NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767915402|ref|XP_011531466|]
View 

T-cell surface glycoprotein CD8 beta chain isoform X1 [Homo sapiens]

Protein Classification

IgV_CD8_beta domain-containing protein( domain architecture ID 10166777)

IgV_CD8_beta domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-135 1.14e-73

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409497  Cd Length: 116  Bit Score: 219.63  E-value: 1.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  22 LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEK--IAVFRDASRF 99
Cdd:cd07700    1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDQEKliILSDSDSSRY 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767915402 100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVV 135
Cdd:cd07700   81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-135 1.14e-73

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 219.63  E-value: 1.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  22 LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEK--IAVFRDASRF 99
Cdd:cd07700    1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDQEKliILSDSDSSRY 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767915402 100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVV 135
Cdd:cd07700   81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-135 2.90e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.50  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402   24 QTPAYIKVQTNKMVMLSCEAKISLSN--MRIYWLRQrqaPSSDSHHEFLALWDSAKGtihgEEVEQEKIAVFRDASR--F 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEasTSVYWYRQ---PPGKGPTFLIAYYSNGSE----EGVKKGRFSGRGDPSNgdG 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767915402  100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVV 135
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-134 2.44e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 2.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402    26 PAYIKVQTNKMVMLSCEAKiSLSNMRIYWLRQRQAPSSdshheflalwdsakgtihgeevEQEKIAVFRDASRFILNLTS 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLA----------------------ESGRFSVSRSGSTSTLTISN 57

                           90       100
                   ....*....|....*....|....*....
gi 767915402   106 VKPEDSGIYFCMIVGSPELTFGkGTQLSV 134
Cdd:smart00410  58 VTPEDSGTYTCAATNSSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-135 1.14e-73

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 219.63  E-value: 1.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  22 LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEK--IAVFRDASRF 99
Cdd:cd07700    1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDQEKliILSDSDSSRY 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767915402 100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVV 135
Cdd:cd07700   81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 22-134 2.34e-31

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 111.66  E-value: 2.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  22 LQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQapssDSHHEFLALWDSAKGTIhGEEVEQEKIAVFRDASRFIL 101
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKP----GQGPEFLIYLSSSKGKT-KGGVPGRFSGSRDGTSSFSL 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767915402 102 NLTSVKPEDSGIYFCMIVGSP---ELTFGKGTQLSV 134
Cdd:cd00099   76 TISNLQPEDSGTYYCAVSESGgtdKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-135 2.90e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.50  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402   24 QTPAYIKVQTNKMVMLSCEAKISLSN--MRIYWLRQrqaPSSDSHHEFLALWDSAKGtihgEEVEQEKIAVFRDASR--F 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEasTSVYWYRQ---PPGKGPTFLIAYYSNGSE----EGVKKGRFSGRGDPSNgdG 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767915402  100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVV 135
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-134 8.38e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 63.06  E-value: 8.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  23 QQTPAYIKVQTNKMVMLSCEAKISLSNMrIYWLRQ--RQAPssdshhEFLAlwdsaKGTIHGEEVEQEKIAVFRDASR-- 98
Cdd:cd04983    2 TQSPQSLSVQEGENVTLNCNYSTSTFYY-LFWYRQypGQGP------QFLI-----YISSDSGNKKKGRFSATLDKSRks 69

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767915402  99 FILNLTSVKPEDSGIYFCMIVGSP---ELTFGKGTQLSV 134
Cdd:cd04983   70 SSLHISAAQLSDSAVYFCALSESGgtgKLTFGKGTRLTV 108
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 24-134 1.34e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 59.60  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  24 QTPAYIKVQTNKMVMLSCEAKISLSNMriYWLRQR--QAPssdshhEFLALWDSaKGTIHGEEVEQEKIAVFR-DASRFI 100
Cdd:cd05899    3 QSPRYLIKRRGQSVTLRCSQKSGHDNM--YWYRQDpgKGL------QLLFYSYG-GGLNEEGDLPGDRFSASRpSLTRSS 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767915402 101 LNLTSVKPEDSGIYFCMIV---GSPELTFGKGTQLSV 134
Cdd:cd05899   74 LTIKSAEPEDSAVYLCASSlggGADEAYFGPGTRLTV 110
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 22-134 8.83e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 57.76  E-value: 8.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  22 LQQTPAYIKVQTNKMVMLSCEAK-ISLSNMRIYWLRQR--QAPssdshhEFLALWDSAKGTIHGEEVEQEKIAVFRDA-- 96
Cdd:cd04982    1 LEQPQLSITREESKSVTISCKVSgIDFSTTYIHWYRQKpgQAL------ERLLYVSSTSAVRKDSGKTKNKFEARKDVgk 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767915402  97 SRFILNLTSVKPEDSGIYFCMIVGSPELT----FGKGTQLSV 134
Cdd:cd04982   75 STSTLTITNLEKEDSATYYCAYWESGSGYyikvFGSGTKLIV 116
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 21-134 8.85e-11

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 57.40  E-value: 8.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  21 VLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQR--QAPssdshhEFLALWDS--AKGTihgeeveQEKIAVFRDA 96
Cdd:cd04980    2 VMTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQKpgQAP------KLLIYYAStlHSGV-------PSRFSGSGSG 68

