMPRLHWLDLEGNHIHN 288
Cdd:cd21340   82 VVE-G-LENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDSL--EPL-APLRNLEQLDASNNQISD 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767932467 289 LRNLTFI--SCSNLTVLVMRKN---KINHLNENTFAPLQKLDELD 328
Cdd:cd21340  157 LEELLDLlsSWPSLRELDLTGNpvcKKPKYRDKIILASKSLEVLD 201
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
435-716 1.02e-16

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 81.05  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVW--VVSAVTCFGNIFVICMRP--YIRSENKLYAMsiisLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTH 510
Cdd:cd15363    4 RIGVWtiAVLALVCNALVTATVFRSplYISSIKLLIGL----IAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVY--------PFRCVRpgkcrtiTVLILIWITGFIVAFIPLSNkeffKNY 582
Cdd:cd15363   80 CQITGFLSIFASESSVFLLTLAALERGFSVKCstkfetksPFLSLK-------AIILLCFLLALTIAVIPLLG----GSE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 583 YGTNGVCFPLHSEDTESIGaqiYSVAIFLgINLAAFIIIVFSYGSMFYSVHQSaitatEIRNQVKKEMIlaKRFFFIVFT 662
Cdd:cd15363  149 YGASPLCLPLPFGEPSAMG---YMVALVL-LNSLCFLVMTIAYTKLYCSLEKG-----ELENIWDCSMV--KHIALLLFT 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 663 DALCWIPIFVVKFLSLLQVE-IPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15363  218 NCILYCPVAFLSFSSLLNLTfISPEVIKFILLVIVPLPACLNPLLYILFNPHFKE 272
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
435-716 9.04e-16

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 78.29  E-value: 9.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICM---RPYIRSENKLyamSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15362    4 RLGVWAIVLVSVLCNGLVILTvfaSPGYLSPVKF---VIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIvypfRCVRP-------GKCRTITVLILIWitGFIVAFIPLsnkeFFKNYYG 584
Cdd:cd15362   81 RATGFLSVFASEASILLLTLAAVQCSVSV----SCVRAygkspslGSVRAAALCCLAL--SLTAAALPL----FSVGEYG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 585 TNGVCFP--LHSEDTESIGaqiYSVAIFLgINLAAFIIIVFSYGSMFYSVHQSAITATEirnqvkkEMILAKRFFFIVFT 662
Cdd:cd15362  151 ASPLCLPspLPDGKPSTLG---FTVALIM-MNTLCFLVITGTYIKLYCDLLKGEFDAIW-------DCAMIKHVAWLIFT 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 663 DALCWIPIFVVKFLSLLQV-EIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15362  220 NCLLYCPVAFLTFSSLLNLfPISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRD 274
LRR_8 pfam13855
Leucine rich repeat;
179-237 9.04e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.17  E-value: 9.04e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467  179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
435-716 9.21e-16

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 78.36  E-value: 9.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICM---RPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15138    4 RLTVWFIFLLALFCNLLVILTvfaSCTSLPPSKLF---IGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIV-AFIPLsnkeFFKNYYGTNGVCF 590
Cdd:cd15138   81 KVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVaAAFPL----FHRGEYGASPLCL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGaqiYSVAIFLgINLAAFIIIVFSYGSMFYSVHQSaitatEIRNQVKKEMIlaKRFFFIVFTDALCWIPI 670
Cdd:cd15138  157 PFPTGEPPSLG---FTVALVL-LNSLCFLLMAVAYTKLYCNLEKG-----DLEENWDCSMV--KHVAWLIFTNCILFCPV 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 671 FVVKFLSLLQ-VEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15138  226 AFLSFASLITlISISPEIMKSVLLVVFPLPACLNPLLYVLFNPHFKE 272
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
511-716 6.30e-15

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 76.27  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKcRTITVLILIWITGFIVAfIP------LSNKEFFKNYYG 584
Cdd:cd15208   73 CKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAK-RARVSILIIWIVSLLIM-IPqaivmeCSRVVPLANKTI 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 585 TNGVCFPlhsEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEI-----------------RNQVK 647
Cdd:cd15208  151 LLTVCDE---RWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSvvqrkwnkprksavaaeEKQLR 227
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 648 KEMILAKRFFFIVFTDALCWIPIF---VVKFLSLLQVEIPGTITSWVVI--FILPINSALNPILYTLTTRPFKE 716
Cdd:cd15208  228 SRRKTAKMLIVVVIMFAICYLPVHllnILRYVFGLFTVDRETIYAWFLFshWLVYANSAINPIIYNFMSGKFRE 301
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
436-716 2.12e-14

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 74.40  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVIC-MRPYIRSENKLYaMSIISLCCADCLmgiYL----FVIGGFDLK--FRGEYNkhaqlwmes 508
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVvMCLSMRPRASMY-VYILNLALADLL---YLltipFYVSTYFLKkwYFGDVG--------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 thCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA-----FIPLSNKEffKNYY 583
Cdd:cd14999   71 --CRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGVIWLLSLLLTlpmaiMIRLVTVE--DKSG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 584 GTNGVCFPLHSEDTEsigaQIYSVAIFLGINLAAFIIIVFSYGSMF--YSVHQSAITATEIRNQVKKEmiLAKRFFFIVF 661
Cdd:cd14999  147 GSKRICLPTWSEESY----KVYLTLLFSTSIVIPGLVIGYLYIRLArkYWLSQAAASNSSRKRLPKQK--VLKMIFTIVL 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 662 TDALCWIPiFVVKFLSLLQVEIPG------TITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd14999  221 VFWACFLP-FWIWQLLYLYSPSLSlsprttTYVNYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
487-707 2.44e-14

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 74.25  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 487 IGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGF 566
Cdd:cd15390   49 ISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLR-PRLSRRTTKIAIAVIWLASF 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 567 IVAFiPL---SNKEFFKNYYG-TNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEI 642
Cdd:cd15390  128 LLAL-PQllySTTETYYYYTGsERTVCFIAWPDGPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENT 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 643 RNQVkkEMILAKR-----FFFIVFTDALCWIPIFVVKFLSLLQVEI---PGTITSWVVIFILPI-NSALNPILY 707
Cdd:cd15390  207 PRQL--ESVRAKRkvvkmMIVVVVIFAICWLPYHLYFILTYLYPDInswKYIQQIYLAIYWLAMsNSMYNPIIY 278
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
428-707 4.18e-14

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 74.02  E-value: 4.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 428 LLASIIqrvfvwvvsAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIyLFVIGGFDLKFRGEYNkhaql 504
Cdd:cd15058    6 LLALII---------LAIVVGNLLVIIA---IARTSRLQTMTnifITSLACADLVMGL-LVVPLGATIVVTGKWQ----- 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 505 wMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFR-CVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNY- 582
Cdd:cd15058   68 -LGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRyQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDp 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 583 -----YgTNGVCFPLHSEDTESIGAQIYSVAIFLginlaafIIIVFSYGSMF-----------------------YSVHQ 634
Cdd:cd15058  147 eandcY-QDPTCCDFRTNMAYAIASSVVSFYIPL-------LIMIFVYARVFliatrqlqlidkrrlrfqsecpaPQTTS 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 635 SAITATEIRNQ----VKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILY 707
Cdd:cd15058  219 PEGKRSSGRRPsrltVVKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLNWLGYINSGLNPIIY 295
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
425-715 4.48e-14

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 73.62  E-value: 4.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 425 LENLLASIIqrvfvwVVSAVTCFGNIFVICMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQL 504
Cdd:cd14992    3 LGVALVVII------LVSVVGNFIVIAALARHKNLRGATNYF---IASLAISDLLMAL-------FCTPFNFTYVVSLSW 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 505 WMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPL---------S 574
Cdd:cd14992   67 EYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPrHRQSYTTTVIIIITIWVVSLLLAIPQLyyattevlfS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 575 NKEFFKNYYGTngvcFPLHSEDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAK 654
Cdd:cd14992  147 VKNQEKIFCCQ----IPPVDNKTYE---KVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKR 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 655 R----FFFIVFTDALCWIPI---FVVKFLSLLQVEIPGTITSWVVIFILPI-NSALNPILYTLTTRPFK 715
Cdd:cd14992  220 RvikmLVCVVVLFVICWLPFhlfFLLRDFFPLIMKEKHTLQVYYFLHWIAMsNSMYNPIIYVTLNNNFR 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
440-718 6.54e-14

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 73.02  E-value: 6.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFR--GEYNKHaqlWM-ESTHCQL 513
Cdd:cd15203    9 LIIVLGVVGNllvIYVVLRNKSMQTVTNIF---ILNLAVSDLLLCL-------VSLPFTliYTLTKN---WPfGSILCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 514 VGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAfIPLS-NKEFFKNYYGTNGVCFPL 592
Cdd:cd15203   76 VPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTR-PRMSKRHALLIIALIWILSLLLS-LPLAiFQELSDVPIEILPYCGYF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 593 HSEDTES-IGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRN--QVKKEMILAKR------FFFIVFTD 663
Cdd:cd15203  154 CTESWPSsSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTlsSRRRRSELRRKrrtnrlLIAMVVVF 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 664 ALCWIPIFVVKFLSLLQVEIPGTITSWVVIFIL----PINSA-LNPILYTLTTRPFKEMI 718
Cdd:cd15203  234 AVCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLIchliAMSSAcVNPLLYGWLNDNFRKEF 293
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
436-715 2.09e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 70.85  E-value: 2.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVI---CMRPYIRSENKLYamsIISLCCADCLMGIylfVIGGFDLKF--RGEYNKHAQLWmesth 510
Cdd:cd15067    4 VVLSLFCLVTVAGNLLVIlavLRERYLRTVTNYF---IVSLAVADLLVGS---IVMPFSILHemTGGYWLFGRDW----- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF--RCvRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGV 588
Cdd:cd15067   73 CDVWHSFDVLASTASILNLCVISLDRYWAITDPIsyPS-RMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 C-FplhsedTESIGAQIYSVAIFLGINLaafIIIVFSYgsmfYSVHQSAItateirnqvkKEMILAKRFFFIVFTDALCW 667
Cdd:cd15067  152 ClF------TDDSGYLIFSSCVSFYIPL---VVMLFTY----YRIYRAAA----------KEQKAAKTLGIVMGVFILCW 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 668 IPIFVVKFLS-------LLQVEIPGTITSWVVIfilpINSALNPILYTLTTRPFK 715
Cdd:cd15067  209 LPFFVTNILIgfcpsncVSNPDILFPLVTWLGY----INSGMNPIIYACSSRDFR 259
LRR_8 pfam13855
Leucine rich repeat;
202-261 7.67e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 7.67e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  202 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 261
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
153-213 1.76e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 1.76e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467  153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 213
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
274-334 4.07e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 4.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467  274 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 334
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
435-716 4.19e-12

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 67.20  E-value: 4.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 435 RVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLV 514
Cdd:cd15361    4 RLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGCKVA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA-FIPLsnkeFFKNYYGTNGVCFPLH 593
Cdd:cd15361   84 GFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAgCLPL----FHGGEYSASPLCLPFP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 594 SEDTESIGaqiYSVAIFLgINLAAFIIIVFSYGSMFYSVHQSAITATEirnqvKKEMIlaKRFFFIVFTDALCWIPIFVV 673
Cdd:cd15361  160 TGETPSLG---FTVTLVL-LNSLAFLLMAVIYTKLYCNLEKEDLSENS-----QSSMI--KHVAWLIFTNCIFFCPVAFF 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 674 KFLSLLQ-VEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15361  229 SFAPLITaISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 272
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
436-718 8.49e-12

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 66.58  E-value: 8.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclMGIYLfvIGGFDLKFRGEYNKhaqLWM-ESTHCQLV 514
Cdd:cd15337    5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISD--FGFSA--VNGFPLKTISSFNK---KWIwGKVACELY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPG-KCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGV---C- 589
Cdd:cd15337   78 GFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMtFKRAFIMIIIIWLWSLLWSIPPF----FGWGRYVPEGFqtsCt 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIgaqIYSVAIFLGINLAAFIIIVFSYGSMFYSV--HQSAITATEIRNQVKK----------EMILAKRFF 657
Cdd:cd15337  154 FDYLSRDLNNR---LFILGLFIFGFLCPLLIIIFCYVNIIRAVrnHEKEMTQTAKSGMGKDtekndarkkaEIRIAKVAI 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 658 FIVFTDALCWIPIFVVKFLSLLQVEipgtitSWVVIFI--LPI----NSAL-NPILYTLTTRPFKEMI 718
Cdd:cd15337  231 ILISLFLLSWTPYAVVALLGQFGPA------YWITPYVseLPVmfakASAIyNPIIYALSHPKFRAAL 292
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
511-716 1.18e-11

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 66.15  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRT-ITVLILIWITGFIVAF-IPLSNKEFFKNYYGTNGV 588
Cdd:cd15095   73 CKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVaVVVSACIWIVSFLLSIpVAIYYRLEEGYWYGPQTY 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 CFPLHSEDTESIGAQIYSVAIFLGINLAafiIIVFSYGSMFY-----SVHQSAITATEIRNQVKKEMILAKRFFFIVFTD 663
Cdd:cd15095  153 CREVWPSKAFQKAYMIYTVLLTYVIPLA---IIAVCYGLILRrlwrrSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLF 229
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 664 ALCWIPIFVVKFLSLLQVEIPGTI-TSWVVIFILPI---NSALNPILYTLTTRPFKE 716
Cdd:cd15095  230 AICWLPNHVLNLWQRFDPNFPETYaTYALKIAALCLsyaNSAVNPFVYAFMGENFRK 286
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
440-721 1.42e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 65.78  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMrpYIRSENKLYAMSII--SLCCADCLMGI-YLFVIGGFDLkfrGEYNKHAQLWMesthcqLVGS 516
Cdd:cd14972    7 VLGVFIVVENSLVLAA--IIKNRRLHKPMYILiaNLAAADLLAGIaFVFTFLSVLL---VSLTPSPATWL------LRKG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP---GKCrtITVLILIWITGFIVAFIPLsnkeffknyYGTNgvCFPLH 593
Cdd:cd14972   76 SLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNvtnKRV--KVLIALVWVWSVLLALLPV---------LGWN--CVLCD 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 594 SEDTESIGAQI-YSVAIF-LGINLAAFIIIVFSYGSMFYSVHQ--SAITATEIR---NQVKKEMILAKRFFFIVFTDALC 666
Cdd:cd14972  143 QESCSPLGPGLpKSYLVLiLVFFFIALVIIVFLYVRIFWCLWRhaNAIAARQEAavpAQPSTSRKLAKTVVIVLGVFLVC 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 667 WIPIFVvkfLSLLQVEIPGTITSWVV--IFILPI--NSALNPILYTLTTrpfKEMIHRF 721
Cdd:cd14972  223 WLPLLI---LLVLDVLCPSVCDIQAVfyYFLVLAllNSAINPIIYAFRL---KEMRRAV 275
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
511-716 1.77e-11

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 65.72  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVaFIPLSNKEFFKNYYGTNGVCF 590
Cdd:cd15207   73 CKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTE-PKLTNRQAFVIIVAIWVLALAI-MIPQALVLEVKEYQFFRGQTV 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGA-QIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRF------FFIVFTD 663
Cdd:cd15207  151 HICVEFWPSDEYrKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASREAQAAVSKKKVrvikmlIVVVVLF 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 664 ALCWIPIFVVKFLSLLqVEIPGTITSWVVIFILPI-------NSALNPILYTLTTRPFKE 716
Cdd:cd15207  231 ALSWLPLHTVTMLDDF-GNLSPNQREVLYVYIYPIahwlayfNSCVNPIVYGYFNRNFRK 289
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
448-715 3.21e-11

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 64.84  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 448 GNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFviggfDLKFRGEYNKHaqlWMESTH-CQLVGSLAILSTEVSV 526
Cdd:cd15391   17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCM-----PFTFTQIMLGH---WVFPAPmCPIVLYVQLVSVTASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 527 LLLTFLTLEKYICIVYPFRCvRPGKCRTITVLILIWITGFIvafipLSNKEFF---KNYYGTNGVCFPLHSE--DTESIG 601
Cdd:cd15391   89 LTNTAIGIDRFFAVIFPLRS-RHTKSRTKCIIASIWAISFS-----LSSVQLFagrTQRYGQYSEGRVLCGEswPGPDTS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 602 AQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEI----RNQVKKEMILAKRFFFIVFTDALCWIP----IFVV 673
Cdd:cd15391  163 RSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNADkgrdDMQIKSKRKVIKMLVFVVLMFGICWLPlhlfNLVQ 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 674 KFLSLLQVEIPGTITS--WVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15391  243 DFSTVFRNMPQHTTRLiyGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
441-716 3.90e-11

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 64.69  E-value: 3.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 441 VSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLW-MESTHCQLVGS 516
Cdd:cd15392   10 IFVLAVGGNglvCYIVVSYPRMRTVTNYF---IVNLALSDILMAV-------FCVPFSFIALLILQYWpFGEFMCPVVNY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFK--NYYGTNGVCFPLHS 594
Cdd:cd15392   80 LQAVSVFVSAFTLVAISIDRYVAIMWPLR-PRMTKRQALLLIAVIWIFALATALPIAITSRLFEdsNASCGQYICTESWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSV--HQSAITATEIRNQ----VKKEMIlaKRFFFIVFTDALCWI 668
Cdd:cd15392  159 SDTNR---YIYSLVLMILQYFVPLAVLVFTYTRIGIVVwaKRTPGEAENNRDQrmaeSKRKLV--KMMITVVAIFALCWL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 669 PIfvvKFLSLLQVEIPgTITSWVVIFILPI--------NSALNPILYTLTTRPFKE 716
Cdd:cd15392  234 PL---NILNLVGDHDE-SIYSWPYIPYLWLaahwlamsHCCYNPFIYCWMNAKFRN 285
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
196-358 6.49e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 64.30  E-value: 6.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 196 AFRGLNSLTKLYLSHNRITFLKPGVFEDLHR---LEWLIIEDNHLS-RISPPTFYGLNSLIL----LVLMNNVLTRLPDK 267
Cdd:cd00116   76 GLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLPPalekLVLGRNRLEGASCE 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 268 PLC---QHMPRLHWLDLEGNHIHN--LRNL--TFISCSNLTVLVMRKNKINHLN----ENTFAPLQKLDELDLGSNKIEN 336
Cdd:cd00116  156 ALAkalRANRDLKELNLANNGIGDagIRALaeGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTD 235
                        170       180
                 ....*....|....*....|....*..
gi 767932467 337 LPPLIFKD-LKELSQ----LNLSYNPI 358
Cdd:cd00116  236 AGAAALASaLLSPNIslltLSLSCNDI 262
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
432-715 8.83e-11

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 63.45  E-value: 8.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICM----RPYIRSENKLyamsIISLCCADCLMGIYLF---VIGGFDlkFRGEYNKHAql 504
Cdd:cd15074    1 IIIGIYLTVIGILSTLGNGTVLFVlyrrRSKLKPAELL----TVNLAVSDLGISVFGYplaIISAFA--HRWLFGDIG-- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 505 wmesthCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYG 584
Cdd:cd15074   73 ------CVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPL----VGWGSYG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 585 TNGvcFPLHSE-----DTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATE----IRNQVKKEMILAKR 655
Cdd:cd15074  143 PEP--FGTSCSidwtgASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGfdsrSKRQHKIERKVTKV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 656 FFFIVFTDALCWIPIFVVKFLSLLQVE--IPgtitswVVIFILPI-----NSALNPILYTLTTRPFK 715
Cdd:cd15074  221 AVLICAGFLIAWTPYAVVSMWSAFGSPdsVP------ILASILPAlfaksSCMYNPIIYLLFSSKFR 281
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
509-718 9.73e-11

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 63.44  E-value: 9.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 THCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV---RPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNyygT 585
Cdd:cd14982   71 FLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRrlrRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKEN---N 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEDTESigAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVK-KEMILakrFFFIVFTda 664
Cdd:cd14982  148 STTCFEFLSEWLAS--AAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKaLRMIL---IVLAVFL-- 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767932467 665 LCWIPIFVVKFLSLL--QVEIPGTITSWVVIFILPI-------NSALNPILYTLTTRPFKEMI 718
Cdd:cd14982  221 VCFLPYHVTRILYLLvrLSFIADCSARNSLYKAYRItlclaslNSCLDPLIYYFLSKTFRKRL 283
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
432-716 9.81e-11

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 63.58  E-value: 9.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiyLFVIggfDLKFRGEYnkhAQLW-MESTH 510
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIG--LFSI---PFQFQAAL---LQRWvLPRFM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFrCVRPGKCRTITVLILIWITGFIVAF---IPLSNKEFF-KNYYGTN 586
Cdd:cd15393   73 CPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPL-KARCSKKSAKIIILIIWILALLVALpvaLALRVEELTdKTNNGVK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSEDTEsigAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAI------TATEIRNQVKKEMIlaKRFFFIV 660
Cdd:cd15393  152 PFCLPVGPSDDW---WKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKApgnaqdVRDDEILKNKKKVI--KMLIIVV 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 661 FTDALCWIPIFVVKFLSllqvEIPGTITSWVVIFILPI--------NSALNPILYTLTTRPFKE 716
Cdd:cd15393  227 ALFALCWLPLQTYNLLN----EIKPEINKYKYINIIWFcshwlamsNSCYNPFIYGLYNEKFKR 286
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
436-716 1.46e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 63.14  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVtcfGN---IFVICMRPYIRSENKLYAMSiisLCCADCLMgiylFVIG-GFDLkFRGEYNKHAQLWMesTHC 511
Cdd:cd14979    8 VAIFVVGIV---GNlltCIVIARHKSLRTTTNYYLFS---LAVSDLLI----LLVGlPVEL-YNFWWQYPWAFGD--GGC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAfIPLSNKEFFKNYYGTN---- 586
Cdd:cd14979   75 KLYYFLFEACTYATVLTIVALSVERYVAICHPLKAkTLVTKRRVKRFILAIWLVSILCA-IPILFLMGIQYLNGPLpgpv 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 ---GVCFPLHSEDTESIGAQIYSVAIFLgINLAAFIIIVFSYGSMFYS------VHQSAIT---ATEIRNQVKKEMIlaK 654
Cdd:cd14979  154 pdsAVCTLVVDRSTFKYVFQVSTFIFFV-LPMFVISILYFRIGVKLRSmrnikkGTRAQGTrnvELSLSQQARRQVV--K 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 655 RFFFIVFTDALCWIPiFVVKFLSLLQVEIPGTITSWVVIFILPI-------NSALNPILYTLTTRPFKE 716
Cdd:cd14979  231 MLGAVVIAFFVCWLP-FHAQRLMFSYASKEDTFLFDFYQYLYPIsgilfylSSAINPILYNLMSSRFRV 298
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
440-715 1.59e-10

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 62.29  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVI-CMRPYIRSENKLYAMsIISLCCADclmgiyLFVIGgFDLKFRGEYNKHAQLWMESTHCQLVGSLA 518
Cdd:cd15001    8 ITFVLGLIGNSLVIfVVARFRRMRSVTNVF-LASLATAD------LLLLV-FCVPLKTAEYFSPTWSLGAFLCKAVAYLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 519 ILSTEVSVLLLTFLTLEKYICIVYPFR----CVRPgkcRTITVLILIWITGFIVAFIPLSNKEfFKNYYGTNGVCFPLHS 594
Cdd:cd15001   80 LLSFICSVLTLTAISIERYYVILHPMKaksfCTIG---RARKVALLIWILSAILASPVLFGQG-LVRYESENGVTVYHCQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESIGA-QIYSVAIFLGINLAAFIIIVFSYGSmfysvhqsaitatEIRNQVKKEMILakrfffIVFTDALCWIPIFVV 673
Cdd:cd15001  156 KAWPSTLYsRLYVVYLAIVIFFIPLIVMTFAYAR-------------DTRKQVIKMLIS------VVVLFAVCWGPLLID 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 674 KFLS---LLQVEIPGTITSWVVIFILP--INSALNPILYTLTTRPFK 715
Cdd:cd15001  217 NLLVsfdVISTLHTQALKYMRIAFHLLsyANSCINPIIYAFMSKNFR 263
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
440-718 2.34e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 62.08  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICM---RPYIRSENKLYamsIISLCCADCLMGIY-----LFVIGGFDLKFrGEynkhaqlwmesTHC 511
Cdd:cd15012    8 LVFCCCFFGNLLVILVvtsHRRMRTITNFF---LANLAVADLCVGIFcvlqnLSIYLIPSWPF-GE-----------VLC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCF 590
Cdd:cd15012   73 RMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLlTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAitATEIRNQVKKEMILakrfffIVFTDALCWIPI 670
Cdd:cd15012  153 EICVLDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSS--SIEARRKVVRLLVA------VVVSFALCNLPY 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 671 FVVKFLSLLQVEIPGTiTSWVVIF------ILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15012  225 HARKMWQYWSEPYRCD-SNWNALLtpltflVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
436-715 2.91e-10

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 61.80  E-value: 2.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRsenKLYA---MSIISLCCADCLMGIYLFVIGGFDLKFRGEYnkhaqlwMESTHCQ 512
Cdd:cd15055    5 IVLSSISLLTVLGNLLVIISISHFK---QLHTptnLLLLSLAVADFLVGLLVMPFSMIRSIETCWY-------FGDTFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcvRPGKCRTITVLILI---WITGFIVAFIPLSNKEFFKNYYGTN--- 586
Cdd:cd15055   75 LHSSLDYILTSASIFNLVLIAIDRYVAVCDPLL--YPTKITIRRVKICIclcWFVSALYSSVLLYDNLNQPGLIRYNscy 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSEdtesigaqIYSVAIFLGINLAAFIIIVFSYGSMFY---------SVHQSAITATEIRNQV--KKEMILAKR 655
Cdd:cd15055  153 GECVVVVNF--------IWGVVDLVLTFILPCTVMIVLYMRIFVvarsqaraiRSHTAQVSLEGSSKKVskKSERKAAKT 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 656 FFFIVFTDALCWIPIFVVkflSLLQVEIPGTITSW-VVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15055  225 LGIVVGVFLLCWLPYYIV---SLVDPYISTPSSVFdVLIWLGYFNSCLNPLIYALFYPWFR 282
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
440-707 3.62e-10

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 61.68  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFgnifvicmrPYIRSenKLYAMSIISLCCADCLMGIYLfviggfdLKFRGeYNKHAQLWMESTHCQLVGSLAI 519
Cdd:cd15057   21 VIAAVLRF---------RHLRS--KVTNYFIVSLAVSDLLVAILV-------MPWAA-VNEVAGYWPFGSFCDVWVSFDI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 520 LSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWITGFIVAFIPLSnKEFFKNYYGTNGVCFPLHSEDTE 598
Cdd:cd15057   82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIaVAWTLSALISFIPVQ-LGWHRADDTSEALALYADPCQCD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 599 SIGAQIYS-VAIFLGINLAAFIIIVFsYGSMFY--------------SVHQSAITATEIRNQVKKEMILAKRFFFIVFTD 663
Cdd:cd15057  161 SSLNRTYAiSSSLISFYIPVAIMIVT-YTRIYRiarrqirriaalerAAQESTNPDSSLRSSLRRETKALKTLSIIMGVF 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 664 ALCWIPIFVVK----FLSLLQVE---IPGTITSWVVIFILpINSALNPILY 707
Cdd:cd15057  240 VCCWLPFFILNcvlpFCDLRTAQfpcVPDTTFIVFVWLGW-ANSSLNPIIY 289
LRR_8 pfam13855
Leucine rich repeat;
226-286 5.90e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.90e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467  226 RLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKpLCQHMPRLHWLDLEGNHI 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
436-715 8.18e-10

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 60.47  E-value: 8.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFVIGgfdLKFRGEYNKHAQLWMESTH-CQLV 514
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAAD-----LVFVLT---LPLWATYTANQYDWPFGAFlCKVS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPF--RCVRPGKCRTITVlILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPL 592
Cdd:cd14985   77 SYVISVNMFASIFLLTCMSVDRYLAIVHPVasRRLRRRRQARVTC-ALIWVVACLLSLPTFLLRSLQAIENLNKTACIML 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 593 HSEDTESIGAQIysVAIFLGInLAAFIIIVFSYgsmfYSVHQSAITATE-IRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd14985  156 YPHEAWHFGLSL--ELNILGF-VLPLLIILTCY----FHIARSLRKRYErTGKNGRKRRKSLKIIFALVVAFLVCWLPFH 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 672 VVKFLSLL---QVEIPGTItSWVVIFILPI-------NSALNPILYTLTTRPFK 715
Cdd:cd14985  229 FFKFLDFLaqlGAIRPCFW-ELFLDLGLPIatclaftNSCLNPFIYVFVDRRFR 281
LRR_8 pfam13855
Leucine rich repeat;
298-358 9.17e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 9.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467  298 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 358
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
511-712 2.69e-09

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 59.20  E-value: 2.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFR-CVRPGKCRTITVLILIWITGFIVAfIP---LSN-KEFFKNYYGT 585
Cdd:cd15927   73 CKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRkHRSQATRRTLVTAASIWIVSILLA-IPeaiFSHvVTFTLTDNQT 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEDTESiGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKR-------FFF 658
Cdd:cd15927  152 IQICYPYPQELGPN-YPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQAAQRQIEARKkvaktvlAFV 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 659 IVFtdALCWIPIFVV----KFLSLLQVEIPG-----TITSWVVIFilpINSALNPI-LYTLTTR 712
Cdd:cd15927  231 VLF--AVCWLPRHVFmlwfHFAPNGLVDYNAfwhvlKIVGFCLSF---INSCVNPVaLYLLSGS 289
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
27-62 2.69e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.69e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932467  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
432-715 2.71e-09

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 58.85  E-value: 2.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADCLmgiylFVIGgfdLKFRGeynkhAQLWMES 508
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNslvIYVILRYSKMKTVTNIY---ILNLAVADEL-----FLLG---LPFLA-----TSYLLGY 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 TH-----CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR---PGKCRTitVLILIWITGFIV---AFIPLSNKE 577
Cdd:cd14970   65 WPfgevmCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRfrtPRKAKL--VSLCVWALSLVLglpVIIFARTLQ 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 578 FFKNYYGTNgvcfpLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY----SVHQSAITATEIRNQVKK--EMI 651
Cdd:cd14970  143 EEGGTISCN-----LQWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRrlrsSRNLSTSGAREKRRARRKvtRLV 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 652 LAkrfffIVFTDALCWIPIFVVKfLSLLQVEIPGTiTSWVVIFILPI-----NSALNPILYTLTTRPFK 715
Cdd:cd14970  218 LV-----VVAVFVVCWLPFHVFQ-IVRLLIDPPET-LTVVGVFLFCIalsyaNSCLNPILYAFLDENFR 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
432-716 3.63e-09

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 58.46  E-value: 3.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADclmgiYLFVIggFDLKFRGEYNKHAQLWMES 508
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNslvILVVLSNQQMRSTTNIL---ILNLAVAD-----LLFVV--FCVPFTATDYVLPTWPFGD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 THCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITgFIVAFIPL--SNKEFFKNYYGT 585
Cdd:cd15096   71 VWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVgIWIV-ILVANIPVlfLHGVVSYGFSSE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 N-GVCFPLHSEDTesiGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVF-TD 663
Cdd:cd15096  150 AySYCTFLTEVGT---AAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQRGKRRVTRLVVVVVvVF 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 664 ALCWIPIFVVKFLSLLQVeIPGTITSwVVIFILP-----INSALNPILYTLTTRPFKE 716
Cdd:cd15096  227 AICWLPIHIILLLKYYGV-LPETVLY-VVIQILSnclayGNSCVNPILYAFLSQNFRK 282
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
436-716 4.68e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 58.22  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFVIGgfdLKFRGEYNKHAQLWM-ESTHCQLV 514
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVAD-----LLFLAT---LPLWATYYSYGYNWLfGSVMCKIC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKE-FFKNYYGTNG--VCFP 591
Cdd:cd15191   77 GSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSLPTFYFRDtYYIEELGVNAciMAFP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTesigaqiYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIF 671
Cdd:cd15191  157 NEKYAQ-------WSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFH 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 672 VVKFLSLLQVEipGTITS-WVVIFI---LPI-------NSALNPILYTLTTRPFKE 716
Cdd:cd15191  230 VLTFLDALARM--GVINNcWVITVIdkaLPFaiclgfsNSCINPFLYCFVGNHFRE 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
153-383 5.42e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 232
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 233 EDNHLS-RISPPTfYGLNSLILLVL-MNNVLTRLPDKPLCQhmpRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKI 310
Cdd:PLN00113 436 SNNNLQgRINSRK-WDMPSLQMLSLaRNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 311 NHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQANqfdyLVKLKSLLEgIEISN 383
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN----LGNVESLVQ-VNISH 580
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
436-708 6.22e-09

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 57.77  E-value: 6.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVI-CMRPYIRSENKLYAMSIISLCCADCLMGiyLFVIGGF-DLKFRGEYNKHaqlwmeSTHCQL 513
Cdd:cd15104    4 VILAVLSPLIITGNLLVIvALLKLIRKKDTKSNCFLLNLAIADFLVG--LAIPGLAtDELLSDGENTQ------KVLCLL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 514 VGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGtnGVCfpl 592
Cdd:cd15104   76 RMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQiMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYK--GKC--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 593 hsedteSIGAQI---YSVAIFLGINLAAFIIIVFSYGSMFY--SVHQSAITATEI-------RNQVKKEMILAKRFFFIV 660
Cdd:cd15104  151 ------SFFAAFhprVLLVLSCMVFFPALLLFVFCYCDILKiaRVHSRAIYKVEHalarqihPRRTLSDFKAARTVAVLI 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 661 FTDALCWIPIFVVKFLSLL-QVEIPgtiTSWVVIFI-LPI--NSALNPILYT 708
Cdd:cd15104  225 GCFLLSWLPFQITGLVQALcDECKL---YDVLEDYLwLLGlcNSLLNPWIYA 273
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
511-716 8.53e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 57.48  E-value: 8.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTI-TVLILIWITGFIVAFIPLSNkefFKNYYGTNGVC 589
Cdd:cd15070   71 CLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIwLALGLCWLVSFLVGLTPMFG---WNRKPSLESVN 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAI-FLGINLAAFIIIVFSYGSMFY----SVHQSAITATEIRNQVKKEMILAKRFFFIVFTDA 664
Cdd:cd15070  148 TTPLQCQFTSVMRMDYMVYFsFFTWILIPLVIMCALYVDIFYiirnKLSQNATGFRETGAFYGREFKTAKSLALVLFLFA 227
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 665 LCWIPIFVVKFLSLLQVEIPgTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15070  228 VCWLPLSIINCVVYFNPKVP-KIALYLGILLSHANSMMNPIVYACKIKKFKE 278
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
433-707 1.50e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 57.00  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 433 IQRVFV-WVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiylFVIGGFDLKFRGEYNkhaqlWM-ESTH 510
Cdd:cd14986    1 VSRVAVlGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVA---FFTVLTQIIWEATGE-----WVaGDVL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGkcRTITVLILI-WITGFIVAfIPlsNKEFFKNYYGTNGV- 588
Cdd:cd14986   73 CRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVaWVLSFLFS-IP--QLVIFVERELGDGVh 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 -CFPLHSEDTesiGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQ--SAITATEIRNQVKKEMILA------------ 653
Cdd:cd14986  148 qCWSSFYTPW---QRKVYITWLATYVFVIPLIILSYCYGRILRTIWIrsRQKTDRPIAPTAMSCRSVScvssrvslisra 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 654 -----KRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILY 707
Cdd:cd14986  225 kiktiKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLAsLNSALNPLIY 284
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
511-718 1.66e-08

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 56.70  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF-----RCVRPGKCrtitVLILIWITGFIVAFIPLSNKEFFKNYYGT 585
Cdd:cd15116   72 CKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVwsqnhRSVRLASL----VSLAVWVVAFFLSSPSFIFRDTAPSQNNN 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCF-------PLHSEDTESIGA---QIYSVAIFLGINLAAFIIIVFSYGSMFYSVHqsaitateiRNQVKKEMILAKR 655
Cdd:cd15116  148 KIICFnnfslsgDNSSPEVNQLRNmrhQVMTITRFLLGFLIPFTIIICCYAAIVLKLK---------RNRLAKSSKPFKI 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932467 656 FFFIVFTDALCWIPIFVVKFLSLLQVEIPGTitswvvIFILPI---------NSALNPILYTLTTRPFKEMI 718
Cdd:cd15116  219 IAAVIVTFFLCWAPYHILNLLEMEATRSPAS------VFKIGLpitsslafiNSCLNPILYVFMGQDFKKFK 284
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
440-715 1.89e-08

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 56.66  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICM---RPYIRS-ENKLYAmsiiSLCCADCLMGIYLFVIGGFDLKFRGeynkhaqlWM-ESTHCQLV 514
Cdd:cd14977    9 VIFAVGIIGNLMVLCIvctNYYMRSvPNILIA----SLALGDLLLLLLCVPLNAYNLLTKD--------WLfGDVMCKLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITV-LILIWITGFIVAFIPLSNKEFFKNYYGTNG---VCF 590
Cdd:cd14977   77 PFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVkLAVIWVGSVLLAVPEAVLSTVARESSLDNSsltVCI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATE-IRNQVKKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd14977  157 MKPSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRgTKKHMKQRRQLAKTVLCLVLVFAFCWLP 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 670 IFVVKFL-SLLQVEIPGTITSWVVI------FILPINSALNPILYTLTTRPFK 715
Cdd:cd14977  237 EHISNILrATLYNEVLIDTRSTLDIldligqFLSFFNSCVNPIALYLLSEPFR 289
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
437-715 2.16e-08

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 56.34  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 437 FVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKfrgeynkhAQLW-MESTHCQLVG 515
Cdd:cd15056    6 FLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELV--------NNRWiYGETFCLVRT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEffkNYYGTNGVCFPLHSE 595
Cdd:cd15056   78 SLDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGW---NHIGIEDLIAFNCAS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 596 DTESIgAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT-ATEIR-----------------NQVKKEMILAKRFF 657
Cdd:cd15056  155 GSTSC-VFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREqAHQIRslqragssnheadqhrnSRMRTETKAAKTLG 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 658 FIVFTDALCWIPIFVVKFLS-LLQVEIPGTItsWVVIFILP-INSALNPILYTLTTRPFK 715
Cdd:cd15056  234 IIMGCFCVCWAPFFVTNIVDpFIGYRVPYLL--WTAFLWLGyINSGLNPFLYAFFNKSFR 291
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
447-707 2.64e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 56.06  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 447 FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIyLFVIGGFDLKFRGEYnkhaqLWmESTHCQLVGSLAILSTEVSV 526
Cdd:cd15958   16 AGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGL-LVVPFGATLVVRGRW-----LY-GSFFCELWTSVDVLCVTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 527 LLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPL-------SNKEFFKNYygTNGVCFPLHSEDTE 598
Cdd:cd15958   89 ETLCVIAIDRYLAITSPFRYQSlLTRARAKGIVCTVWAISALVSFLPImmhwwrdEDDQALKCY--EDPGCCDFVTNRAY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 599 SIGAQIYSVAIFLginlaafIIIVFSYGSMFYSV---------------HQSAITATEIRNQVKKEMILA-----KRFFF 658
Cdd:cd15958  167 AIASSIISFYIPL-------LIMIFVYLRVYREAkkqikkidkcegrfhNTLTGLGRKCKRRPSRILALReqkalKTLGI 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 659 IVFTDALCWIPIFVVKFLSLLQVEIpgtITSWVVIFILPI---NSALNPILY 707
Cdd:cd15958  240 IMGVFTLCWLPFFLVNVVNVFNREL---VPDWLFVFFNWLgyaNSAFNPIIY 288
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
444-707 3.36e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 56.07  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 444 VTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIyLFVIGGFDLKFRGEYNkhaqlwMESTHCQLVGSLAIL 520
Cdd:cd15959   13 VIVGGNLLVIVA---IAKTPRLQTMTnvfVTSLACADLVMGL-LVVPPGATILLTGHWP------LGTTVCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCF--PLHSEDT 597
Cdd:cd15959   83 CVTASIETLCAIAVDRYLAITNPLRYeALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQRCYdnPRCCDFV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 598 ESIGAQIYSVAIFLGINLaafIIIVFSYGSMFY--SVHQSAITATEIR-NQVK--------------------KEMILAK 654
Cdd:cd15959  163 TNMPYAIVSSTVSFYVPL---LVMIFVYVRVFVvaTRQVRLIRKDKVRfPPEEsppaesrpacgrrpsrllaiKEHKALK 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 655 RFFFIVFTDALCWIPIFVVkflSLLQVEIPGTITSWVVIFIL---PINSALNPILY 707
Cdd:cd15959  240 TLGIIMGTFTLCWLPFFVA---NIIKVFCRSLVPDPAFLFLNwlgYANSAFNPIIY 292
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
436-715 3.47e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 55.51  E-value: 3.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFdlkfrgeYNKHAQLWMESTHCQ 512
Cdd:cd15050    5 IALSTISLITVILNLLVLYA---VRTERKLHTVGnlyIVSLSVADLIVGAVVMPLNIV-------YLLESKWILGRPVCL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAfIPLSNKEFFKNyygtNGVCFP 591
Cdd:cd15050   75 FWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISgAWLLSFLWV-IPILGWHHFAR----GGERVV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSE-DTESIGAQIYSV-AIFLGINLAAFIIIVFsYGSMFYSVHqsaitateirnqvkKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd15050  150 LEDKcETDFHDVTWFKVlTAILNFYIPSLLMLWF-YAKIFKAVN--------------RERKAAKQLGFIMAAFILCWIP 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 670 IFVV-KFLSLLQVEIPGTItSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15050  215 YFILfMVIAFCKNCCNENL-HMFTIWLGYINSTLNPFIYPLCNENFK 260
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
511-716 3.90e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 55.80  E-value: 3.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKC-RTITVLILIWITGFIVAfIPlsnkefFKNYYGTNGVC 589
Cdd:cd15134   74 CKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLsRAIRIIIAIWIIAFVCA-LP------FAIQTRIVYLE 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHS----EDTESIGAQIYSVAIFLGINLAAFI-------IIVFSYGSMFYSVHQSAI--------TATEIRNQVKK-- 648
Cdd:cd15134  147 YPPTSgealEESAFCAMLNEIPPITPVFQLSTFLffiipmiAIIVLYVLIGLQLRRSTLlrrgqrsvSGGRRSSQSRRtv 226
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 649 -EMILAkrfffIVFTDALCWIPIFVVKFLSL------LQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15134  227 lRMLVA-----VVVAFFICWAPFHAQRLLTVyaknmtPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
451-715 4.37e-08

