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Conserved domains on  [gi|767933086|ref|XP_011530723|]
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A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 237-438 5.26e-96

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 304.55  E-value: 5.26e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  237 YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIeRGNPSRSLENVCRW 316
Cdd:cd04273     1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLI-SGNAQKSLKSFCRW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  317 ASQQQRSDLNHSEHHDHAIFLTRQDF----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ 392
Cdd:cd04273    80 QKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 767933086  393 GNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLL 438
Cdd:cd04273   160 GNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 24-182 1.98e-39

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 142.45  E-value: 1.98e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086    24 ELVTPVSTNlegrylshtlsASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITD 103
Cdd:pfam01562    1 EVVIPVRLD-----------PSRRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPP 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   104 PINNHqpgsatyrirrteplqtnCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLErgKQMEEEKGRIHVVY 182
Cdd:pfam01562   70 VQTDH------------------CYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLE--KYSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 695-808 1.34e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.16  E-value: 1.34e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   695 TVKGTFTRTPRKlGYLKMFDIPPGARHVLIQEDEASPHILAIKNqATGHYILNGKGE-EAKSRTFIDLGVEWDYNI-EDD 772
Cdd:pfam05986    1 TVSGSFTEGRAK-GYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767933086   773 IESLHTDGPLHDPVIVLIIPQ-ENDTRSSLTYKYIIH 808
Cdd:pfam05986   79 LEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 453-521 4.78e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 93.56  E-value: 4.78e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   453 PGINYSMDEQCRFDFGVGYKMCTAFrTFDPCKQLWCSHPDNPYfCKTKKGPPLDGTECAAGKWCYKGHC 521
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKC 67
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 535-586 1.59e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.55  E-value: 1.59e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767933086    535 WGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 586
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 951-996 1.33e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 1.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767933086   951 WKTGPWSECSVTCGEGTEVRQVLCR--------AGDHCDG-EKPESVRACQLPPC 996
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsivPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 830-885 3.44e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 3.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767933086   830 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPkPIRRMCNIQEC 885
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 890-947 1.66e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   890 WVAEEWEHCTKTCGsSGYQLRTVRCLQPlldGTNRSVHSKYC-MGDRPESRRPCNRVPC 947
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQK---GGGSIVPDSECsAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 592-693 1.05e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   592 DFRAQQCQQRNSHFEYQN----TKHHW---LPYEHPDpkKRCHLYCQSkeTGDVAYMKQ--LVHDGTHCSYKDP-----Y 657
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGD--ALCRHMCRA--IGESFIMKRgdSFLDGTRCMPSGPredgtL 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767933086   658 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHC 693
Cdd:pfam19236   80 SLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1004-1032 8.61e-03

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 34.82  E-value: 8.61e-03
                           10        20
                   ....*....|....*....|....*....
gi 767933086  1004 DKSIFCQMEVLARYCSIPGYNKLCCESCS 1032
Cdd:pfam08686    3 DKFANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 237-438 5.26e-96

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 304.55  E-value: 5.26e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  237 YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIeRGNPSRSLENVCRW 316
Cdd:cd04273     1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLI-SGNAQKSLKSFCRW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  317 ASQQQRSDLNHSEHHDHAIFLTRQDF----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ 392
Cdd:cd04273    80 QKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 767933086  393 GNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLL 438
Cdd:cd04273   160 GNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 24-182 1.98e-39

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 142.45  E-value: 1.98e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086    24 ELVTPVSTNlegrylshtlsASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITD 103
Cdd:pfam01562    1 EVVIPVRLD-----------PSRRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPP 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   104 PINNHqpgsatyrirrteplqtnCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLErgKQMEEEKGRIHVVY 182
Cdd:pfam01562   70 VQTDH------------------CYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLE--KYSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 695-808 1.34e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.16  E-value: 1.34e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   695 TVKGTFTRTPRKlGYLKMFDIPPGARHVLIQEDEASPHILAIKNqATGHYILNGKGE-EAKSRTFIDLGVEWDYNI-EDD 772
Cdd:pfam05986    1 TVSGSFTEGRAK-GYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767933086   773 IESLHTDGPLHDPVIVLIIPQ-ENDTRSSLTYKYIIH 808
Cdd:pfam05986   79 LEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 239-441 1.42e-23

