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Conserved domains on  [gi|767932477|ref|XP_011530481|]
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relaxin receptor 1 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-387 2.86e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932477 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 387
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 4.35e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.35e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932477  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-387 2.86e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932477 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 387
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 154-399 2.06e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 154 NVTAMSLQWNLIRKLppDCFKNYHDLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRITFLKPgvFEDLHRLEWLIIE 233
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 234 DNHLSRISppTFYGLNSLILLVLMNNVLTrlPDKPLCQhmprlhwldlegnhihNLRNLTFISCSnLTVLVMRKNKINHL 313
Cdd:cd21340   77 GNRISVVE--GLENLTNLEELHIENQRLP--PGEKLTF----------------DPRSLAALSNS-LRVLNISGNNIDSL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 314 NEntFAPLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKiQANQFDYLVkLKSLSLE---GIEISNiQQR 388
Cdd:cd21340  136 EP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK-KPKYRDKII-LASKSLEvldGKEITD-TER 210

                        250
                 ....*....|.
gi 767932477 389 MFrpLMNLSHM 399
Cdd:cd21340  211 QF--LKRLKAR 219
LRR_8 pfam13855
Leucine rich repeat;
179-237 3.60e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 3.60e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932477  179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 4.35e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.35e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932477  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 153-364 1.53e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 232
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 233 EDNHLSRISPPTFYGLNSLILLVL-MNNVLTRLPDKPLCQhmpRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKIN 311
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSLaRNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932477 312 HLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQAN 364
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN 566
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-59 1.05e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767932477    26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 3.17e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 3.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932477   25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-387 2.86e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 173 FKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRITFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLI 252
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 253 LLVLMNNVLTRLPDkPLCQhMPRLHWLDLEGNHIHNLrNLTFISCSNLTVLVMRKNKINHLNEntFAPLQKLDELDLGSN 332
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767932477 333 KIENLPPLifKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 387
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
137-412 4.19e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 4.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 137 ELDCDETNLRAVPSV---SSNVTAMSLQWNLIRKLPPDcFKNYHDLQKLYLQNNKITSISIyAFRGLNSLTKLYLSHNRI 213
Cdd:COG4886  117 SLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 214 TFLkPGVFEDLHRLEWLIIEDNHLSRIsPPTFYGLNSLILLVLMNNVLTRLPDkpLCQhMPRLHWLDLEGNHIHNLRNLT 293
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGN-LTNLEELDLSNNQLTDLPPLA 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 294 fiSCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIfkDLKELSQLNLSYNPIQKIQANQFDYLVKLK 373
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI--LLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767932477 374 SLSLEGIEISNIQQRMFRPLMNLSHMYHNLLGSDFYSAH 412
Cdd:COG4886  346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 154-399 2.06e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 154 NVTAMSLQWNLIRKLppDCFKNYHDLQKLYLQNNKITSISiyAFRGLNSLTKLYLSHNRITFLKPgvFEDLHRLEWLIIE 233
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 234 DNHLSRISppTFYGLNSLILLVLMNNVLTrlPDKPLCQhmprlhwldlegnhihNLRNLTFISCSnLTVLVMRKNKINHL 313
Cdd:cd21340   77 GNRISVVE--GLENLTNLEELHIENQRLP--PGEKLTF----------------DPRSLAALSNS-LRVLNISGNNIDSL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 314 NEntFAPLQKLDELDLGSNKIENLPPL--IFKDLKELSQLNLSYNPIQKiQANQFDYLVkLKSLSLE---GIEISNiQQR 388
Cdd:cd21340  136 EP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK-KPKYRDKII-LASKSLEvldGKEITD-TER 210

                        250
                 ....*....|.
gi 767932477 389 MFrpLMNLSHM 399
Cdd:cd21340  211 QF--LKRLKAR 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
152-385 1.78e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 152 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLI 231
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 232 IEDNhlsrispPTFYGLNSLILLVLMNNVLTRLPDKplCQHMPRLHWLDLEGNHIHNLRNlTFISCSNLTVLVMRKNKIN 311
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932477 312 HLNENtFAPLQKLDELDLGSNKIENLPPLIFKdLKELSQLNLSYNPIQKIqANQFDYLVKLKSLSLEGIEISNI 385
Cdd:COG4886  173 DLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL 243
LRR_8 pfam13855
Leucine rich repeat;
179-237 3.60e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 3.60e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767932477  179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
202-261 1.82e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.82e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477  202 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 261
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
153-213 3.98e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 3.98e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932477  153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 213
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
274-334 8.38e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 8.38e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932477  274 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 334
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 196-358 3.35e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 3.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 196 AFRGLNSLTKLYLSHNRITFLKPGVFEDLHR---LEWLIIEDNHLS-RISPPTFYGLNSLIL----LVLMNNVLTRLPDK 267
Cdd:cd00116   76 GLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLPPalekLVLGRNRLEGASCE 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 268 PLC---QHMPRLHWLDLEGNHIHN--LRNL--TFISCSNLTVLVMRKNKINHLN----ENTFAPLQKLDELDLGSNKIEN 336
Cdd:cd00116  156 ALAkalRANRDLKELNLANNGIGDagIRALaeGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTD 235

                        170       180
                 ....*....|....*....|....*..
gi 767932477 337 LPPLIFKD-LKELSQ----LNLSYNPI 358
Cdd:cd00116  236 AGAAALASaLLSPNIslltLSLSCNDI 262
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-62 4.35e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.35e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767932477  27 CSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LRR_8 pfam13855
Leucine rich repeat;
226-286 1.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932477  226 RLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKpLCQHMPRLHWLDLEGNHI 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
298-358 1.32e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932477  298 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 358
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 153-364 1.53e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 153 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 232
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 233 EDNHLSRISPPTFYGLNSLILLVL-MNNVLTRLPDKPLCQhmpRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKIN 311
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSLaRNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767932477 312 HLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ-KIQAN 364
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN 566
LRR_8 pfam13855
Leucine rich repeat;
322-379 7.63e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932477  322 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 379
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-59 1.05e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767932477    26 KCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADE 59
Cdd:smart00192   1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 179-377 1.00e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMN 258
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQD 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 259 NVLT-RLPDKplCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPlQKLDELDLGSNKIENL 337
Cdd:PLN00113 414 NSFSgELPSE--FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGA 490

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767932477 338 PPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 377
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDL 530
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-62 3.17e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 3.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767932477   25 VKCSLGYFPCGNiTKCLPQLLHCNGVDDCGNQADEDNC 62
Cdd:pfam00057   1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
137-326 2.32e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 137 ELDCDETNLRAVPSV---SSNVTAMSLQWNLIRKLPpdCFKNYHDLQKLYLQNNKITSISIYAfrGLNSLTKLYLSHNRI 213
Cdd:COG4886  209 ELDLSGNQLTDLPEPlanLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 214 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 293
Cdd:COG4886  285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767932477 294 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDE 326
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 179-334 4.52e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 4.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 179 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMN 258
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD 293

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932477 259 NVLT-RLPDkpLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 334
Cdd:PLN00113 294 NSLSgEIPE--LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 167-260 4.01e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477  167 KLPPDCFKNyHDLQKLYLQNNkITSISIYAFRGLNSLTKLYLShNRITFLKPGVFEDLHrLEWLIIEDNhLSRISPPTFY 246
Cdd:pfam13306   2 SIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFS 76

                          90
                  ....*....|....
gi 767932477  247 GLNSLILLVLMNNV 260
Cdd:pfam13306  77 NCSNLKSITLPSNL 90
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-261 8.27e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 8.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 152 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLI 231
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                         90       100       110
                 ....*....|....*....|....*....|
gi 767932477 232 IEDNHLSRISPPTFYGLNSLILLVLMNNVL 261
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 174-375 8.74e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 8.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 174 KNYHDLQKLYLQNNKIT---SISI-YAFRGLNSLTKLYLSHNRITFlkPGVFEDLHRLEwliiednhlsrispptfyGLN 249
Cdd:COG5238  261 KNNTTVETLYLSGNQIGaegAIALaKALQGNTTLTSLDLSVNRIGD--EGAIALAEGLQ------------------GNK 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 250 SLILLVLMNNVLTRLPDKPLCQHM---PRLHWLDLEGNHIHNlrnltfISCSNLtvlvmrknkINHLNENTfaplqKLDE 326
Cdd:COG5238  321 TLHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIGD------EGAIAL---------AKYLEGNT-----TLRE 380

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767932477 327 LDLGSNKIENLPPL-IFKDLKE--LSQLNLSYNPI-QKIQANQFDYLVKLKSL 375
Cdd:COG5238  381 LNLGKNNIGKQGAEaLIDALQTnrLHTLILDGNLIgAEAQQRLEQLLERIKSV 433
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 179-211 8.79e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 8.79e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767932477  179 LQKLYLQNNKITSISiyAFRGLNSLTKLYLSHN 211
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 163-356 1.54e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 163 NLIRKLPPDCFKNYHDLQKLYLQNNKIT-SISiyafRG-LNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRI 240
Cdd:PLN00113 104 QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIP----RGsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932477 241 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQhMPRLHWLDLEGNhihNLRNLTFISCSNLTVLvmrknkiNHLN------ 314
Cdd:PLN00113 180 IPNSLTNLTSLEFLTLASNQLVGQIPRELGQ-MKSLKWIYLGYN---NLSGEIPYEIGGLTSL-------NHLDlvynnl 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767932477 315 ----ENTFAPLQKLDELDLGSNKIEN-LPPLIFkDLKELSQLNLSYN 356
Cdd:PLN00113 249 tgpiPSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDN 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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