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 55.66  E-value: 4.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 451 FVICMRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDlkfrgeyNKHAQLWMESTHCQLVGSLAILSTEVSVLLLT 530
Cdd:cd15980   23 FIVLRSKHMRTVTNLF---ILNLAISDLLVGIFCMPTTLLD-------NIIAGWPFGSTVCKMSGMVQGISVSASVFTLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 531 FLTLEKYICIVYPFRCVRPGKCRTItVLILIWITGFIV-----AFIPLSNKEFFKNYYGTNGVCFPLH--SEDTESIGA- 602
Cdd:cd15980   93 AIAVDRFRCIVYPFKQKLTISTAVV-IIVIIWVLAIAImcpsaVMLHVQEEKNYRVVLGSQNKTSPVYwcREDWPNQEMr 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 603 QIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQ------VKKEMILAKRFFFIVFTDALCWIPIFVVKFL 676
Cdd:cd15980  172 KIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQeqrhvvSRKKQKVIKMLLIVALLFILSWLPLWTLMML 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 677 SLLqVEIPGTITSWVVIFILPI-------NSALNPILYTLTTRPFK 715
Cdd:cd15980  252 SDY-ANLSPNQLQIINIYIYPFahwlaffNSSVNPIIYGFFNENFR 296
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
440-707 4.48e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 54.93  E-value: 4.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiyLFVIGGfdlkfrgeynkhaQLWMESTH--------C 511
Cdd:cd15196    9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVA--LFNVLP-------------QLIWDITYrfyggdllC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA----FIplsnkefFKNYYGTNG 587
Cdd:cd15196   74 RLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSipqlFI-------FSYQEVGSG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 V--CFPLHSEDTesiGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAItateirNQVKkeMILAkrfffIVFTDAL 665
Cdd:cd15196  147 VydCWATFEPPW---GLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRAKI------KTVK--LTLV-----VVACYIV 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767932467 666 CWIPIFVVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILY 707
Cdd:cd15196  211 CWTPFFVVQMWAAWDPTAPIEGPAFVIIMLLAsLNSCTNPWIY 253
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
470-715 5.81e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 54.94  E-value: 5.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 470 IISLCCADCLMGIYL--FVIG---GFDLKFRGeynkhaqlwmesthCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF 544
Cdd:cd15069   39 LVSLAAADVAVGLFAipFAITislGFCTDFHS--------------CLFLACFVLVLTQSSIFSLLAVAVDRYLAIKVPL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 545 R--CVRPGKcRTITVLILIWITGFIVAFIPL---------SNKEFFKNYYGTNGVCFpLHSEDTESIGAQIYSVAI-FLG 612
Cdd:cd15069  105 RykSLVTGK-RARGVIAVLWVLAFGIGLTPFlgwnkamsaTNNSTNPADHGTNHSCC-LISCLFENVVPMSYMVYFnFFG 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 613 INLAAFIIIVFSYGSMFYsVHQSAITATEI----RNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTIT 688
Cdd:cd15069  183 CVLPPLLIMLVIYIKIFL-VACRQLQRTELmdhsRTTLQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKP 261
                        250       260       270
                 ....*....|....*....|....*....|
gi 767932467 689 SWVV---IFILPINSALNPILYTLTTRPFK 715
Cdd:cd15069  262 KWAMnvaILLSHANSVVNPIVYAYRNRDFR 291
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
440-715 6.01e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 54.81  E-value: 6.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVIC---MRPYIRSENKLYamsIISLCCADCLMGIYLfviggfdLKFRGEyNKHAQLWM-ESTHCQLVG 515
Cdd:cd15063    9 FLNVLVVLGNLLVIAavlCSRKLRTVTNLF---IVSLACADLLVGTLV-------LPFSAV-NEVLDVWIfGHTWCQIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRcvRPG---KCRTITVLILIWITGFIVAFIPL----SNKEFFKNYYGTNGV 588
Cdd:cd15063   78 AVDVWMCTASILNLCAISLDRYLAITRPIR--YPSlmsTKRAKCLIAGVWVLSFVICFPPLvgwnDGKDGIMDYSGSSSL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 cfPLHSEDTESIGAQIYSVaifLGINLAAFIIIVFSYGsmfysvhqsaitatEIRNQVKKEMILAKRFFFIVFTDALCWI 668
Cdd:cd15063  156 --PCTCELTNGRGYVIYSA---LGSFYIPMLVMLFFYF--------------RIYRAARMETKAAKTVAIIVGCFIFCWL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 669 PIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15063  217 PFFTVYLVRAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
511-716 6.27e-08

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 54.74  E-value: 6.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPgkcRTITV----LILIWITGFiVAFIP---LSNKEFFKNYY 583
Cdd:cd15192   73 CKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLR---RTLVVarvtCIVIWLLAG-VASLPaiiHRDVFFIENTN 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 584 GTngVCFPLHSEDTESIGAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQS-AITATEIRNQVKKEMILAKRFFFIvft 662
Cdd:cd15192  149 IT--VCAFHYPSQNSTLLVGLGLMKNLLGF-LIPFLIILTCYTLIGKALKKAyEIQRNKPRNDEIFKMIMAVVLFFF--- 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767932467 663 daLCWIPIFVVKFLSLL-------QVEIPGTITSWV--VIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15192  223 --FCWIPHQIFTFLDVLiqlkviqDCHIADIVDTAMpfTICIAYFNSCLNPILYGFVGKNFRK 283
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
26-59 6.36e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767932467    26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
444-707 6.76e-08

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 54.87  E-value: 6.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 444 VTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEynKHAQLWmesthCQLVGSLAILSTE 523
Cdd:cd15957   13 AIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTW--TFGNFW-----CEFWTSIDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTITVLILIWITGFIVAFIPL------SNKEFFKNYYGTNGVCFpLHSED 596
Cdd:cd15957   86 ASIETLCVIAVDRYFAITSPFKYQSLlTKNKARVIILMVWIVSGLTSFLPIqmhwyrATHQEAINCYAEETCCD-FFTNQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 597 TESIGAQIYSVAIFLginlaafIIIVFSYGSMFYSVHQ--SAITATEIRNQVK---------------------KEMILA 653
Cdd:cd15957  165 AYAIASSIVSFYVPL-------VIMVFVYSRVFQEAKRqlQKIDKSEGRFHNQnidqngsgggggnrrrskfclKEHKAL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 654 KRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILY 707
Cdd:cd15957  238 KTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
440-715 1.08e-07

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 54.08  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTcfGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiylfvigGFDLKFRGEYNKHAQLWMESTHCQLVGSLAI 519
Cdd:cd16004   11 VLVAVT--GNATVIWIILAHRRMRTVTNYFIVNLALADLSMA-------AFNTAFNFVYASHNDWYFGLEFCRFQNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 520 LSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAFiPLSNKEFFKNYYGTNgVCFPLHSEDTES 599
Cdd:cd16004   82 TAMFVSIYSMTAIAADRYMAIIHPFK-PRLSAGSTKVVIAGIWLVALALAF-PQCFYSTVTMDQGRT-KCIVAWPGDSGG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRF----FFIVFTDALCWIPIFVVKF 675
Cdd:cd16004  159 KHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFvktmVVVVVTFAICWLPYHLYFI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 676 LSLLQVEI---PGTITSWVVIFILPINSAL-NPILYTLTTRPFK 715
Cdd:cd16004  239 LGSFNEDIycqKYIQQVYLAIFWLAMSSTMyNPIIYCCLNQRFR 282
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
440-716 1.28e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 53.80  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCL-------MGIYLFVIGGFDLkfrgeynkhaqlwmESTHCQ 512
Cdd:cd15307    9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMvavlvmpLGILTLVKGHFPL--------------SSEHCL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITV-LILIWITGfIVAFIPLSnKEFFKNYYGT--NGVC 589
Cdd:cd15307   75 TWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLkIVFVWLLS-IAMSLPLS-LMYSKDHASVlvNGTC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 fplhsEDTESIGAQIYSVAIF---LGINLAAFIIIVFSYGsmfysvHQSAITATEIRNQVKKEMILAKRFFFIVftdaLC 666
Cdd:cd15307  153 -----QIPDPVYKLVGSIVCFyipLGVMLLTYCLTVRLLA------RQRSRHGRIIRLEQKATKVLGVVFFTFV----IL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 667 WIPIFVVKFLSLLQVEIPGTITSW---VVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15307  218 WSPFFVLNLLPTVCAECEERISHWvfdVVTWLGYASSMVNPIFYTIFNKVFRQ 270
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
511-716 1.30e-07

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 54.00  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRpGKCRTITVLI--LIWITGFIVAfIPL---SNKEFFKNyyGT 585
Cdd:cd15088   73 CKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTK-YRTRFVAKLVnvGLWAASFLSI-LPVwvySSLIYFPD--GT 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSED---TESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAItateiRNQVKKemiLAKRFFFIVFT 662
Cdd:cd15088  149 TFCYVSLPSPDdlyWFTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHG-----SSRTKR---VTKMVILIVVV 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 663 DALCWIPIFVVKflsLLQVEIPGTITSWVVIFILPI-----NSALNPILYTLTTRPFKE 716
Cdd:cd15088  221 FIVCWLPFHVVQ---LVNLAMNRPTLAFEVAYFLSIclgyaNSCLNPFVYILVSENFRK 276
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
511-710 1.35e-07

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 53.65  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTIT-VLILIWITGFIVAFIPLSNKEFFKNYYGTNGVC 589
Cdd:cd15122   74 CKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRkILLAIWLLALLLALPAFVYRHVWKDEGMNDRIC 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAqiYSVAIFLGInLAAFIIIVFSygsmfYSVHQSAITATEIRNQVKKEMILAKrfffIVFTDALCWIP 669
Cdd:cd15122  154 EPCHASRGHAIFH--YTFETLVAF-VLPFGVILFS-----YSVILVRLKGARFRRRARVEKLIAA----IVVAFALLWVP 221
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 670 IFVVKFLSLLQVEIPGTITSWV----------VIFILPINSALNPILYTLT 710
Cdd:cd15122  222 YHVVNLLQVVANLAPGEVLEKLggaakaaragATALAFFSSSVNPLLYVFA 272
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
511-716 1.53e-07

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 53.46  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC---VRPGKCRTITVliLIWITGFIVaFIPLSNKEFFKNYYGTNG 587
Cdd:cd14974   72 CKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAqnhRTVRLASVVCV--GIWILALVL-SVPYFVFRDTVTHHNGRS 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHSEDTESIGAQ-IYSVAIFLGINLAAFIIIVFSYgsmfysvhqSAITATEIRNQVKKemilAKRFFFI----VFT 662
Cdd:cd14974  149 CNLTCVEDYDLRRSRHkALTVIRFLCGFLLPLLIIAICY---------SVIAVKLRRKRLAK----SSKPLRVllavVVA 215
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 663 DALCWIPIFVVKFLSLLQVEIPGTI--TSWVVIFILPI-NSALNPILYTLTTRPFKE 716
Cdd:cd14974  216 FFLCWLPYHVFALLELVAAAGLPEVvlLGLPLATGLAYfNSCLNPILYVFMGQDFRK 272
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
428-710 1.55e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 53.73  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 428 LLASIIqrVFVWVVSavtCFGNIFVIcmrpYIRSENK-LYA---MSIISLCCADCLMGIYL--FViggfdlkfrgeYNKH 501
Cdd:cd15079    2 LLGFIY--IFLGIVS---LLGNGLVI----YIFSTTKsLRTpsnMLVVNLAISDFLMMIKMpiFI-----------YNSF 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 502 AQLWM-ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkEFFK 580
Cdd:cd15079   62 YEGWAlGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWALLPL---LFGW 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 581 NYYGTNGV---CfplhSED--TESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSV--HQSAitateIRNQVKK----- 648
Cdd:cd15079  139 GRYVPEGFltsC----SFDylTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVfaHEKA-----LREQAKKmnvvs 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 649 ------------EMILAKRFFFIVFTDALCWIPIFVVKFLSLlqVEIPGTITSwvVIFILP-----INSALNPILYTLT 710
Cdd:cd15079  210 lrsnadankqsaEIRIAKVALTNVFLWFIAWTPYAVVALIGA--FGNQSLLTP--LVSMIPalfakTAACYNPIVYAIS 284
LRR_8 pfam13855
Leucine rich repeat;
322-375 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767932467  322 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
470-715 1.66e-07

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 53.68  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 470 IISLCCADCLMgiylfVIGGFDLKFRGEYNKHaqLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP 549
Cdd:cd15080   39 LLNLAVADLFM-----VFGGFTTTMYTSMHGY--FVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRF 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 550 GKCRTITVLILIWITGFIVAFIPLSNkefFKNYY--GTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGS 627
Cdd:cd15080  112 GENHAIMGVAFTWVMALACAAPPLVG---WSRYIpeGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGR 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 628 MFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKF-LSLLQVEIPGTITSWVVIFILPINSALNPIL 706
Cdd:cd15080  189 LVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFyIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVI 268

                 ....*....
gi 767932467 707 YTLTTRPFK 715
Cdd:cd15080  269 YILMNKQFR 277
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
440-716 1.96e-07

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 53.04  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICmrPYIRSEN--KLYAMSIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMESTHCQLVGSL 517
Cdd:cd15210    9 VFMVVGVPGNLLTVL--ALLRSKKlrTRTNAFIINLSISDLLFCA-------FNLPLAASTFLHQAWIHGETLCRVFPLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 518 AILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSED 596
Cdd:cd15210   80 RYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAgTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 597 TESIGAQIYSVAIFLGinlaaFIIIVFSYgsmfysvhqsaitateIRNQVKK--EMILAKRFFFIVftdalCWIPIFVVK 674
Cdd:cd15210  160 GRSPKTFLFVFGFVLP-----CLVIIICY----------------ARREDRRltRMMLVIFLCFLV-----CYLPITLVN 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767932467 675 FLSLLQVEIPGTITSWVVIFilpINSALNPILYTLTTRPFKE 716
Cdd:cd15210  214 VFDDEVAPPVLHIIAYVLIW---LSSCINPIIYVAMNRQYRQ 252
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
436-711 2.19e-07

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 53.25  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRpyIRSENKLyamsiislccadclmGIYLFVIGGFDLKFRG------EYNKHAQLWMEST 509
Cdd:cd15365    8 IFVIVISIPSNCISLYVSCLQ--IRKKNEL---------------GVYLFNLSLSDLLYIVilplwiDYLWNGDNWTLSG 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 510 H-CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRT-ITVLILIWITGFIVAFIPLSNKEFFKNYYGtNG 587
Cdd:cd15365   71 FvCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTaLSVSVAIWLLEICFNAVILTWEDSFHESSS-HT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFplHSEDTESIGAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILakrfffIVFTDALCW 667
Cdd:cd15365  150 LCY--DKFPLEDWQARLNLFRICLGY-LLPLLIILFCYWKIYQAVRSNQATEDQEKKKIFKLLLL------ITVTFVICF 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 668 IPIFVVKFL-SLLQVEIPGTITSWVVIF-----ILPINSALNPILYTLTT 711
Cdd:cd15365  221 TPYHVVLLIrSIVEPCDCRNAKWLYTLYkitvaLTSLNCIADPFLYCFVT 270
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
432-718 2.49e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 53.02  E-value: 2.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVIC--MRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMEST 509
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVvlTRKSMRSSTNVY---LAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 510 HCQLVgsLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKC-RTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGV 588
Cdd:cd14978   78 PYIYP--LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPrRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 CFPLHSEDT---ESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIR-------NQVKKEMILAKRFFF 658
Cdd:cd14978  156 YYYVIPTLLrqnETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRrrrrllsRSQRRERRTTIMLIA 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 659 IVFTDALCWIPIFVVKFLSLLqVEIPGTITSWVVI-----FILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd14978  236 VVIVFLICNLPAGILNILEAI-FGESFLSPIYQLLgdisnLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
440-715 3.18e-07

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 52.93  E-value: 3.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMG---IYLFVIGGFDLKfrgeynkhaqlwMESTHCQLVGS 516
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalvIPLAIIINIGPQ------------TEFYSCLMVAC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWITGFIVAFIP------LSNKEFFKNYYGT-NGV 588
Cdd:cd15071   77 PVLILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIaGCWILSFLVGLTPmfgwnnLNAVERAWAANSSmGEL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 CFPLHSEDTESIGAQIYSVaiFLGINLAAFIIIVFSYGSMFYSVHQS-----AITATEIRNQVKKEMILAKRFFFIVFTD 663
Cdd:cd15071  157 VIKCQFETVISMEYMVYFN--FFVWVLPPLLLMLLIYLEVFYLIRKQlnkkvSSSSSDPQKYYGKELKIAKSLALILFLF 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 664 ALCWIPIFVVKFLSLL--QVEIPGTITsWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15071  235 ALSWLPLHILNCITLFcpSCKKPMILT-YIAIFLTHGNSAMNPIVYAFRIKKFR 287
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
437-715 3.25e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 52.32  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 437 FVWVVSAVTCFGNIFViCMRpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFDLKFrgeynkHAQLWMESTHCQL 513
Cdd:cd15052    6 LLLLLVIATIGGNILV-CLA--ISLEKRLQNVTnyfLMSLAIADLLVGLLVMPLSILTELF------GGVWPLPLVLCLL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 514 VGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAfIPLSNKEFFK-NYYGTNGVCFP 591
Cdd:cd15052   77 WVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIvWLISIGIS-SPIPVLGIIDtTNVLNNGTCVL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 lhsedtESIGAQIY-SVAIFLginlAAFIIIVFSYgsmfysvhqsAITATEIRNQVKKEMILAKRFFFIVftdaLCWIPI 670
Cdd:cd15052  156 ------FNPNFVIYgSIVAFF----IPLLIMVVTY----------ALTIRLLSNEQKASKVLGIVFAVFV----ICWCPF 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 671 FVVKFLSLLQVEIPGTITSW---VVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15052  212 FITNILTGLCEECNCRISPWllsVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
436-709 3.29e-07

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 52.35  E-value: 3.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGI-------YLFVIGGFdlkfrgeynkhaqlW-ME 507
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAIlvmpfavYVEVNGGK--------------WyLG 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAfIPLsnkeffknYYGTN 586
Cdd:cd15053   71 PILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIvWVVSAAIA-CPL--------LFGLN 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVcfPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYgsmfysvhqsAITATEIRNQVKKEMILAkrfffIVFTDAL- 665
Cdd:cd15053  142 NV--PYRDPEECRFYNPDFIIYSSISSFYIPCIVMLLLY----------YRIFRALRREKKATKTLA-----IVLGVFLf 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 666 CWIPIFVVKFLSLL-------QVEIPGTITSWVViFILPINSALNPILYTL 709
Cdd:cd15053  205 CWLPFFTLNILNAIcpklqnqSCHVGPALFSLTT-WLGYVNSFLNPIIYTI 254
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
438-716 3.60e-07

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 52.62  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 438 VWVVSAVTCFGNIFVICMRPYIRSENklyAMSIISLCCADclmgiYLFViggFDLKFRGEYNKHAQLWMESTHCQLVGSL 517
Cdd:cd15155   10 VFILGLITNCASLFVFCFRMKMRNET---AIFMTNLAVSD-----LLFV---FTLPFKIFYNFNRHWPFGDSLCKISGTA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 518 AILSTEVSVLLLTFLTLEKYICIVYPFRCvRPGKCRTITVLIL--IWIT----GFIVAFIPLSNKEffknyyGTNGVCFP 591
Cdd:cd15155   79 FLTNIYGSMLFLTCISVDRFLAIVYPFRS-RTIRTRRNSAIVCagVWILvlsgGISASLFSTTNVS------NTSTTCFE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTesigAQIYSVAIFLGINLAAFIIIVF---SYGSMFYSVHQSAITATEIRNQVKK--EMILAKRFFFIVftdalC 666
Cdd:cd15155  152 GFSKSI----WKTYLSKITIFIEVVGFIIPLLlnlTCSSLVLRTLRKPATLSQIGTNKEKvlKMILVHVAIFVV-----C 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 667 WIPIFVVKFLSLL---------QVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15155  223 FVPYNSILFLYALvrsqaiancGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQK 281
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
436-715 3.88e-07

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 52.36  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiylfVIGGFDLKFRGEYNKHAQLWMESThCQLVG 515
Cdd:cd15182    5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISD--------LLFTFTLPFWASYHSSGWIFGEIL-CKAVT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGfIVAFIPlsNKEFFKNYYGTNGVCFPLHS 594
Cdd:cd15182   76 SIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRyASLVSVAVWVIS-ILASLP--ELILSTVMKSDEDGSLCEYS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESIGAQIYSVAIFLginlAAFIIIVFSYgsmfysvhqSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVK 674
Cdd:cd15182  153 SIKWKLGYYYQQNLFFL----IPLGIIVYCY---------VRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVI 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767932467 675 FLSLLQ-VEIPGTITSWVVIFILPI--NSA-----LNPILYTLTTRPFK 715
Cdd:cd15182  220 FLRSLKdLTIPICECSKQLDYAFYIcrNIAfshccLNPVFYVFVGVKFR 268
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
508-715 3.89e-07

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 52.17  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRpgkCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNG 587
Cdd:cd15973   69 SAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAAR---YRRPTVAKMINICVWILSLLVISPIIIFADTATRKG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 ---VCFPLHSEDTESIGAQIYSVaiflginLAAFIIIVFSYGsMFYSVHQSAITATEIR----NQVKKEMILAKRFFFIV 660
Cdd:cd15973  146 qavACNLIWPHPAWSAAFVIYTF-------LLGFLLPVLAIG-LCYILIIGKMRAVALKagwqQRRKSEKKITRMVLMVV 217
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 661 FTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPiNSALNPILYTLTTRPFK 715
Cdd:cd15973  218 TVFVICWMPFYVVQLLNLFLPRLDATVNHASLILSYA-NSCANPILYGFLSDNFR 271
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
440-716 4.51e-07

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 52.11  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADclmgiYLFVIGgfdLKFRGEYNKHAQLWMESTHCQLVGS 516
Cdd:cd15972    9 VVCVVGLGGNtlvIYVVLRYSASESVTNIY---ILNLALAD-----ELFMLG---LPFLAAQNALSYWPFGSFMCRLVMT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPfrcVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSED 596
Cdd:cd15972   78 VDAINQFTSIFCLTVMSVDRYLAVVHP---IRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 597 TE--SIGAQIYSVAifLGInLAAFIIIVFSYGSMFYSVHQSA--ITATEIRNQvKKEMILAKRFFFIVFTDALCWIPIFV 672
Cdd:cd15972  155 AQvwRAGFIIYTAT--LGF-FCPLLVICLCYLLIVVKVRSSGrrVRATSTKRR-GSERKVTRMVVIVVAAFVLCWLPFYA 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 673 VKFLSLLQV--EIPGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15972  231 LNIVNLVCPlpEEPSLFGLYFFVVVLSyANSCANPIIYGFLSDNFKQ 277
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
511-715 5.46e-07

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 52.00  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRT-ITVLILIWITGFIVAFIPLSNKEFFKNYYgTNGVC 589
Cdd:cd15160   73 CKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFaLKVSASIWVLELGTHSVFLGHDELFRDEP-NHTLC 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGINLAafiIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTdalcwiP 669
Cdd:cd15160  152 YEKYPMEGWQASYNYARFLVGFLIPLS---LILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFL------P 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 670 IFVVKFL-SLLQVEIPGT--------ITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15160  223 YHVVLLVrSVIELVQNGLcgfekrvfTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
441-716 6.96e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 51.86  E-value: 6.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 441 VSAVTCFGNIFV---ICMRPYIRSENKLYamsIISLCCADCLMGIY-----LFVIGGFDLKFRGeynkhaqlwmesthCQ 512
Cdd:cd15068   10 IAVLAILGNVLVcwaVWLNSNLQNVTNYF---VVSLAAADIAVGVLaipfaITISTGFCAACHG--------------CL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFR--CVRPGKcRTITVLILIWITGFIVAFIPL---SNKEFFKNYYGTNG 587
Cdd:cd15068   73 FIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRynGLVTGT-RAKGIIAICWVLSFAIGLTPMlgwNNCGQPKEGKNHSQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHS----EDTESIGAQIY-----SVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFF 658
Cdd:cd15068  152 GCGEGQVaclfEDVVPMNYMVYfnffaCVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 659 IVFTDALCWIPIFVVKFLSLL--QVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15068  232 IVGLFALCWLPLHIINCFTFFcpDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
505-715 7.36e-07

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 51.49  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 505 WMEST-HCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKC-RTITVLILIWITGFIVA-----FIPLSNKE 577
Cdd:cd15125   66 WMFGTvGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVlRTCLKAIAIWVVSVLLAvpeavFSEVAHIM 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 578 FFKNYYGTNGVCFPLhsedTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITAT-EIRNQVKKEMILAKRF 656
Cdd:cd15125  146 PDDNTTFTACIPYPQ----TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPgEYSEHSKRQMETRKRL 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 657 FFIVFT----DALCWIPIFVV-KFLSLLQVEIPGTITSWVVIFILPI----NSALNPILYTLTTRPFK 715
Cdd:cd15125  222 AKIVLVfvglFAFCWFPNHVLyMYRSFNYNEIDSSLGHMIVTLVARVlsfcNSCVNPFALYLLSESFR 289
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
511-716 8.78e-07

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 51.44  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITV-LILIWITGFIVAfIPLSNKEFFKNYY--GTNG 587
Cdd:cd15124   73 CKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLkAALIWILSMLLA-IPEAVFSDLHPFYdkSTNK 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 V---CFPL-HSEDtesIGAQIYSVAIFLginlaAFIIIVFSYGSMFYS-VHQSAITA---------TEIRNQVKKEMILA 653
Cdd:cd15124  152 TfvsCAPYpHSNE---LHPKIHSMASFL-----IFYVIPLSIISVYYYfIAKNLIRSaynlpvegnVHVRRQIESRKRLA 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 654 KRFFFIVFTDALCWIPIFVVKF-----LSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15124  224 KTVLVFVGLFAFCWLPNHIIYLyrsyhYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRK 291
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
505-716 1.01e-06

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 50.83  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 505 WMESTH-CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRtitVLILI-WITGFIVAFIPLSNKEFFKNY 582
Cdd:cd15213   66 WIFGDIfCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRAK---ILIAVsWVLSFCVSFPPLVGWGKYEFP 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 583 YGTNGVCFplhsEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITA-TEIrnqvkkeMILakrffFIVF 661
Cdd:cd15213  143 PRAPQCVL----GYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTRAfTTI-------LIL-----FIGF 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 662 TdaLCWIPIFVVKFLSLLQVEIPGT-ITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15213  207 S--VCWLPYTVYSLLSVFSRYSSSFyVISTCLLWLSYLKSAFNPVIYCWRIKKFRE 260
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
436-715 1.07e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 50.93  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGN---IFVICMRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDLKFRGeynkhaqlWM-ESTHC 511
Cdd:cd14971    5 LFFALIFLLGLVGNslvILVVARNKPMRSTTNLF---ILNLAVADLTFLLFCVPFTATIYPLPG--------WVfGDFMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCF 590
Cdd:cd14971   74 KFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRnALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT--ATEIRNQVKKE---MILAkrfffIVFTDAL 665
Cdd:cd14971  154 EAWPSRAHR---RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRpvLSEGSRRAKRKvtrLVLV-----VVVLFAA 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 666 CWIPIFVVKFLSLLQVE--IPGTITSWVVIFILP-INSALNPILYTLTTRPFK 715
Cdd:cd14971  226 CWGPIHAILLLVALGPFplTYATYALRIWAHCLAySNSAVNPVLYAFLSEHFR 278
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
444-715 1.10e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 50.82  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 444 VTCFGNIFVI---CMRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFDLKFrgeynkhaQLW-MESTHCQLVGSLAI 519
Cdd:cd15061   12 FTIFGNLLVIlavATTRRLRTITNCY---IVSLATADLLVGVLVLPLAIIRQLL--------GYWpLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 520 LSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAFIPL--SNKEFFKnyygTNGVCFPlhsed 596
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAvWVISLLITSPPLvgPSWHGRR----GLGSCYY----- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 597 TESIGAQIYSVaifLGINLAAFIIIVFSYGSMFYSVHqsaitateirnqvkKEMILAKRFFFIVFTDALCWIPIFVVKFL 676
Cdd:cd15061  152 TYDKGYRIYSS---MGSFFLPLLLMLFVYLRIFRVIA--------------KERKTAKTLAIVVGCFIVCWLPFFIMYLI 214
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767932467 677 SLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15061  215 EPFCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFR 253
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
511-716 1.22e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.14  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTITVLILIWITGFI----VAFIPlsnkeFFKNYYGT 585
Cdd:cd14997   74 CKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVcTKRRALVIIALIWLLALLtsspVLFIT-----EFKEEDFN 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NG----VCfplhseDTESIGAqiYSVAIFLGINLAAFIIIVFSYgSMFYSV----------------HQSAITATEIRNQ 645
Cdd:cd14997  149 DGtpvaVC------RTPADTF--WKVAYILSTIVVFFVVPLAIL-SGLYSVicrrlvghpalesrraDAANRHTLRSRRQ 219
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 646 VKKEMILAKRFFFIvftdalCWIPIFVVKFLSLL----QVEIPGTITSWVVI----FILPINSALNPILYTLTTRPFKE 716
Cdd:cd14997  220 VVYMLITVVVLFFV------CLLPFRVVTLWIIFapdeDLQALGLEGYLNLLvfcrVMVYLNSALNPILYNLMSTKFRS 292
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
511-715 1.27e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 50.66  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcvRPG---KCRTITVLILIWITGFIVAFIPLSN-KEffknyygtn 586
Cdd:cd15326   73 CDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQ--YPTivtRKRAILALLGVWVLSTVISIGPLLGwKE--------- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 gvcfPLHSEDTESIGAQIYSVAIFlgINLAAFIIIVFSYGSMFYSVHQSAItateirnQVKKEMILAKRFFFIVFTDALC 666
Cdd:cd15326  142 ----PAPPDDKVCEITEEPFYALF--SSLGSFYIPLIVILVMYCRVYIVAL-------KFSREKKAAKTLGIVVGMFILC 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 667 WIPIFVVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILYTLTTRPFK 715
Cdd:cd15326  209 WLPFFIALPLGSLFSHLKPPETLFKIIFWLGyFNSCLNPIIYPCSSKEFK 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
432-715 1.33e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 50.75  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLfviggfdLKFRGEYNKHAQLWMESTHC 511
Cdd:cd15330    1 IITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLV-------LPMAALYQVLNKWTLGQVTC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWITGFIVAFIPLSNKEFFKNYYGTNGVCF 590
Cdd:cd15330   74 DLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLIsLTWLIGFSISIPPMLGWRTPEDRSDPDACTI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 plhSEDTesiGAQIYSVaifLGINLAAFIIIVFSYGSMFYSvhqsaitATEIRNQVKKEMILAKRFFfivftdaLCWIPI 670
Cdd:cd15330  154 ---SKDP---GYTIYST---FGAFYIPLILMLVLYGRIFKA-------AARERKTVKTLGIIMGTFI-------LCWLPF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 671 FVVKFL------SLLQVEIPGTITSWVVIfilpINSALNPILYTLTTRPFK 715
Cdd:cd15330  211 FIVALVlpfcesTCHMPELLGAIINWLGY----SNSLLNPIIYAYFNKDFQ 257
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
445-716 1.36e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 50.35  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 445 TCFGNIFVICMRPYIRsenKLYAMS---IISLCCADCLMGIYLFVIGGFDLKFRGeynkhaqlWM-ESTHCQLVGSLAIL 520
Cdd:cd15329   14 TVVGNALVIIAVCLVK---KLRTPSnylIVSLAVSDLLVALLVMPLAIIYELSGY--------WPfGEILCDVWISFDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFR-CVRPGKCRTITVLILIWITGFIVAFIPLSNkefFKNYYGTNGVCFPlhsedTES 599
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTyAVKRTPKRMALMIAIVWLLSALISIPPLFG---WKNKVNDPGVCQV-----SQD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGAQIYSVAIFLGINLAAFIIIvfsYGSMFysvhqsaitateirNQVKKEMILAKRFFFIV--FTdaLCWIPIFVVKFL- 676
Cdd:cd15329  155 FGYQIYATFGAFYIPLIVMLVL---YYKIY--------------RAAKSERKAIKTLGIIMgaFT--LCWLPFFILALLr 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767932467 677 SLLQVEIPGTITSWVVIFILPI---NSALNPILYTLTTRPFKE 716
Cdd:cd15329  216 PFLKPIKCSCIPLWLSRLFLWLgyaNSFLNPIIYAKFNREFRT 258
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
433-709 1.50e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 50.89  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 433 IQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIyLFVIGGFDLKFRGEYnkHAQLWMesthCQ 512
Cdd:cd15197    2 EQLATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGL-INVLTDIIWRITVEW--RAGDFA----CK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGkcRTITVLILI-WITGFIVAfIPlSNKEFFKNYYGTNGV-CF 590
Cdd:cd15197   75 VIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSG--RQARVLICVaWILSALFS-IP-MLIIFEKTGLSNGEVqCW 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDtesIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSV-HQSAITATEIRNQVKKE---------MI------LAK 654
Cdd:cd15197  151 ILWPEP---WYWKVYMTIVAFLVFFIPATIISICYIIIVRTIwKKSKIQVTINKAGLHDGssrrsssrgIIprakikTIK 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 655 RFFFIVFTDALCWIPIFVVKFLSLLQVeIPGTITSWVV-IFI---LPINSALNPILYTL 709
Cdd:cd15197  228 MTFVIVTVFIICWSPYFVFDLLDVFGL-LPRSKTKIAAaTFIqslAPLNSAINPLIYCL 285
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
511-718 1.53e-06

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 50.48  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR--TITVLILIWITGFIVAFIPLSNKEFFKNyygTNGV 588
Cdd:cd15161   73 CRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLyaHVVCGFLWVIVTVAMAPLLVSPQTVEVN---NTTV 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 CFPLHSEdTESIGAQIYSVAIFlginLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIvftdalCWI 668
Cdd:cd15161  150 CLQLYRE-KASRGALVSLAVAF----TIPFVTTVTCYLLIIRSLRTGKREEKPLKDKAIKMIILVLTIFLI------CFV 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767932467 669 PIFVVKFLSLLQVEIPGT-------------ITSWVVIfilpINSALNPILYTLTTRPFKEMI 718
Cdd:cd15161  219 PYHISRYIYILSHNGAGAscssrrglalanrITSCLTC----LNGALDPVMYFFVAEKFRETL 277
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
437-716 1.67e-06

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 50.44  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 437 FVWVVSAVTCFGNIFVICMRPYIRSENKLyAMSIISLCCADCLMgiyLFVIGGFDlkfrGEYNKHAQLWMESTHCQLVGS 516
Cdd:cd15383    8 FVLFVLSACSNLAVLWSATRNRRRKLSHV-RILILHLAAADLLV---TFVVMPLD----AAWNVTVQWYAGDLACRLLMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVRpGKCRTITVLILIWITGFIVAFIPLSnkeFFKNYYGTNGV----C--- 589
Cdd:cd15383   80 LKLFAMYSSAFVTVVISLDRHAAILNPLAIGS-ARRRNRIMLCAAWGLSALLALPQLF---LFHTVTATPPVnftqCath 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 --FPLHSEDTesigaqIYSVAIFLGINLAAFIIIVFSYGSMFYSV-HQSAITATEIRNQV----------KKEMILAKRF 656
Cdd:cd15383  156 gsFPAHWQET------LYNMFTFFCLFLLPLLIMIFCYTRILLEIsRRMKEKKDSAKNEValrsssdnipKARMRTLKMT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 657 FFIVFTDALCWIPIFVVKFL-----SLLQVEIPGTITSWVVIFILpINSALNPILYTLTTRPFKE 716
Cdd:cd15383  230 IVIVSSFIVCWTPYYLLGLWywfspEMLEQTVPESLSHILFLFGL-LNACLDPLIYGLFTISFRR 293
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
512-712 1.81e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 50.22  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTflTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLSNKeffkNYYGTNGVC- 589
Cdd:cd15099   76 KLGGVTMAFTASVGSLLLT--ALDRYLCIYQPSNYKLlVTRTRAKVAILLMWCVTIIISFLPLMGW----RCKTWDSPCs 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 --FPLHSEDTesigaqiysVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATE---IRNQVKK------EMILAKRFFF 658
Cdd:cd15099  150 rlFPYIDRHY---------LASWTGLQLVLLFLIIYAYPYILWKAHRHEANMGGpklGRQQVKGqarmrmDIRLAKTLSL 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 659 IVFTDALCWIPIfvvkfLSLLQVEIPGTITSWV------VIFILPINSALNPILYTLTTR 712
Cdd:cd15099  221 ILLVLAICWLPV-----LAFMLVDVRVTLTNKQkrmfafCSMLCLVNSCVNPIIYALRSR 275
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 2.04e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 2.04e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932467   25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
508-715 3.74e-06

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 49.50  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFiPLSNKEFFKNYYGTN 586
Cdd:cd15131   70 DLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAkVVVTKRRVKLVILVLWAVSFLSAG-PIFVLVGVEHENGTN 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVcfplhseDTESIGAQIYSV-----AIFLGINLAAFIIIVFSYgSMFYSV---------HQSAITATEIRNQVKKEMIl 652
Cdd:cd15131  149 PI-------DTNECKATEYAVrsgllTIMVWVSSVFFFLPVFCL-TVLYSLigrklwrrrRENIGPNASHRDKNNRQTV- 219
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 653 aKRFFFIVFTDALCWIPIFVVKFL-------SLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15131  220 -KMLAVVVFAFVLCWLPFHVGRYLfsksfeaGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
432-715 4.42e-06

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 48.97  E-value: 4.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGgfdlkfrgEYNKHAQLWMESTH- 510
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLN--------VAYFLLGKWLFGIHl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPfrcVRPGKCRTIT-VLILI---WITGFIVAFIPLsnkeffknyYGTN 586
Cdd:cd15060   73 CQMWLTCDILCCTASILNLCAIALDRYWAIHDP---INYAQKRTLKrVLLMIvvvWALSALISVPPL---------IGWN 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSED----TESIGAQIYSVaifLGINLAAFIIIVFSYGSMFYSVhqsaitateirnqvKKEMILAKRFFFIVFT 662
Cdd:cd15060  141 DWPENFTETTpctlTEEKGYVIYSS---SGSFFIPLLIMTIVYVKIFIAT--------------SKERRAARTLGIIMGV 203
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 663 DALCWIPIFVVK-FLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15060  204 FVVCWLPFFLMYvILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFR 257
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
440-715 4.75e-06

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 49.16  E-value: 4.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFdlkfrgeYNKHAQLWMESTHCQLVGS 516
Cdd:cd16003    9 FVVAVAVFGNLIVIWI---ILAHKRMRTVTnyfLVNLAFSDASMAAFNTLINFI-------YALHSEWYFGEAYCRFHNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAFiPLSnkeffknYYGTNGV------CF 590
Cdd:cd16003   79 FPITSVFASIYSMTAIAVDRYMAIIDPLK-PRLSATATKVVIGSIWILAFLLAF-PQC-------LYSKTKVmpgrtlCF 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESigAQIYSVAIFLGINLAAFIIIVFSY---GSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCW 667
Cdd:cd16003  150 VAWPGGPDQ--HFTYHIIVIVLVYCLPLLVMGITYtivGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICW 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 668 IPIFVVKFLSLLQVEIPG---TITSWVVIFILPINSAL-NPILYTLTTRPFK 715
Cdd:cd16003  228 LPYHIYFIVTGLYQQLNRwkyIQQVYLASFWLAMSSTMyNPIIYCCLNKRFR 279
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
436-707 6.19e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 48.78  E-value: 6.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRS----ENKLyamsIISLCCADCLMGIYLFViggFDLKFRGEYNkhaqLWMESTHC 511
Cdd:cd15314    5 IFLGLISLVTVCGNLLVIISIAHFKQlhtpTNYL----ILSLAVADLLVGGLVMP---PSMVRSVETC----WYFGDLFC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAI-LSTeVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-W----ITGFIVAFIPLSNKEFFKNYYGT 585
Cdd:cd15314   74 KIHSSFDItLCT-ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILIsWsvsaLVGFGIIFLELNIKGIYYNHVAC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEdtesIGAQIYSVAIFLginLAAFIIIVFsYGSMFY-------SVHQSAITATEIRNqvKKEMILAKRFFF 658
Cdd:cd15314  153 EGGCLVFFSK----VSSVVGSVFSFY---IPAVIMLCI-YLKIFLvaqrqarSIQSARTKSGASSS--KMERKATKTLAI 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 659 IVFTDALCWIPIFV-VKFLSLLQVEIPGTITSWVVIFILpINSALNPILY 707
Cdd:cd15314  223 VMGVFLLCWTPFFLcNIIDPFINYSIPPVLIEVLNWLGY-SNSTLNPFIY 271
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
511-716 7.51e-06