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767915402  97 SRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSV 134
Cdd:cd04980   69 TDFTLTISSVEPEDAAVYYCQQGYTFPYTFGGGTKLEI 106
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-134 2.44e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 2.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402    26 PAYIKVQTNKMVMLSCEAKiSLSNMRIYWLRQRQAPSSdshheflalwdsakgtihgeevEQEKIAVFRDASRFILNLTS 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLA----------------------ESGRFSVSRSGSTSTLTISN 57

                           90       100
                   ....*....|....*....|....*....
gi 767915402   106 VKPEDSGIYFCMIVGSPELTFGkGTQLSV 134
Cdd:smart00410  58 VTPEDSGTYTCAATNSSGSASS-GTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
39-116 1.55e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 1.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402    39 LSCEAK-ISLSNMRIYWLRQRQapssDSHHEFLALWDSAKGTIHGEEVEqEKIAVFRDASR--FILNLTSVKPEDSGIYF 115
Cdd:smart00406   4 LSCKFSgSTFSSYYVSWVRQPP----GKGLEWLGYIGSNGSSYYQESYK-GRFTISKDTSKndVSLTISNLRVEDTGTYY 78


                   .
gi 767915402   116 C 116
Cdd:smart00406  79 C 79
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 37-134 1.64e-08

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 51.54  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  37 VMLSCEAK-ISLSNMRIYWLRQrqAPSSDShhEFLALWDSAKGTIHGEEVEQEKIAVFRDASR--FILNLTSVKPEDSGI 113
Cdd:cd04981   16 LKLSCKASgFTFTSYGMGWVRQ--APGKGL--EWIGLIYPGGGDTYYADSFKGRFTITRDTSKstAYLQLNSLTSEDTAV 91

                         90       100
                 ....*....|....*....|....*.
gi 767915402 114 YFCMIVGSPELTF-----GKGTQLSV 134
Cdd:cd04981   92 YYCARGLGGYGYSyfdywGQGTTVTV 117
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 24-134 3.83e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 50.21  E-value: 3.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  24 QTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRqaPSsdshHEFLALwdsakgtIHGEEVEQEKIA-----VFRDASR 98
Cdd:cd07706    4 QAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQL--PS----GEMTFL-------IRQDSSEQNAKSgrysvNFQKAQK 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767915402  99 -FILNLTSVKPEDSGIYFCMIVGSPE---LTFGKGTQLSV 134
Cdd:cd07706   71 sISLTISALQLEDSAKYFCALSLPYDtdkLIFGKGTRLTV 110
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 37-126 5.83e-04

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 38.62  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  37 VMLSCEAKISLSNmRIYWLRQRQAPSSDSHheFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFC 116
Cdd:cd05720   16 VELVCEVLNSVPQ-GCSWLFQPRGSAPQPT--FLLYLSSSNKTKWAEGLDSKRFSGSRSGSSYVLTLKDFRKEDEGYYFC 92

                         90
                 ....*....|
gi 767915402 117 MIVGSPELTF 126
Cdd:cd05720   93 SVISNSVLYF 102
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 21-134 6.39e-04

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 38.21  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  21 VLQQtPAYIKVQTNKMVMLSCE-AKISLSNMRIYWLRQRqapsSDSHHEFLALWDSAKGTihGEEveqEKIAVFRDASRF 99
Cdd:cd04984    1 VLTQ-PSSLSVSPGETVTITCTgSSGNISGNYVNWYQQK----PGSAPRYLIYEDKHRPS--GIP---DRFSGSKSGNTA 70

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767915402 100 ILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSV 134
Cdd:cd04984   71 SLTISGAQTEDEADYYCQVWDSNSYVFGGGTKLTV 105
IgV_CD79b_beta cd16096
Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are ...
 24-134 1.83e-03

Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are composed of the immunoglobulin variable domain (IgV) of the Cluster of Differentiation (CD) 79B (also known as CD79b molecule, immunoglobulin-associated beta (Ig-beta), and B29). The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409515  Cd Length: 96  Bit Score: 36.85  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402  24 QTPAYIKVQTNKMVMLSCEAKISlSNMRIYWLRQRQAPSSdshhefLALwdsakgtihgeevEQEKIAVFRDASRFILNL 103
Cdd:cd16096    3 QHPRFAAKKRSSMVKFHCYTNYS-GVMTWFRKKGNQRPQE------LFP-------------EDGRISQTQNGSVYTLTI 62

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767915402 104 TSVKPEDSGIYFCMI---VGSPELTFGKGTQLSV 134
Cdd:cd16096   63 QNIQYEDNGIYFCQQkcnSTEPDVTDGCGTELLV 96
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 21-116 6.86e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.46  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915402   21 VLQQTPAYIKVQTNKMVMLSCEAKiSLSNMRIYWLRQRQAPSSDSHheflalwdsakgtihgeeveqekIAVFRDASRFI 100
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEAT-GSPPPTITWYKNGEPISSGST-----------------------RSRSLSGSNST 58

                          90
                  ....*....|....*.
gi 767915402  101 LNLTSVKPEDSGIYFC 116
Cdd:pfam13927  59 LTISNVTRSDAGTYTC 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH