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Conserved domains on  [gi|767932543|ref|XP_011530512|]
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sulfotransferase 1E1 isoform X2 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-165 3.40e-55

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.84  E-value: 3.40e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932543   37 PDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIF---NRIPFLECR----KENLMNGVKQLDEMNSPRIVKTHLP 109
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932543  110 PELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQ 165
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGK 136
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-165 3.40e-55

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.84  E-value: 3.40e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932543   37 PDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIF---NRIPFLECR----KENLMNGVKQLDEMNSPRIVKTHLP 109
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932543  110 PELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQ 165
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGK 136
PLN02164 PLN02164
sulfotransferase
 31-164 9.82e-13

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 64.94  E-value: 9.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932543  31 EAFQARPDDLVIATYPKSGTTWVSEIVYMIykegdVEKCKEDVIFNR---------IPFLECrKENLMNGVKQLDEMNSP 101
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAI-----ANRSRFDDSSNPllkrnphefVPYIEI-DFPFFPSVDVLKDKGNT 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932543 102 rIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNP-GSFPEFVEKFMQG 164
Cdd:PLN02164 147 -LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRG 209
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-165 3.40e-55

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.84  E-value: 3.40e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932543   37 PDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIF---NRIPFLECR----KENLMNGVKQLDEMNSPRIVKTHLP 109
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767932543  110 PELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQ 165
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGK 136
PLN02164 PLN02164
sulfotransferase
 31-164 9.82e-13

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 64.94  E-value: 9.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932543  31 EAFQARPDDLVIATYPKSGTTWVSEIVYMIykegdVEKCKEDVIFNR---------IPFLECrKENLMNGVKQLDEMNSP 101
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAI-----ANRSRFDDSSNPllkrnphefVPYIEI-DFPFFPSVDVLKDKGNT 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767932543 102 rIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNP-GSFPEFVEKFMQG 164
Cdd:PLN02164 147 -LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRG 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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