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 48.56  E-value: 7.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAfIPLSnkeFFKNYYGTNGV-- 588
Cdd:cd15002   74 CKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLP-LPQW---LFRTVKQSEGVyl 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 ---CFPLHSEDTESIgaqiYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMiLAKRFFFIVFTDAL 665
Cdd:cd15002  150 cilCIPPLAHEFMSA----FVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRK-LTHMLLSVVLAFTI 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 666 CWIPIFVvkfLSLLQVEI-------PGTITSWVVIFILPINSAlNPILYTLTTRPFKE 716
Cdd:cd15002  225 LWLPEWV---AWLWLIHIkssgsspPQLFNVLAQLLAFSISSV-NPIIFLLMSEEFRE 278
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
436-716 8.26e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 48.48  E-value: 8.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFViCMRpyIRSENKLYAMS---IISLCCADCLMGiyLFViggfdLKFRGEYNKHAQLWMESTHCQ 512
Cdd:cd15051    5 VVLAVIILLTVIGNVLV-CLA--VAVNRRLRNLTnyfIVSLAVTDLLLG--LLV-----LPFSAIYELRGEWPLGPVFCN 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWITGFIVAFIPL-----SNKEFFKNYYGTN 586
Cdd:cd15051   75 IYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALaAIWVVSLAVSFLPIhlgwnTPDGRVQNGDTPN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSedtesigaqIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSA---ITATEIRNQVKKEMILAKR-------F 656
Cdd:cd15051  155 QCRFELNP---------PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAkriNALTPASTANSSKSAATARehkatvtL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 657 FFIVFTDALCWIPIFVV-KFLSLLQVEIPGTITSwVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15051  226 AAVLGAFIICWFPYFTYfTYRGLCGDNINETALS-VVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
510-715 1.06e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 48.25  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 510 HCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAfIPL-------SNKEFFKNY 582
Cdd:cd15135   77 ACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVWLTSALVA-LPLlfamgteDPLEAFPSY 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 583 YGTNGVCFPLHSEDT--ESIGAQ--IYSVAIFlginlAAFII-------IVFSYGSMFYSVHQSAITATEIRNQVKKEMI 651
Cdd:cd15135  156 RGTRHHCQDQKSNLTicTSLSSKwtVFQASIF-----SAFVLyllvlasVAFMCRRMMRALMGSKKGAVAVKGPGGSVQL 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 652 LAK--------------RFF-FIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW-VVIFILPI-------NSALNPILYT 708
Cdd:cd15135  231 LRKhesaegktarkqtiLFLgLIVGTLAVCWMPNQIRRIMAAAKPKDDWTRSYFrAYIILLPIadtffylSSVLNPLLYN 310

                 ....*..
gi 767932467 709 LTTRPFK 715
Cdd:cd15135  311 LSSQQFR 317
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
432-715 1.11e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 47.76  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLmgiyLFVIGGFDLKFRGEYNKHAQLWMESThC 511
Cdd:cd14995    1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLM----VLVAAGLPNEIESLLGPDSWIYGYAG-C 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-----VRPGKCrtitVLILIWITG--------FIVAFIPLS---- 574
Cdd:cd14995   76 LLITYLQYLGINASSLSITAFTIERYIAICHPMKAqfictVSRAKK----IICFVWIFTslycspwlFLLDLSIKHygdd 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 575 ---------NKEFFKNYYGTNGVCFplhsedtesigaqiYSVAIFLGINLAAFIIIVFSYGsmfysvhqsaitateiRNQ 645
Cdd:cd14995  152 ivvrcgykvSRHYYLPIYLADFVLF--------------YVIPLLLAIVLYGLIGRILFSS----------------RKQ 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 646 VKKEMILakrfffIVFTDALCWIP--IFVV--KFLSllqveiPGTITSWVVIF---ILPINSALNPILYTLTTRPFK 715
Cdd:cd14995  202 VTKMLAV------VVVLFALLWMPyrTLVVynSFAS------PPYLDLWFLLFcrtCIYLNSAINPILYNLMSQKFR 266
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
432-715 1.11e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 47.80  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVI----CMRPYIRSENKlyAMSIISLCCADclmgiYLFVIggFDLKFRGEYNKHAQLWME 507
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVItvlaRVKPGKRRSTT--NVFILNLSIAD-----LFFLL--FCVPFQATIYSLPEWVFG 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITV-LILIWITGFIVAFIPLSNKEFFKNYYGTN 586
Cdd:cd15098   72 AFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLgVLVIWVLSLAMASPVAVHQDLVHHWTASN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 -GVCFPLHSEDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMilAKRFFFIVFTDAL 665
Cdd:cd15098  152 qTFCWENWPEKQQK---PVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSKKKT--AQTVLVVVVVFGI 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 666 CWIPIFVVKflslLQVE---IPGTITSwvviFILPI--------NSALNPILYTLTTRPFK 715
Cdd:cd15098  227 SWLPHHIIH----LWVEfgdFPLTQAS----FVLRItahclayaNSCVNPIIYAFLSENFR 279
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
438-716 1.12e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 47.72  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 438 VWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIylfVIGGFDL--KFRGEYnkhaqlWMESTHCQLVG 515
Cdd:cd15059    7 VSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGL---LIMPFSLvnELMGYW------YFGSVWCEIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAFIPLSNKEFFKNYYGTNGVCfplhs 594
Cdd:cd15059   78 ALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAaVWIISAVISLPPLFGWKDEQPWHGAEPQC----- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESIGAQIYSVAIFLGINLAaFIIIVFSygsMFYSVHQsaitateirnqvKKEmilaKRFFFI------VFTdaLCWI 668
Cdd:cd15059  153 ELSDDPGYVLFSSIGSFYIPLL-IMIIVYA---RIYRAAK------------RKE----RRFTLVlgvvmgAFV--LCWL 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 669 PIFVvkFLSLLQVEIPGTITSWVVIFILPI---NSALNPILYTLTTRPFKE 716
Cdd:cd15059  211 PFFF--TYPLVVVCKTCGVPELLFKFFFWLgycNSALNPVIYTIFNKDFRR 259
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
511-715 1.23e-05

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 47.60  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV---RPGKCRTITVLILIWITGFIVAFIPLSNKEffKNYYGTNG 587
Cdd:cd15970   72 CRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAAryrRPTVAKMVNLGVWVFSILVILPIIIFSNTA--PNSDGSVA 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 vCFPLHSEDTESIGAqIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITAT-EIRNQVKKEMILAKRFFFIVFTdaLC 666
Cdd:cd15970  150 -CNMQMPEPSQRWLA-VFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGwQQRKRSERKITLMVMMVVTVFV--IC 225
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767932467 667 WIPIFVVKFLSLLQVEIPGTITSWVVIFILPiNSALNPILYTLTTRPFK 715
Cdd:cd15970  226 WMPFYVVQLVSVFVGQHDATVSQLSVILGYA-NSCANPILYGFLSDNFK 273
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
524-716 1.24e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 47.90  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITvliLIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGaq 603
Cdd:cd15078   86 VSIMTLTVLAYERYIRVVHAKVVNFSWSWRAIT---YIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPNDTS-- 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 604 iYSVAIFLGINLAAFIIIVFSYGSMFYSVH-----QSAITATEIRnQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSL 678
Cdd:cd15078  161 -FVLLFFLGCLVVPLGIMAYCYGHILYEIRmlrsvEDLQTFQVIK-ILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVT 238
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767932467 679 LQVEIPGTITSWVVIFILPI-NSALNPILYTLTTRPFKE 716
Cdd:cd15078  239 SGYSKLVTPTIAIIPSLFAKsSTAYNPVIYIFMIRKFRQ 277
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
440-715 1.24e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 47.62  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLwmesthCQLVGS 516
Cdd:cd15304    9 IVIILTIAGNILVIMA---VSLEKKLQNATnyfLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKL------CAVWIY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIW-ITGFIVAFIPL----SNKEFFKNyygtnGVCF 590
Cdd:cd15304   80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRfNSRTKAFLKIIAVWtISVGISMPIPVfglqDDSKVFKE-----GSCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 pLHSEDTESIGAqiySVAIFLginlaAFIIIVFSYGSMFYSVHQSaitateIRNQVKKEMILAKRFFFIVftdaLCWIPI 670
Cdd:cd15304  155 -LADENFVLIGS---FVAFFI-----PLTIMVITYFLTIKSLQQS------ISNEQKASKVLGIVFFLFV----VMWCPF 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767932467 671 FVVKFLSLLQVEI--PGTITSWVVIFILP--INSALNPILYTLTTRPFK 715
Cdd:cd15304  216 FITNVMAVICKEScnEVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYR 264
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
447-716 1.35e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 47.37  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 447 FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiyLFVIGgfdlkfrgeYNKHAQL---WM-ESTHCQLVGSLAILST 522
Cdd:cd15066   15 FGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVA--LCAMT---------FNASVEItgrWMfGYFMCDVWNSLDVYFS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 523 EVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAFIPLsnkefFKNYYGTNG--VCFPLHSEDTES 599
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLAnVWISPALISFLPI-----FLGWYTTEEhlQYRKTHPDQCEF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGAQIYSV---AIFLGInlaAFIIIVFsygsMFYSVHQSAitateirnqvKKEMILAKRFFFIVFTDALCWIPIFVVKFL 676
Cdd:cd15066  159 VVNKIYALissSVSFWI---PCIVMIF----TYYRIYLEA----------KREHKAAKTLGIIMGAFILCWLPFFLWYVT 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 677 SLL------QVEIPGTITSWVVIFilpiNSALNPILYTLTTRPFKE 716
Cdd:cd15066  222 TTLcgdacpYPPILVSILFWIGYF----NSTLNPLIYAYFNRDFRE 263
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
432-715 1.47e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 47.35  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFDlkfrgEYNKHaqLWMES 508
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAA---ILLERSLQGVSnylILSLAVADLMVAVLVMPLSAVY-----EVSQH--WFLGP 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 THCQLVGSLAILSTEVSVLLLTFLTLEKY---ICIVYpfrcVRPGKCRTITVLI-LIWITGFIVAFIPL---SNKEFFKN 581
Cdd:cd15331   71 EVCDMWISMDVLCCTASILHLVAIALDRYwavTNIDY----IRRRTAKRILIMIaVVWFVSLIISIAPLfgwKDEDDLDR 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 582 YYGTnGVCfpLHSEDtesIGAQIYSVAIFLGINLAAFIIIvfsygsmFYSVHQSAitateirnqvKKEMILAKRFFFIVF 661
Cdd:cd15331  147 VLKT-GVC--LISQD---YGYTIFSTVGAFYVPLLLMIII-------YWKIYQAA----------KRERKAARTLAIITG 203
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 662 TDALCWIPIFVVKFLS-LLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15331  204 AFVVCWLPFFLVALVMpFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
511-716 1.53e-05

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 47.46  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV---RPGKCRTITVliLIWITGFIVAFIPLSNKEFFKNYYGTng 587
Cdd:cd15093   72 CRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSArwrRPRVAKVVNL--AVWVASLLVILPVVVFAGTRENQDGS-- 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQvKKEMILAKRFFFIVFTDALCW 667
Cdd:cd15093  148 SACNMQWPEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRK-RSERKVTRMVVMVVVVFVICW 226
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 668 IPIFVVKFLSL---LQVEiPGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15093  227 LPFYVLQLVNVfvqLPET-PALVGVYHFVVILSyANSCANPILYGFLSDNFKK 278
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
450-715 1.77e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 47.48  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 450 IFVICMRPYIRSENKLYamsIISLCCADCLmgiyLFVIGGFDLkfrgeynkhAQLW------MESTHCQLVGSLAILSTE 523
Cdd:cd15928   22 VLVIGRSRDMRTTTNLY---LSSLAVSDLL----IFLVLPLDL---------YRLWryrpwrFGDLLCRLMYFFSETCTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWitgfIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTES-IG 601
Cdd:cd15928   86 ASILHITALSVERYLAICHPLRAkVLVTRGRVKLLIAVIW----AVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVnVS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 602 AQIYSVAIFLGIN--LAAFIIIVFSYGSM---FYSVHQSAITATEIRNQVKKEMILaKRFFFIVFTDALCWIPIFVVKFL 676
Cdd:cd15928  162 SGLLSVMLWVSTSffFVPMVCLSLLYGLIgraLWDRRQRSRTAGASRRDNNHRQTV-RMLAVIVLAFVLCWLPFHVGRVI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 677 ---------SLLQVEIPGTITSWVVIFilpINSALNPILYTLTTRPFK 715
Cdd:cd15928  241 fnhsrastkHLHYVSQYFNLVSFVLFY---LSAAINPILYNLMSKRYR 285
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
432-715 1.99e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 47.12  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFV---ICMRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMES 508
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVcwiIFKNQRMRTVTNYF---IVNLAVADIMITL-------FNTPFTFVRAVNNTWIFGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 THCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAF-IPLSNKEFFKNYYG--T 585
Cdd:cd15202   71 FMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLK-PRISKTKAKFIIAVIWTLALAFALpHAICSKLETFKYSEdiV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEDTEsIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAI----TATEIRNQVKKEMILAKRFFFIVF 661
Cdd:cd15202  150 RSLCLEDWPERAD-LFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMpgdaTTERYFALRRKKKKVIKMLMVVVV 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 662 TDALCWIPIFVvkFLSLLQVEIPGTITS----WVVIFILPI-NSALNPILYTLTTRPFK 715
Cdd:cd15202  229 LFALCWLPFNI--YVLLLSSKPDYLIKTinavYFAFHWLAMsSTCYNPFIYCWLNERFR 285
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
440-716 2.03e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 46.94  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVIC---MRPYIRSENKLYamsIISLCCADCLMGIylfviggFDLKFRGEYNKHAQLWMESTHCQLVGS 516
Cdd:cd15300    9 VVSLITIVGNVLVMIsfkVNSQLKTVNNYY---LLSLACADLIIGI-------FSMNLYTSYILMGYWALGSLACDLWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYP--FRCVRPGKcRTITVLILIWITGFIVAFIPLSNKEFFknyYGTNGVcfPLHS 594
Cdd:cd15300   79 LDYVASNASVMNLLVISFDRYFSITRPltYRAKRTPK-RAGIMIGLAWLISFILWAPPILCWQYF---VGKRTV--PERE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESigaqIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAItateirnqvkKEMILAKRFFFIVFTDALCWIPIFVVK 674
Cdd:cd15300  153 CQIQF----LSEPTITFGTAIAAFYIPVSVMTILYCRIYKETI----------KERKAAQTLSAILLAFIITWTPYNIMV 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 675 FLSLLQVE-IPgtITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15300  219 LVSTFCSDcIP--LTLWHLGYWLCyVNSTVNPMCYALCNKTFRK 260
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
525-715 2.12e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 47.16  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 525 SVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAfIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQ 603
Cdd:cd15357   88 SILSVTTVSVERYVAILHPFRAkLNSTRERALKIIVVLWVLSVLFS-IPNTSIHGIKLQYFPNGTLIPDSATCTVVKPLW 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 604 IYSVAI----FLGINLAAFIIIVFSY--GSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVK-FL 676
Cdd:cd15357  167 IYNLIIqitsLLFYVLPMGVISVLYYlmGLKLRGDKSLEADEMNVNIQRPSRKSVTKMLFVLVLVFAICWAPFHVDRlFF 246
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767932467 677 SLLQVEIPGTITSWVVIFILP-----INSALNPILYTLTTRPFK 715
Cdd:cd15357  247 SFVVEWTEPLANVFNLIHVVSgvffyLSSAVNPIIYNLLSRRFR 290
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
511-715 2.14e-05

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 46.87  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV---RPGKCRTITvlILIWITGFIVAFiPLSNKEFFKNYYGTNG 587
Cdd:cd15089   72 CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALdfrTPAKAKLIN--ICIWVLSSGVGV-PIMVMAVTKTPRDGAV 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFpLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY---SVHQSAITATEIRNQVK-KEMILAKRFFFIVftd 663
Cdd:cd15089  149 VCM-LQFPSPSWYWDTVTKICVFIFAFVVPILVITVCYGLMILrlrSVRLLSGSKEKDRNLRRiTRMVLVVVAAFII--- 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 664 alCWIPI---FVVKFLSLLQVEIPGTITSW-VVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15089  225 --CWTPIhifVIVWTLVDIDRRNPLVVAALhLCIALGYANSSLNPVLYAFLDENFK 278
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
440-716 2.15e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 46.93  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIY------LFVIGGFdlkfrgeynkhaqlWMESTH-CQ 512
Cdd:cd15049    9 SLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVsmnlytVYLVMGY--------------WPLGPLlCD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPF--RCVRPGKcRTITVLILIWITGFIVAFIPLSNKEFFKNYYGT-NGVC 589
Cdd:cd15049   75 LWLALDYVASNASVMNLLLISFDRYFSVTRPLtyRAKRTPK-RAILMIALAWVISFVLWAPAILGWQYFVGERTVpDGQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FplhsedtesigAQ-IYSVAIFLGINLAAFIIIVFSYGSMFYSvhqsaITATEIRNQVKKEMILAKRFFFIVftdalCWI 668
Cdd:cd15049  154 Y-----------IQfLDDPAITFGTAIAAFYLPVLVMTILYWR-----IYRETARERKAARTLSAILLAFII-----TWT 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 669 P--IFVVkFLSLLQVEIPGTItsWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15049  213 PynILVL-VSTFCAKCIPDTL--WSFGYWLCyINSTINPFCYALCNKTFRK 260
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
514-718 2.27e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 47.12  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 514 VGSLAILSTEVSvllLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGV---CF 590
Cdd:cd15076   79 VGSLAGLVTGWS---LAFLAFERYIVICKPFGNFRFGSKHALGAVVATWIIGIGVSLPPF----FGWSRYIPEGLqcsCG 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPi 670
Cdd:cd15076  152 PDWYTVGTKYRSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESASTQKAEREVSRMVVVMVGSFCLCYVP- 230
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 671 FVVKFLSLLQVEIPGTITSWVVI--FILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15076  231 YAALAMYMVNNRDHGLDLRLVTIpaFFSKSSCVYNPIIYCFMNKQFRACI 280
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
511-718 2.34e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 47.01  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCvrPGKCRTITVLIL---IWITGFIVAFIPLSNKEFFKNYYGTNG 587
Cdd:cd15114   72 CKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWC--QNHRRARLAWIAcgaAWLLALLLTVPSFIYRRIHQEHFPEKT 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFP--LHSEDTESIGAQIYSVAIFLGinlaAFIIIVFSYGSMFysVHQSAITATEIRNQVKKEMILAKRFFfivftdaL 665
Cdd:cd15114  150 VCVVdyGGSTGVEWAVAIIRFLLGFLG----PLVVIASCHGVLL--VRTWSRRRQKSRRTLKVVTAVVVGFF-------L 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 666 CWIPIFVVK------------FLSLLQVEipgtitSWVVIFILpINSALNPILYTLTTRPFKEMI 718
Cdd:cd15114  217 CWTPYHVVGliiaasapnsrlLANALKAD------PLTVSLAY-INSCLNPIIYVVAGRGFRKSL 274
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
448-710 2.41e-05