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 99.68  E-value: 1.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   239 IEVLLGVDDSVVRFHGK--EHVQNYLLTLMNIVNEIYHdeslGVHINVVLVRMIMLGYAKSISLIerGNPSRSLENVCRW 316
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSdtTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDKIDVS--GDANDTLRNFLKW 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   317 asqqQRSDLNHSEHHDHAIFLTRQDFGpAGMQGYAPVTGMCHPVRSCTLN---HEDGFSSAFVVAHETGHVLGMEHDGQG 393
Cdd:pfam01421   77 ----RQEYLKKRKPHDVAQLLSGVEFG-GTTVGAAYVGGMCSLEYSGGVNedhSKNLESFAVTMAHELGHNLGMQHDDFN 151

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 767933086   394 NRCGDETAMGSVMAPLVQAAFHRyHWSRCSGQELKRYIHSYD--CLLDDP 441
Cdd:pfam01421  152 GGCKCPPGGGCIMNPSAGSSFPR-KFSNCSQEDFEQFLTKQKgaCLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 453-521 4.78e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 93.56  E-value: 4.78e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   453 PGINYSMDEQCRFDFGVGYKMCTAFrTFDPCKQLWCSHPDNPYfCKTKKGPPLDGTECAAGKWCYKGHC 521
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKC 67
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 535-586 1.59e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.55  E-value: 1.59e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767933086    535 WGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 586
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 951-996 1.33e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 1.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767933086   951 WKTGPWSECSVTCGEGTEVRQVLCR--------AGDHCDG-EKPESVRACQLPPC 996
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsivPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 830-885 3.44e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 3.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767933086   830 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPkPIRRMCNIQEC 885
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 890-947 1.66e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   890 WVAEEWEHCTKTCGsSGYQLRTVRCLQPlldGTNRSVHSKYC-MGDRPESRRPCNRVPC 947
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQK---GGGSIVPDSECsAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 951-996 2.56e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.13  E-value: 2.56e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767933086    951 WKTGPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESvRACQLPPC 996
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCcspppqNGGGPCTGEDVET-RACNEQPC 52
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 592-693 1.05e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   592 DFRAQQCQQRNSHFEYQN----TKHHW---LPYEHPDpkKRCHLYCQSkeTGDVAYMKQ--LVHDGTHCSYKDP-----Y 657
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGD--ALCRHMCRA--IGESFIMKRgdSFLDGTRCMPSGPredgtL 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767933086   658 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHC 693
Cdd:pfam19236   80 SLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP_1 pfam00090
Thrombospondin type 1 domain;
533-586 1.52e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 48.95  E-value: 1.52e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767933086   533 GNWGSWTkfgSCSRTCGTGVRFRTRQCNNPMPinGGQDCPGVNFEYQLCNTEEC 586
Cdd:pfam00090    1 SPWSPWS---PCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 893-948 1.47e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 1.47e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767933086    893 EEWEHCTKTCGsSGYQLRTVRCLQPlldgtNRSVHSKYCMGDRPESrRPCNRVPCP 948
Cdd:smart00209    5 SEWSPCSVTCG-GGVQTRTRSCCSP-----PPQNGGGPCTGEDVET-RACNEQPCP 53
M6dom_TIGR03296 TIGR03296
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a ...
 364-404 4.79e-03

M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.


Pssm-ID: 274507 [Multi-domain]  Cd Length: 285  Bit Score: 40.47  E-value: 4.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767933086   364 TLNHEDGfsSAFVVAHETGHVLGM------EHDGQGNRCGDETAMGS 404
Cdd:TIGR03296  158 TIQPEDG--GIGVFAHELGHDLGLpdlydtQYDGGGEPVGYWSLMSS 202
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 829-885 5.57e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767933086    829 EWAlkSWSQCSKPCGGGFQYTKYGCrrKSDNKMVHRSFCEankKPKPIRRMCNIQEC 885
Cdd:smart00209    3 EWS--EWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCT---GEDVETRACNEQPC 52
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1004-1032 8.61e-03

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 34.82  E-value: 8.61e-03
                           10        20
                   ....*....|....*....|....*....
gi 767933086  1004 DKSIFCQMEVLARYCSIPGYNKLCCESCS 1032
Cdd:pfam08686    3 DKFANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 237-438 5.26e-96

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 304.55  E-value: 5.26e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  237 YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIeRGNPSRSLENVCRW 316
Cdd:cd04273     1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLI-SGNAQKSLKSFCRW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  317 ASQQQRSDLNHSEHHDHAIFLTRQDF----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ 392
Cdd:cd04273    80 QKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 767933086  393 GNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLL 438
Cdd:cd04273   160 GNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 24-182 1.98e-39

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 142.45  E-value: 1.98e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086    24 ELVTPVSTNlegrylshtlsASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITD 103
Cdd:pfam01562    1 EVVIPVRLD-----------PSRRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPP 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   104 PINNHqpgsatyrirrteplqtnCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLErgKQMEEEKGRIHVVY 182
Cdd:pfam01562   70 VQTDH------------------CYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLE--KYSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 695-808 1.34e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 131.16  E-value: 1.34e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   695 TVKGTFTRTPRKlGYLKMFDIPPGARHVLIQEDEASPHILAIKNqATGHYILNGKGE-EAKSRTFIDLGVEWDYNI-EDD 772
Cdd:pfam05986    1 TVSGSFTEGRAK-GYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767933086   773 IESLHTDGPLHDPVIVLIIPQ-ENDTRSSLTYKYIIH 808
Cdd:pfam05986   79 LEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 238-439 9.11e-30

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 117.33  E-value: 9.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  238 NIEVLLGVDDSVVRFHGK--EHVQNYLLTLMNIVNEIYHDeslgVHINVVLVRMIMLGYAKSISLieRGNPSRSLENVCR 315
Cdd:cd04269     2 YVELVVVVDNSLYKKYGSnlSKVRQRVIEIVNIVDSIYRP----LNIRVVLVGLEIWTDKDKISV--SGDAGETLNRFLD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  316 WasqqQRSDLNHSEHHDHAIFLTRQDFGPaGMQGYAPVTGMCHPVRSCTLNHEDG---FSSAFVVAHETGHVLGMEHDGQ 392
Cdd:cd04269    76 W----KRSNLLPRKPHDNAQLLTGRDFDG-NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGMEHDDG 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767933086  393 GNRCGDETAmgsVMAPlvQAAFHRYHWSRCSGQELKRYIHSYD--CLLD 439
Cdd:cd04269   151 GCTCGRSTC---IMAP--SPSSLTDAFSNCSYEDYQKFLSRGGgqCLLN 194
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 239-423 1.24e-25

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 105.19  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  239 IEVLLGVDDSVVR-FHGKE-HVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIErGNPSRSLENVCRW 316
Cdd:cd04267     3 IELVVVADHRMVSyFNSDEnILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPID-SDASNTLNSFSFW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  317 aSQQQRSdlnhseHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTL--NHEDGFSSAFVVAHETGHVLGMEHDGQGN 394
Cdd:cd04267    82 -RAEGPI------RHDNAVLLTAQDFIEGDILGLAYVGSMCNPYSSVGVveDTGFTLLTALTMAHELGHNLGAEHDGGDE 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 767933086  395 RCGDETAMGS-VMAPlVQAAFHRYHWSRCS 423
Cdd:cd04267   155 LAFECDGGGNyIMAP-VDSGLNSYRFSQCS 183
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 239-441 1.42e-23

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 99.68  E-value: 1.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   239 IEVLLGVDDSVVRFHGK--EHVQNYLLTLMNIVNEIYHdeslGVHINVVLVRMIMLGYAKSISLIerGNPSRSLENVCRW 316
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSdtTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDKIDVS--GDANDTLRNFLKW 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   317 asqqQRSDLNHSEHHDHAIFLTRQDFGpAGMQGYAPVTGMCHPVRSCTLN---HEDGFSSAFVVAHETGHVLGMEHDGQG 393
Cdd:pfam01421   77 ----RQEYLKKRKPHDVAQLLSGVEFG-GTTVGAAYVGGMCSLEYSGGVNedhSKNLESFAVTMAHELGHNLGMQHDDFN 151

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 767933086   394 NRCGDETAMGSVMAPLVQAAFHRyHWSRCSGQELKRYIHSYD--CLLDDP 441
Cdd:pfam01421  152 GGCKCPPGGGCIMNPSAGSSFPR-KFSNCSQEDFEQFLTKQKgaCLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 453-521 4.78e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 93.56  E-value: 4.78e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   453 PGINYSMDEQCRFDFGVGYKMCTAFrTFDPCKQLWCSHPDNPYfCKTKKGPPLDGTECAAGKWCYKGHC 521
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKC 67
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 535-586 1.59e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.55  E-value: 1.59e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767933086    535 WGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 586
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 951-996 1.33e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 1.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767933086   951 WKTGPWSECSVTCGEGTEVRQVLCR--------AGDHCDG-EKPESVRACQLPPC 996
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsivPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 830-885 3.44e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 3.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767933086   830 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPkPIRRMCNIQEC 885
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 239-431 9.14e-12

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 64.47  E-value: 9.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  239 IEVLLGVDDsvvRFHGKEHVQNYLLTLMNIVNEIYHDEsLGVHInvvlvrmimlgyakSISLIERGnpsrslenvcrwas 318
Cdd:cd00203     3 IPYVVVADD---RDVEEENLSAQIQSLILIAMQIWRDY-LNIRF--------------VLVGVEID-------------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  319 qqqrsdlnhseHHDHAIFLTRQDFgPAGMQGYAPVTGMCHPVRSCTL---NHEDGFSSAFVVAHETGHVLGMEHDGqGNR 395
Cdd:cd00203    51 -----------KADIAILVTRQDF-DGGTGGWAYLGRVCDSLRGVGVlqdNQSGTKEGAQTIAHELGHALGFYHDH-DRK 117

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 767933086  396 CGDE------------TAMGSVMAPLVQAAFH--RYHWSRCSGQELKRYI 431
Cdd:cd00203   118 DRDDyptiddtlnaedDDYYSVMSYTKGSFSDgqRKDFSQCDIDQINKLY 167
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
241-408 7.94e-11

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 62.44  E-value: 7.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   241 VLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESlgvHINVVLVRMIMLGYAKSISLIERGNPSRSLenvcRWASQQ 320
Cdd:pfam13688    7 LLVAADCSYVAAFGGDAAQANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPACSTGDSSD----RLSEFQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   321 QRSDLNHSEHHDHAIFLTRQDFGPAGMqGYAPVTGMCHPVRSCTLNHEDGF------SSAFVVAHETGHVLGMEHDGQGN 394
Cdd:pfam13688   80 DFSAWRGTQNDDLAYLFLMTNCSGGGL-AWLGQLCNSGSAGSVSTRVSGNNvvvstaTEWQVFAHEIGHNFGAVHDCDSS 158

                          170
                   ....*....|....
gi 767933086   395 RCGDETAMGSVMAP 408
Cdd:pfam13688  159 TSSQCCPPSNSTCP 172
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 890-947 1.66e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767933086   890 WVAEEWEHCTKTCGsSGYQLRTVRCLQPlldGTNRSVHSKYC-MGDRPESRRPCNRVPC 947
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQK---GGGSIVPDSECsAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 951-996 2.56e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.13  E-value: 2.56e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 767933086    951 WKTGPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESvRACQLPPC 996
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCcspppqNGGGPCTGEDVET-RACNEQPC 52
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 592-693 1.05e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086   592 DFRAQQCQQRNSHFEYQN----TKHHW---LPYEHPDpkKRCHLYCQSkeTGDVAYMKQ--LVHDGTHCSYKDP-----Y 657
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGD--ALCRHMCRA--IGESFIMKRgdSFLDGTRCMPSGPredgtL 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767933086   658 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHC 693
Cdd:pfam19236   80 SLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP_1 pfam00090
Thrombospondin type 1 domain;
953-996 8.44e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 8.44e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767933086   953 TGPWSECSVTCGEGTEVRQVLCRA----GDHCDGEKPEsVRACQLPPC 996
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIE-TQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
533-586 1.52e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 48.95  E-value: 1.52e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767933086   533 GNWGSWTkfgSCSRTCGTGVRFRTRQCNNPMPinGGQDCPGVNFEYQLCNTEEC 586
Cdd:pfam00090    1 SPWSPWS---PCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 533-586 4.07e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.66  E-value: 4.07e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767933086   533 GNWGSWTkfgSCSRTCGTGVRFRTRQCNNPmPINGGQDCPGVNfEYQLCNTEEC 586
Cdd:pfam19028    4 SEWSEWS---ECSVTCGGGVQTRTRTVIVE-PQNGGRPCPELL-ERRPCNLPPC 52
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 238-434 4.34e-07

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 51.97  E-value: 4.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  238 NIEVLLGVDDSVVRFHGK-EHVQNYLLTLMNIVNEIYHDESlGVHINVVLVRMIMLGYAKSISLIERGNP-----SRSLE 311
Cdd:cd04272     2 YPELFVVVDYDHQSEFFSnEQLIRYLAVMVNAANLRYRDLK-SPRIRLLLVGITISKDPDFEPYIHPINYgyidaAETLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767933086  312 NVCRWASQQqrsdlNHSEHHDHAIFLTRQDF-----GPA--GMQGYAPVTGMC--HPVRSCtlnhED---GFSSAFVVAH 379
Cdd:cd04272    81 NFNEYVKKK-----RDYFNPDVVFLVTGLDMstysgGSLqtGTGGYAYVGGACteNRVAMG----EDtpgSYYGVYTMTH 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767933086  380 ETGHVLGMEHDGQ---GNRCGDETAM------GSVMAPLVQAAFHrYHWSRCSGQELKRYIHSY 434
Cdd:cd04272   152 ELAHLLGAPHDGSpppSWVKGHPGSLdcpwddGYIMSYVVNGERQ-YRFSQCSQRQIRNVFRRL 214
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 893-948 1.47e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 1.47e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767933086    893 EEWEHCTKTCGsSGYQLRTVRCLQPlldgtNRSVHSKYCMGDRPESrRPCNRVPCP 948
Cdd:smart00209    5 SEWSPCSVTCG-GGVQTRTRSCCSP-----PPQNGGGPCTGEDVET-RACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 954-996 5.96e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.50  E-value: 5.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767933086   954 GPWSECSVTCGEGTEVRQ--VLCRA---GDHCdgekPES--VRACQLPPC 996
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRTrtVIVEPqngGRPC----PELleRRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 539-586 2.07e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.43  E-value: 2.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767933086   539 TKFGSCSRTCGTGVRFRTRQCNNPMP--INGGQDCPGVN--FEYQLCNTEEC 586
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCVQKGGgsIVPDSECSAQKkpPETQSCNLKPC 55
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 947-996 3.09e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 36.54  E-value: 3.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767933086   947 CPAQwkTGPWSECSVTCGEGTEVRQVlcRAGDHCDGEKpESvRACQLPPC 996
Cdd:pfam19035    1 CEEQ--STEWSPCSKTCGMGVSTRVS--NDNAECKLVT-ET-RLCQLRPC 44
M6dom_TIGR03296 TIGR03296
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a ...
 364-404 4.79e-03

M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.


Pssm-ID: 274507 [Multi-domain]  Cd Length: 285  Bit Score: 40.47  E-value: 4.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767933086   364 TLNHEDGfsSAFVVAHETGHVLGM------EHDGQGNRCGDETAMGS 404
Cdd:TIGR03296  158 TIQPEDG--GIGVFAHELGHDLGLpdlydtQYDGGGEPVGYWSLMSS 202
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 829-885 5.57e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767933086    829 EWAlkSWSQCSKPCGGGFQYTKYGCrrKSDNKMVHRSFCEankKPKPIRRMCNIQEC 885
Cdd:smart00209    3 EWS--EWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCT---GEDVETRACNEQPC 52
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1004-1032 8.61e-03

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 34.82  E-value: 8.61e-03
                           10        20
                   ....*....|....*....|....*....
gi 767933086  1004 DKSIFCQMEVLARYCSIPGYNKLCCESCS 1032
Cdd:pfam08686    3 DKFANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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