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 46.73  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 448 GNIFVICMRPYIRSENKLYAMSIISLCCADClmgiYLFVIGGFDLKFRGEYNkhaqlW-MESTHCQLVGSLAILSTEVSV 526
Cdd:cd15121   17 GNLFVVWSVLCRMKKRSVTCILVLNLALADA----AVLLTAPFFLHFLSGGG-----WeFGSVVCKLCHYVCGVSMYASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 527 LLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAfIPLSNKEFFKNYYGTNGVCFPLHsedtESIGAQIY 605
Cdd:cd15121   88 FLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLaIWIVAFLLS-LPMPFYRTVLKKNINMKLCIPYH----PSVGHEAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 606 SVaIFLGIN--LAAFIIIVFSygsmfYSVHQSAITATEIRNQVKKEMILAkrffFIVFTDALCWIPIFVVKFL------- 676
Cdd:cd15121  163 QY-LFETITgfLLPFTAIVTC-----YSTIGRRLRSARFRRKRRTNRLVV----LIIATFALFWLPYHVVNLIqvagalq 232
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767932467 677 ---SLLQVEIPGTITSWVVIFILPINSALNPILYTLT 710
Cdd:cd15121  233 nqaGNASVLKAAKLARPNVTALAFLSSSVNPVLYAFA 269
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
436-707 2.52e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 46.82  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFViggFDLKFRGeYNKHAQLWMESTHCQLVG 515
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALAD-----LLFV---LTLPFWA-VYAADGWVFGSFLCKLVS 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGK-CRTITVLILIWITGFIVAfIPlsnkEF-FKNYYGTNG--VCFP 591
Cdd:cd14984   76 ALYTINFYSGILFLACISIDRYLAIVHAVSALRARTlLHGKLTCLGVWALALLLS-LP----EFiFSQVSEENGssICSY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTEsigaQIYSVAIFLGINLAAFII--IVFSYgsmFYSVhqsaITATEIRNQVKKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd14984  151 DYPEDTA----TTWKTLLRLLQNILGFLLplLVMLF---CYSR----IIRTLLRARNHKKHRALRVIFAVVVVFFLCWLP 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 670 IFVVKFLS---LLQVEIPG-------TITSWVVIFILPINSALNPILY 707
Cdd:cd14984  220 YNIVLLLDtlqLLGIISRScelskslDYALQVTESLAFSHCCLNPVLY 267
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
524-716 2.58e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.77  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGVcfplhsEDTESIGAQ 603
Cdd:cd15085   86 VSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPL----FGWSSYGPEGV------QTSCSIGWE 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 604 -------IYSVAIFLGINLAAFIIIVFSYGSMFYSVHQ--SAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVK 674
Cdd:cd15085  156 erswsnySYLILYFLMCFVIPVAIIGFSYGNVLRSLHKlnKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFA 235
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767932467 675 FLSLL--QVEIPGTITSwVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15085  236 LIVVVnpELSISPLAAT-MPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
440-716 2.62e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 46.50  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVIC---MRPYIRSENKLYamsIISLCCADclmgiylFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGS 516
Cdd:cd17790    9 ILSLVTVTGNLLVLIsfkVNSELKTVNNYF---LLSLACAD-------LIIGAFSMNLYTTYILMGHWALGTVACDLWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYP--FRCVRPGKcRTITVLILIWITGFIV---AFIplsnkeFFKNYYGTNGVcfp 591
Cdd:cd17790   79 LDYVASNASVMNLLIISFDRYFSITRPltYRAKRTPR-RAAIMIGLAWLISFVLwapAIL------FWQYLVGERTV--- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 lhseDTESIGAQIYSVAIF-LGINLAAFIIIVFSYGSMFYSVHQSAItateirnqvkKEMILAKRFFFIVFTDALCWIPI 670
Cdd:cd17790  149 ----LAGQCYIQFLSQPIItFGTAIAAFYLPVTIMIILYWRIYRETI----------KEKKAARTLSAILLAFILTWTPY 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 671 FVVKFLSLL-QVEIPGTItsWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd17790  215 NIMVLVSTFcKDCVPKTL--WELGYWLCyVNSTVNPMCYALCNKSFRD 260
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
492-716 2.69e-05

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 46.67  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 492 LKFRGEYNKHAQLWM-ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVA 569
Cdd:cd15162   53 LPFKIAYHIHGNNWIfGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRlRARRYALGTCLAIWLLALLVT 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 570 FIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMfysVHQSAITATEIRNQVKKE 649
Cdd:cd15162  133 LPLYLVKQTIFLPALDITTCHDVLPEQLLVGDWFYYFLSLAIVGFLIPFILTASCYVAT---IRTLAALEDENSEKKKKR 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 650 MILAKRFFFIVFTdaLCWIP---IFVVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15162  210 AIKLAATVLAIFI--ICFAPsnlLLLAHYSLISSSGTGHLYFAYLLALCLStLNSCIDPFIYYFVSKEFRD 278
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
511-718 2.82e-05

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 46.72  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTIT-VLILIWItGFIVAFIPLSNKEFfkNYYGTNGVC 589
Cdd:cd15920   69 CKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSaASGGVWL-LLLACMIPFLFESR--NEGPCDNKC 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGInlaaFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFF-FIVFTdaLCWI 668
Cdd:cd15920  146 FHFRSKGLTAGGINLTAVVIFYIL----SLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIvLAIFI--VCFV 219
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 669 PIFVVKFLSLL-QVEIPGT--------ITSWVVIFILPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15920  220 PYHIVRVPYVLaQIDVISSlpwkqtlhIANELVLCLSALNSCLDPIIYFFLSSSFRRAV 278
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
525-721 3.23e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 46.31  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 525 SVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVcFPLHSEDTesigaQI 604
Cdd:cd15102   86 SVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALDACSTV-LPLYSKHY-----VL 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 605 YSVAIFLGINLAafiiIVFSYGSMFYSVHQSAITATEIRNQvKKEMILAKRFFFIVFTDALCWIPIFvvkflSLLQVEIP 684
Cdd:cd15102  160 FCVTIFAGILAA----IVALYARIYCLVRASGRKATRASAS-PRSLALLKTVLIVLLVFIACWGPLF-----ILLLLDVA 229
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767932467 685 GTITSWVVIF-------ILPINSALNPILYTLTTRpfkEMIHRF 721
Cdd:cd15102  230 CPVKTCPILYkadwflaLAVLNSALNPIIYTLRSR---ELRRAV 270
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
511-716 3.25e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 46.35  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV-RPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVC 589
Cdd:cd15339   72 CTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTsLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCA 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDT---ESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQvkKEMILAKRFFFIVFTDALC 666
Cdd:cd15339  152 FNLTSPDDvlwYTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQ--RVMRLTKMVLVLVGVFLVS 229
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 667 WIPIFVVKflsLLQVEIPGTITSWVVIFILPI-----NSALNPILYTLTTRPFKE 716
Cdd:cd15339  230 AAPYHVIQ---LVNLSVSQPTLAFYVSYYLSIclsyaSSSINPFLYILLSGNFRK 281
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
432-716 3.27e-05

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 46.43  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVIcmrpYIRSENKLYAMSIISLCCADCLMGIYLFVIggfDLKFRGEYNKHAQLWM-ESTH 510
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVL----YLMKSKQGWKKSSINLFVTSLAVTDFQFVL---TLPFWAVENALDFTWLfGKAM 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAfipLSNKEFFKNYYGTNG-- 587
Cdd:cd15926   74 CKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRrRGCCSAKWLCVLIWVLAILAS---LPNAIFSTTATVSNEel 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 --VCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIV-FSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFivftda 664
Cdd:cd15926  151 clVKFPDNRGNAQFWLGLYHAQKVLLGFLIPLGIISLcYLLLVRFITDKNITGSSTKRRSKVTKSVTIVVLSFF------ 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932467 665 LCWIPIFVVKFLSLL-QVEIPGTITSWVV--IFILPI-------NSALNPILYTLTTRPFKE 716
Cdd:cd15926  225 LCWLPNQALTTWGILiKLNVVHFSYEYFTtqVYIFPItvclahsNSCLNPILYCLMRREFRK 286
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
525-712 3.77e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 46.32  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 525 SVLLLTFLTLEKYICIVYPFRCVRPGKC-RTITVLILIWITGFIVAFIPLsnkeffknyYGTNGVC--------FPLHSE 595
Cdd:cd15349   86 STFSLLVTAVERYATMVRPVAENTATKTyRVYGMIVLCWILAFLIGFLPL---------LGWNCLCdfrscsslLPLYSK 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 596 DTesigaQIYSVAIFLGINLAafiiIVFSYGSMFYSVHQSAITATEiRNQVKKEMILAKRFFFIVFTDALCWIPIF---V 672
Cdd:cd15349  157 SY-----ILFCLVIFFIILLT----IIGLYFAIYCLVRASGQRVIS-ARSRRRSLRLLKTVLMILGAFMVCWGPLFillL 226
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767932467 673 VKFLSLLQVEIPGTITSWVVIFILpINSALNPILYTLTTR 712
Cdd:cd15349  227 VDFFCSSRSCKPLFGMEWVLALAV-LNSAINPLIYSFRSL 265
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
436-716 4.04e-05

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 46.34  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMrpyIRSENKLYAMSIISLCCADCLMGIYLFVIggfDLKFRGEYNKHAQLWMESTH-CQLV 514
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYL---LKSNKKLRQQSESNKFVFNLALTDLIFVL---TLPFWAVEYALDFVWPFGTAmCKVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 515 GSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVL-ILIWITGFIVAfipLSNKEFFKNYYGTNGVCFPLH 593
Cdd:cd14976   79 RYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATtIAIWAAAALAA---IPEAIFSTDTWSSVNHTLCLL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 594 SEDTESIGAQIYSvaiFLGIN-----LAAFI----IIVFSYGSMFYSVHQSAITATEIRNQVkkemilAKRFFFIVFTDA 664
Cdd:cd14976  156 RFPKNSSVTRWYN---WLGMYqlqkvVLGFFlplgIITLSYLLLLRFLQRKRGGSKRRKSRV------TKSVFIVVLSFF 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 665 LCWIPIFVvkfLSLLQVEIPGTITSW-------------VVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd14976  227 ICWLPNQA---LSLWSALIKFDDVPFsdaffafqtyafpVAICLAHSNSCLNPVLYCLVRREFRD 288
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
179-334 4.39e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMN 258
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD 293
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 259 NVLT-RLPDkpLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 334
Cdd:PLN00113 294 NSLSgEIPE--LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
447-716 4.71e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 45.65  E-value: 4.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 447 FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLfviggfdLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSV 526
Cdd:cd15325   16 LGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTV-------LPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 527 LLLTFLTLEKYICIVYPFRcvRPG---KCRTITVLILIWITGFIVAFIPLSNkeFFKNYYGTNGVCfplhsEDTESIGAQ 603
Cdd:cd15325   89 MSLCIISIDRYIGVSYPLR--YPSimtERRGLLALLCVWVLSLVISIGPLFG--WKEPAPEDETIC-----QITEEPGYA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 604 IYSVaiFLGINLAAFIIIVfsygsMFYSVHQSAItateirnQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEI 683
Cdd:cd15325  160 LFSA--LGSFYLPLAIILV-----MYCRVYVVAL-------KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAY 225
                        250       260       270
                 ....*....|....*....|....*....|....
gi 767932467 684 PGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15325  226 KPSDTVFKITFWLGyFNSCINPIIYPCSSQEFKK 259
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
511-709 4.86e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 45.97  E-value: 4.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIvafipLSNKEFFknyygtngvCF 590
Cdd:cd15385   73 CRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFI-----LSTPQYF---------IF 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTES------------IGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQS--AITATEIRNQVKKEMILA--- 653
Cdd:cd15385  139 SLSEIENGSgvydcwanfivpWGIKAYITWITISIFVVPVIILLTCYGFICYNIWRNikCKTRRGLSDNALKNILLAvcv 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 654 --------------KRFFFIVFTDALCWIPIFVVKFLSLLQ-----VEIPGTITSwVVIFILPINSALNPILYTL 709
Cdd:cd15385  219 ssvktisrakirtvKMTFVIVLAYIVCWAPFFTIQMWSVWDqnfpwDESENTAVT-ITALLASLNSCCNPWIYMF 292
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
525-717 6.48e-05

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 45.39  E-value: 6.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 525 SVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWitgfIVAFIPLSNKEFFKNYYGTNG--VCFPLHSEDtESIG 601
Cdd:cd15168   87 SILFLTCISVHRYLGICHPLRSLGKLKKRhAVAISVAVW----ILVLLQLLPILFFATTGRKNNrtTCYDTTSPE-ELND 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 602 AQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSA--ITATEIRNQVKKEMILAKRFFfivftdALCWIPIFVVK--FLS 677
Cdd:cd15168  162 YVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLgeGVTSALRRKSIRLVIIVLALF------AVCFLPFHVTRtiNLA 235
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 678 LLQVEIPGTITSWVVIF--------ILPINSALNPILYTLTTRPFKEM 717
Cdd:cd15168  236 ARLLSGTASCATLNGIYvaykvtrpLASLNSCLNPLLYFLAGDKFRRR 283
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
498-707 7.10e-05

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 45.63  E-value: 7.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 498 YNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWITGFIVAFiPLSnke 577
Cdd:cd16002   60 YAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQ-PRLSATATKVVICVIWVLAFLLAF-PQG--- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 578 FFKNYYGTNG--VCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRN---QVKKEMIL 652
Cdd:cd16002  135 YYSDTEEMPGrvVCYVEWPEHEERKYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRyheQVSAKRKV 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932467 653 AKRFFFIVFTDALCWIPiFVVKFlsLLQVEIPGTITS------WVVIFILPINSAL-NPILY 707
Cdd:cd16002  215 VKMMIVVVCTFAICWLP-YHIYF--LLQYFHPELYEQkfiqqvYLAIMWLAMSSTMyNPIIY 273
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
509-707 7.22e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 45.45  E-value: 7.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 509 THCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVrpGKC-RTITVLI--LIWitgfIVAFIPLSNKEFFKNYYGT 585
Cdd:cd15967   71 VFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVM--GRItTTHSVVIsaLVW----LLVVIQSLPDLFFSKTNSN 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFplHSEDTESIGAQI-YSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFfivftdA 664
Cdd:cd15967  145 GTKCF--DTTFNDYLESYLtYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDKGLKQRCLKLVIILIVLF------S 216
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 665 LCWIPIFVVKFLSLLQ--VEIPGTITSWVV-IFI--------LPINSALNPILY 707
Cdd:cd15967  217 VCYIPYHVFRNLNLLSriLQKQGSCTQWFRgIYIahqvsrglVCLNSALNPLVY 270
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
436-715 7.49e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 45.29  E-value: 7.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLfviggfdLKFRGEYNKHAQLWMESTHCQLVG 515
Cdd:cd15327    5 VFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTV-------LPFSATLEVLGFWAFGRVFCDIWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYI----CIVYPFRCVRPgkcRTITVLILIWITGFIVAFIPLSN-KEffknyygtngvcf 590
Cdd:cd15327   78 AVDVLCCTASILSLCVISVDRYVgvkhSLKYPTIMTER---KAGVILVLLWVSSMVISIGPLLGwKE------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSED-----TESIGAQIYSVAIFLGINLAAFIIivfsygsMFYSVHQSAItateirnQVKKEMILAKRFFFIVFTDAL 665
Cdd:cd15327  142 PPPPDEsicsiTEEPGYALFSSLFSFYLPLMVILV-------MYFRVYVVAL-------KFSREKKAAKTLAIVVGVFIL 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 666 CWIPIFVVKFLSLLQVEIPGTITSWVVIFILP-INSALNPILYTLTTRPFK 715
Cdd:cd15327  208 CWFPFFFVLPLGSFFPALKPSEMVFKVIFWLGyFNSCVNPIIYPCSSKEFK 258
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
511-716 7.96e-05

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 45.22  E-value: 7.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTI-TVLILIWITGFIVaFIPLSNKEFFKNYYGtNGVC 589
Cdd:cd15971   72 CRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAkMINMAVWGVSLLV-ILPIMIYAGVQTKHG-RSSC 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQSAITATEIRNQvKKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd15971  150 TIIWPGESSAWYTGFIIYTFILGF-FVPLTIICLCYLFIIIKVKSSGIRVGSSKRK-KSEKKVTRMVSIVVAVFVFCWLP 227
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 670 IFVVKF--LSLLQVEIPGTITSWVVIFILPI-NSALNPILYTLTTRPFKE 716
Cdd:cd15971  228 FYIFNVssVSVSISPTPGLKGMFDFVVVLSYaNSCANPILYAFLSDNFKK 277
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
445-721 8.30e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 45.21  E-value: 8.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 445 TCFGNIFVICMrpyIRSENKL-YAMS--IISLCCADCLMGIYLFVIGGFDLKFRgeynkhaQLW-MESTHCQLVGSLAIL 520
Cdd:cd15306   14 TIGGNILVILA---VSLEKKLqYATNyfLMSLAVADLLVGLFVMPIALLTILFE-------AMWpLPLVLCPIWLFLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAF-IPLSNKEffknyygtNGVCFPlhSEDTE 598
Cdd:cd15306   84 FSTASIMHLCAISLDRYIAIKKPIQASQyNSRATAFIKITVVWLISIGIAIpVPIKGIE--------TDVDNP--NNITC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 599 SIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHqsAITATEIRNQVKKEMILAKRFFFIVFTdalcWIPIFVVKFLSL 678
Cdd:cd15306  154 VLTKERFGDFILFGSLAAFFTPLAIMIVTYFLTIH--ALRKQTITNEQRASKVLGIVFFLFLLM----WCPFFITNITSV 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767932467 679 LQVEIPGTITSW---VVIFILPINSALNPILYTLTTRPFKEMIHRF 721
Cdd:cd15306  228 LCDSCNQTTLQMlmeIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY 273
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
174-376 8.60e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 8.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 174 KNYHDLQKLYLQNNKIT---SISI-YAFRGLNSLTKLYLSHNRITFlkPGVFEdlhrlewlIIEdnHLSRISPptfygln 249
Cdd:COG5238  261 KNNTTVETLYLSGNQIGaegAIALaKALQGNTTLTSLDLSVNRIGD--EGAIA--------LAE--GLQGNKT------- 321
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 250 sLILLVLMNNVLTRLPDKPLCQHM---PRLHWLDLEGNHIHNlrnltfISCSNLtvlvmrknkINHLNENTfaplqKLDE 326
Cdd:COG5238  322 -LHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIGD------EGAIAL---------AKYLEGNT-----TLRE 380
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 327 LDLGSNKIENLPPL-IFKDLKE--LSQLNLSYNPI-QKIQANQFDYLVKLKSLL 376
Cdd:COG5238  381 LNLGKNNIGKQGAEaLIDALQTnrLHTLILDGNLIgAEAQQRLEQLLERIKSVY 434
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
163-375 8.75e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 163 NLIRKLPPDcFKNYHDLQKLYLQNNKIT-SI--SIYAFRGL-------NSLTK--------------LYLSHNRITFLKP 218
Cdd:PLN00113 247 NLTGPIPSS-LGNLKNLQYLFLYQNKLSgPIppSIFSLQKLisldlsdNSLSGeipelviqlqnleiLHLFSNNFTGKIP 325
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 219 GVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT-RLPD-----------------------KPL--CQH 272
Cdd:PLN00113 326 VALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEglcssgnlfklilfsnslegeipKSLgaCRS 405
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 273 MPRL---------------------HWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPlQKLDELDLGS 331
Cdd:PLN00113 406 LRRVrlqdnsfsgelpseftklplvYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSR 484
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 332 NKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSL 375
Cdd:PLN00113 485 NQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSL 528
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
179-211 9.28e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 9.28e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767932467  179 LQKLYLQNNKITSISiyAFRGLNSLTKLYLSHN 211
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
447-715 1.02e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 44.74  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 447 FGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFViggFDLKFRGEYNKHAQLWMESTH-CQLVGSLAILSTEVS 525
Cdd:cd15193   16 LGNLFVIALMSKRSTTKRLVDTFVLNLAVAD-----LVFV---LTLPFWAASTALGGQWLFGEGlCKLSSFIIAVNRCSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 526 VLLLTFLTLEKYICIV--YPFRCVRPGKCRTITVLIlIWITGFIVAFIPLSNKEFFKNYYgtngvCfplhSEDTESIGAQ 603
Cdd:cd15193   88 ILFLTGMSVDRYLAVVklLDSRPLRTRRCALITCCI-IWAVSLVLGIPSLVYRNLINESV-----C----VEDSSSRFFQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 604 IYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMilaKRFFFIVFTDALCWIPIFVVK---FLSLLQ 680
Cdd:cd15193  158 GISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSL---RIVFAIVTAFVLSWLPFNTLKavrLLLELG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767932467 681 VEIPGTITSWVVIFILPI-------NSALNPILYTLTTRPFK 715
Cdd:cd15193  235 GGVLPCHTTVAIRQGLTItaclafvNSCVNPLIYSLLDRHFR 276
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
433-715 1.16e-04

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 44.76  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 433 IQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCAD-----CLMGIYLFVIGGFDLKFrgeynkhaqlwmE 507
Cdd:cd15381    2 FQPIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADlllvcCLPFWAINISNGFNWPF------------G 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVY--PFRCVRPGKCRTITVLIlIWITGFIVA--FIPLSNKEFFKNYY 583
Cdd:cd15381   70 EFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKtmSSGRMRRPACAKLNCLI-IWMFGLLMStpMIVFRTVMYFPEYN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 584 GTNGVCFPlhsedtesiGAQIYSVAIFLGINLAAFII--IVFSYGSMFYSVHQSAITATEIRnQVKKEMILAKRFFFIVF 661
Cdd:cd15381  149 ITACVLDY---------PSEGWHVALNILLNVVGFLIplSIITFCSTQIIQVLRNNKMQKFK-EIQTERKATVLVLAVLL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767932467 662 TDALCWIPIFVVKFLSLLQVE--IPGT-------ITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15381  219 MFFICWLPFHIFTFLDTLHKLglISGCrwedildIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
444-707 1.17e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 44.65  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 444 VTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiylFVIGGFDLkFRgeynkhaqlWMES------THCQLVGSL 517
Cdd:cd15312   13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLG---FLVMPYSM-VR---------SVEScwyfgdLFCKIHSSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 518 AILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILI-WITGFIVAFiplsnkeffknyygtnGVCFP-LHSE 595
Cdd:cd15312   80 DMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVIsWSVPCLFAF----------------GVVFSeVNLE 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 596 DTESIGAQIYSV-AIFLGIN----LAAFIIIVFSYGSMFYSV----------------HQSAITATEIRNQV--KKEMIL 652
Cdd:cd15312  144 GIEDYVALVSCTgSCVLIFNklwgVIASLIAFFIPGTVMIGIyikiffvarkhakvinNRPSVTKGDSKNKLskKKERKA 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 653 AKRFFFIVFTDALCWIPIFVV----KFLSLLQVEIPGTITSWVVIFilpiNSALNPILY 707
Cdd:cd15312  224 AKTLSIVMGVFLLCWLPFFVAtlidPFLNFSTPVDLFDALVWLGYF----NSTCNPLIY 278
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
441-716 1.20e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 44.63  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 441 VSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiylFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAIL 520
Cdd:cd15298   10 LSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACAD-------LIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFrcVRPGKcRTITVLILIWITGFIVAFIPLSNKEFFKNY-YGTNGVcfplhsEDTES 599
Cdd:cd15298   83 VSNASVMNLLIISFDRYFCVTKPL--TYPAR-RTTKMAGLMIAAAWVLSFVLWAPAILFWQFvVGKRTV------PDNQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGAQIYSVAIFLGINLAAFIIIVFSYGSMFysVHQSAITATEIRnqvkkemiLAKRFFFIVFTDALCWIPIFVVKFLSLL 679
Cdd:cd15298  154 FIQFLSNPAVTFGTAIAAFYLPVVIMTVLY--IHISLASARERK--------VTRTIFAILLAFILTWTPYNVMVLVNTF 223
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767932467 680 -QVEIPGTItsWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15298  224 cQSCIPDTV--WSIGYWLCyVNSTINPACYALCNATFKK 260
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
480-709 1.40e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 44.40  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 480 MGIYLFVIGGFDLKFRG------EYNKHAQLWMESTH-CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKC 552
Cdd:cd15366   35 LGVYLLNLSVSDLLYIAtlplwiDYFLHRDNWIHGPEsCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 553 RT-ITVLILIWITGFIVAFIPLSNKEFFKNYYgTNGVCFPLHSEDTESIGAQIYSVaiFLGInLAAFIIIVFSYGSMFYS 631
Cdd:cd15366  115 KTaVAVSAVVWAIEIGANSAPLFHDELFRDRY-NHTFCFEKYPMEDWVAWMNLYRV--FVGF-LFPWVLMLFSYRGILRA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 632 VHQSAITATEIRNQVKKemiLAKRFFFIVFtdaLCWIPIFVVKFL-SLLQVEIPGTITSWVVIF--------ILPINSAL 702
Cdd:cd15366  191 VRGNVSTEQQEKAKIKR---LALSLIAIVL---LCFAPYHVLLLSrSVVYLGKPCDCGFEERVFtayhvslaLTSLNCVA 264

                 ....*..
gi 767932467 703 NPILYTL 709
Cdd:cd15366  265 DPILYCL 271
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
446-715 1.54e-04

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 44.43  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 446 CFGNIFVICmrpYIRSENK----LYAMSIISLCCADCLMGIYLFVIGGFDLKFRGeynkhaqlW-MESTHCQLVGSLAIL 520
Cdd:cd15981   14 CMVGNGLVC---FIVLKNRqmrtVTNMFILNLAVSDLLVGIFCMPTTLVDNLITG--------WpFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVlILIWITGFIV----AFIPLSNKEFFKNYYGTNGVCFPLHS-- 594
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTI-VIIWVLALIImcpsAVTLTVTREEHHFMVDDYNNSYPLYScw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 -EDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITA-------TEIRNQVKKEMILAKRFFFIVFTDALC 666
Cdd:cd15981  162 eAWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIrgsqgeeEEGRRVSKRKIKVINMLIIVALFFTLS 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 667 WIPIFVVKF------LSLLQVEIpgtITSWVVIF---ILPINSALNPILYTLTTRPFK 715
Cdd:cd15981  242 WLPLWTLMLltdyghLSEDQLNL---VTVYVFPFahwLAFFNSSVNPIIYGYFNENFR 296
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
440-715 1.54e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 44.51  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 440 VVSAVTCFGNIFVICMrpyIRSENKLYAMS---IISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLwmesthCQLVGS 516
Cdd:cd15305    9 IIIILTIGGNILVIMA---VSLEKKLQNATnffLMSLAVADMLVGILVMPVSLIAILYDYAWPLPRYL------CPIWIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAF----IPLSNKE-FFKNyygtnGVCF 590
Cdd:cd15305   80 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRfNSRTKAMMKIAAVWTISIGISMpipvIGLQDDEkVFVN-----GTCV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 pLHSEDTESIGAqiySVAIFLginlaAFIIIVFSYGSMFYSVHQSaitaTEIRNQVKKEMILAKRFFFIVFTdalcWIPI 670
Cdd:cd15305  155 -LNDENFVLIGS---FVAFFI-----PLIIMVITYCLTIQVLQRQ----QAINNERRASKVLGIVFFLFLIM----WCPF 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767932467 671 FVVKFLSLLQVEI--PGTITSWVVIFILP--INSALNPILYTLTTRPFK 715
Cdd:cd15305  218 FITNILSVLCKEAcdQKLMEELLNVFVWVgyVSSGINPLVYTLFNKTYR 266
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
511-712 1.58e-04

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 44.40  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVA--FIPLSNKEFFKNyygtNG 587
Cdd:cd14975   72 CKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGwRAKALAHKVLAIIWLLAVLLAtpVIAFRHVEETVE----NG 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHSEDtesiGAQIYSVAIFLGINLAA-FIIIVFSYGSMFysvhqSAITATEIRNQVKKEMILAKrfffIVFTDALC 666
Cdd:cd14975  148 MCKYRHYSD----GQLVFHLLLETVVGFAVpFTAVVLCYSCLL-----RRLRRRRFRRRRRTGRLIAS----VVVAFAAC 214
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767932467 667 WIPIFVVKFLSLLQVEIPGTITS-----------WVVIFILPINSALNPILYTLTTR 712
Cdd:cd14975  215 WLPYHVGNLLEVVSELIGGSKMAgtlgkvaeagrPIAGALAFLSSSINPLLYAFAAR 271
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
605-716 1.69e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 44.38  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 605 YSVAIFLGINLAAFIIIVFSYGSMFYSVHQSA-ITATEIRNQVKKEMILAKRFFFIVFTDALCWIP--IFVVKFLSLLQV 681
Cdd:cd15075  164 YILCYFSFCFAIPFAIILVSYGYLLWTLRQVAkLGVAEGGSTAKAEVQVARMVVVMVMAFLLCWLPyaAFALTVVSKPDV 243
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767932467 682 EIPGTITSwVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15075  244 YINPLIAT-VPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
432-715 1.73e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 43.86  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFV---ICM-RPYIRSENKLyamsIISLCCADCLMGIYLFVIGG-FDLkfRGEYNkhaqlwM 506
Cdd:cd15064    1 VLISVLLSLIILATILGNALViaaILLtRKLHTPANYL----IASLAVADLLVAVLVMPLSAvYEL--TGRWI------L 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 507 ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV-RPGKCRTITVLILIWITGFIVAFIPLsnkeFF--KNYY 583
Cdd:cd15064   69 GQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAhKRTPKRAAVMIALVWTLSICISLPPL----FGwrTPDS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 584 GTNGVCfpLHSEDtesIGAQIYSVAIFLGINLAAFIIivfsygsMFYSVHQSAitateirnqvKKEMILAKRFFFIVFTD 663
Cdd:cd15064  145 EDPSEC--LISQD---IGYTIFSTFGAFYIPLLLMLI-------LYWKIYRAA----------ARERKAAKTLGIILGAF 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 664 ALCWIPIFVVKFLSLL--QVEIPGTITSwVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15064  203 IVCWLPFFLVALIVPLcsHCWIPLALKS-FFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
511-715 2.33e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 43.76  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLIL-IWITGFIVAFIPLsnkeFFKNYYGTNG-- 587
Cdd:cd15335   73 CEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILtVWTISIFISIPPL----FWRNHHDANIps 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 VCFPLHsedtESIGAQIYSVaiflginLAAFIIIVFSYGSMFYSVHQSAitateirnqvKKEMILAKRFFFIVFTDALCW 667
Cdd:cd15335  149 QCIIQH----DHVIYTIYST-------FGAFYIPLTLILILYYRIYHAA----------SRERKAARILGLILGAFILSW 207
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 668 IPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15335  208 LPFFIKELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFK 255
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
436-716 2.43e-04

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 43.64  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFVIGgfdLKFRGEYNKHAQLWMESTHCQLVG 515
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVAD-----ELFMLG---LPFLATQNAISYWPFGSFLCRLVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVL-ILIWITGFIVAfIPLSNKEFFKNYYGTNGVCFPlHS 594
Cdd:cd15974   77 TVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLInATVWTLSFLVV-LPVIIFSDVQPDLNTCNISWP-EP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 EDTESIGAQIYSVAifLGInLAAFIIIVFSYGSMFYSVHQSAITATEIRNQvKKEMILAKRFFFIVFTDALCWIPIFVVK 674
Cdd:cd15974  155 VSVWSTAFIIYTAV--LGF-FGPLLVICLCYLLIVIKVKSSGLRVGSTKRR-KSERKVTRMVVIIVVVFVFCWLPFYMLN 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767932467 675 FLSLLQV--EIPGTITSWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15974  231 IVNLIVIlpEEPAFVGVYFFVVVLSyANSCANPILYGFLSDNFKQ 275
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
436-707 2.49e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 43.97  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLmgIYLFVIGGfdlkfRGEYNKHAQLWMESTHCQLVG 515
Cdd:cd15384    5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLL--VTFFCIPS-----EAIWAYTVAWLAGNTMCKLVK 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPF-RCVRPGKCRTItvLILIWITGFIV----AFIPLSNKEFFKNYYgTNGVCF 590
Cdd:cd15384   78 YLQVFGLYLSTYITVLISLDRCVAILYPMkRNQAPERVRRM--VTVAWILSPIFsipqAVIFHVERGPFVEDF-HQCVTY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSV------HQSAITATEIRNQVKKEMILAKRF------FF 658
Cdd:cd15384  155 GFYTAEWQE---QLYNMLSLVFMFPIPLVIMVTCYVLIFITLskssrdFQGLEIYTRNRGPNRQRLFHKAKVkslrmsAV 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767932467 659 IVFTDALCWIPIFVVKFLSL-LQVEIPGTITSWVVIFILPINSALNPILY 707
Cdd:cd15384  232 IVTAFILCWTPYYVIMIWFLfFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
511-660 3.31e-04

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 43.21  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFR--CVRPGKCRTItVLILIWITGFIVAFIPLSNKEFFKNYYgTNGV 588
Cdd:cd15367   73 CKICGILLYENIYISIGFLCCISVDRYLAVVHPFRfhAFRTMKAATL-VSTVIWLKELMTCVFFFLHGEISKDKE-NHSV 150
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932467 589 CFPLHSEDTESIGAQIYSvaiFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKeMILAKRFFFIV 660
Cdd:cd15367  151 CFEHYPIKAWEHNINYYR---FYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIKR-LVLSTVVIFLV 218
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
441-716 3.55e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 43.03  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 441 VSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiylFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAIL 520
Cdd:cd15297   10 LSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD-------LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRcvRPGKcRTITVLILIWITGFIVAFIPLSNKEFFKNYYgTNGVCFPlhseDTESI 600
Cdd:cd15297   83 VSNASVMNLLIISFDRYFCVTKPLT--YPVK-RTTKMAGMMIAAAWVLSFILWAPAILFWQFI-VGGRTVP----EGECY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 601 GAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAitateirnqvKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQ 680
Cdd:cd15297  155 IQFFSNAAVTFGTAIAAFYLPVIIMTVLYWQISRAS----------SREKKVTRTILAILLAFIITWTPYNVMVLINTFC 224
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767932467 681 VE-IPGTItsWVVIFILP-INSALNPILYTLTTRPFKE 716
Cdd:cd15297  225 AScIPNTV--WTIGYWLCyINSTINPACYALCNATFKK 260
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
437-715 4.04e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 43.01  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 437 FVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADclmgiylFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGS 516
Cdd:cd15299    9 LTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACAD-------LIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTEVSVLLLTFLTLEKYICIVYP--FRCVRPGKcRTITVLILIWITGFIVAFIPLSnkeFFKNYYGTNGV----CF 590
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPltYRAKRTTK-RAGVMIGLAWVISFVLWAPAIL---FWQYFVGKRTVppdeCF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 -PLHSEDTesigaqiysvaIFLGINLAAFIIIVFSYGSMFYSVHQSAItateirnqvkKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd15299  158 iQFLSEPI-----------ITFGTAIAAFYLPVTIMTILYWRIYKETI----------KEKKAAQTLSAILLAFIITWTP 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767932467 670 IFVVKFL-SLLQVEIPGTItsWVVIFILP-INSALNPILYTLTTRPFK 715
Cdd:cd15299  217 YNIMVLVnTFCDSCIPKTY--WNLGYWLCyINSTVNPVCYALCNKTFR 262
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
511-714 5.78e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 42.84  E-value: 5.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV-RPGKCRTITVLILIWITGfIVAFIPLSNKEFFKNYYGTNgVC 589
Cdd:PHA03087 111 CKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNkINTVKYGYIVSLVIWIIS-IIETTPILFVYTTKKDHETL-IC 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQSAItateirNQVKKEMIlaKRFFFIVFTDALCWIP 669
Cdd:PHA03087 189 CMFYNNKTMNWKLFINFEINIIGM-LIPLTILLYCYSKILITLKGINK------SKKNKKAI--KLVLIIVILFVIFWLP 259
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932467 670 IFVVKFLSLLQV--EIPGTITSWVVIFILPI-------NSALNPILYTLTTRPF 714
Cdd:PHA03087 260 FNVSVFVYSLHIlhFKSGCKAVKYIQYALHVteiislsHCCINPLIYAFVSEFF 313
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
436-707 6.38e-04

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 42.26  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVtcfGN---IFVICMRPYIRSENKLYAMSiisLCCADCLMGiylfviggFDLKFRGEYNKHAqlWMESTH-C 511
Cdd:cd15178    8 VLVFLLSLP---GNslvVLVILYNRRSRSSTDVYLLH---LAIADLLFA--------LTLPFWAVSVVKG--WIFGTFmC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFP 591
Cdd:cd15178   72 KLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCYE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 LHSEDTesigAQIYSVAIFLGINLAAF----IIIVFSYGSMFYSVHQSaitateiRNQVK-KEMilaKRFFFIVFTDALC 666
Cdd:cd15178  152 NLGNES----ADKWRVVLRILRHTLGFllplVVMLFCYGFTIKTLLQT-------RSFQKhRAM---RVIFAVVLAFLLC 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 667 WIPIFVVKFLSLL--------QVEIPGTItsWVVIFILPI----NSALNPILY 707
Cdd:cd15178  218 WLPYNVTVLIDTLmrtkliteTCELRNHV--DVALYVTQIlgflHSCINPVLY 268
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
517-707 6.75e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.45  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 517 LAILSTevsvLLLTFLTLEKYICIVYPFRcVRPGKCRTITVLILIWIT--GFIVAFIPLSNKEFFKNYYGTNGVCFPLHS 594
Cdd:cd15212   84 FGIVST----LTMTLISFDRYYAIVRQPQ-GKIGRRRALQLLAAAWLTalGFSLPWYLLASAPEYYEKLGFYHCLYVLHS 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 595 eDTESIGAQiYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAI-----TATEIRNQVKKEMILAKRFFFIVFTDALCWIP 669
Cdd:cd15212  159 -GPSRLGAA-YSSVLIVLCYLLPFALMCFCHYNICKTVRLSESrvrpvTTYAHLLRFYSEMRTATTVLIMIVFIICCWGP 236
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767932467 670 -IFVVKFLSLLQVEIPGTITSwVVIFILPINSALNPILY 707
Cdd:cd15212  237 yCLLGLVAAAGGYQFPPLMDT-VAIWMAWANGAINPLIY 274
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
508-716 6.88e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 42.38  E-value: 6.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 508 STHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVaFIPLSnkeFFKNYYGTN 586
Cdd:cd15206   70 EVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSrVWQTLSHAYKVIAGIWLLSFLI-MSPIL---VFSNLIPMS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSEDTESIGA-QIYSVAIFLGINLAAFIIIVFSYGsmfysvhqsaITATEIRnQVKKEMIlaKRFFFIVFTDAL 665
Cdd:cd15206  146 RPGGHKCREVWPNEIAeQAWYVFLDLMLLVIPGLVMSVAYG----------LISWTLL-EAKKRVI--RMLFVIVVEFFI 212
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 666 CWIPIFVVKFLSLLQVEIPGTITSWVVIFILP----INSALNPILYTLTTRPFKE 716
Cdd:cd15206  213 CWTPLYVINTWKAFDPPSAARYVSSTTISLIQllayISSCVNPITYCFMNKRFRQ 267
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
511-715 7.60e-04

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 42.29  E-value: 7.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYP-----FRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEffkNYYGT 585
Cdd:cd15090   72 CKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPvkaldFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR---QGSID 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEDTESIgaqiYSVAIFLGINLAAFIIIVFSYGSMFY---SVHQSAITATEIRNQVK-KEMILAKRFFFIVf 661
Cdd:cd15090  149 CTLTFSHPSWYWENL----LKICVFIFAFIMPVLIITVCYGLMILrlkSVRMLSGSKEKDRNLRRiTRMVLVVVAVFIV- 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932467 662 tdalCWIPIFVVKFLSLLqVEIPG----TITSWVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15090  224 ----CWTPIHIYVIIKAL-VTIPEttfqTVSWHFCIALGYTNSCLNPVLYAFLDENFK 276
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
511-715 7.61e-04

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 42.04  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNgVC 589
Cdd:cd15119   72 CKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRyRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVT-IC 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 ---FPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAItateirnqvkkemILAKRFFFIVFTDA-- 664
Cdd:cd15119  151 fnnFHKHDGDLIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTL-------------LISSKFFWTISAVIva 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 665 --LCWIPIFVvkfLSLLQVEIPGTITSWVVIFI-LP-------INSALNPILYTLTTRPFK 715
Cdd:cd15119  218 ffVCWTPYHI---FSILELSIHHSSYLHNVLRAgIPlatslafINSCLNPILYVLIGKKFK 275
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
436-718 7.62e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 42.32  E-value: 7.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCAD---CLMGIYLFVIGGFDLKfrgeynkhaqlWMES-THC 511
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDflmCILNCPLMVISSFSGR-----------WIFGkTGC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF-RCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGV-- 588
Cdd:cd15083   74 DMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMkASVRISHRRALIVIAVVWLYSLLWVLPPL----FGWSRYVLEGLlt 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 589 -C-FPLHSEDTESigaQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEI--------RNQVKK----EMILAK 654
Cdd:cd15083  150 sCsFDYLSRDDAN---RSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMakrfskseLSSPKArrqaEVKTAK 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 655 RFFFIVFTDALCWIPIFVVKFLSLL--QVEIPGTITSWVVIFIlPINSALNPILYTLTTRPFKEMI 718
Cdd:cd15083  227 IALLLVLLFCLAWTPYAVVALIGQFgyLEVLTPLATAIPAAFA-KTSAIYNPVIYAFSHPKFRRAL 291
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
511-716 7.99e-04

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 42.03  E-value: 7.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF-----RCVRpgkcRTITVLILIWITGFIVAFIPLsnkeFFKNYYGT 585
Cdd:cd15117   72 CKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVwarnhRTPA----RAALVAVGAWLLALALSGPHL----VFRDTRKE 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 586 NGVCFPLHSEDTESIGAQIYSVAIFLGIN-LAAFIIIVFSYGsmfYSVHQSAIT--ATEIRNQV-KKEMILAKRFFFI-- 659
Cdd:cd15117  144 NGCTHCYLNFDPWNETAEDPVLWLETVVQrLSAQVITRFVLG---FLVPLVIIGgcYGLIAARLwREGWVHSSRPFRVlt 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767932467 660 --VFTDALCWIPIFVVKFLSLL----QVEIPGTITSWVV---IFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15117  221 avVAAFFLCWFPFHLVSLLELVvilnQKEDLNPLLILLLplsSSLACVNSCLNPLLYVFVGRDFRE 286
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
525-712 8.03e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 42.13  E-value: 8.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 525 SVLLLTFltlEKYICIVYPFRC-VRPGKCRTITVLILIWITGFIVAFIPLSNKeffkNYYGTNGVC---FPLHSEDtesi 600
Cdd:cd15341   90 SLLLMAF---DRYVCIYYPSEYkALVTRKRALVALAVMWVLTALIAYLPLMGW----NCCPLNSPCselFPLIPND---- 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 601 gaQIYSVAIFLGInlaAFIIIVFSYGSMFYSVHQSAITATEIRNQ-------VKKEMILAKRFFFIVFTDALCWIPIFVV 673
Cdd:cd15341  159 --YLLSWLLLVAI---LLSGIIYTYGHVLWKAHKHVVYMEKHQDQqgpgnarMRLDVRLAKTLGLVLAVLLICWSPVLAL 233
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767932467 674 KFLSLLQVEIPGTITSWVVIFILP-INSALNPILYTLTTR 712
Cdd:cd15341  234 MMHSLFTSLSDHIKKAFAFCSTLClVNSMVNPIIYALRSR 273
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
163-356 8.14e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 8.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 163 NLIRKLPPDCFKNYHDLQKLYLQNNKIT-SISiyafRG-LNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRI 240
Cdd:PLN00113 104 QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIP----RGsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 241 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQhMPRLHWLDLEGNhihNLRNLTFISCSNLTVLvmrknkiNHLN------ 314
Cdd:PLN00113 180 IPNSLTNLTSLEFLTLASNQLVGQIPRELGQ-MKSLKWIYLGYN---NLSGEIPYEIGGLTSL-------NHLDlvynnl 248
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 315 ----ENTFAPLQKLDELDLGSNKIEN-LPPLIFkDLKELSQLNLSYN 356
Cdd:PLN00113 249 tgpiPSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDN 294
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
511-707 8.62e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 42.06  E-value: 8.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVC 589
Cdd:cd15190   84 CKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKlRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVIC 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 FPLHSEDTESIGAQIYSVAIFLGINLAAFiIIVFSYGSMFYSVHQSAIT---ATEIRNQVKKEMILAKRFFFIVFTDALC 666
Cdd:cd15190  164 DMDYSGVVSNESEWAWIAGLGLSSTVLGF-LLPFLIMLTCYFFIGRTVArhfSKLRRKEDKKKRRLLKIIITLVVTFALC 242
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767932467 667 WIPIFVVKFLSLLQ----VEIPGTITSWVVIF------ILPINSALNPILY 707
Cdd:cd15190  243 WLPFHLVKTLYALMylgiLPFSCGFDLFLMNAhpyatcLAYVNSCLNPFLY 293
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
450-715 8.66e-04

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 42.11  E-value: 8.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 450 IFVICMRPYIRSENKLYAMSIISLCCADclmgiYLFVIGgfdLKFRGEYNKHAQLW-MESTHCQLVGSLAILSTEVSVLL 528
Cdd:cd15338   22 IYTIVKKSKFRCQQTVPDIFIFNLSIVD-----LLFLLG---MPFLIHQLLGNGVWhFGETMCTLITALDTNSQITSTYI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 529 LTFLTLEKYICIVYPFRCVRPGK-CRTITVLILIWITGFI--------VAFIPLSNkeffknyyGTNGVCFPLHSEDTES 599
Cdd:cd15338   94 LTVMTLDRYLATVHPIRSTKIRTpRVAVAVICLVWILSLLsitpvwmyAGLMPLPD--------GSVGCALLLPNPETDT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGAQIYSVAIFLGINLAAFIIIVFS-YGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVftdalCWIPIFVvkfLSL 678
Cdd:cd15338  166 YWFTLYQFFLAFALPLVVICVVYFKiLQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFI-----CWAPFYI---LQL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767932467 679 LQVEIPGTITSWVVIFILPI-----NSALNPILYTLTTRPFK 715
Cdd:cd15338  238 AHLSIDRPSLAFLYAYNVAIsmgyaNSCINPFLYIMLSETFK 279
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
450-564 8.92e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 42.06  E-value: 8.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 450 IFVICMRPYIRSENKLYamsIISLCCADCLMGIYL-FVIggfdlkfrgeYNKHAQLWMESTHCQLVGSLAILSTEVSVLL 528
Cdd:cd15923   22 LWVFCWRLKKWTETNIY---MTNLAVADLLLLISLpFKM----------HSYRRESAGLQKLCNFVLSLYYINMYVSIFT 88
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767932467 529 LTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWIT 564
Cdd:cd15923   89 ITAISVDRYVAIRYPLRARELRSPRKAAVVCaVIWVL 125
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
444-709 9.31e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 42.05  E-value: 9.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 444 VTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGiyLFViggfdLKFRGEYNKHAQLWMESTHCQLVGSLAILSTE 523
Cdd:cd15317   13 ITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLG--LCV-----MPFSMIRTVETCWYFGDLFCKFHTGLDLLLCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRcvRPGKCRTITVLILIWITGFIVAFIplsnkEFFKNYYGTNGVCFPLHSEDTESIGA- 602
Cdd:cd15317   86 TSIFHLCFIAIDRYYAVCDPLR--YPSKITVQVAWRFIAIGWLVPGIY-----TFGLIYTGANDEGLEEYSSEISCVGGc 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 603 -----QIYSVAIFLGINLAAFIIIVFsYGSMFYSVHQSA--ITATEIRNQVKKEMIL----------AKRFFFIVFTDAL 665
Cdd:cd15317  159 qllfnKIWVLLDFLTFFIPCLIMIGL-YAKIFLVARRQArkIQNMEDKFRSSEENSSkasasrerkaAKTLAIVMGIFLF 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 666 CWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTL 709
Cdd:cd15317  238 CWLPYFIDTIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAF 281
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
152-261 1.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 152 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLI 231
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553
                         90       100       110
                 ....*....|....*....|....*....|
gi 767932467 232 IEDNHLSRISPPTFYGLNSLILLVLMNNVL 261
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
447-716 1.08e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 41.49  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 447 FGNIFViCMRpyIRSENKLYAMS---IISLCCADCLMG-------IYLFVIGGfdlkfrgeynkhaqLWMES-THCQLVG 515
Cdd:cd15310   16 FGNVLV-CMA--VLRERALQTTTnylVVSLAVADLLVAtlvmpwvVYLEVTGG--------------VWNFSrICCDVFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFR---CVRPGKCRTITVLIL-IWITGFIVAfIPLSnkeFFKNYYGTNGVCfp 591
Cdd:cd15310   79 TLDVMMCTASILNLCAISIDRYTAVVMPVHyqhGTGQSSCRRVSLMITaVWVLAFAVS-CPLL---FGFNTTGDPTVC-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 592 lhsedteSIGAQ---IYS--VAIFLginlaAFIIIVFSYGSMFYSVhqsaitateIRNQVKKEMILAKRFFFIVftdalC 666
Cdd:cd15310  153 -------SISNPdfvIYSsvVSFYL-----PFGVTLLVYVRIYVVL---------LREKKATQMLAIVLGAFIV-----C 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 667 WIPIFVVKFLSL--LQVEIPGTITSwVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15310  207 WLPFFLTHILNThcQACHVPPELYS-ATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
524-715 1.31e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 41.26  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 524 VSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNG---VC-FPLHSEDTES 599
Cdd:cd15086   86 VSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPL----LGWSSYGPEGpgtTCsVQWTSRSANS 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 600 IGaqiYSVAIFLGINLAAFIIIVFSYGSMFYSVHQ-SAITATEIRnqvKKEmilaKRFFFIVFTDA----LCWIPIFVVK 674
Cdd:cd15086  162 IS---YIICLFIFCLLLPFLVMVYCYGRLLYAIKQvGKINKSTAR---KRE----QHVLLMVVTMVicylLCWLPYGVMA 231
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767932467 675 FLSLLQVeiPGTITSWVVIF--ILPINSAL-NPILYTLTTRPFK 715
Cdd:cd15086  232 LLATFGK--PGLVTPVASIVpsILAKSSTVvNPIIYVFMNKQFY 273
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
483-718 1.35e-03

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 41.24  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 483 YLFViggFDLKFRGEYNKHAQLWM-ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVL-IL 560
Cdd:cd15157   47 LMFV---STLPFRADYYLMGSHWVfGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILcAV 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 561 IWItgFIVAfipLSNKEFFKNYYGTNGV--CFPLHSEDTESIgAQIYSVAIFLGINLAAFIIIVfSYGSMFYSVHQSAIT 638
Cdd:cd15157  124 IWI--FVMA---ASSPLLSKGTSKYNSQtkCLDLHPSKIDKL-LILNYIVLVVGFILPFCTLSI-CYILIIKALLKPRVP 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 639 ATEIRNQVKKE--MILAKRFFFIvftdaLCWIPIFVVKFLSLLQVEIPGTIT----SWVVIFILPI-NSALNPILYTLTT 711
Cdd:cd15157  197 QSKLRVSHKKAllTIIITLILFL-----LCFLPYHILRTVHLMQWSEGQCNLrlhkAVVITLCLAAaNSCLDPLLYYFAG 271

                 ....*..
gi 767932467 712 RPFKEMI 718
Cdd:cd15157  272 ENFKERL 278
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
445-707 1.49e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 41.48  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 445 TCFGNIFV---ICMRPYIRSenKLYAMSIISLCCADCLMGIYLFviggfDLKFRGEYNKHaqlWMESTHCQLVGSLAILS 521
Cdd:cd15319   14 TLLGNILVcaaVVRFRHLRS--KVTNIFIVSLAVSDLFVALLVM-----PWKAVAEVAGY---WPFGAFCDVWVAFDIMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 522 TEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLI-LIWITGFIVAFIPLS---NKEFFKNYYGTNGVCFPLH-SED 596
Cdd:cd15319   84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMIsVAWTLSVLISFIPVQlnwHKDSGDDWVGLHNSSISRQvEEN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 597 TESIGAQIYSVAIFLGINLAAFIIIVFSYgSMFYSVHQSAITA------------------------TEIRNQVKKEMIL 652
Cdd:cd15319  164 CDSSLNRTYAISSSLISFYIPVAIMIVTY-TRIYRIAQIQIRRissleraaehaqscrsnridchhhTSLRTSIKKETKV 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932467 653 AKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPG----------TITSWVVIFILPINSALNPILY 707
Cdd:cd15319  243 LKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPAdpdaglpcvsETTFDVFVWFGWANSSLNPIIY 307
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
511-716 1.65e-03

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 40.91  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPgkcRTIT----VLILIWITGFIVAFIPLSNKEFFKNyyGTN 586
Cdd:cd15115   72 CKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNH---RSVLlaclLCGCIWILALLLCLPVFIYRTTVTD--GNH 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSedtesigAQIYSVAIFLGInLAAFIIIVFSYGSMFYSVHQSaiTATEIRNQVKKEMILAKRFFFIvftdalC 666
Cdd:cd15115  147 TRCGYDFL-------VAITITRAVFGF-LLPLLIIAACYSFIAFRMQRG--RFAKSQSKTFRVIIAVVVAFFV------C 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932467 667 WIPIFVVKFLSLLQVEIPG-TITSW--VVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15115  211 WAPYHIIGILSLYGDPPLSkVLMSWdhLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
511-669 2.19e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 40.68  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPF-RCVRPGKCRTITVLILIWITGFIVAfIPlsnKEFFKNYYG----- 584
Cdd:cd15123   73 CKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLeLQTSDAVLKTCCKAGCVWIVSMLFA-IP---EAVFSDLYSfrdpe 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 585 ---TNGVCFPLHSedTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITA-----TEIRNQVKKEMILAKRF 656
Cdd:cd15123  149 kntTFEACAPYPV--SEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMpaeehSHARKQIESRKRVAKTV 226
                        170
                 ....*....|...
gi 767932467 657 FFIVFTDALCWIP 669
Cdd:cd15123  227 LVLVALFAFCWLP 239
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
511-711 2.71e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 40.57  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTitVLILIWITGFIVAfIPlsNKEFFKNYYGTNGVcF 590
Cdd:cd15387   73 CRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRV--YVLFSWLLSLVFS-IP--QVHIFSLREVGNGV-Y 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 591 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQS------AITATEIRNQVKKEMILA----------- 653
Cdd:cd15387  147 DCWADFIQPWGPKAYITWITLSVYIIPVLILSVCYGLISFKIWQNvklktrRETKTPLSSAASGGAALArvssvkliska 226
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932467 654 -----KRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFIL-PINSALNPILYTLTT 711
Cdd:cd15387  227 kirtvKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLaSLNSCCNPWIYMFFT 290
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
167-260 3.10e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467  167 KLPPDCFKNyHDLQKLYLQNNkITSISIYAFRGLNSLTKLYLShNRITFLKPGVFEDLHrLEWLIIEDNhLSRISPPTFY 246
Cdd:pfam13306   2 SIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFS 76
                          90
                  ....*....|....
gi 767932467  247 GLNSLILLVLMNNV 260
Cdd:pfam13306  77 NCSNLKSITLPSNL 90
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
436-715 3.46e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 40.16  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 436 VFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLfviggfdLKFRGEYNKHAQLWMESTHCQLVG 515
Cdd:cd15062    5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTV-------LPFSATLEVLGYWAFGRIFCDVWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 516 SLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLSN-KEFFKNYYGTNGVcfplh 593
Cdd:cd15062   78 AVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTiVTARRATVALLIVWVLSLVISIGPLLGwKEPAPADEQACGV----- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 594 sedTESIGAQIYSVAIFLGINLAafIIIVfsygsMFYSVHqsaITATEIRNQVKKemilAKRFFFIVFTDALCWIPIFVV 673
Cdd:cd15062  153 ---NEEPGYVLFSSLGSFYLPLA--IILV-----MYCRVY---VVAFKFSREKKA----AKTLGIVVGAFVLCWFPFFVV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767932467 674 KFLSLL--QVEIPGTITSwVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15062  216 LPLGSLfsTLKPPEPVFK-VVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
521-708 4.52e-03

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 39.62  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPlsnkeffknYYGTNGVCfplhSEDTESI 600
Cdd:cd15344   82 SLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIP---------SVGWNCIC----DIENCSN 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 601 GAQIYSVA--IFLGI-NLAAFIIIVFSYGSMFYSVHQ-----SAITATEIRNQvKKEMILAKRFFFIVFTDALCWIPIFV 672
Cdd:cd15344  149 MAPLYSDSylVFWAIfNLVTFVVMVVLYAHIFGYVRQrtmrmSRHSSGPRRNR-DTMMSLLKTVVIVLGAFIICWTPGLV 227
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767932467 673 VKFLSLLQVEIPGTITSWVVIFILPINSALNPILYT 708
Cdd:cd15344  228 LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYS 263
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
432-725 5.20e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 39.59  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 432 IIQRVFVWVVSAVTCFGNIFVICMrpYIRSEN--KLYAMSIISLCCADclmgiylFVIGGFDLKFRGEYNKhAQLWMEST 509
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILA--FIKDKKlrTVSNFFLLNLAVAD-------FLVGLVSMPFYIPYTL-TGKWPFGK 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 510 H-CQLVGSLAILSTEVSVLLLTFLTLEKYICIVY-PFRCVRPGKCRTITVLILIWITGF------IVAFIPLSNK----- 576
Cdd:cd15048   71 VfCKAWLVVDYTLCTASALTIVLISLDRYLSVTKaVKYRAKQTKRRTVLLMALVWILAFllygpaIIGWDLWTGYsivpt 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 577 -----EFFKNYYGTNGVCF-----PLhsedtesigaqiYSVAIFlgiNLAAFI-IIVFSYGSMFYSV-----HQSAITAT 640
Cdd:cd15048  151 gdcevEFFDHFYFTFITSVleffiPF------------ISVSFF---NLLIYLnIRKRSRRRPLRSVpilpaSQNPSRAR 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 641 EIRNQVK--KEMILAKRFFFIVFTDALCWIPIfvvKFLSLLQVEIPGT-ITS-WVVIF--ILPINSALNPILYTLTTRpf 714
Cdd:cd15048  216 SQREQVKlrRDRKAAKSLAILVLVFLICWAPY---TILTIIRSFCSGScVDSyLYEFTfwLLWTNSAINPFLYAACHP-- 290
                        330
                 ....*....|.
gi 767932467 715 kemihRFWYNY 725
Cdd:cd15048  291 -----RFRKAF 296
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
437-716 6.69e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.26  E-value: 6.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 437 FVWVVSAVTCFGNIFV---ICMRPYIRSENKLYamsIISLCCADCLMGIYLFVIGGFdlkfrgeyNKHAQLWMES-THCQ 512
Cdd:cd15065    5 FLSLIIVLAIFGNVLVclaIFTDRRLRKKSNLF---IVSLAVADLLVALLVMTFAVV--------NDLLGYWLFGeTFCN 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 513 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLS-----NKEFFKNYYGTN 586
Cdd:cd15065   74 IWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERwMTTRRALVVIASVWILSALISFLPIHlgwhrLSQDEIKGLNHA 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVCFPLHSEDTESIGAQIYSVAIFlginLAAFIIIVFSYGSMFYSV--HQSAITATEI-----------------RNQVK 647
Cdd:cd15065  154 SNPKPSCALDLNPTYAVVSSLISF----YIPCLVMLLIYSRLYLYArkHVVNIKSQKLpsesgskfqvpslsskhNNQGV 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767932467 648 KEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 716
Cdd:cd15065  230 SDHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRR 298
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
165-284 6.86e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 165 IRKLPPDcFKNYHDLQKLYLQNNKITSISIYA----FRGLNSLTKLYLSHNRITflkpgvfedlhrlewliieDNHLSRI 240
Cdd:cd00116  182 IRALAEG-LKANCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLT-------------------DAGAAAL 241
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767932467 241 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQ---HMPRLHWLDLEGN 284
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaEKESLLELDLRGN 288
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
521-708 8.01e-03

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 39.03  E-value: 8.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 521 STEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPlsnkeffknYYGTNGVCfplhSEDTESI 600
Cdd:cd15101   82 SLTASVANLLAIAVERHISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIP---------SVGWNCLC----AIDACSN 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 601 GAQIYS---VAIFLGINLAAFIIIVFSYGSMFYSVHQ-----SAITATEIRNQvKKEMILAKRFFFIVFTDALCWIPIFV 672
Cdd:cd15101  149 MAPLYSrsyLVFWAISNLVTFLVMVVVYARIFVYVRRrtnrmSPHTSGSIRNR-DTMMSLLKTVVIVLGAFVVCWTPGLV 227
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767932467 673 VKFLSLLQVEIPGTITSWVVIFILP-INSALNPILYT 708
Cdd:cd15101  228 VLLLDGLCCRQCNVLAVEKFFLLLAeFNSAVNPIIYS 264
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
511-708 8.21e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 38.99  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA----FIplsnkefFKNYYGTN 586
Cdd:cd15388   73 CRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILSlpqvFI-------FSKVEVAP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 587 GVcFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIR-----------------NQVKKE 649
Cdd:cd15388  146 GV-YECWACFIEPWGLKAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIvavvkkkqllssrassvAEVSKA 224
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932467 650 MI-LAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFIL-PINSALNPILYT 708
Cdd:cd15388  225 MIkTVKMTLVIVLVYVLCWAPFFLVQLWSVWDPKAPTEGATFTILMLLaSLNSCTNPWIYM 285
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
512-715 8.60e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 39.12  E-value: 8.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 512 QLVGSLAILSTEVSVLLLTflTLEKYICIVYPFRCVR-PGKCRTITVLILIWITGFIVAFIPLsnkeFFKNYYGTNGVC- 589
Cdd:cd15340   76 KLGGVTASFTASVGSLFLT--AIDRYISIHRPLAYKRiVTRTKAVIAFCVMWTIAIVIAVLPL----LGWNCKKLNSVCs 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 590 --FPLHSEDTesigaqiysVAIFLGINLAAFIIIVFSYGSMFYSVHQSAI--------------------TATEIRNQVK 647
Cdd:cd15340  150 diFPLIDETY---------LMFWIGVTSVLLLFIVYAYMYILWKAHHHAVrmlqrgtqksiivytsedgkVQTTRPDQTR 220
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 648 KEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQV--EIPGTITSWVVIFILpINSALNPILYTLTTRPFK 715
Cdd:cd15340  221 MDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKmnKLIKTVFAFCSMLCL-LNSTVNPIIYALRSKDLR 289
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
511-715 9.80e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 38.78  E-value: 9.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 511 CQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCV---RPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNg 587
Cdd:cd15091   72 CKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALdfrTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTE- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932467 588 vCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVhQSAITATEIRNQVKKEMILAKRFFFIVFTDALCW 667
Cdd:cd15091  151 -CSLQFPDDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRL-KSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCW 228
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767932467 668 IPIFVVKFLSLLqVEIPGTITS----WVVIFILPINSALNPILYTLTTRPFK 715
Cdd:cd15091  229 TPIHIFILVEAL-GSVSHSTAAvssyYFCIALGYTNSSLNPILYAFLDENFK 279
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
322-363 9.98e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767932467  322 QKLDELDLGSNKIENLPPLifKDLKELSQLNLSYN-PIQKIQA 363
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL--AKLPNLETLDLSGNnKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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